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Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 16, pp. 7193 - 7207
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 02/2014, Volume 26, Issue 2, pp. 287 - 294
Apoptosis triggered by endoplasmic reticulum (ER) stress is associated with rapid attenuation of the IRE1α and ATF6 pathways but persistent activation of the... 
UPR | Melanoma | ERK | Endoplasmic reticulum stress | CANCER-CELLS | ACTIVATION | INDUCED APOPTOSIS | GRP78 | DEATH | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | INHIBITION | RESISTANCE | UP-REGULATION | Endoribonucleases - genetics | eIF-2 Kinase - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Activating Transcription Factor 6 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Eukaryotic Initiation Factor-2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Thapsigargin - toxicity | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | Melanoma - metabolism | Tunicamycin - toxicity | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Melanoma - pathology | Unfolded Protein Response | Activating Transcription Factor 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Eukaryotic Initiation Factor-2 - genetics | Cell Line, Tumor | Activating Transcription Factor 6 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Stress (Physiology) | Index Medicus | Stresses | Deregulation | Pathways | Attenuation | Activation | Endoplasmic reticulum | Survival | Apoptosis
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, pp. 13280 - 13280
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis;... 
IL-1-BETA PRODUCTION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | LACTATE | HMGB1 RELEASE | SEPTIC SHOCK | INTRACELLULAR LPS | SEPSIS | PKR ACTIVATION | INNATE IMMUNITY | Interleukin-18 - immunology | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Male | HMGB1 Protein - immunology | HMGB1 Protein - secretion | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - secretion | Female | Membrane Proteins - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Disease Models, Animal | eIF-2 Kinase - genetics | Interleukin-1beta - secretion | Sepsis - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Coinfection - immunology | Carrier Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Membrane Proteins - immunology | Naphthoquinones - pharmacology | Thyroid Hormones - genetics | eIF-2 Kinase - antagonists & inhibitors | Mice, Knockout | Thyroid Hormones - immunology | Carrier Proteins - genetics | Coinfection - microbiology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Membrane Proteins - antagonists & inhibitors | Thyroid Hormones - metabolism | Inflammasomes - immunology | Myeloid Cells - metabolism | Interleukin-18 - secretion | Mice | Mice, Inbred BALB C | Glycolysis - immunology | Sepsis - microbiology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1251 - 1266
HIV-1 infection results in a chronic illness because longterm highly active antiretroviral therapy can lower viral titers to an undetectable level. However,... 
TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | TUMOR-NECROSIS-FACTOR | MULTIPLE-SCLEROSIS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | MONONUCLEAR-CELLS | INFECTED-CELLS | SMALL NONCODING RNAS | NF-KAPPA-B | Exosomes - metabolism | eIF-2 Kinase - metabolism | Humans | MicroRNAs - metabolism | Lymphotoxin-alpha - metabolism | Toll-Like Receptor 3 - antagonists & inhibitors | Leukocytes - immunology | HIV Infections - immunology | Lymphotoxin-alpha - secretion | Activating Transcription Factors - metabolism | Exosomes - immunology | Toll-Like Receptor 3 - genetics | Active Transport, Cell Nucleus | Interleukin-6 - metabolism | Exosomes - virology | eIF-2 Kinase - genetics | HIV Infections - blood | Cell Line | Cytokines - metabolism | HIV Infections - virology | Cells, Cultured | Cytokines - secretion | Mice, Transgenic | Toll-Like Receptor 3 - metabolism | Interleukin-6 - secretion | eIF-2 Kinase - antagonists & inhibitors | HIV-1 - immunology | Animals | Leukocytes - virology | Leukocytes - secretion | Mice, Inbred NOD | MicroRNAs - blood | Leukocytes - metabolism | Cell Line, Transformed | Cell Transformation, Viral | Index Medicus | exosome (vesicle) | Molecular Bases of Disease | protein kinase RNA-activated (PKR) | TAR RNA | human immunodeficiency virus (HIV) | cytokinesis | macrophage | toll-like receptor (TLR)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14050 - 14065
Nonalcoholic fatty liver disease (steatosis) is the most prevalent liver disease in the Western world. One of the advanced pathologies is nonalcoholic... 
Non-alcoholic Fatty Liver Disease - pathology | Transcription Factor CHOP - genetics | Liver - pathology | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Vesicular Transport Proteins - metabolism | eIF-2 Kinase - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Green Fluorescent Proteins - genetics | Liver - physiopathology | Recombinant Fusion Proteins - metabolism | Endoplasmic Reticulum - pathology | Liver - immunology | RNA Interference | eIF-2 Kinase - genetics | Biomarkers - metabolism | Green Fluorescent Proteins - metabolism | Liver - metabolism | Non-alcoholic Fatty Liver Disease - immunology | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Transcription Factor CHOP - antagonists & inhibitors | Non-alcoholic Fatty Liver Disease - metabolism | Non-alcoholic Fatty Liver Disease - physiopathology | Unfolded Protein Response | Disease Progression | eIF-2 Kinase - antagonists & inhibitors | Hep G2 Cells | Protein Transport | Carrier Proteins - genetics | Carrier Proteins - metabolism | Biopsy | Endoplasmic Reticulum Stress | Endoplasmic Reticulum - immunology | Autophagy-Related Protein 5 - metabolism | Recombinant Fusion Proteins - genetics | Transcription Factor CHOP - metabolism | Index Medicus | eukaryotic initiation factor 2 (eIF2) | autophagy | eukaryotic translation initiation | translation control | unfolded protein response (UPR) | Protein Synthesis and Degradation
Journal Article
Cancer Letters, ISSN 0304-3835, 2008, Volume 274, Issue 1, pp. 40 - 46
Abstract We studied potential interactions between the endoplasmic reticulum (ER) stress response and the MEK/ERK pathway. Induction of ER stress did not... 
Hematology, Oncology and Palliative Medicine | ER stress | GRP78 | Gastric cancer | MEK/ERK | Apoptosis | PATHWAYS | TRANSCRIPTION | MITOCHONDRIA | DEATH | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | CYTOCHROME-C | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | MELANOMA-CELLS | EXPRESSION | Up-Regulation | Endoribonucleases - genetics | Adenocarcinoma - pathology | Molecular Chaperones - metabolism | eIF-2 Kinase - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Endoribonucleases - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Activating Transcription Factor 6 - genetics | MAP Kinase Kinase 1 - genetics | Adenocarcinoma - metabolism | Caspases - metabolism | Endoplasmic Reticulum - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adenocarcinoma - genetics | Tumor Cells, Cultured | Protein-Serine-Threonine Kinases - metabolism | eIF-2 Kinase - genetics | Stomach Neoplasms - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Antiviral Agents - pharmacology | Endoribonucleases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase 1 - metabolism | Blotting, Western | eIF-2 Kinase - antagonists & inhibitors | Activating Transcription Factor 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Tunicamycin - pharmacology | Thapsigargin - pharmacology | Activating Transcription Factor 6 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Kinases | Protein folding | Stress | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 2017, Volume 140, Issue 6, pp. 1768 - 1783
Signalling through the PERK/eIF2 alpha-P branch of the unfolded protein response plays a critical role in controlling protein synthesis rates in cells. This... 
Drug repurposing | Neurodegeneration | Therapeutics | Dementia | therapeutics | OXIDATIVE STRESS | INITIATION | ALZHEIMERS-DISEASE | ER STRESS | neurodegeneration | MECHANISMS | SUPPRESSION | NEUROSCIENCES | CLINICAL NEUROLOGY | drug repurposing | UNFOLDED PROTEIN RESPONSE | MOUSE MODEL | dementia | DIBENZOYLMETHANE | PLASTICITY | Index Medicus | Abridged Index Medicus | Original
Journal Article