X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1720) 1720
eif-2 kinase - metabolism (1647) 1647
animals (1553) 1553
eif-2 kinase - genetics (1058) 1058
mice (928) 928
phosphorylation (926) 926
biochemistry & molecular biology (705) 705
apoptosis (616) 616
cell biology (591) 591
cell line (490) 490
activation (489) 489
signal transduction (472) 472
unfolded protein response (466) 466
eukaryotic initiation factor-2 - metabolism (464) 464
proteins (464) 464
eif-2 kinase (394) 394
er stress (383) 383
viruses (381) 381
protein-serine-threonine kinases - metabolism (373) 373
kinases (368) 368
endoplasmic-reticulum stress (365) 365
male (357) 357
pkr (344) 344
expression (342) 342
interferon (339) 339
double-stranded-rna (335) 335
female (331) 331
protein biosynthesis (326) 326
molecular sequence data (322) 322
gene expression (310) 310
cells, cultured (309) 309
virology (309) 309
cell line, tumor (305) 305
endoplasmic reticulum (302) 302
rna (297) 297
nf-kappa-b (273) 273
eif-2 kinase - antagonists & inhibitors (268) 268
endoplasmic reticulum - metabolism (262) 262
research (258) 258
gene-expression (255) 255
mutation (252) 252
research article (249) 249
cells (245) 245
endoplasmic reticulum stress (240) 240
enzyme activation (239) 239
translation (233) 233
protein kinases (232) 232
protein folding (231) 231
base sequence (229) 229
messenger-rna (228) 228
amino acid sequence (226) 226
mice, knockout (226) 226
gene expression regulation (223) 223
hela cells (223) 223
stress (220) 220
virus diseases (218) 218
multidisciplinary sciences (216) 216
protein-serine-threonine kinases - genetics (216) 216
immunology (215) 215
oncology (212) 212
oxidative stress (212) 212
protein binding (211) 211
apoptosis - drug effects (205) 205
signal transduction - drug effects (205) 205
translational control (199) 199
inhibition (197) 197
cancer (196) 196
eif-2 kinase - physiology (196) 196
mice, inbred c57bl (194) 194
rna, messenger - genetics (194) 194
rna, messenger - metabolism (193) 193
transfection (191) 191
rats (182) 182
rna, double-stranded - metabolism (180) 180
blotting, western (177) 177
endoribonucleases - metabolism (177) 177
analysis (176) 176
endoplasmic reticulum stress - drug effects (175) 175
perk (169) 169
biology (167) 167
health aspects (166) 166
dependent protein-kinase (163) 163
kinase (162) 162
physiological aspects (160) 160
transcription factor chop - metabolism (159) 159
eukaryotic initiation factor-2 - genetics (156) 156
activating transcription factor 4 - metabolism (151) 151
environment and public health (147) 147
genetic aspects (146) 146
medicine (144) 144
protein kinase (144) 144
transcription factors - metabolism (144) 144
heat-shock proteins - metabolism (143) 143
dna-binding proteins - metabolism (142) 142
nf-kappa b - metabolism (141) 141
activating transcription factor 6 - metabolism (138) 138
autophagy (138) 138
biochemical phenomena, metabolism, and nutrition (137) 137
protein-kinase pkr (135) 135
inflammation (134) 134
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2615) 2615
Japanese (23) 23
Chinese (6) 6
Polish (3) 3
French (2) 2
Russian (2) 2
Ukrainian (2) 2
German (1) 1
Hungarian (1) 1
Norwegian (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular cancer, ISSN 1476-4598, 2017, Volume 16, Issue 1, pp. 91 - 13
Journal Article
by Liu, Z and Lv, Y and Zhao, N and Guan, G and Wang, J
Cell death & disease, ISSN 2041-4889, 2015, Volume 6, Issue 7, pp. e1822 - e1822
Journal Article
Cardiovascular diabetology, ISSN 1475-2840, 2013, Volume 12, Issue 1, pp. 158 - 158
.... Moreover, in order to clarify the roles of IRE1 (inositol - requiring enzyme-1), PERK (protein kinase RNA (PKR)-like ER kinase) and ATF6 (activating transcription factor-6... 
Diabetic cardiomyopathy | Oxidative stress | Apoptosis | Endoplasmic reticulum stress | MITOCHONDRIAL OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | ER STRESS | PREVENTION | SUPPRESSION | RAT MODEL | MYOCARDIAL APOPTOSIS | CELL-DEATH | HEART | ENDOCRINOLOGY & METABOLISM | MICE | CONTRIBUTES | Free Radical Scavengers - pharmacology | Diabetic Cardiomyopathies - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | eIF-2 Kinase - metabolism | eIF-2 Kinase - drug effects | Activating Transcription Factor 6 - genetics | Activating Transcription Factor 6 - drug effects | Gene Knockdown Techniques | Membrane Proteins - metabolism | Diabetes Mellitus, Experimental - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Endoplasmic Reticulum Stress - drug effects | Membrane Proteins - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Rats, Sprague-Dawley | Activating Transcription Factor 6 - metabolism | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Acetylcysteine - pharmacology | Protein-Serine-Threonine Kinases - drug effects | Glucose - metabolism | Membrane Proteins - drug effects | Myocytes, Cardiac - metabolism | Signal Transduction - physiology | Apoptosis - physiology | Endoplasmic Reticulum Stress - physiology | Studies | Kinases | Rodents | Animal models
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 10, p. e45078
Journal Article
European journal of immunology, ISSN 0014-2980, 2013, Volume 43, Issue 5, pp. 1147 - 1152
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43651 - 43664
.... Here we demonstrate that direct activation of RNase L coordinates the activation of c-Jun N-terminal kinase (JNK... 
CANCER-CELLS | BCL-X-L | INTERFERON ACTION | APOPTOSIS | ENCEPHALOMYOCARDITIS VIRUS | ACTIVATION | BECLIN 1 | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | JNK1-MEDIATED PHOSPHORYLATION | Cardiovirus Infections - genetics | Endoribonucleases - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | eIF-2 Kinase - metabolism | Humans | Cardiovirus Infections - pathology | Mitogen-Activated Protein Kinase 9 - genetics | Autophagy | Embryo, Mammalian - metabolism | MAP Kinase Signaling System | Heat-Shock Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitogen-Activated Protein Kinase 8 - genetics | RNA, Double-Stranded - metabolism | Encephalomyocarditis virus - physiology | Fibroblasts - metabolism | Respirovirus Infections - genetics | eIF-2 Kinase - genetics | Sendai virus - physiology | Embryo, Mammalian - pathology | Endoribonucleases - metabolism | Mitogen-Activated Protein Kinase 9 - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Cardiovirus Infections - metabolism | Fibroblasts - pathology | Mice, Knockout | Animals | Adaptor Proteins, Signal Transducing - genetics | RNA, Double-Stranded - genetics | Cell Line, Tumor | Respirovirus Infections - metabolism | Respirovirus Infections - pathology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Virus Replication - physiology | Host-Pathogen Interactions | Signal Transduction | PKR | RNase L | Innate Immunity | Antiviral Effect | Ribonuclease | Jun N-terminal Kinase (JNK)
Journal Article
PloS one, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0160484
... such as hypodiploid cells, DNA ladders, chromatin-condensed cells, and cleaved caspase (Casp)-3/poly(ADP ribose) polymerase (PARP) proteins. Pharmacological studies using chemical inhibitors of mitogen-activated protein kinase... 
SURVIVAL | JNK ACTIVATION | THERAPY | ASSAY | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | MITOCHONDRIA | BAX | DEATH | PERK | Kidney Neoplasms - genetics | Apoptosis - drug effects | eIF-2 Kinase - metabolism | Humans | Caspase 3 - metabolism | Carcinoma, Renal Cell - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Kidney Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspase 3 - genetics | Indoles - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Carcinoma, Renal Cell - drug therapy | eIF-2 Kinase - genetics | Adenine - analogs & derivatives | Signal Transduction | Carcinoma, Renal Cell - pathology | Gene Expression Regulation | Adenine - pharmacology | Anthracenes - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Kidney Neoplasms - pathology | Mitogen-Activated Protein Kinases - genetics | Protein Kinase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Kidney Neoplasms - drug therapy | Quinazolines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Chemical inhibitors | Phosphorylation | Physiological aspects | Genetic aspects | Carcinoma, Renal cell | Research | Risk factors | Apoptosis | Chromatin | Transcription factors | Bcl-2 protein | Kinases | Autophagy | Cancer therapies | Proteins | Mitochondria | Ribose | Rodents | Membrane potential | Growth factors | Deoxyribonucleic acid--DNA | Medical research | Enzymes | c-Jun protein | Poly(ADP-ribose) polymerase | Caspase | Adenosine diphosphate | MAP kinase | Pharmacology | Permeability | Ribonucleic acid--RNA | Chemicals | 1-Phosphatidylinositol 3-kinase | Inhibitors | Protein kinase | Cell death | In vivo methods and tests | Endoplasmic reticulum | Viability | Ladders | Clear cell-type renal cell carcinoma | Kidney transplantation | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 7, p. e67750
Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV... 
REPLICATION | TUMOR-SUPPRESSOR FUNCTION | RNA | MALIGNANT-TRANSFORMATION | PKR | MULTIDISCIPLINARY SCIENCES | LIVER | GENE-EXPRESSION | INITIATION-FACTOR EIF-2 | CELL-LINE | INTERLEUKIN-8 | Phosphorylation | Cell Proliferation | Hepatitis C - metabolism | eIF-2 Kinase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Aged, 80 and over | Adult | Female | Hepacivirus - physiology | Liver Neoplasms - pathology | eIF-2 Kinase - genetics | Liver Neoplasms - virology | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Proto-Oncogene Proteins c-jun - genetics | Proto-Oncogene Proteins c-fos - metabolism | Hepatitis C - genetics | Carcinoma, Hepatocellular - virology | Host-Pathogen Interactions | Mitogen-Activated Protein Kinase 3 - metabolism | Proto-Oncogene Proteins c-jun - metabolism | Carcinoma, Hepatocellular - pathology | Hepatitis C - virology | Liver Neoplasms - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Aged | Hepatitis C - pathology | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Physiological aspects | Development and progression | Genetic aspects | Cellular signal transduction | Research | Hepatoma | Hepatitis C virus | Protein kinases | Cell proliferation | Biotechnology | eIF-2 kinase | Transcription factors | Genes | Viruses | Hepatocellular carcinoma | Infections | Kinases | Western blotting | Proteins | Hepatitis | Liver cancer | Cell growth | Transfection | Replicating | Protein kinase R | Gastroenterology | c-Fos protein | Deoxyribonucleic acid--DNA | University graduates | RNA viruses | Cytokines | Double-stranded RNA | Extracellular signal-regulated kinase | c-Jun protein | siRNA | Gene expression | Ribonucleic acid--RNA | Medicine | Signaling | Hospitals | Hepatitis C | Binding sites | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal Article
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2018, Volume 172, Issue 4, pp. 811 - 824.e14
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such... 
type I interferon | neuronal progenitor cells | RNA editing | innate immunity | PKR | Aicardi-Goutieres syndrome | Alu elements | translation | AGS | ADAR1 | MDA5 | INTERFERON | COMPLEX | INHIBITION | PROTEIN-KINASE PKR | LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING | CELL BIOLOGY | Inflammation - pathology | RNA-Binding Proteins - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Protein Biosynthesis | Nervous System Malformations - immunology | Adenosine Deaminase - metabolism | eIF-2 Kinase - metabolism | Humans | Cell Death - immunology | eIF-2 Kinase - immunology | RNA Polymerase II - metabolism | Neural Stem Cells - cytology | RNA Polymerase II - immunology | Inflammation - metabolism | Neural Stem Cells - immunology | Cell Death - genetics | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | HEK293 Cells | RNA, Double-Stranded - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | eIF-2 Kinase - genetics | Adenosine Deaminase - genetics | RNA-Binding Proteins - immunology | Interferon-Induced Helicase, IFIH1 - metabolism | Inflammation - immunology | Gene Knockout Techniques | Interferon-Induced Helicase, IFIH1 - immunology | Neural Stem Cells - pathology | Autoimmune Diseases of the Nervous System - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | Inflammation - genetics | RNA Polymerase II - genetics | Alu Elements | Neural Stem Cells - metabolism | Adenosine Deaminase - immunology | RNA-Binding Proteins - metabolism | Prevention | Medical colleges | Enzymes | Messenger RNA | Microbiology