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Cardiovascular diabetology, ISSN 1475-2840, 2013, Volume 12, Issue 1, pp. 158 - 158
.... Moreover, in order to clarify the roles of IRE1 (inositol - requiring enzyme-1), PERK (protein kinase RNA (PKR)-like ER kinase) and ATF6 (activating transcription factor-6... 
Diabetic cardiomyopathy | Oxidative stress | Apoptosis | Endoplasmic reticulum stress | MITOCHONDRIAL OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | ER STRESS | PREVENTION | SUPPRESSION | RAT MODEL | MYOCARDIAL APOPTOSIS | CELL-DEATH | HEART | ENDOCRINOLOGY & METABOLISM | MICE | CONTRIBUTES | Free Radical Scavengers - pharmacology | Diabetic Cardiomyopathies - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | eIF-2 Kinase - metabolism | eIF-2 Kinase - drug effects | Activating Transcription Factor 6 - genetics | Activating Transcription Factor 6 - drug effects | Gene Knockdown Techniques | Membrane Proteins - metabolism | Diabetes Mellitus, Experimental - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Endoplasmic Reticulum Stress - drug effects | Membrane Proteins - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Rats, Sprague-Dawley | Activating Transcription Factor 6 - metabolism | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Acetylcysteine - pharmacology | Protein-Serine-Threonine Kinases - drug effects | Glucose - metabolism | Membrane Proteins - drug effects | Myocytes, Cardiac - metabolism | Signal Transduction - physiology | Apoptosis - physiology | Endoplasmic Reticulum Stress - physiology | Studies | Kinases | Rodents | Animal models
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7413, pp. 670 - 674
...)-1 beta, IL-18 and high-mobility group box 1 (HMGB1)(1-5). By studying HMGB1 release mechanisms, here we identify a role for double-stranded RNA-dependent protein kinase... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e55108
.... Although protein kinase regulated by double-stranded RNA (PKR) has been found to promote the innate signaling in response to infection by several viruses, its role in the innate response to DENV infection is still unclear... 
DOUBLE-STRANDED-RNA | PKR-DEPENDENT ACTIVATION | MULTIDISCIPLINARY SCIENCES | RIG-I | INFECTION | INDUCTION | CELLULAR ACTIVATOR | BINDING PROTEIN | ADAPTER IPS-1 | TRANSLATION | NF-KAPPA-B | Interferons - biosynthesis | eIF-2 Kinase - metabolism | Humans | Alveolar Epithelial Cells - virology | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Alveolar Epithelial Cells - immunology | Gene Knockdown Techniques | Interferon-Induced Helicase, IFIH1 | RNA, Double-Stranded - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | DEAD-box RNA Helicases - metabolism | Dengue - immunology | Dengue - genetics | eIF-2 Kinase - genetics | Cell Line | DEAD Box Protein 58 | Gene Expression Regulation | Alveolar Epithelial Cells - metabolism | Immunity, Innate | Hep G2 Cells | DEAD-box RNA Helicases - genetics | Virus Replication | Poly I-C - metabolism | Dengue - metabolism | Interferon Regulatory Factor-3 - metabolism | Dengue Virus - physiology | Adaptor Proteins, Signal Transducing - metabolism | Infection | Medical research | RNA | Dengue viruses | Medicine, Experimental | Interferon | Vaccines | Biological response modifiers | Health aspects | Mitogens | Protein kinases | eIF-2 kinase | Epithelial cells | Viral diseases | Viruses | Innate immunity | Infections | Kinases | Immunity | Tropical diseases | Cell growth | Cascades | Rodents | Binding | Vector-borne diseases | NF-κB protein | Immune response | RNA-mediated interference | Dengue fever | Dengue | Double-stranded RNA | JNK protein | Gene expression | Ribonucleic acid--RNA | Signaling | Microscopy | Lungs | Protein kinase | Immunofluorescence | Interferon regulatory factor | Viral infections | Ribonucleic acid
Journal Article
Circulation research, ISSN 1524-4571, 2007, Volume 101, Issue 9, pp. 919 - 927
Journal Article
Hypertension (Dallas, Tex. 1979), ISSN 1524-4563, 2014, Volume 64, Issue 4, pp. 738 - 744
Journal Article
Molecular carcinogenesis, ISSN 0899-1987, 2015, Volume 54, Issue 10, pp. 1096 - 1109
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2013, Volume 288, Issue 5, pp. 3571 - 3584
Autophagy has been shown to facilitate replication or production of avian reovirus (ARV); nevertheless, how ARV induces autophagy remains largely unknown.... 
DOUBLE-STRANDED-RNA | HEPATITIS-C VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASS GENOME SEGMENTS | SIGMA-C | MAMMALIAN AUTOPHAGY | VERO CELLS | CULTURED-CELLS | CONJUGATION SYSTEM | CELL-DEATH | APOPTOSIS INDUCTION | AMP-Activated Protein Kinases - metabolism | Microtubule-Associated Proteins - metabolism | eIF-2 Kinase - metabolism | Humans | RNA, Messenger - metabolism | Autophagy | Gene Knockdown Techniques | Eukaryotic Initiation Factor-2 - metabolism | RNA, Double-Stranded - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Line | PTEN Phosphohydrolase - genetics | Capsid Proteins - metabolism | Orthoreovirus, Avian - metabolism | Phagosomes - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | PTEN Phosphohydrolase - metabolism | Signal Transduction - genetics | Orthoreovirus, Avian - physiology | Orthoreovirus, Avian - growth & development | Apoptosis Regulatory Proteins - metabolism | Animals | Models, Biological | Chickens | Viral Nonstructural Proteins - metabolism | Mice | Enzyme Activation | Virus Replication - physiology | AMP-Activated Protein Kinases - genetics | Capsid Proteins - genetics | Viral Replication | Signal Transduction | Avian Reovirus | mTOR | Protein Kinase RNA (PKR) | PTEN | AMP-activated Kinase (AMPK) | p17 Protein
Journal Article
Nature communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 13280
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis;... 
IL-1-BETA PRODUCTION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | LACTATE | HMGB1 RELEASE | SEPTIC SHOCK | INTRACELLULAR LPS | SEPSIS | PKR ACTIVATION | INNATE IMMUNITY | Interleukin-18 - immunology | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Male | HMGB1 Protein - immunology | HMGB1 Protein - secretion | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - secretion | Female | Membrane Proteins - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Disease Models, Animal | eIF-2 Kinase - genetics | Interleukin-1beta - secretion | Sepsis - immunology | DNA-Binding Proteins - immunology | Pyruvate Kinase - metabolism | Membrane Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Coinfection - immunology | Carrier Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Membrane Proteins - immunology | Naphthoquinones - pharmacology | Thyroid Hormones - genetics | eIF-2 Kinase - antagonists & inhibitors | Mice, Knockout | Thyroid Hormones - immunology | Carrier Proteins - genetics | Coinfection - microbiology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Membrane Proteins - antagonists & inhibitors | Thyroid Hormones - metabolism | Inflammasomes - immunology | Myeloid Cells - metabolism | Interleukin-18 - secretion | Mice | Mice, Inbred BALB C | Pyruvate Kinase - genetics | Glycolysis - immunology | Sepsis - microbiology
Journal Article
Molecular cell, ISSN 1097-2765, 2006, Volume 21, Issue 4, pp. 521 - 531
Oxygen (O 2) deprivation, or hypoxia, has profound effects on cell metabolism and growth... 
RNA | CELLCYCLE | SIGNALING | MAMMALIAN TARGET | RAPAMYCIN | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | GAP | ELONGATION-FACTOR-2 | TSC2 | TUBEROUS-SCLEROSIS | MTOR | CELL BIOLOGY | Protein Kinases - metabolism | Protein Biosynthesis | eIF-2 Kinase - metabolism | Humans | Multienzyme Complexes - metabolism | Ras Homolog Enriched in Brain Protein | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Hypoxia-Inducible Factor 1 - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Peptide Elongation Factor 2 - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Eukaryotic Initiation Factor-2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | Cell Line | Tumor Suppressor Proteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Gene Expression Regulation | Neuropeptides - metabolism | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Energy Metabolism | Monomeric GTP-Binding Proteins - metabolism | Hypoxia | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Enzyme Activation | Peptide Elongation Factor 2 - metabolism | Messenger RNA | Growth | Energy conservation | Oncology, Experimental | Physiological aspects | Research | Cancer | eEF2 | Rheb | mTOR | AMPK | eIF2
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2009, Volume 274, Issue 1, pp. 40 - 46
... enzyme 1 (IRE1) and double-stranded RNA-activated protein kinase-like ER kinase (PERK) [1–3] . Under unstressed conditions, the luminal domains of these sensors... 
Hematology, Oncology and Palliative Medicine | GRP78 | ER stress | Gastric cancer | MEK/ERK | Apoptosis | PATHWAYS | TRANSCRIPTION | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | RELEASE | CYTOCHROME-C | UNFOLDED PROTEIN RESPONSE | MELANOMA | ONCOLOGY | EXPRESSION | BRAIN | Up-Regulation | Endoribonucleases - genetics | Adenocarcinoma - pathology | Molecular Chaperones - metabolism | eIF-2 Kinase - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Endoribonucleases - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Activating Transcription Factor 6 - genetics | MAP Kinase Kinase 1 - genetics | Adenocarcinoma - metabolism | Caspases - metabolism | Endoplasmic Reticulum - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adenocarcinoma - genetics | Tumor Cells, Cultured | Protein-Serine-Threonine Kinases - metabolism | eIF-2 Kinase - genetics | Stomach Neoplasms - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Antiviral Agents - pharmacology | Endoribonucleases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase 1 - metabolism | Blotting, Western | eIF-2 Kinase - antagonists & inhibitors | Activating Transcription Factor 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Tunicamycin - pharmacology | Thapsigargin - pharmacology | Activating Transcription Factor 6 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article