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Journal Article
Cancer Science, ISSN 1347-9032, 04/2018, Volume 109, Issue 4, pp. 919 - 925
Double‐stranded (ds) RNA‐dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate... 
mitogen‐activated protein kinase (MAPK) | hepatitis C virus (HCV) | hepatocellular carcinoma (HCC) | interferon | double‐stranded (ds) RNA‐dependent protein kinase (PKR) | mitogen-activated protein kinase (MAPK) | double-stranded (ds) RNA-dependent protein kinase (PKR) | INTERFERON ACTION | DOUBLE-STRANDED-RNA | AUTOPHOSPHORYLATION SITES | INDUCED APOPTOSIS | CHRONIC HEPATITIS-C | HEPATOCELLULAR-CARCINOMA | TUMOR-SUPPRESSOR FUNCTION | ONCOLOGY | MALIGNANT-TRANSFORMATION | SIGNALING PATHWAY | VIRUS CORE PROTEIN | Liver cancer | RNA | Liver | Interferon | B cells | Biological response modifiers | Hepatitis C virus | Hepatitis C | Health aspects | Mitogens | Liver cirrhosis | Protein kinases | eIF-2 kinase | Phosphorylation | Transcription | Leukemia | Homeostasis | Hepatocellular carcinoma | Infections | Kinases | Autophagy | Proteins | Signal transduction | Hepatitis | Cell growth | Protein kinase R | Tumor necrosis factor-TNF | Colon | Cytokines | Threonine | Immunoregulation | Research & development--R&D | Therapeutic applications | Double-stranded RNA | MAP kinase | Inflammation | Roles | Ribonucleic acid--RNA | Metabolism | Lymphocytes B | Protein synthesis | Breast | Tumor suppressor genes | Protein-serine/threonine kinase | Alzheimers disease | Endoplasmic reticulum | Metabolic disorders | Apoptosis | Review
Journal Article
Cellular Signalling, ISSN 0898-6568, 02/2014, Volume 26, Issue 2, pp. 287 - 294
Apoptosis triggered by endoplasmic reticulum (ER) stress is associated with rapid attenuation of the IRE1α and ATF6 pathways but persistent activation of the... 
UPR | Melanoma | ERK | Endoplasmic reticulum stress | CANCER-CELLS | ACTIVATION | INDUCED APOPTOSIS | GRP78 | DEATH | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | INHIBITION | RESISTANCE | UP-REGULATION | Endoribonucleases - genetics | eIF-2 Kinase - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Activating Transcription Factor 6 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Eukaryotic Initiation Factor-2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Thapsigargin - toxicity | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | Melanoma - metabolism | Tunicamycin - toxicity | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Melanoma - pathology | Unfolded Protein Response | Activating Transcription Factor 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Eukaryotic Initiation Factor-2 - genetics | Cell Line, Tumor | Activating Transcription Factor 6 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Stress (Physiology) | Stresses | Deregulation | Pathways | Attenuation | Activation | Endoplasmic reticulum | Survival | Apoptosis
Journal Article
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, p. 13280
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis;... 
IL-1-BETA PRODUCTION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | LACTATE | HMGB1 RELEASE | SEPTIC SHOCK | INTRACELLULAR LPS | SEPSIS | PKR ACTIVATION | INNATE IMMUNITY | Interleukin-18 - immunology | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Male | HMGB1 Protein - immunology | HMGB1 Protein - secretion | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - secretion | Female | Membrane Proteins - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Disease Models, Animal | eIF-2 Kinase - genetics | Interleukin-1beta - secretion | Sepsis - immunology | DNA-Binding Proteins - immunology | Pyruvate Kinase - metabolism | Membrane Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Coinfection - immunology | Carrier Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Membrane Proteins - immunology | Naphthoquinones - pharmacology | Thyroid Hormones - genetics | eIF-2 Kinase - antagonists & inhibitors | Mice, Knockout | Thyroid Hormones - immunology | Carrier Proteins - genetics | Coinfection - microbiology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Membrane Proteins - antagonists & inhibitors | Thyroid Hormones - metabolism | Inflammasomes - immunology | Myeloid Cells - metabolism | Interleukin-18 - secretion | Mice | Mice, Inbred BALB C | Pyruvate Kinase - genetics | Glycolysis - immunology | Sepsis - microbiology
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24343 - 24358
Previously, using primary hepatocytes residing in early G 1 phase, we demonstrated that expression of the cyclin-dependent kinase (CDK) inhibitor protein p21... 
PATHWAYS | ACTIVATION | FAS RECEPTOR | RAT HEPATOCYTES | PHOSPHORYLATION | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | MDM2 | CELL-DEATH | P53 | Cholagogues and Choleretics - pharmacology | Proto-Oncogene Proteins c-mdm2 - genetics | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | eIF-2 Kinase - metabolism | Bile - metabolism | Male | Autophagy - physiology | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Hepatocytes - metabolism | fas Receptor - metabolism | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | MAP Kinase Kinase 1 - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cyclin-Dependent Kinase Inhibitor Proteins - genetics | Hepatocytes - cytology | fas Receptor - genetics | Phosphorylation - drug effects | MAP Kinase Kinase 2 - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | bcl-2-Associated X Protein - genetics | eIF-2 Kinase - genetics | Gene Expression | Adenine - analogs & derivatives | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | MAP Kinase Kinase 1 - metabolism | Adenine - pharmacology | MAP Kinase Kinase 2 - metabolism | Rats, Sprague-Dawley | Mice, Knockout | Animals | Apoptosis Regulatory Proteins | Deoxycholic Acid - pharmacology | Autophagy-Related Protein 5 | Deoxycholic Acid - metabolism | Mice | Apoptosis - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Tumor Suppressor Proteins | Cyclin-Dependent Kinase Inhibitor Proteins - antagonists & inhibitors | Index Medicus | Mechanisms of Signal Transduction
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43651 - 43664
Autophagy is a tightly regulated mechanism that mediates sequestration, degradation, and recycling of cellular proteins, organelles, and pathogens. Several... 
CANCER-CELLS | BCL-X-L | INTERFERON ACTION | APOPTOSIS | ENCEPHALOMYOCARDITIS VIRUS | ACTIVATION | BECLIN 1 | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | JNK1-MEDIATED PHOSPHORYLATION | Cardiovirus Infections - genetics | Endoribonucleases - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | eIF-2 Kinase - metabolism | Humans | Cardiovirus Infections - pathology | Mitogen-Activated Protein Kinase 9 - genetics | Autophagy | Embryo, Mammalian - metabolism | MAP Kinase Signaling System | Heat-Shock Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitogen-Activated Protein Kinase 8 - genetics | RNA, Double-Stranded - metabolism | Encephalomyocarditis virus - physiology | Fibroblasts - metabolism | Respirovirus Infections - genetics | eIF-2 Kinase - genetics | Sendai virus - physiology | Embryo, Mammalian - pathology | Endoribonucleases - metabolism | Mitogen-Activated Protein Kinase 9 - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Cardiovirus Infections - metabolism | Fibroblasts - pathology | Mice, Knockout | Animals | Adaptor Proteins, Signal Transducing - genetics | RNA, Double-Stranded - genetics | Cell Line, Tumor | Respirovirus Infections - metabolism | Respirovirus Infections - pathology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Virus Replication - physiology | Host-Pathogen Interactions | Signal Transduction | PKR | RNase L | Innate Immunity | Antiviral Effect | Ribonuclease | Jun N-terminal Kinase (JNK)
Journal Article