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Autophagy, ISSN 1554-8627, 07/2018, Volume 14, Issue 7, pp. 1288 - 1289
The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution... 
EIF5A | translation | ATG3 | ribosome | autophagy | lipidation | CELL BIOLOGY
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 01/2018, Volume 17, Issue 1, pp. 374 - 385
Journal Article
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 03/2016, Volume 7, Issue 2016, pp. 245 - 245
Journal Article
Amino acids, ISSN 0939-4451, 11/2017, Volume 49, Issue 11, pp. 1793 - 1804
Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that... 
polyamine | hypusine | enzyme assay | post-translational modification | deoxyhypusine synthase | eIF5A
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2017, Volume 68, Issue 3, pp. 515 - 527.e6
Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation... 
EF-P | RNA | prolines | stalling | a-IF5A | single particle cryo-EM | ribosome | nascent chain | translation elongation | eIF5A | MOLECULAR-DYNAMICS | AMINOACYL-TRANSFER-RNA | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDE-BOND FORMATION | CRYO-EM | FACTOR EIF5A | PROTEIN-SYNTHESIS | 70S RIBOSOME | PROLINE RESIDUES | CELL BIOLOGY | Peptide Elongation Factors - metabolism | Protein Biosynthesis | Ribosomes - metabolism | Escherichia coli Proteins - ultrastructure | Structure-Activity Relationship | RNA, Messenger - metabolism | Peptide Initiation Factors - chemistry | Peptides - metabolism | Escherichia coli - metabolism | RNA, Transfer - genetics | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | Peptide Elongation Factors - genetics | Peptides - chemistry | RNA, Transfer - metabolism | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Ribosomes - chemistry | Escherichia coli Proteins - metabolism | Molecular Dynamics Simulation | Cryoelectron Microscopy | Peptide Initiation Factors - metabolism | Peptide Elongation Factors - chemistry | Ribosomes - ultrastructure | Escherichia coli - genetics | Peptide Elongation Factors - ultrastructure | Escherichia coli Proteins - genetics | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | Molecular Docking Simulation | Mutation | Escherichia coli Proteins - chemistry | RNA-Binding Proteins - metabolism | Proteins | Proline | Transfer RNA | Codon | Lysine | Cells | Protein binding | Index Medicus
Journal Article
Journal of Virology, ISSN 0022-538X, 10/2018, Volume 92, Issue 20
Polyamines and hypusinated eIF5A have been implicated in the replication of diverse viruses; however, defining their roles in supporting virus replication is... 
Ebola virus | Polyamines | Hypusination | Spermidine | eIF5A | hypusination | spermidine | MESSENGER-RNAS | PROTEIN | VIROLOGY | TRANSCRIPTION | polyamines | PROMOTES TRANSLATION | 100K | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1997 - 2007
In pancreatic ductal adenocarcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1,... 
BREAST-CANCER | OCT4 | CARCINOGENESIS | ONCOLOGY | DUCTAL ADENOCARCINOMA | SELF-RENEWAL | YAP | KRAS | TAZ | TRANSLATION FACTOR EIF5A | NANOG EXPRESSION | RNA-Binding Proteins - genetics | Pancreatic Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Octamer Transcription Factor-3 - biosynthesis | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Peptide Initiation Factors - biosynthesis | Carcinoma, Pancreatic Ductal - genetics | Octamer Transcription Factor-3 - genetics | RNA-Binding Proteins - biosynthesis | Protein-Tyrosine Kinases - genetics | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Protein-Tyrosine Kinases - biosynthesis | Phosphoproteins - biosynthesis | Signal Transduction | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Pancreatic Neoplasms - genetics | Transcription Factors - biosynthesis | Phosphoproteins - genetics | Transcription Factors - genetics | Carcinoma, Pancreatic Ductal - pathology | Peptide Initiation Factors - metabolism | Transcription Factors - metabolism | Peptide Initiation Factors - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Cycle - physiology | Cell Line, Tumor | Cytoskeleton - metabolism | Adaptor Proteins, Signal Transducing - biosynthesis | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Adenocarcinoma | Translation | Transcription factors | Oct-4 protein | c-Myc protein | Translation initiation | Tumorigenicity | Myc protein | Kinases | Adhesion | K-Ras protein | Proteins | Yes-associated protein | Signal transduction | Signaling | Pathways | Pancreatic cancer | Proteomics | Interrogation | Stem cells | Cytoskeleton | Protein expression | Focal adhesion kinase | Cancer | Index Medicus | YAP1 | PEAK1 | pancreatic ductal adenocarcinoma | eIF5A
Journal Article
American journal of reproductive immunology (New York, N.Y. : 1989), ISSN 1046-7408, 3/2014, Volume 71, Issue 3, pp. 229 - 240
Journal Article
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 04/2012, Volume 11, Issue 4, pp. 2316 - 2330
Aaptamine is a marine compound isolated from the sponge Aaptos aaptos showing antiproliferative properties via an undefined mode of action. We analyzed the... 
hypusination | differentiation | aaptamine | marine alkaloids | germ cell cancer | proteome analysis | antiproliferative activity | eIF5A | CARCINOMA-CELLS | TARGET | FACTOR 5A EIF5A | BIOCHEMICAL RESEARCH METHODS | DOWN-REGULATION | NEURONAL DIFFERENTIATION | HYPUSINE | SPONGE | RETINOIC ACID RECEPTOR | DEOXYHYPUSINE SYNTHASE | BINDING PROTEIN-II | Proteome - genetics | Humans | Molecular Sequence Data | Proteome - drug effects | Electrophoresis, Gel, Two-Dimensional | Biological Products - pharmacology | Proteins - analysis | Neoplasms, Germ Cell and Embryonal - chemistry | Dose-Response Relationship, Drug | HEK293 Cells | Neoplasms, Germ Cell and Embryonal - drug therapy | Antineoplastic Agents - pharmacology | Lysine - metabolism | Proteomics - methods | Amino Acid Sequence | Cell Survival - drug effects | Lysine - analogs & derivatives | Reproducibility of Results | Oxidoreductases Acting on CH-NH Group Donors - genetics | Neoplasms, Germ Cell and Embryonal - metabolism | Oxidoreductases Acting on CH-NH Group Donors - metabolism | Proteome - analysis | Peptide Initiation Factors - metabolism | Proteins - genetics | Proteins - metabolism | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Neoplasms, Germ Cell and Embryonal - pathology | Proteome - metabolism | Naphthyridines - pharmacology | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 1/2011, Volume 75, Issue 1, pp. 167 - 178
Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein known to contain the unusual amino acid hypusine. It is a highly conserved... 
Life Sciences | Plant Pathology | Biochemistry, general | Rosa chinensis | Resistance | Abiotic stress | Arabidopsis | Plant Sciences | eIF5A | FACTOR EIF-5A | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | EIF5A MUTANT | SACCHAROMYCES-CEREVISIAE | PLANT SCIENCES | HYPUSINE-CONTAINING PROTEIN | DEOXYHYPUSINE SYNTHASE | FACTOR 4D | PLANT-GROWTH | EXPRESSION | NUCLEOCYTOPLASMIC TRANSPORT | RNA-Binding Proteins - genetics | Arabidopsis - physiology | Oxidative Stress | Sodium Chloride - pharmacology | Stress, Physiological | Molecular Sequence Data | Osmosis | Phylogeny | Adaptation, Physiological - genetics | Lithium Chloride - pharmacology | Plants, Genetically Modified | Rosa - metabolism | Cadmium Chloride - pharmacology | Amino Acid Sequence | Hydrochloric Acid - pharmacology | Peptide Initiation Factors - classification | Adaptation, Physiological - physiology | Hot Temperature | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - genetics | Peptide Initiation Factors - metabolism | RNA-Binding Proteins - classification | Sequence Homology, Amino Acid | Peptide Initiation Factors - genetics | Gene Expression Regulation, Plant - drug effects | Rosa - genetics | RNA-Binding Proteins - metabolism | Arabidopsis thaliana | Biotechnology | Cellular proteins | Messenger RNA | Genetically engineered foods | Genetically modified organisms | Food | Proteins | Amino acids | Cellular biology | Stress | Botany | Index Medicus
Journal Article
Journal Article
Journal Article