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2005, 1, ISBN 9780824754242, xviii, 486
This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the... 
Vascular endothelium | Endothelins | Endothelial Cells | Endothelium | Other branches of medicine | Hematology | Oncology
Book
Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1202 - 1213
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch... 
LYMPHATIC ENDOTHELIUM | KINASE-ACTIVITY | VASCULAR NETWORK FORMATION | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | EXTRACELLULAR-MATRIX | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | FACTOR RECEPTOR-3 | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Signal transduction | Immunoglobulins | Membranes | Biochemistry | Kinases | Binding sites | Index Medicus | Biological Sciences
Journal Article
Angiogenesis, ISSN 0969-6970, 6/2012, Volume 15, Issue 2, pp. 171 - 185
Pharmacological inhibition of VEGF-A has proven to be effective in inhibiting angiogenesis and vascular leak associated with cancers and various eye diseases.... 
Biomedicine | Age-related macular degeneration | Cancer Research | Oncology | Affinity | Ophthalmology | VEGF receptor | Cardiology | Aflibercept | Placental growth factor | Biomedicine general | Cell Biology | EYE DISEASE | MACULAR DEGENERATION | PHASE-II | CHOROIDAL NEOVASCULARIZATION | FACTOR THERAPY | IN-VITRO | PROLIFERATIVE DIABETIC-RETINOPATHY | PATHOLOGICAL CONDITIONS | RETINAL DISEASES | PERIPHERAL VASCULAR DISEASE | INTRAVITREAL BEVACIZUMAB | Angiogenesis Inhibitors - immunology | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor B - antagonists & inhibitors | Recombinant Fusion Proteins - pharmacology | Endothelial Cells - metabolism | Humans | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor B - immunology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - immunology | Enzyme Activation - drug effects | Bevacizumab | Endothelial Cells - immunology | Vascular Endothelial Growth Factor B - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | HEK293 Cells | Ranibizumab | Vascular Endothelial Growth Factor Receptor-1 - immunology | Antibodies, Monoclonal, Humanized - immunology | Index Medicus | Original Paper
Journal Article
Circulation Research, ISSN 0009-7330, 04/2017, Volume 120, Issue 9, pp. 1414 - 1425
RATIONALE:Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas... 
Blood vessels | vascular leakage | VE-Cadherin | vascular biology | VEGF receptor regulation | REGRESSION | LYMPHATIC ENDOTHELIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | RECEPTOR VEGFR-3 | ANGIOGENESIS | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | blood vessels | IN-VIVO | PERIPHERAL VASCULAR DISEASE | ADHERENS JUNCTIONS | HEMATOLOGY | Cadherins - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic | Capillary Permeability - drug effects | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Carcinoma, Lewis Lung - blood supply | Adherens Junctions - metabolism | Antigens, CD - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Transfection | Female | Vascular Endothelial Growth Factor A - pharmacology | Tight Junctions - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Vascular Endothelial Growth Factor Receptor-2 - deficiency | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Genotype | Retinal Vessels - drug effects | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Carcinoma, Lewis Lung - metabolism | Mice, Knockout | Phenotype | Animals | Signal Transduction - drug effects | Lung - blood supply | Neovascularization, Physiologic | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Leakage | Phosphorylation | Kidneys | Cell junctions | Permeability | Gene deletion | Cadherin | Endothelial cells | Vascular endothelial growth factor receptors | Gene silencing | Angiogenesis | Clonal deletion | Rodents | Fibrinogen | Localization | Vascular endothelial growth factor | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 110 - 114
Developing tissues and growing tumours produce vascular endothelial growth factors (VEGFs), leading to the activation of the corresponding receptors in... 
TIP CELL-FORMATION | DLL4 | ACTIVATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | GROWTH | NETWORK FORMATION | KINASE INHIBITORS | TUMOR ANGIOGENESIS | EXPRESSION | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Up-Regulation | Vascular Endothelial Growth Factor Receptor-3 - biosynthesis | Receptors, Notch - metabolism | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intracellular Signaling Peptides and Proteins - deficiency | Membrane Proteins - deficiency | Receptors, Notch - antagonists & inhibitors | HEK293 Cells | Female | Transcription, Genetic | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Endothelial Cells - metabolism | Membrane Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - deficiency | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Neovascularization, Physiologic - physiology | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | Models, Biological | Mice | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Cellular control mechanisms | Physiological aspects | Growth factor receptors | Neovascularization | Research | Vascular endothelial growth factor | Endothelium | Angiogenesis | Ligands | Kinases | Rodents | Index Medicus
Journal Article
1999, Current topics in microbiology and immunology, ISBN 3540647317, Volume 237, 189
Book
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5178 - 16
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2015, Volume 290, Issue 26, pp. 16451 - 16462
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2167 - 2180
Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and... 
VASCULAR DEVELOPMENT | MEDICINE, RESEARCH & EXPERIMENTAL | EMBRYONIC LYMPHANGIOGENESIS | SKELETAL-MUSCLE | CCBE1 | LYMPHATIC VESSELS | FACTOR-C | TYROSINE KINASES | LIGAND | LYMPHEDEMA | ENDOTHELIAL GROWTH-FACTOR | Cell Proliferation | Humans | Vascular Endothelial Growth Factor D - deficiency | Vascular Endothelial Growth Factor C - deficiency | ADAMTS Proteins - deficiency | Lymphatic Vessels - metabolism | Procollagen N-Endopeptidase - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | HEK293 Cells | Vascular Endothelial Growth Factor D - genetics | Peptide Hydrolases - metabolism | Calcium-Binding Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | ADAMTS Proteins - metabolism | Endothelial Cells - metabolism | Procollagen N-Endopeptidase - genetics | Lymphangiogenesis - physiology | Calcium-Binding Proteins - deficiency | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Vascular Endothelial Growth Factor D - metabolism | Animals | Endothelial Cells - cytology | Models, Biological | Vascular Endothelial Growth Factor C - metabolism | Ligands | Mice | Lymphangiogenesis - genetics | ADAMTS Proteins - genetics | Calcium-Binding Proteins - genetics | Genetic aspects | Neovascularization | Proteolysis | Vascular endothelial growth factor | Health aspects | Studies | Lymphatic system | Lymphedema | Rodents | Cloning | Zebrafish | Skin | Experiments | Defects | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 27265 - 27278
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit... 
LYMPHATIC VESSELS | ACTIVATION | METASTASIS | SPECIFICITY | VEGF-D PROMOTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR LYMPHANGIOGENESIS | GENE-THERAPY | LIGAND | SPREAD | CANCER | Humans | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Lymphatic Vessels - metabolism | Female | Lymphangiogenesis | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor D - genetics | Vascular Endothelial Growth Factor D - chemistry | Antibodies, Neutralizing | Dermis - metabolism | Mutagenesis, Site-Directed | Signal Transduction | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Mice, SCID | Mutation - genetics | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor D - metabolism | Animals | Endothelium, Vascular - metabolism | Vascular Endothelial Growth Factor C - metabolism | Lymphatic Vessels - pathology | Dermis - pathology | Endothelium, Vascular - pathology | Mice, Inbred NOD | Neovascularization, Pathologic - metabolism | Vascular Endothelial Growth Factor Receptor-3 - genetics | Index Medicus | receptor | angiogenesis | endothelial cell | lymphangiogenesis | mutagenesis in vitro | vascular endothelial growth factor (VEGF) | Cell Biology
Journal Article
STEM CELLS, ISSN 1066-5099, 04/2017, Volume 35, Issue 4, pp. 952 - 966
The capability to derive endothelial cell (ECs) from induced pluripotent stem cells (iPSCs) holds huge therapeutic potential for cardiovascular disease. This... 
Vascular disease | QKI‐5 | Angiogenesis | Endothelial cell differentiation | Induced pluripotent stem cells | QKI-5 | PROGENITOR CELLS | DEFINED FACTORS | RNA-BINDING PROTEIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | ONCOLOGY | BLOOD-VESSEL DEVELOPMENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CARDIAC-HYPERTROPHY | IN-VIVO | HUMAN FIBROBLASTS | VE-CADHERIN | HEMATOLOGY | EXPRESSION | Human Umbilical Vein Endothelial Cells - metabolism | Endothelial Cells - metabolism | Humans | Mice, Inbred C57BL | 3' Untranslated Regions - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - metabolism | Regional Blood Flow | Animals | Endothelial Cells - cytology | Hindlimb - blood supply | Hindlimb - pathology | Protein Binding | Cadherins | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Ischemia - pathology | Neovascularization, Physiologic | RNA-Binding Proteins - metabolism | STAT3 Transcription Factor - metabolism | Antigens, CD | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Neovascularization | Cell differentiation | Analysis | Endothelium | Therapy | Stabilization | Differentiation (biology) | Stem cell transplantation | Cardiovascular disease | Activation | Qk protein | Recovery | Nuclei | Blood | Regeneration (physiology) | Vascularization | Proteins | Vascular diseases | Allografts | Ischemia | Transcription activation | Vascular endothelial growth factor receptor 2 | Vascular endothelial growth factor | Autografts | Secretion | Medical treatment | Stat3 protein | Ribonucleic acid--RNA | Endothelial cells | Blood flow | Regeneration | RNA-binding protein | Molecular modelling | 3' Untranslated regions | Stem cells | Cardiovascular diseases | Immunofluorescence | Pluripotency | Inhibitory postsynaptic potentials | Index Medicus | Regenerative Medicine
Journal Article