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Journal of Molecular Catalysis B: Enzymatic, ISSN 1381-1177, 12/2013, Volume 97, p. 196
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 01/2015, Volume 197, pp. 87 - 96
The clinical development of neuropeptides has been limited by a combination of the short plasma half-life of these drugs and their ultimate failure to permeate... 
Self assembly | N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) | Peptide nanofibres | Tyrosinyl1 −palmitate-leucine5-enkephalin (TPLENK) | Blood brain barrier | Peptide delivery | Tyrosinyl | palmitate-leucine | enkephalin (TPLENK) | Tyrosinyl-palmitate-leucine-enkephalin (TPLENK) | PALMITOYL GLYCOL CHITOSAN | MICROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | ENKEPHALIN | RAMAN-SCATTERING | NANOPARTICLES | N,N-trimethyl-6-O-glycolchitosan (GCPQ) | METABOLISM | N-palmitoyl-N-monomethyl-N,N-dimethyl-N | IN-VIVO | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | SCAFFOLD | BLOOD | Prodrugs - administration & dosage | Male | Analgesics - pharmacokinetics | Enkephalin, Leucine - administration & dosage | Prodrugs - chemistry | Brain - metabolism | Enkephalin, Leucine - analogs & derivatives | Nanofibers - administration & dosage | Pain - drug therapy | Animals, Outbred Strains | Chitosan - analogs & derivatives | Nanofibers - chemistry | Enkephalin, Leucine - pharmacokinetics | Liver - metabolism | Chitosan - administration & dosage | Analgesics - administration & dosage | Rats, Sprague-Dawley | Enkephalin, Leucine - chemistry | Administration, Intravenous | Animals | Chitosan - chemistry | Prodrugs - pharmacokinetics | Analgesics - chemistry | Chitosan - pharmacokinetics | Mice, Inbred BALB C | Cytokinins | Neuropeptides | Coatings | Liver | Enzymes
Journal Article
Peptides, ISSN 0196-9781, 05/2017, Volume 91, pp. 40 - 48
We previously reported a series of novel endomorphin analogs with unnatural amino acid modifications. These analogs display good binding affinity and... 
Spinal antinociception | Antagonist | Endomorphin | Antibody | Dynorphin | SYSTEM | CORD | MORPHINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | RELEASE | POTENT | PAIN | ADMINISTERED ENDOMORPHIN-1 | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGY & PHARMACY | OPIOID RECEPTORS | AGONIST | Analgesics, Opioid - antagonists & inhibitors | Naltrexone - analogs & derivatives | Opioid Peptides - pharmacology | Analgesics, Opioid - pharmacology | Male | Enkephalin, Leucine - administration & dosage | Opioid Peptides - administration & dosage | Receptors, sigma - antagonists & inhibitors | Dynorphins - chemistry | Enkephalin, Methionine - pharmacology | Pain - metabolism | Enkephalin, Leucine - antagonists & inhibitors | Naltrexone - pharmacology | Enkephalin, Methionine - chemistry | Pain - drug therapy | Enkephalin, Leucine - pharmacology | Analgesics, Opioid - chemistry | Antibodies - immunology | Enkephalin, Methionine - administration & dosage | Naltrexone - administration & dosage | Oligopeptides - chemistry | Enkephalin, Methionine - antagonists & inhibitors | Injections, Spinal | Oligopeptides - antagonists & inhibitors | Receptors, Opioid, kappa - antagonists & inhibitors | Receptors, Opioid, mu - antagonists & inhibitors | Dynorphins - antagonists & inhibitors | Enkephalin, Leucine - chemistry | Analgesia | Opioid Peptides - chemistry | Animals | Dynorphins - administration & dosage | Analysis of Variance | Analgesics, Opioid - administration & dosage | Naloxone - pharmacology | Opioid Peptides - antagonists & inhibitors | Narcotic Antagonists - pharmacology | Dynorphins - pharmacology | Mice | Oligopeptides - administration & dosage | Naloxone - administration & dosage | Oligopeptides - pharmacology | Pain Measurement | Fluorine - chemistry | Viral antibodies | Antibodies | Yuan (China) | Analysis
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2012, Volume 26, Issue 12, pp. 5161 - 5171
Inflammatory pain can be controlled by endogenous opioid peptides. Here we blocked the degradation of opioids in peripheral injured tissue to locally augment... 
Immune cells | Analgesia | Ory nerves | DEGRADING ENZYMES | NEUROGENIC INFLAMMATION | SYNOVIAL-FLUID | CATABOLIZING ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | analgesia | immune cells | SPINAL-CORD | BETA-ENDORPHIN | sensory nerves | CELL BIOLOGY | RECEPTORS MEDIATING ANTINOCICEPTION | BIOLOGY | INFLAMMATORY PAIN | RAT-BRAIN | NEUTRAL ENDOPEPTIDASE ENKEPHALINASE | Leucine - pharmacology | Opioid Peptides - pharmacology | Rats, Wistar | Thiorphan - pharmacology | Opioid Peptides - immunology | Male | Enkephalin, Methionine - pharmacology | Leukocytes - enzymology | Enkephalin, Methionine - metabolism | Dose-Response Relationship, Drug | Narcotic Antagonists | Alanine - analogs & derivatives | Enkephalin, Methionine - immunology | Hindlimb - physiopathology | Inflammation - complications | Flow Cytometry | Pain - complications | Pain - enzymology | Enkephalin, Leucine - pharmacology | Antibodies - immunology | Pain Threshold - drug effects | Dynorphins - metabolism | Neurons - drug effects | Leucine - analogs & derivatives | Alanine - pharmacology | Receptors, Opioid - metabolism | Amino Acid Sequence | Enkephalin, Leucine - metabolism | Pain - prevention & control | CD13 Antigens - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Hindlimb - innervation | Enkephalin, Leucine - immunology | Neprilysin - metabolism | CD13 Antigens - metabolism | Opioid Peptides - metabolism | Antibodies - pharmacology | Dynorphins - immunology | Animals | Neurons - enzymology | Phosphinic Acids - pharmacology | Neprilysin - antagonists & inhibitors | Hindlimb - drug effects | Leukocytes - drug effects | Dynorphins - pharmacology | Inflammation - prevention & control | Inflammation - enzymology
Journal Article
Journal Article
Brain Research, ISSN 0006-8993, 2015, Volume 1609, Issue 1, pp. 1 - 11
Abstract To meet the challenge of identification of new treatments for stroke, this study was designed to evaluate a potent, nonselective opioid receptor (OR)... 
Neurology | Neuroprotection | Stroke | Opioid receptors | Neuropeptide | Blood–brain barrier | Blood-brain barrier | ACTIVATION | DELTA | FOCAL CEREBRAL-ISCHEMIA | MOUSE | MECHANISMS | NEUROSCIENCES | PEPTIDE | BRAIN EDEMA | CELL-DEATH | KAPPA | NITRIC-OXIDE | Receptors, Opioid, delta - metabolism | Motor Activity - physiology | Neurons - pathology | Reperfusion Injury - drug therapy | Analgesics, Opioid - pharmacology | Motor Activity - drug effects | Brain Infarction - pathology | Receptors, Opioid, mu - agonists | Stroke - physiopathology | Stroke - pathology | Neuroprotective Agents - pharmacology | Analgesics, Opioid - chemistry | Enkephalin, Ala-MePhe-Gly- - chemistry | Neurons - drug effects | Brain Infarction - drug therapy | Enkephalin, D-Penicillamine (2,5)- - chemistry | Ischemia - pathology | Severity of Illness Index | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - chemistry | Neuroprotective Agents - chemistry | Reperfusion Injury - pathology | Enkephalin, Ala-MePhe-Gly- - pharmacology | Receptors, Opioid, mu - metabolism | Brain Edema - pathology | Receptors, Opioid, kappa - agonists | Cells, Cultured | Receptors, Opioid, kappa - metabolism | Brain Ischemia - physiopathology | Enkephalins - chemistry | Stroke - drug therapy | Brain Infarction - physiopathology | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Brain Edema - physiopathology | Ischemia - drug therapy | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Enkephalin, D-Penicillamine (2,5)- - pharmacology | Brain Edema - drug therapy | Enkephalins - pharmacology | Glutamic Acid - toxicity | Receptors, Opioid, delta - agonists | Stroke (Disease) | Drugstores | Comparative analysis | Glutamate | Animal behavior | Pharmacy | blood-brain barrier | opioid receptors | stroke | neuropeptide | neuroprotection
Journal Article
Neuron, ISSN 0896-6273, 02/2017, Volume 93, Issue 4, pp. 822 - 839.e6
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 649, Issue 1, pp. 336 - 341
Pruritus is a common adverse effect of opioid treatment. However, the mechanism by which pruritus is induced by opioid administration is unclear. In this... 
Naloxone methiodide | Peripheral opioid receptor | Loperamide | Itch | DAMGO | SYSTEM | INDUCED PRURITUS | ACTIVATION | MORPHINE | DELTA | NALOXONE | RESPONSES | KAPPA | PHARMACOLOGY & PHARMACY | SKIN | Analgesics, Opioid - antagonists & inhibitors | Analgesics, Opioid - toxicity | Opioid-Related Disorders - drug therapy | Loperamide - toxicity | Enkephalin, Ala-MePhe-Gly- - administration & dosage | Antipruritics - therapeutic use | Analgesics, Opioid - pharmacology | Male | Receptors, Opioid, mu - agonists | Antipruritics - pharmacology | Dose-Response Relationship, Drug | Loperamide - antagonists & inhibitors | Pruritus - drug therapy | Behavior, Animal - drug effects | Receptors, Opioid, delta - antagonists & inhibitors | Enkephalin, Ala-MePhe-Gly- - antagonists & inhibitors | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - toxicity | Enkephalin, D-Penicillamine (2,5)- - toxicity | Pruritus - chemically induced | Injections, Intradermal | Receptors, Opioid, kappa - antagonists & inhibitors | Loperamide - administration & dosage | Enkephalin, Ala-MePhe-Gly- - pharmacology | Quaternary Ammonium Compounds - therapeutic use | Receptors, Opioid, kappa - agonists | Loperamide - pharmacology | Antipruritics - administration & dosage | Naloxone - therapeutic use | Receptors, Opioid, mu - antagonists & inhibitors | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Mice, Inbred ICR | Naloxone - analogs & derivatives | Animals | Analgesics, Opioid - administration & dosage | Enkephalin, Ala-MePhe-Gly- - toxicity | Naloxone - pharmacology | Quaternary Ammonium Compounds - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - pharmacology | Mice | Naloxone - administration & dosage | Receptors, Opioid, delta - agonists | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - therapeutic use | Skin - drug effects | Quaternary Ammonium Compounds - pharmacology | Receptors, Opioid, mu - physiology | Pruritus | Acetic acid
Journal Article