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PLoS pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 9, p. e1003618
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-1) vaccine candidate is the ability to induce broadly neutralizing... 
ENVELOPE GLYCOPROTEIN TRIMERS | PROTEIN | VACCINE | GP41 | MICROBIOLOGY | GP120 | CONFORMATIONAL EPITOPE | POTENT | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | BINDING-SITE | MONOCLONAL-ANTIBODIES | PARASITOLOGY | Protein Aggregates | Antibody Specificity | HIV Infections - prevention & control | Molecular Weight | Humans | Antibodies, Neutralizing - metabolism | env Gene Products, Human Immunodeficiency Virus - metabolism | AIDS Vaccines - therapeutic use | HIV Infections - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | Immunoglobulin Fab Fragments - metabolism | env Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Protein Stability | Mutant Proteins - antagonists & inhibitors | Peptide Fragments - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | HIV Antibodies - metabolism | Peptide Fragments - metabolism | Solubility | Antibody Affinity | Mutant Proteins - metabolism | Epitopes | Recombinant Fusion Proteins - chemistry | HIV-1 - immunology | Peptide Fragments - chemistry | Peptide Fragments - antagonists & inhibitors | Mutant Proteins - chemistry | Antibodies, Monoclonal - metabolism | Amino Acid Substitution | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | HIV (Viruses) | Gene expression | Health aspects | DNA sequencing | Medical research | AIDS | Human immunodeficiency virus | Vaccines | HIV | Acquired immune deficiency syndrome
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e21225
Background: The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a... 
RESPONSES | IMMUNITY | ASSAY | SAFETY | MULTIDISCIPLINARY SCIENCES | ANTIBODY | IMMUNOGENICITY EVALUATION | CANDIDATE | INFECTION | STEP | MEMORY T-CELLS | env Gene Products, Human Immunodeficiency Virus - immunology | Immunization, Secondary - adverse effects | Immunoglobulin G - blood | Human Immunodeficiency Virus Proteins - immunology | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Male | Antibodies, Viral - blood | Vaccines, DNA - administration & dosage | Young Adult | env Gene Products, Human Immunodeficiency Virus - genetics | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Adenoviridae - genetics | Adult | Female | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Immunization - adverse effects | Enzyme-Linked Immunosorbent Assay | Immunization - methods | Anemia - chemically induced | Immunization, Secondary - methods | HIV-1 - genetics | HIV-1 - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | Interferon-gamma - immunology | Adolescent | Antibodies, Viral - immunology | Human Immunodeficiency Virus Proteins - genetics | T-Lymphocytes - immunology | AIDS Vaccines - administration & dosage | gag Gene Products, Human Immunodeficiency Virus - immunology | Interferon-gamma - blood | Cohort Studies | Oligomers | AIDS vaccines | Adenoviruses | Immunotherapy | DNA | Clinical trials | Product development | Interferon | Biological response modifiers | T cells | HIV (Viruses) | Antigenic determinants | Health care | CD8 antigen | Antibodies | Lymphocytes T | Infections | Vaccines | Epidemiology | Randomization | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Inserts | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Recombinant | Binding | Medical research | Immunoglobulins | Cytokines | Epitopes | Immune response (humoral) | CD4 antigen | Disease prevention | Hospitals | Infectious diseases | Immunogenicity | γ-Interferon | Adults | Cancer | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7358, pp. 96 - 101
Natural killer (NK) cells have an important role in the control of viral infections, recognizing virally infected cells through a variety of activating and... 
MHC CLASS-I | RESPONSES | NATURAL-KILLER-CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | HLA-B | INHIBITORY RECEPTOR | BINDING-SITE | KIR3DL1 | VIRAL PEPTIDES | env Gene Products, Human Immunodeficiency Virus - immunology | Human Immunodeficiency Virus Proteins - immunology | Humans | env Gene Products, Human Immunodeficiency Virus - metabolism | Host-Pathogen Interactions - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV-1 - physiology | Receptors, KIR2DL2 - genetics | Adaptation, Physiological - genetics | Receptors, KIR - metabolism | Receptors, KIR2DL2 - deficiency | Killer Cells, Natural - immunology | CD4-Positive T-Lymphocytes - virology | Receptors, KIR - deficiency | Receptors, KIR - genetics | Receptors, KIR2DL2 - immunology | Viral Regulatory and Accessory Proteins - immunology | HIV Infections - virology | Receptors, KIR2DL2 - chemistry | Viral Regulatory and Accessory Proteins - genetics | Genotype | HIV-1 - genetics | Viral Regulatory and Accessory Proteins - metabolism | Polymorphism, Genetic | Human Immunodeficiency Virus Proteins - metabolism | Adaptation, Physiological - immunology | HIV-1 - immunology | Virus Replication | Human Immunodeficiency Virus Proteins - genetics | Decision Trees | Immune Evasion - immunology | Receptors, KIR - immunology | Evolution, Molecular | Killer cells | Immune response | Management | Research | Observations | HIV infection | Hepatitis | Viruses | Immunology | Acids | Multivariate analysis | Viral infections
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23293
HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of... 
REPLICATION | PHOSPHORYLATION | TAT | MULTIDISCIPLINARY SCIENCES | KINASE | IMMUNODEFICIENCY-VIRUS TYPE-1 | SH3 DOMAINS | SHORT LINEAR MOTIFS | BINDING | VIRAL-INFECTION | NEF | rev Gene Products, Human Immunodeficiency Virus - chemistry | Humans | env Gene Products, Human Immunodeficiency Virus - metabolism | rev Gene Products, Human Immunodeficiency Virus - metabolism | nef Gene Products, Human Immunodeficiency Virus - chemistry | tat Gene Products, Human Immunodeficiency Virus - chemistry | CREB-Binding Protein - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | env Gene Products, Human Immunodeficiency Virus - genetics | Human Immunodeficiency Virus Proteins - chemistry | Databases, Protein | nef Gene Products, Human Immunodeficiency Virus - metabolism | gag Gene Products, Human Immunodeficiency Virus - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Calmodulin - metabolism | Protein Structure, Secondary | tat Gene Products, Human Immunodeficiency Virus - genetics | Models, Molecular | gag Gene Products, Human Immunodeficiency Virus - chemistry | Binding Sites - genetics | Human Immunodeficiency Virus Proteins - metabolism | Proteins - genetics | Protein Interaction Mapping - methods | Proteins - metabolism | nef Gene Products, Human Immunodeficiency Virus - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Human Immunodeficiency Virus Proteins - genetics | rev Gene Products, Human Immunodeficiency Virus - genetics | Amino Acid Motifs - genetics | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Casein Kinase II - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Physiological aspects | Viral proteins | HIV (Viruses) | Genomics | Protein binding | Phenotypes | Phosphorylation | Hot spots | Crosstalk | Amino acid sequence | Viruses | Genomes | Kinases | Proteins | Conserved sequence | Human immunodeficiency virus--HIV | Computer applications | Mutation | Localization | Bioinformatics | Binding sites | HIV | Human immunodeficiency virus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 24, pp. E3413 - E3422
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7420, pp. 417 - 420
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2008, Volume 105, Issue 21, pp. 7552 - 7557
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the... 
Datasets | Disease transmission | Viremia | Vaccination | Viruses | Evolution | Infections | Genetic mutation | Modeling | HIV 1 | Transmitted HIV-1 envelope | HIV-1 vaccines | Virus transmission | Viral evolution | RECOMBINATION | DIVERSIFICATION | VARIANTS | MULTIDISCIPLINARY SCIENCES | virus transmission | POPULATIONS | TYPE-1 INFECTION | SELECTIVE TRANSMISSION | IN-VIVO | viral evolution | DYNAMICS | DIVERSITY | transmitted HIV-1 envelope | NEUTRALIZATION | env Gene Products, Human Immunodeficiency Virus - immunology | HIV Infections - virology | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | RNA, Viral - blood | Phylogeny | HIV-1 - genetics | Genetic Variation | HIV Infections - immunology | Receptors, CCR5 - metabolism | env Gene Products, Human Immunodeficiency Virus - genetics | HIV-1 - physiology | RNA, Viral - genetics | Sequence Analysis, RNA | HIV Antibodies - immunology | HIV-1 - isolation & purification | Models, Biological | Base Sequence | HIV Infections - transmission | Disease Transmission, Infectious | Mutation | Evolution, Molecular | Evaluation | Viral envelopes | Medical examination | Development and progression | Research | Properties | Poisson distribution | HIV infection | Genotype & phenotype | Human immunodeficiency virus--HIV | Genomics | Glycoproteins | Mathematical models | Biological Sciences
Journal Article