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European Journal of Immunology, ISSN 0014-2980, 12/2018, Volume 48, Issue 12, pp. 1944 - 1957
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2010, Volume 53, Issue 3, pp. 951 - 965
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 05/2016, Volume 10, Issue 5, p. e0004695
Zika virus (ZIKV) is an emerging flavivirus typically causing a dengue-like febrile illness, but neurological complications, such as microcephaly in newborns,... 
TRANSMISSION | ENCEPHALITIS | PARASITOLOGY | TROPICAL MEDICINE | Microbial enzymes | Viral vaccines | Research | Studies | Epidemics | Mosquitoes | Archives & records | Cytokines | Zika virus | Infections | Experiments | Viral infections | Fever | Chemokines
Journal Article
2012, Methods in molecular biology, ISBN 1617793361, Volume 795., xi, 256
Book
Chemical Biology & Drug Design, ISSN 1747-0277, 01/2011, Volume 77, Issue 1, pp. 1 - 11
The BCR‐ABL inhibitor imatinib has revolutionized the treatment of chronic myeloid leukemia. However, drug resistance caused by kinase domain mutations has... 
kinase | ponatinib | AP24534 | drug discovery | X‐ray crystallography | structure‐based drug design | X-ray crystallography | Structure-based drug design | Drug discovery | Ponatinib | Kinase | structure-based drug design | C-ABL | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BMS-354825 | DOMAIN MUTATIONS | CANCER | CHRONIC MYELOID-LEUKEMIA | STRATEGIES | THERAPY | IMATINIB | T315I MUTANT | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Piperazines - chemistry | Structure-Activity Relationship | Pyridazines - pharmacology | Pyridazines - chemical synthesis | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Protein Binding - drug effects | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Pyridazines - therapeutic use | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Imidazoles - pharmacology | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Drug Resistance, Neoplasm - genetics | Fusion Proteins, bcr-abl - genetics | Animals | Mutation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Benzamides | Fluoroimmunoassay | Fusion Proteins, bcr-abl - metabolism | Drug Resistance, Neoplasm - drug effects | Drug resistance | Analysis | Leukemia | STRUCTURE-ACTIVITY RELATIONSHIPS | MUTANTS | BASIC BIOLOGICAL SCIENCES | ENZYME INHIBITORS | TYROSINE | GENE MUTATIONS | PHOSPHOTRANSFERASES | MYELOID LEUKEMIA | MUTATIONS | ANTINEOPLASTIC DRUGS | 60 APPLIED LIFE SCIENCES | RESIDUES
Journal Article
Food Analytical Methods, ISSN 1936-9751, 9/2018, Volume 11, Issue 9, pp. 2431 - 2437
Journal Article
2008, 2nd rev. ed., Milestones in drug therapy, ISBN 3764386924, x, 189
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the... 
Aromatase Inhibitors | drug therapy | Breast Neoplasms | therapeutic use | Clinical & internal medicine | Breast | Chemotherapy | Inhibitors | Aromatase | Therapeutic use | Cancer | Cancer Research | Oncology | Internal Medicine | Biomedicine | Pharmacology/Toxicology | Cell Biology
Book
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 01/2013, Volume 33, Issue 1, pp. 139 - 189
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to... 
antioxidant drugs | CDK5 inhibitors | anti‐inflammatory drugs | AChE peripheral anionic site | CK‐1 inhibitors | ERK2‐inhibitors | Ca2+ dyshomeostasis | BACE‐1 inhibitors | amyloid–β antiaggregating agents | NSAIDs | neuroprotection | multitarget drugs | GSK‐3β inhibitors | dual AChE inhibitors | metal chelators | Alzheimer's disease | Ca2+ overload | oxidative stress | multiactive compounds | 1,4‐dihydropyridines | voltage‐dependent calcium channels | Neuroprotection | Oxidative stress | Dual AChE inhibitors | Anti-inflammatory drugs | GSK-3β inhibitors | Antioxidant drugs | overload | Metal chelators | Multitarget drugs | Voltage-dependent calcium channels | CK-1 inhibitors | BACE-1 inhibitors | dyshomeostasis | 1,4-dihydropyridines | ERK2-inhibitors | Multiactive compounds | Amyloid-β antiaggregating agents | GSK-3 ss inhibitors | anti-inflammatory drugs | voltage-dependent calcium channels | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | POTENT ACETYLCHOLINESTERASE INHIBITORS | amyloid-ss antiaggregating agents | M1 MUSCARINIC AGONISTS | CHEMISTRY, MEDICINAL | AMYLOID PRECURSOR PROTEIN | MOLECULAR MODELING INVESTIGATIONS | HERPES-SIMPLEX-VIRUS | TACRINE-DIHYDROPYRIDINE HYBRIDS | PERIPHERAL ANIONIC SITE | NMDA RECEPTOR ANTAGONIST | Calcium Channels - metabolism | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | tau Proteins - metabolism | Receptors, N-Methyl-D-Aspartate | Alzheimer Disease - enzymology | Enzyme Inhibitors - therapeutic use | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Ligands | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Binding Sites | Acetylcholinesterase - metabolism | Care and treatment | Calcium channels | Glycogen | Development and progression | Glutamate | Target marketing | Antioxidants | Methyl aspartate | Enzyme inhibitors | Synthesis | Surface active agents | Drug therapy | Cancer
Journal Article