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1. Full Text Structures of β-klotho reveal a â € zip code'-like mechanism for endocrine FGF signalling
by Lee, Sangwon and Choi, Jungyuen and Mohanty, Jyotidarsini and Sousa, Leiliane P and Tome, Francisco and Pardon, Els and Steyaert, Jan and Lemmon, Mark A and Lax, Irit and Schlessinger, Joseph and Argonne National Lab. (ANL), Argonne, IL (United States)
Nature (London), ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, pp. 501 - 505
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Signal Transduction | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Extracellular Space - metabolism | Membrane Proteins - chemistry | Receptors, Fibroblast Growth Factor - metabolism | HEK293 Cells | Glycoside Hydrolases - chemistry | Protein Binding | Protein Domains | Ligands | Membrane Proteins - metabolism | Glycoside Hydrolases - metabolism | Binding Sites | Fibroblast growth factor | Fibroblast growth factor 23 | Paracrine signalling | Amino acids | Intracellular signalling | Hormones | Tissues | Cell surface | Experiments | Proteins | Receptors | Fibroblasts | Catalysis | Autocrine signalling | Lipogenesis | Growth factors | Sugar | Crystal structure | Enzymes | Proteoglycans | Energy expenditure | Metabolism | Insulin | Chemical compounds | Biological activity | Klotho protein | Heparan sulfate proteoglycans | Receptor mechanisms | Cooperativity | Sulfate | Fibroblast growth factor receptors | Index Medicus | Ectopic hormones | X-ray crystallography | BASIC BIOLOGICAL SCIENCES
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2. Full Text Exploring the Mechanism of β‑Lactam Ring Protonation in the Class A β‑lactamase Acylation Mechanism Using Neutron and X‑ray Crystallography
by Vandavasi, Venu Gopal and Weiss, Kevin L and Cooper, Jonathan B and Erskine, Peter T and Tomanicek, Stephen J and Ostermann, Andreas and Schrader, Tobias E and Ginell, Stephan L and Coates, Leighton and Argonne National Lab. (ANL), Argonne, IL (United States)
Journal of medicinal chemistry, ISSN 0022-2623, 01/2016, Volume 59, Issue 1, pp. 474 - 479
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Catalytic Domain | Cefotaxime - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Anti-Bacterial Agents - metabolism | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Mutation - genetics | beta-Lactams - chemistry | beta-Lactamases - chemistry | beta-Lactamases - genetics | Drug Design | Protein Conformation | Catalysis | Neutron Diffraction | beta-Lactamases - metabolism | Acylation | Index Medicus | RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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3. Full Text Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms
by Shaw, Pallab and Chattopadhyay, Ansuman
Journal of cellular physiology, ISSN 0021-9541, 04/2020, Volume 235, Issue 4, pp. 3119 - 3130
stress response | Nrf2 | oxidative stress | ROS | xenobiotic metabolizing enzymes | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animals | Signal Transduction - drug effects | Humans | NF-E2-Related Factor 2 - metabolism | Antioxidants - pharmacology | Homeostasis - drug effects | Oxidative Stress - drug effects | Antioxidants | Oxidative stress | Toxicants | Oxidants | Transcription | Metals | Oxidizing agents | Regulatory mechanisms (biology) | Homeostasis | Inducers | Index Medicus
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4. Full Text Molecular toxicity mechanism of nanosilver
by McShan, Danielle and Ray, Paresh C and Yu, Hongtao
Yàowu shi͡p︡in fenxi, ISSN 1021-9498, 03/2014, Volume 22, Issue 1, pp. 116 - 127
Toxicity mechanism | Nanosilver | Silver nanoparticle | Food Science & Technology | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Metal Nanoparticles - toxicity | Animals | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress | DNA Repair | Humans | Metal Nanoparticles - chemistry | Silver - chemistry | Cell Membrane - metabolism | DNA Damage | Enzymes | Oxidative stress | Reactive oxygen species | Toxicity | Consumer products | DNA damage | Nucleic acids | Molecular chains | Oxidation rate | Proteins | Antioxidants | Silver | Cell growth | Antibiotics | Oxidation | Sulfur | Damage | Protective coatings | Deoxyribonucleic acid--DNA | Glutathione | Historical metallurgy | Index Medicus
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5. Full Text Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
by Ma, Ming-zhe and Chen, Gang and Wang, Peng and Lu, Wen-hua and Zhu, Chao-feng and Song, Ming and Yang, Jing and Wen, Shijun and Xu, Rui-hua and Hu, Yumin and Huang, Peng
Cancer letters, ISSN 0304-3835, 2015, Volume 368, Issue 1, pp. 88 - 96
Hematology, Oncology and Palliative Medicine | xCT | Sulfasalazine | Chemosensitization | Cisplatin | Colorectal cancer | ROS | XCT | Life Sciences & Biomedicine | Oncology | Science & Technology | Reactive Oxygen Species - metabolism | Glutathione - metabolism | HCT116 Cells | Humans | Sulfasalazine - pharmacology | Antioxidants - pharmacology | Cisplatin - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | HT29 Cells | Amino Acid Transport System y+ - metabolism | Amino Acid Transport System y+ - antagonists & inhibitors | Cell Proliferation - drug effects | Histones - metabolism | Oxidative Stress - drug effects | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus
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6. Full Text Beyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C–H activation
by Huang, Xiongyi and Huang, Xiongyi and Groves, John T and Groves, John T and Energy Frontier Research Centers (EFRC) (United States). Center for Catalytic Hydrocarbon Functionalization (CCHF)
Journal of biological inorganic chemistry, ISSN 0949-8257, 4/2017, Volume 22, Issue 2, pp. 185 - 207
Life Sciences | Biochemistry, general | Oxygenase | C–H activation | Microbiology | Iron | Rebound | Metal oxo | Radical | Biochemistry & Molecular Biology | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Life Sciences & Biomedicine | Science & Technology | Carbon - metabolism | Ferric Compounds - metabolism | Hydroxylation | Oxygenases - metabolism | Biotransformation | Ferric Compounds - chemistry | Oxygenases - chemistry | Hydrogen - chemistry | Carbon - chemistry | Hydrogen - metabolism | Enzymes | Hydroxides | Biomimetics | Hydrogen | Analysis | Competition | Oxygen | Molecular modelling | Catalysts | Electron transfer | Intermediates | Index Medicus | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | Minireview
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