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Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2013, Volume 269, Issue 3, pp. 215 - 225
Journal Article
Toxicology, ISSN 0300-483X, 2010, Volume 274, Issue 1, pp. 42 - 48
Abstract Cytochrome P450 (CYP) 1 families including CYP1A1, 1A2 and 1B1 are well known to be deeply involved in the initiation of several cancers, due to the... 
Emergency | Benzo[ a]pyrene | Chrysoeriol | DNA adducts | Cytochrome P450 1 family | Liquid chromatography–tandem mass spectrometry | Liquid chromatography-tandem mass spectrometry | Benzo[a]pyrene | DIOL EPOXIDE | POLYCYCLIC AROMATIC-HYDROCARBONS | TRANSLESION SYNTHESIS | XENOBIOTIC-METABOLIZING ENZYMES | AH RECEPTOR ANTAGONIST | TANDEM MASS-SPECTROMETRY | NEWBORN MICE | ASPALATHUS-LINEARIS | LIQUID-CHROMATOGRAPHY | spectrometry | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Liquid chromatography-tandem mass | MOUSE SKIN | Carcinogens, Environmental - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 Enzyme Inhibitors | Flavones | Gene Expression - drug effects | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Humans | Cytochrome P-450 Enzyme System - metabolism | Carcinogens - metabolism | Breast Neoplasms - metabolism | DNA Adducts | Carcinogens - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Female | Benzo(a)pyrene - pharmacology | Deoxyguanosine - analogs & derivatives | Cells - drug effects | DNA - pharmacology | Chemoprevention | Receptors, Aryl Hydrocarbon - genetics | DNA - metabolism | Cytochrome P-450 CYP1A1 - metabolism | DNA - genetics | Flavonoids | Breast Neoplasms - genetics | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - analogs & derivatives | Carcinogens, Environmental - pharmacology | Cell Line, Tumor | Cells - metabolism | Cytochrome P-450 CYP1B1 | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP1A1 - pharmacology | DNA Damage | Aryl Hydrocarbon Hydroxylases | Benzo(a)pyrene - metabolism | Oncology, Experimental | Cytochrome P-450 | Breast cancer | Research | Gene expression | Prevention | Analysis | DNA | Family | Genetic aspects | Universities and colleges | Mass spectrometry | Cancer
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 9, pp. 1389 - 1397
Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine... 
Time correlated single photon counting | Structure activity relationship | Tabun | Time-resolved fluorescence | Russian VX | Oxime | Cyclosarin | HI-6 | Reactivator | Acetylcholinesterase | Fluorescence decay spectroscopy | Crystal structure | COMPLEX | DESIGN | REACTION-PRODUCTS | CRYSTAL-STRUCTURES | OXIMES | PERIPHERAL ANIONIC SITE | PHARMACOLOGY & PHARMACY | HISTIDINE-447 | DEALKYLATION | ORGANOPHOSPHORUS COMPOUNDS | CHOLINESTERASES | Antidotes - pharmacology | Antidotes - chemistry | Catalytic Domain | Humans | Cholinesterase Inhibitors - chemistry | Models, Molecular | Spectrometry, Fluorescence | Substrate Specificity | Crystallography, X-Ray | Organophosphorus Compounds - chemistry | Acetylcholinesterase - chemistry | Chemical Warfare Agents - chemistry | Organothiophosphorus Compounds - chemistry | Oximes - chemistry | Pyridinium Compounds - pharmacology | Animals | Oximes - pharmacology | Organophosphates - chemistry | Protein Conformation | Mice | Pyridinium Compounds - chemistry | Fluorescence | Nitriles | Enzyme inhibitors | Structure | Crystals | Biological Sciences | reactivator | Structural Biology | acetylcholinesterase | oxime | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Strukturbiologi | Biochemistry and Molecular Biology | cyclosarin | Natural Sciences | structure activity relationship | tabun
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2007, Volume 129, Issue 51, pp. 15750 - 15751
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2008, Volume 230, Issue 2, pp. 135 - 143
Benzo[ ]pyrene (BaP), a polyaromatic hydrocarbon produced by the combustion of cigarettes and coke ovens, is a known procarcinogen. BaP activates the aryl... 
CYP1A2 | CYP1A1 | DNA adduct | CYP1B1 | GST | AhR | Epoxide hydrolase | ACTIVATION | PYRENE | POLYCYCLIC AROMATIC-HYDROCARBONS | HUMAN CYTOCHROME-P450 | MOUSE | BENZOPYRENE | CARCINOGENESIS | epoxide hydrolase | ENZYMES | DETOXICATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | AH GENE BATTERY | Cell Line | Microsomes - metabolism | Enzyme Inhibitors | Glutathione S-Transferase pi - metabolism | Cytochrome P-450 Enzyme Inhibitors | DNA Adducts - drug effects | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Carcinogens - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Enzyme Activation - drug effects | Cytochrome P-450 CYP1A2 - metabolism | Blotting, Western | Aryl Hydrocarbon Hydroxylases - metabolism | Microsomes - drug effects | Carcinogens - pharmacology | Plasmids - genetics | Cytochrome P-450 CYP1B1 | Benzo(a)pyrene - pharmacology | Benzo(a)pyrene - metabolism | Isoenzymes - antagonists & inhibitors | Hydrocarbons | Polycyclic aromatic hydrocarbons | DNA | Cytochrome P-450 | Index Medicus | DETOXIFICATION | COMBUSTION | METABOLIC ACTIVATION | TOXICITY | 60 APPLIED LIFE SCIENCES | EPOXIDES | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | GLUTATHIONE | GENES | GLYCOLS | POLYCYCLIC AROMATIC HYDROCARBONS | RECEPTORS | DEACTIVATION
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 02/2005, Volume 44, Issue 5, pp. 1583 - 1594
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 06/2008, Volume 46, Issue 6, pp. 2296 - 2302
Journal Article