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Journal Article
Progress in Lipid Research, ISSN 0163-7827, 01/2016, Volume 61, pp. 149 - 162
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key decisive factor controlling the development of adipocytes. Ligand-mediated... 
Lipoxygenases | Cyclooxygenases | Reactive oxygen species | Polyunsaturated fatty acids | PPARγ | Adipogenesis | AF-1 ligand-independent activation function | NOS nitric oxide synthase | ADH alcohol dehydrogenase | ELOVL3 elongation of very long chain fatty acids 3 | FFA free fatty acid | DPEP dipeptidase | LNO | RXR retinoic X receptor | PTM post-translational modification | prostaglandin J | NOX4 NADPH oxidase 4 | azPC azelayol phosphatidylcholine | HPETE hydroperoxyeicosatetraenoic acid | GGT gamma-glutamyltransferase | MEF mouse embryonic fibroblast | C/EBP CCAAT/enhancer binding protein | TZD thiazolidinedione | Mo-Co molybdenum cofactor | CBR carbonyl reductase | HPODE hydroperoxyoctadecadienoic acid | AA arachidonic acid | HETE hydroxyeicosatrienoic acid | MAPK mitogen-activated protein kinase | PL phospholipase | pRB retinoblastoma protein | Abbreviations NO nitric oxide | cPLA | PTGR prostaglandin reductase | EET epoxyeicosatrienoic | PPARγ peroxisome proliferator-activated receptor γ | ROS reactive oxygen species | cytosolic PLA | EH epoxide hydrolase | BAT Brown adipose tissue | HODE hydroxyoctdecenonic acid | PTGES prostaglandin E synthase | LOX lipoxygenase | Epac exchange protein directly activated by cAMP | LPA lysophosphatidic acid | ChREBP carbohydrate element binding protein | NR nuclear receptor | LA linoleic acid | XOR xanthine oxidoreductase | CPA cyclic phosphatidic acid | AF-2 ligand-dependent activation function | TX thromboxane | 15-deoxy-Δ | PGDH 15-hydroxyprostaglandin dehydrogenase | PGFS prostaglandin F synthase | KETE ketoeicosatetraenoic acid | SREBP-1c sterol-regulatory element binding protein 1c | eLOX3 epidermis lipoxygenase type 3 | GPC glycerophosphocholine | LBD ligand binding domain | nitrolinoleic acid | PTGIS prostacyclin synthase | ONO | PG prostaglandin | RetSat retinol saturase | dioxide radical | EPA eicosapentaenoic acid | MUFA monounsaturated fatty acid | GPx glutathione peroxidase | LTC4S leukotriene C4 synthase | COX cyclooxygenase | IBMX isobutyl-methylxanthine | peroxynitrite | PPRE peroxisome proliferator response element | HPGD 15-hydroxyprostaglandin dehydrogenase | 15-dPGJ | DHET dihydroxyeicosatrienoic acid | FAS fatty acid synthase | PTGDS prostaglandin D2 synthase | sEH soluble epoxide hydrolase | UCP1 uncoupling protein 1 | CYP cytochrome P450 monooxygenase | WAT white adipose tissue | superoxide | FAD flavin adenine dinucleotide | PUFA polyunsaturated fatty acid | TBXAS thromboxane A synthase | INHIBITS ADIPOCYTE DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMINANT-NEGATIVE MUTATIONS | CELL-DERIVED ADIPOCYTES | MITOTIC CLONAL EXPANSION | PROLIFERATOR-ACTIVATED-RECEPTOR | PPAR gamma | WHITE ADIPOSE-TISSUE | NUTRITION & DIETETICS | 3T3-L1 PREADIPOCYTE DIFFERENTIATION | POLYUNSATURATED FATTY-ACIDS | LIGAND-BINDING DOMAIN | PROSTAGLANDIN F-2 ALPHA | PPAR gamma - physiology | Prostaglandins | Animals | Oxidation-Reduction | Humans | Lipid Metabolism | Adipocytes - physiology | Fatty Acids - metabolism
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 04/2015, Volume 1851, Issue 4, pp. 356 - 365
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2007, Volume 403, Issue 1, pp. 109 - 118
AA (arachidonic acid) hydroxylation to 20-HETE (20-hydroxy-eicosatetraenoic acid) influences renal vascular and tubular function. To identify the CYP... 
Hydroxyeicosatetraenoic acid (HETE) | Gender | Arachidonic acid | Mouse kidney | Eicosapentaenoic acid | Cytochrome P450 | arachidonic acid | CYTOCHROME-P450 | gender | hydroxyeicosatetraenoic acid (HETE) | ENDOTHELIAL DYSFUNCTION | DEOXYCORTICOSTERONE ACETATE-SALT | BIOCHEMISTRY & MOLECULAR BIOLOGY | FATTY-ACIDS | cytochrome P450 | ARACHIDONIC-ACID | mouse kidney | eicosapentaenoic acid | METABOLISM | CARDIOVASCULAR-DISEASE | HUMAN CYP1A1 | HYPERTENSION | Species Specificity | Isoenzymes - genetics | Kidney - enzymology | Molecular Sequence Data | Male | DNA Primers | RNA - genetics | Gene Expression Regulation, Enzymologic | Fatty Acids, Nonesterified - metabolism | Hydroxyeicosatetraenoic Acids - biosynthesis | RNA - isolation & purification | Animals | Base Sequence | Cloning, Molecular | Cytochrome P450 Family 4 | Cytochrome P-450 Enzyme System - genetics | Female | Mice | EET, epoxyeicosatrienoic acid | DHT, dihydrotestosterone | OH-LA, hydroxy LA | HETE, hydroxyeicosatetraenoic acid | EETeTr, epoxyeicosatetraenoic acid | cytb5, cytochrome b5 | DTT, dithiothreitol | DDDA, dodecan-1,12-dioic acid | HEPE, hydroxyeicosapentaenoic acid | RT, reverse transcriptase | 20-COOH-AA, eicosatetraen-1,20-dioic acid | PUFA, polyunsaturated fatty acid | CYP, cytochrome P450 | EPA, eicosapentaenoic acid | BK channel, calcium-activated potassium channel | Ang II, angiotensin II | LA, lauric acid | AA, arachidonic acid | RP-HPLC, reverse-phase HPLC | CPR, NADPH-CYP reductase | DOCA, deoxycorticosterone acetate | NP-HPLC, normal-phase HPLC
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 12/2010, Volume 51, Issue 12, pp. 3481 - 3490
Journal Article
Journal Article
Prostaglandins and Other Lipid Mediators, ISSN 1098-8823, 2011, Volume 96, Issue 1, pp. 99 - 108
► EPA and DHA protect against arrhythmia and sudden cardiac death. ► CYP enzymes efficiently hydroxylate and epoxidize EPA and DHA. ► Dietary EPA/DHA... 
Eicosanoids | Cardioprotection | Arrhythmia | DHA | Cytochrome P450 | EPA | ACTIVATED PROTEIN-KINASE | SENSITIVE K+ CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-KAPPA-B | ARACHIDONIC-ACID | L-TYPE CA2 | CELL BIOLOGY | SOLUBLE EPOXIDE HYDROLASE | POLYUNSATURATED FATTY-ACIDS | CORONARY-HEART-DISEASE | HUMAN CYTOCHROMES P450 | EPOXYEICOSATRIENOIC ACIDS | Arachidonic Acid - metabolism | Anti-Arrhythmia Agents - pharmacology | Cardiotonic Agents - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | Death, Sudden, Cardiac - prevention & control | Anti-Arrhythmia Agents - metabolism | Arrhythmias, Cardiac - physiopathology | Myocytes, Cardiac - enzymology | Eicosapentaenoic Acid - pharmacology | Myocardium - metabolism | Animals, Newborn | Arrhythmias, Cardiac - metabolism | Arrhythmias, Cardiac - prevention & control | Myocytes, Cardiac - cytology | Reperfusion Injury | Eicosapentaenoic Acid - metabolism | Cardiomegaly - physiopathology | Rats | Myocardium - pathology | Cardiotonic Agents - pharmacology | Fish Oils - pharmacology | Docosahexaenoic Acids - pharmacology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Fish Oils - metabolism | Mice | Cardiomegaly - metabolism | Docosahexaenoic Acids - metabolism | Prostaglandins | Omega-3 fatty acids | Cytochrome P-450 | Anti-arrhythmia drugs | Dietary supplements
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e56564
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes... 
RHEUMATOID-ARTHRITIS | POPULATION | LOW-DENSITY LIPOPROTEINS | PLASMA | CROHNS-DISEASE | SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | CALORIC RESTRICTION | FATTY-ACIDS | IDENTIFICATION | EPOXYEICOSATRIENOIC ACIDS | Metabolomics | Biomarkers - urine | Demography | Humans | Middle Aged | Male | Metagenome - physiology | Young Adult | Amino Acids - metabolism | Mass Spectrometry | Aged, 80 and over | Chromatography, Liquid | Adult | Female | Child | Magnetic Resonance Spectroscopy | Gastrointestinal Tract - microbiology | Metabolome | Lipid Metabolism | Biomarkers - blood | Eicosanoids - blood | Phenotype | Adolescent | Italy | Aged | Longevity - physiology | Cohort Studies | Physiological aspects | Tryptophan | Unsaturated fatty acids | Lipids | Biological products | Microbiota (Symbiotic organisms) | Elderly people | Cytochrome | Health sciences | Nuclear magnetic resonance--NMR | Profiling | Enzyme activity | Disease | Lipid peroxidation | Amino acids | Sphingolipids | Arachidonic acid | Remodeling | Cresol | p-Cresol | Genotype & phenotype | Microbiota | Enzymatic activity | Aging | Lipid metabolism | Pharmaceutical sciences | Age | Peroxidation | Urine | Mortality | Cytochrome P450 | Detoxification | Shading | Inflammation | Longevity | Metabolism | Low density lipoprotein | Fatty acids | Biological activity | Linoleic acid | Pathology | Centenarians | Rheumatoid arthritis | Proteomics | Oldest old people | Sulfate | Elderly | Geriatrics | Nuclear magnetic resonance | NMR
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 12/2017, Volume 180, pp. 62 - 76
Journal Article