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eukaryotic initiation factor-2 - metabolism (87) 87
phosphorylation (79) 79
animals (76) 76
index medicus (67) 67
humans (63) 63
biochemistry & molecular biology (55) 55
cell biology (40) 40
mice (38) 38
eif-2 kinase - metabolism (30) 30
eukaryotic initiation factor-2 - genetics (30) 30
protein biosynthesis (30) 30
endoplasmic-reticulum stress (26) 26
unfolded protein response (26) 26
er stress (25) 25
signal transduction (21) 21
gene-expression (20) 20
translation (20) 20
activation (19) 19
article (19) 19
gene expression regulation (19) 19
translational control (19) 19
amino acid sequence (18) 18
endoplasmic reticulum - metabolism (18) 18
protein synthesis (18) 18
proteins (18) 18
translation initiation (18) 18
apoptosis (17) 17
cells, cultured (17) 17
molecular sequence data (17) 17
mutation (17) 17
expression (16) 16
phosphorylation - drug effects (16) 16
base sequence (15) 15
eif-2 kinase - genetics (15) 15
endoplasmic-reticulum (15) 15
mammalian-cells (15) 15
messenger-rna (15) 15
oxidative stress (15) 15
stress (15) 15
cell line (14) 14
enzyme activation (13) 13
rna, messenger - genetics (13) 13
alpha-subunit (12) 12
cell line, tumor (12) 12
eif2α (12) 12
endoplasmic reticulum (12) 12
kinases (12) 12
male (12) 12
protein-serine-threonine kinases - metabolism (12) 12
rats (12) 12
transfection (12) 12
amino acids (11) 11
biophysics (11) 11
double-stranded-rna (11) 11
gene expression (11) 11
hela cells (11) 11
inhibition (11) 11
kinase (11) 11
proteins - metabolism (11) 11
saccharomyces-cerevisiae (11) 11
stress response (11) 11
viruses (11) 11
articles (10) 10
enzymes and coenzymes (10) 10
protein binding (10) 10
protein kinases (10) 10
rna, messenger - metabolism (10) 10
unfolded-protein response (10) 10
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eif2 alpha (9) 9
endoplasmic reticulum stress (9) 9
eukaryotic initiation factor-2 - chemistry (9) 9
genetic translation (9) 9
neurosciences (9) 9
perk (9) 9
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nf-kappa-b (8) 8
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saccharomyces cerevisiae - genetics (8) 8
transfer-rna (8) 8
yeast (8) 8
analysis (7) 7
biochemistry (7) 7
blotting, western (7) 7
cinnamates - pharmacology (7) 7
dephosphorylation (7) 7
gcn2 (7) 7
gene (7) 7
gene expression regulation, fungal (7) 7
immunoblotting (7) 7
initiation (7) 7
multidisciplinary sciences (7) 7
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Journal Article
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 04/2004, Volume 24, Issue 8, pp. 3415 - 3429
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2004, Volume 23, Issue 4, pp. 959 - 968
Journal Article
by Liu, J and He, K.-L and Li, X and Li, R.-J and Liu, C.-L and Zhong, W and Li, S
Current Medicinal Chemistry, ISSN 0929-8673, 12/2012, Volume 19, Issue 35, pp. 6072 - 6079
Salubrinal is a selective inhibitor of endoplasmic reticulum (ER) stress and affords remarkable protection to cardiomyocytes. By studying the... 
Eukaryotic translation initiation factor 2 subunit α (eIF2α) phosphorylation | PP1/GADD34 complex inhibitor | Endoplasmic reticulum (ER) stress | UPR | Cardiomyocytes protection | Predicted abilities | CoMFA model | Structure-activity relationships (SAR) | MTT | Salubrinal | salubrinal | CELLS | ACTIVATION | CHEMISTRY, MEDICINAL | INDUCED APOPTOSIS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | eukaryotic translation initiation factor 2 subunit alpha (eIF2 alpha) phosphorylation | ENDOPLASMIC-RETICULUM STRESS | endoplasmic reticulum (ER) stress | structure-activity relationships (SAR) | HEART | predicted abilities | DEPHOSPHORYLATION | PHARMACOLOGY & PHARMACY | DYSFUNCTION | INHIBITOR | Phosphorylation | Endoplasmic Reticulum Stress - drug effects | Myocytes, Cardiac - cytology | eIF-2 Kinase - metabolism | Cells, Cultured | Rats | Cardiotonic Agents - chemistry | Cardiotonic Agents - pharmacology | Thiourea - chemistry | Thiourea - pharmacology | Cinnamates - pharmacology | Animals | Myocytes, Cardiac - drug effects | Thiazoles - chemical synthesis | Thiourea - chemical synthesis | Cardiotonic Agents - chemical synthesis | Cinnamates - chemical synthesis | Myocytes, Cardiac - metabolism | Thiazoles - chemistry | Thiazoles - pharmacology | Cinnamates - chemistry | Quantitative Structure-Activity Relationship | Thiourea - analogs & derivatives
Journal Article
Translational Stroke Research, ISSN 1868-4483, 12/2013, Volume 4, Issue 6, pp. 635 - 642
The endoplasmic reticulum (ER) functions in the synthesis, folding, modification, and transport of newly synthesized transmembrane and secretory proteins. The... 
Neurology | ER Ca 2+ dysregulation | Eukaryotic translation initiation factor 2α subunit | Neurosciences | Biomedicine | Vascular Surgery | Neurosurgery | Cardiology | C/EBP homologous protein | ER-associated protein degradation | Unfolded protein response | dysregulation | ER Ca | OXIDATIVE STRESS | ER Ca2+ dysregulation | ENDOPLASMIC-RETICULUM STRESS | ANTI-INFLAMMATION | Eukaryotic translation initiation factor 2 alpha subunit | NEUROSCIENCES | CLINICAL NEUROLOGY | INTRACELLULAR CA2 | TRAUMATIC BRAIN-INJURY | DOCOSAHEXAENOIC ACID | GENE-EXPRESSION | POLYUNSATURATED FATTY-ACIDS | SPINAL-CORD-INJURY | Neuroprotective Agents | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Brain Injuries - drug therapy | Calcium Signaling - physiology | Humans | Endoplasmic Reticulum - physiology | Brain Injuries - physiopathology | Docosahexaenoic Acids - pharmacology | Animals | Proteins - metabolism | Calcium Signaling - drug effects | Protein Folding - drug effects | Endoplasmic Reticulum - drug effects | Proteins - drug effects | Protein Biosynthesis - drug effects | Stress, Physiological - drug effects | Unfolded Protein Response - physiology | Endoplasmic Reticulum Stress - physiology | unfolded protein response | EBP homologous protein | eukaryotic translation initiation factor 2α subunit
Journal Article
FEBS Letters, ISSN 0014-5793, 2007, Volume 581, Issue 19, pp. 3634 - 3640
Redox imbalance in the endoplasmic reticulum lumen is the most frequent cause of endoplasmic reticulum stress and consequent apoptosis. The mechanism involves... 
NADPH | Ascorbate | Oxidative protein folding | Endoplasmic reticulum | Unfolded protein response | Glutathione | glucose-6-phosphate transporter | PERK/PEK | BiP | Ero1 | inositol-requiring enzyme 1 | InsP3R | PDI | UPR | IRE1 | immunoglobulin heavy chain-binding protein | glucose-regulated protein of molecular weight 78 kDa | PKR-like ER protein kinase/pancreatic eIF2α (eukaryotic translation initiation factor 2, α subunit) kinase | ERp44 and 57 | hexose-6-phosphate dehydrogenase | dehydroascorbate reductase | protein disulfide isomerase | GRP78 | 11βHSD1 | DHAR | SERCA | endoplasmic reticulum protein of molecular weight 44 or 57 kDa | unfolded protein response | G6PT | endoplasmic reticulum oxidoreductin 1 | H6PDH | 11β-hydroxysteroid dehydrogenase type 1 | inositol 1,4,5-trisphosphate receptor | sarco/endoplasmic reticulum Ca2+-ATPase | ATF6 | activating transcription factor 6 | endoplasmic reticulum | PROTEIN-DISULFIDE-ISOMERASE | MICROSOMAL GLUCOSE-6-PHOSPHATE TRANSLOCASE | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | glutathione | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BOND FORMATION | ENDOPLASMIC-RETICULUM STRESS | oxidative protein folding | CELL BIOLOGY | HEXOSE-6-PHOSPHATE DEHYDROGENASE | BIOPHYSICS | RYANODINE RECEPTOR | INSULIN-RESISTANCE | ascorbate | LIVER-MICROSOMES | Sulfhydryl Compounds - metabolism | Animals | Molecular Chaperones - metabolism | Biological Transport | Oxidation-Reduction | Heat-Shock Proteins - metabolism | Humans | Stress, Physiological - metabolism | Endoplasmic Reticulum - metabolism | Vitamins - metabolism | Mice
Journal Article
Experimental Parasitology, ISSN 0014-4894, 11/2007, Volume 117, Issue 3, pp. 304 - 317
Schistosome parasites have co-evolved an intricate relationship with their human and snail hosts as well as a novel interplay between the adult male and female... 
e2IFα | GPI | extracellular signal-regulated kinase | histone acetyltransferase | latency associated protein | short interfering RNA | SmInACT | transforming growth factor β-induced gene-human clone 3 | anti-Mullerian hormone | RT-PCR | Common-Smads | cDNA | CREB binding protein | TβRII | AMH | TGF-b type I receptor | beta-ig-h3 | receptor kinase | Schistosoma mansoni | TβRI | GCN5 | RNAi | Schistactivin receptor-like kinasesosoma mansoni | GS region | Co-Smads | alternating glycine and serine residues | GDFs | FK506-binding protein | growth/differentiation factors | MAPK | N-terminal extracellular domain | IL-7 | BMPs | activin type Ib receptor | receptor-regulated Smads | Smad | SIP | ERK | RNA interference | Smad anchor for receptor activation | transforming growth factor beta | I-Smads | complementary deoxyribonucleic acid | Interleukin-7 | ActRIb | EGFR | Host–parasite interactions | CBP | mitogen-activated protein kinase | Mad homology region | reverse transcriptase polymerase chain reaction | TGF-β | general control nonderepressible-5 protein | SARA | SmRK1-interacting protein | human | bone morphogenetic proteins | SmInhibin/activin-like molecule | eukaryotic translation initiation factor 2α subunit | epidermal growth factor receptor | ECD | inhibitory Smads | siRNA | gynecophoral canal protein | ALKs | Male–female interactions | FKBP | GCP | LTBP | R-Smads | activin receptor-like kinases | TGF-b type II receptor | HAT | LAP | glycosylphosphatidylinositol | latent TGF-β binding protein | Male-female interactions | Host-parasite interactions | ECD, N-terminal extracellular domain | HAT, historic acetyltransferase | CELL-MEMBRANE | RNAi, RNA interference | ALKs, activin receptor-like kinases | e2IF alpha, eukaryotic translation initiation factor 2 alpha subunit | RECEPTOR SERINE/THREONINE KINASE | TGF-beta | MAD-RELATED PROTEIN | SIP, SmRK1-interacting protein | TGF-beta, transforming growth factor beta | PARASITOLOGY | male-female interactions | IL-7, Interleukin-7 | SARA, Smad anchor for receptor activation | SMAD PROTEINS | CRYSTAL-STRUCTURE | AMH, anti-Mullerian hormone | CBP, CREB binding protein | FKBP, FK506-binding protein | RK, receptor kinase | EGFR, epidermal growth factor receptor | SmInACT, SmInhibin/activin-like molecule | cDNA, complementary deoxyribonucleic acid | MH, Mad homology region | GDFs, growth/differentiation factors | Sm, Schistosoma mansoni | GCP, gynecophoral canal protein | LTBP, latent TGF-beta binding protein | MAPK, mitogen-activated protein kinase | RT-PCR, reverse transcriptase polymerase chain reaction | h, human | beta-ig-h3, transforming growth factor beta-induced gene-human clone 3, Host-parasite interactions | siRNA, short interfering RNA | REPRODUCTIVE DEVELOPMENT | GS region, alternating glycine and serine residues | GCN5, general control nonderepressible-5 protein | DNA-BINDING | I-Smads, inhibitory Smads | ActRIb, activin type Ib receptor | BMPs, bone morphogenetic proteins | Co-Smads, Common-Smads | GPI, glycosylphosphatidylinositol | HISTONE ACETYLTRANSFERASE | T beta RII, TGF-b type II receptor | GROWTH-FACTOR-BETA | ERK, extracellular signal-regulated kinase | R-Smads, receptor-regulated Smads | HOST-PARASITE RELATIONSHIPS | LAP, latency associated protein | T beta RI, TGF-b type I receptor | Schistosoma mansoni - physiology | Protein-Serine-Threonine Kinases - physiology | Humans | Transforming Growth Factor beta - physiology | Reproduction - physiology | Skin - parasitology | Male | Smad Proteins - physiology | Animals | Schistosomiasis mansoni - parasitology | Snails - parasitology | Helminth Proteins - physiology | Sex Factors | Female | Ligands | Signal Transduction - physiology | Host-Parasite Interactions | Liver - parasitology | Schistosoma mansoni - growth & development | Life Cycle Stages - physiology
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 04/2000, Volume 20, Issue 7, pp. 2505 - 2516
Induction of GCN4 translation in amino acid-starved cells involves the inhibition of initiator tRNA(Met) binding to eukaryotic translation initiation factor 2... 
YEAST | CELL VIABILITY | MESSENGER-RNA | IDENTITY DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-KINASE GCN2 | PSEUDOURIDINE SYNTHASES | SACCHAROMYCES-CEREVISIAE GENE | RIBOSOMAL-RNA | TRANSFER RIBONUCLEIC-ACIDS | TRANSFER-RNA-SYNTHETASE | CELL BIOLOGY | tRNA fMet | GCN4 protein | PUS4 gene | LOS1 gene | tRNA Val | initiation factor eIF-2 | GCN2 protein | ribonuclease P
Journal Article