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Nuclear Medicine and Biology, ISSN 0969-8051, 11/2019, Volume 78-79, pp. 31 - 40
[ Lu]Lu-DOTA-Ahx-Lys40-Exendin-4 ([ Lu]Lu-DOTA-Exendin-4) is a potential agent for radiotherapy of insulinomas owing to its specificity towards GLP-1 (Glucagon... 
[177Lu]LuCl3 | Radionuclide therapy of Insulinoma | [177Lu]Lu-DOTA-Exendin-4 | DOTA-Exendin-4 | Radiolabeled Exendin
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 07/2015, Volume 56, Issue 7, pp. 1075 - 1078
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2015, Volume 764, pp. 346 - 352
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 02/2013, Volume 54, Issue 2, pp. 244 - 251
Because islet transplantation has become a promising treatment option for patients with type 1 diabetes, a noninvasive imaging method is greatly needed to... 
RAT | HUMAN-PANCREAS | INSULINOMA | HELODERMA-SUSPECTUM VENOM | islet imaging | GLUCAGON-LIKE PEPTIDE-1 | EXENDIN-4 | F-18-labeled exendin-4 | BETA-CELL MASS | GLP-1 RECEPTOR | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | GLP-1R | AGONIST
Journal Article
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 03/2012, Volume 39, Issue 3, pp. 463 - 473
Purpose Glucagon-like peptide type 1 (GLP-1) is an incretin peptide that augments glucose-stimulated insulin release following oral consumption of nutrients.... 
GLYCEMIC CONTROL | VIVO | Insulinoma | STABILITY | BETA-CELLS | RECEPTOR | F-18 | Exendin-4 | PLASMA IN-VITRO | GLUCAGON-LIKE PEPTIDE-1 | SYNTHETIC EXENDIN-4 | PROTEINS | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | GLP-1R
Journal Article
Clinical Science, ISSN 0143-5221, 05/2012, Volume 122, Issue 10, pp. 473 - 483
Diabetes is a strong risk factor for premature and severe stroke. The GLP-IR (glucagon-like peptide-1 receptor) agonist Ex-4 (exendin-4) is a drug for the... 
Neuroprotection | Exendin-4 (Ex-4) | Goto-Kakizaki (GK) rat | Neurogenesis | Middle cerebral artery occlusion (MCAO) | MEDICINE, RESEARCH & EXPERIMENTAL | middle cerebral artery occlusion (MCAO) | RISK-FACTORS | ADULT BRAIN | TOTAL NUMBER | DOPAMINERGIC-NEURONS | SUBVENTRICULAR ZONE | EXENDIN-4 | exendin-4 (Ex-4) | neuroprotection | neurogenesis | ANIMAL-MODEL | CEREBRAL-ISCHEMIA | HIPPOCAMPAL NEUROGENESIS | PARKINSONS-DISEASE | Neuroprotective Agents - therapeutic use | Receptors, Glucagon - agonists | Microglia - drug effects | Rats | Stroke Volume - drug effects | Male | Stroke - drug therapy | Hyperglycemia - drug therapy | Animals | Glucagon-Like Peptide-1 Receptor | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Venoms - therapeutic use | Cell Proliferation - drug effects | Neurogenesis - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Peptides - therapeutic use | Index Medicus | T2D, Type 2 diabetes | BrdU, bromodeoxyuridine | MCAO, MCA occlusion | DAPI, 4′,6-diamidino-2-phenylindole | DCX, doublecortin | GK, Goto–Kakizaki | Goto–Kakizaki (GK) rat | CNS, central nervous system | MCA, middle cerebral artery | IHC, immunohistochemistry | Ex-4, exendin-4 | bw, body weight | GLP-1R, glucagon-like peptide-1 receptor | SVZ, subventricular zone | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Biomedicinsk laboratorievetenskap/teknologi | Biomedical Laboratory Science/Technology
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 12/2018, Volume 45, Issue 13, pp. 2318 - 2327
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 496, Issue 2, pp. 294 - 301
This study aimed to explore the mechanism of impaired autophagy flux induced by exendin-4 and its role on cell apoptosis in pancreatic AR42J cells. The AR42J... 
Impaired autophagy | Pancreas | Exendin-4 | Apoptosis | Analysis | Pancreatitis
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 10/2018, Volume 315, Issue 4, pp. R708 - R720
Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose metabolism via vagal afferent neurons (VANs). Recently, VANs have received... 
Energy expenditure | Obesity | High-fat diet | Vagal afferent neurons | Exendin-4 | PHYSIOLOGY | FOOD-INTAKE | energy expenditure | SYMPATHETIC OUTFLOW | vagal afferent neurons | BODY-WEIGHT | GLUCAGON-LIKE-PEPTIDE-1 RECEPTOR | ENERGY-EXPENDITURE | NUCLEUS | high-fat diet | FAT | NEURONS | SECRETION | exendin-4 | obesity | HYPOTHALAMUS
Journal Article
Current Diabetes Reviews, ISSN 1573-3998, 2013, Volume 9, Issue 2, pp. 161 - 193
Journal Article
NeuroReport, ISSN 0959-4965, 06/2018, Volume 29, Issue 12, pp. 1046 - 1053
The present study investigated the relationship between accumbal ghrelin and glucagon-like peptide 1 (GLP-1) signaling in alcohol reward in female rats.... 
estrous | JMV2959 | nucleus accumbens | mesolimbic | ethanol | exendin-4 | DRINKING | FOOD-INTAKE | NEUROSCIENCES | NUCLEUS-ACCUMBENS | AGONIST EXENDIN-4 | NEURONS | RECEPTOR AGONIST | EXPRESSION | STOMACH | ESTROUS-CYCLE | Alcoholic beverages | Cellular signal transduction | Research | Glucagon | Ghrelin | Health aspects
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 07/2015, Volume 56, Issue 7, pp. 1075 - 1078
In-111-DOTA-exendin-4 SPECT/CT has been shown to be highly efficient in the detection of insulinomas. We aimed at determining whether novel PET/CT imaging with... 
Ga-68 | insulinoma | glucagon-like peptide-1 receptor targeting | exendin-4 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 07/2019, Volume 74-75, pp. 19 - 24
Glucagon-like peptide-1 receptor (GLP-1R) is a kind of G protein coupled receptor which regulates the insulin secretion and serves as potential target in the... 
Pancreas islet | Gallium-68 | Insulinoma | PET/CT | Exendin-4 | GLP-1R
Journal Article
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 09/2019, Volume 16, Issue 9, pp. 3760 - 3769
The glucagon-like peptide-1 receptor (GLP-1R) is highly and specifically expressed on the pancreatic beta-cells. It plays an important role in glucose... 
MEDICINE, RESEARCH & EXPERIMENTAL | LOCALIZATION | beta-cell imaging | GA-68-NOTA-EXENDIN-4 | TUMORS | GLUCAGON-LIKE PEPTIDE-1 | insulinoma | PET/CT | PHARMACOLOGY & PHARMACY | beta-cells | albumin binder | BETA-CELL MASS | exendin-4 | GLP-1R
Journal Article
by Xu, YP and Pan, DH and Xu, Q and Zhu, C and Wang, LZ and Chen, F and Yang, RL and Luo, SN and Yang, M
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, ISSN 0171-5216, 09/2014, Volume 140, Issue 9, pp. 1479 - 1488
Glucagon-like peptide-1 receptor (GLP-1R) is a specific target for insulinomas imaging since it is overexpressed in the tumor. Exendin-4 exhibits high affinity... 
NEUROENDOCRINE TUMORS | PET imaging | F-18-FBEM | ANALOGS | Insulinoma | THERAPY | Cys-exendin-4 | ONCOLOGY | EXENDIN-4 | GLP-1 RECEPTOR | EXPRESSION | PET | GLP-1R
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 1, pp. 42 - 48
The purpose of this study was to investigate the gastrointestinal stability of exenatide to determine the key factor(s) contributing to peptide degradation... 
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 09/2018, Volume 64-65, pp. 22 - 27
Radiolabeled exendin derivatives have been developed to visualize and quantify pancreatic beta cells. However, there are currently no established methods for... 
In-vivo | Quantification | ROI | SPECT | Exendin-4
Journal Article
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