2010, ISBN 0470998091, xvii, 485
"In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue...
toxicity | Toxicology | Models, Biological | methods | adverse effects | Mathematical models | Environmental Exposure | Hazardous Substances | Toxicity Tests | Biological models
toxicity | Toxicology | Models, Biological | methods | adverse effects | Mathematical models | Environmental Exposure | Hazardous Substances | Toxicity Tests | Biological models
Book
Statistics in Medicine, ISSN 0277-6715, 02/2014, Volume 33, Issue 5, pp. 881 - 899
In biomedical research, a health effect is frequently associated with protracted exposures of varying intensity sustained in the past. The main complexity of...
delayed effects | splines | exposure–lag–response | distributed lag models | latency | Distributed lag models | Exposure-lag-response | Splines | Delayed effects | Latency | MORTALITY | MEDICINE, RESEARCH & EXPERIMENTAL | URANIUM MINERS COHORT | MEDICAL INFORMATICS | STATISTICS & PROBABILITY | TIME | CANCER | AIR-POLLUTION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TEMPERATURE | MATHEMATICAL & COMPUTATIONAL BIOLOGY | LATENCY ANALYSIS | exposure-lag-response | EPIDEMIOLOGY | Data Interpretation, Statistical | Radon - adverse effects | Occupational Exposure - adverse effects | Humans | Middle Aged | Risk | Models, Statistical | Lung Neoplasms - etiology | Time Factors | Computer Simulation | Aged, 80 and over | Adult | Aged | Index Medicus
delayed effects | splines | exposure–lag–response | distributed lag models | latency | Distributed lag models | Exposure-lag-response | Splines | Delayed effects | Latency | MORTALITY | MEDICINE, RESEARCH & EXPERIMENTAL | URANIUM MINERS COHORT | MEDICAL INFORMATICS | STATISTICS & PROBABILITY | TIME | CANCER | AIR-POLLUTION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TEMPERATURE | MATHEMATICAL & COMPUTATIONAL BIOLOGY | LATENCY ANALYSIS | exposure-lag-response | EPIDEMIOLOGY | Data Interpretation, Statistical | Radon - adverse effects | Occupational Exposure - adverse effects | Humans | Middle Aged | Risk | Models, Statistical | Lung Neoplasms - etiology | Time Factors | Computer Simulation | Aged, 80 and over | Adult | Aged | Index Medicus
Journal Article
Environmental Pollution, ISSN 0269-7491, 02/2014, Volume 185, pp. 69 - 76
Concerns about the environmental risks of engineered nanomaterials (ENM) are growing, however, currently very little is known about their concentrations in the...
Production estimates | Material flow modelling | Probability distributions | Environmental concentrations | Engineered nanomaterials (ENM) | PLANT | BEHAVIOR | RISK | RELEASE | FATE | SILVER NANOPARTICLES | ENVIRONMENTAL SCIENCES | PRODUCTS | TITANIUM-DIOXIDE NANOPARTICLES | EXPOSURE | WATER | Environmental Pollution - statistics & numerical data | Environment | Nanostructures - analysis | Models, Statistical | Chemical Engineering | Environmental Exposure - statistics & numerical data | Environmental Pollutants - analysis | Hunger | Analysis | Nanotechnology | Environmental engineering | Distribution (Probability theory) | Compartments | Probability theory | Nanomaterials | Mathematical models | Nanostructure | Models | Estimates | Titanium dioxide
Production estimates | Material flow modelling | Probability distributions | Environmental concentrations | Engineered nanomaterials (ENM) | PLANT | BEHAVIOR | RISK | RELEASE | FATE | SILVER NANOPARTICLES | ENVIRONMENTAL SCIENCES | PRODUCTS | TITANIUM-DIOXIDE NANOPARTICLES | EXPOSURE | WATER | Environmental Pollution - statistics & numerical data | Environment | Nanostructures - analysis | Models, Statistical | Chemical Engineering | Environmental Exposure - statistics & numerical data | Environmental Pollutants - analysis | Hunger | Analysis | Nanotechnology | Environmental engineering | Distribution (Probability theory) | Compartments | Probability theory | Nanomaterials | Mathematical models | Nanostructure | Models | Estimates | Titanium dioxide
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 01/2015, Volume 79, Issue 1, pp. 56 - 71
In oncology trials, overall survival (OS) is considered the most reliable and preferred endpoint to evaluate the benefit of drug treatment. Other relevant...
time‐to‐event | PKPD | biomarkers | population modelling | tumour | oncology | time-to-event | PHARMACOKINETIC/PHARMACODYNAMIC MODEL | PROGRESSION-FREE SURVIVAL | TIME-COURSE | CELL LUNG-CANCER | EXPOSURE-RESPONSE | DECISION-MAKING | THYROID-CANCER | DRUG DEVELOPMENT | TUMOR-SIZE | PHARMACOLOGY & PHARMACY | DISEASE PROGRESSION | Time Factors | Antineoplastic Agents - adverse effects | Models, Biological | Computer Simulation | Humans | Biomarkers, Pharmacological | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - therapeutic use | Biomarkers, Tumor | Neoplasms - drug therapy | Reviews | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
time‐to‐event | PKPD | biomarkers | population modelling | tumour | oncology | time-to-event | PHARMACOKINETIC/PHARMACODYNAMIC MODEL | PROGRESSION-FREE SURVIVAL | TIME-COURSE | CELL LUNG-CANCER | EXPOSURE-RESPONSE | DECISION-MAKING | THYROID-CANCER | DRUG DEVELOPMENT | TUMOR-SIZE | PHARMACOLOGY & PHARMACY | DISEASE PROGRESSION | Time Factors | Antineoplastic Agents - adverse effects | Models, Biological | Computer Simulation | Humans | Biomarkers, Pharmacological | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - therapeutic use | Biomarkers, Tumor | Neoplasms - drug therapy | Reviews | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Environmental Research, ISSN 0013-9351, 2008, Volume 106, Issue 1, pp. 7 - 16
There are acknowledged difficulties in epidemiological studies to accurately assign exposure to air pollution for large populations, and large, long-term...
Geographic information systems (GIS) | Air pollution | Road traffic | Land-use regression (LUR) | Exposure assessment | MORTALITY | road traffic | CITIES | exposure assessment | SPATIAL VARIABILITY | SYMPTOMS | SULFUR | CHILDHOOD ASTHMA | CHILDREN | AMBIENT NITROGEN-DIOXIDE | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | land-use regression (LUR) | INDICATORS | geographic information systems (GIS) | air pollution | ASSOCIATION | Models, Theoretical | Air Pollutants - analysis | Humans | Environmental Monitoring - methods | Environmental Monitoring - statistics & numerical data | Air Pollution - analysis | Inhalation Exposure - analysis | Kinetics | Seasons | Urban Health | Ontario | Measurement | Models | Nitrogen dioxide | Toluene | Analysis | GEOGRAPHIC INFORMATION SYSTEMS | BENZENE | POLLUTANTS | TOLUENE | SULFUR DIOXIDE | AIR POLLUTION | INTERNATIONAL AGREEMENTS | SEASONS | NITROGEN DIOXIDE | CHRONIC EXPOSURE | AIR QUALITY | URBAN AREAS
Geographic information systems (GIS) | Air pollution | Road traffic | Land-use regression (LUR) | Exposure assessment | MORTALITY | road traffic | CITIES | exposure assessment | SPATIAL VARIABILITY | SYMPTOMS | SULFUR | CHILDHOOD ASTHMA | CHILDREN | AMBIENT NITROGEN-DIOXIDE | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | land-use regression (LUR) | INDICATORS | geographic information systems (GIS) | air pollution | ASSOCIATION | Models, Theoretical | Air Pollutants - analysis | Humans | Environmental Monitoring - methods | Environmental Monitoring - statistics & numerical data | Air Pollution - analysis | Inhalation Exposure - analysis | Kinetics | Seasons | Urban Health | Ontario | Measurement | Models | Nitrogen dioxide | Toluene | Analysis | GEOGRAPHIC INFORMATION SYSTEMS | BENZENE | POLLUTANTS | TOLUENE | SULFUR DIOXIDE | AIR POLLUTION | INTERNATIONAL AGREEMENTS | SEASONS | NITROGEN DIOXIDE | CHRONIC EXPOSURE | AIR QUALITY | URBAN AREAS
Journal Article
Risk Analysis, ISSN 0272-4332, 2013, Volume 33, Issue 5, pp. 772 - 788
The devastating impact by Hurricane Sandy (2012) again showed New York City (NYC) is one of the most vulnerable cities to coastal flooding around the globe....
New York City | hurricane | Catastrophe model | flood risk | uncertainty | Uncertainty | Hurricane | Flood risk | WIND | HURRICANES | UNCERTAINTIES | INSURANCE | DAMAGE | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SOCIAL SCIENCES, MATHEMATICAL METHODS | IMPACTS | EXPOSURE | Models, Theoretical | Risk Assessment | Probability | Floods | Cyclonic Storms | Risk assessment | Models | Storms | Risk | Hurricanes | Storm surges | Damage | Risk analysis | Flood damage | U.S.A
New York City | hurricane | Catastrophe model | flood risk | uncertainty | Uncertainty | Hurricane | Flood risk | WIND | HURRICANES | UNCERTAINTIES | INSURANCE | DAMAGE | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SOCIAL SCIENCES, MATHEMATICAL METHODS | IMPACTS | EXPOSURE | Models, Theoretical | Risk Assessment | Probability | Floods | Cyclonic Storms | Risk assessment | Models | Storms | Risk | Hurricanes | Storm surges | Damage | Risk analysis | Flood damage | U.S.A
Journal Article
IEEE Transactions on Industrial Electronics, ISSN 0278-0046, 02/2015, Volume 62, Issue 2, pp. 953 - 959
In this paper, we review relevant problems in the modeling of dc-dc converters with switched capacitors. We study several approaches that overcome the exposed...
Linear systems | Computational modeling | Capacitors | Switches | Mathematical model | Integrated circuit modeling | Equations | Averaging | modeling | dc-dc converters | switched capacitors (SCs) | switched systems | BOOST CONVERTER | INSTRUMENTS & INSTRUMENTATION | SIMULATION | EFFICIENCY | AUTOMATION & CONTROL SYSTEMS | ENGINEERING, ELECTRICAL & ELECTRONIC | Usage | Models | Electric current converters | Industrial electronics | Dynamic tests | Dynamics | Mathematical analysis | Converters | Mathematical models | Exposure
Linear systems | Computational modeling | Capacitors | Switches | Mathematical model | Integrated circuit modeling | Equations | Averaging | modeling | dc-dc converters | switched capacitors (SCs) | switched systems | BOOST CONVERTER | INSTRUMENTS & INSTRUMENTATION | SIMULATION | EFFICIENCY | AUTOMATION & CONTROL SYSTEMS | ENGINEERING, ELECTRICAL & ELECTRONIC | Usage | Models | Electric current converters | Industrial electronics | Dynamic tests | Dynamics | Mathematical analysis | Converters | Mathematical models | Exposure
Journal Article
Environmental Science & Technology, ISSN 0013-936X, 05/2016, Volume 50, Issue 9, pp. 4701 - 4711
The need for an environmental risk assessment for engineered nanomaterials (ENM) necessitates the knowledge about their environmental concentrations. Despite...
ENVIRONMENTAL SCIENCES | ENGINEERING, ENVIRONMENTAL | SILVER | ZINC-OXIDE NANOPARTICLES | RISK | FLOWS | FATE | EXPOSURE | TRANSFORMATIONS | TIO2 NANOPARTICLES | WATER | Models, Theoretical | Nanostructures - chemistry | Environment | Environmental Pollutants | Soil - chemistry
ENVIRONMENTAL SCIENCES | ENGINEERING, ENVIRONMENTAL | SILVER | ZINC-OXIDE NANOPARTICLES | RISK | FLOWS | FATE | EXPOSURE | TRANSFORMATIONS | TIO2 NANOPARTICLES | WATER | Models, Theoretical | Nanostructures - chemistry | Environment | Environmental Pollutants | Soil - chemistry
Journal Article
Environmental Science & Technology, ISSN 0013-936X, 06/2008, Volume 42, Issue 12, pp. 4447 - 4453
The aim of this study was to use a life-cycle perspective to model the quantities of engineered nanoparticles released into the environment. Three types of...
Environmental Modeling | RISKS | ENVIRONMENTAL SCIENCES | PARTICLES | ENGINEERING, ENVIRONMENTAL | BEHAVIOR | NANOMATERIALS | TOXICITY | TIO2 | Nanoparticles | Environmental Exposure
Environmental Modeling | RISKS | ENVIRONMENTAL SCIENCES | PARTICLES | ENGINEERING, ENVIRONMENTAL | BEHAVIOR | NANOMATERIALS | TOXICITY | TIO2 | Nanoparticles | Environmental Exposure
Journal Article
Epidemiology, ISSN 1044-3983, 05/2019, Volume 30, Issue 3, pp. 458 - 465
BACKGROUND:Few studies have modeled smoking histories by combining smoking intensity and duration to show what profile of smoking behavior is associated with...
DNA-ADDUCTS | Pooled analysis | INTENSITY | Smoking history | Bladder cancer | Cancer risk | TOBACCO SMOKING | LUNG-CANCER | CIGARETTE-SMOKING | POLYMORPHISMS | statistical modeling | OCCUPATIONAL RISK-FACTORS | CUMULATIVE EXPOSURE | CONSUMPTION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Health aspects | Epidemiology | Analysis | Risk factors | Smoking
DNA-ADDUCTS | Pooled analysis | INTENSITY | Smoking history | Bladder cancer | Cancer risk | TOBACCO SMOKING | LUNG-CANCER | CIGARETTE-SMOKING | POLYMORPHISMS | statistical modeling | OCCUPATIONAL RISK-FACTORS | CUMULATIVE EXPOSURE | CONSUMPTION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Health aspects | Epidemiology | Analysis | Risk factors | Smoking
Journal Article
11.
Full Text
Surface complexation modeling of Cu(II) sorption to montmorillonite–bacteria composites
Science of the Total Environment, ISSN 0048-9697, 12/2017, Volume 607-608, pp. 1408 - 1418
Surface complexation modeling, isothermal titration calorimetry, and batch adsorption were employed to characterize the adsorption of Cu onto montmorillonite,...
Surface complexation model | Copper adsorption | Site masking | Montmorillonite | Bridging | Pseudomonas putida | CLAY-MINERALS | EXTRACELLULAR POLYMERIC SUBSTANCES | PSEUDOMONAS-PUTIDA | HEAVY-METAL ADSORPTION | IRON-OXIDE | ENVIRONMENTAL SCIENCES | HUMAN EXPOSURE | BACILLUS-SUBTILIS | RISK-ASSESSMENT | HUMIC-ACID | BIOFILM FORMATION | Clay | Bacteria | Models | Adsorption | Analysis | Thermodynamics
Surface complexation model | Copper adsorption | Site masking | Montmorillonite | Bridging | Pseudomonas putida | CLAY-MINERALS | EXTRACELLULAR POLYMERIC SUBSTANCES | PSEUDOMONAS-PUTIDA | HEAVY-METAL ADSORPTION | IRON-OXIDE | ENVIRONMENTAL SCIENCES | HUMAN EXPOSURE | BACILLUS-SUBTILIS | RISK-ASSESSMENT | HUMIC-ACID | BIOFILM FORMATION | Clay | Bacteria | Models | Adsorption | Analysis | Thermodynamics
Journal Article
Pediatric Research, ISSN 0031-3998, 05/2011, Volume 69, Issue 5, pp. 34R - 40R
A variety of features of autism can be simulated in rodents, including the core behavioral hallmarks of stereotyped and repetitive behaviors, and deficits in...
HIPPOCAMPUS | PRENATAL EXPOSURE | SYNAPTIC-TRANSMISSION | MOUSE | HYPOTHESIS | MATERNAL IMMUNE ACTIVATION | SCHIZOPHRENIA | PEDIATRICS | INFECTION | DYSFUNCTION | BRAIN | Autistic Disorder - pathology | Animals | Humans | Risk Factors | Disease Models, Animal
HIPPOCAMPUS | PRENATAL EXPOSURE | SYNAPTIC-TRANSMISSION | MOUSE | HYPOTHESIS | MATERNAL IMMUNE ACTIVATION | SCHIZOPHRENIA | PEDIATRICS | INFECTION | DYSFUNCTION | BRAIN | Autistic Disorder - pathology | Animals | Humans | Risk Factors | Disease Models, Animal
Journal Article
Science of the Total Environment, ISSN 0048-9697, 10/2016, Volume 568, pp. 770 - 784
MERLIN-Expo is a library of models that was developed in the frame of the FP7 EU project 4FUN in order to provide an integrated assessment tool for...
PBPK | Uncertainty | Exposure | MERLIN-Expo | Multimedia modelling | PHARMACOKINETIC MODEL | ORGANIC-CHEMICALS | INTERINDIVIDUAL VARIABILITY | ENVIRONMENTAL SCIENCES | RATE CONSTANTS | FISH | METABOLIC BIOTRANSFORMATION RATES | SPECIES WEIGHT | ACCUMULATION | EQUILIBRIUM RATIOS | VENICE LAGOON | Multimedia | Milk - chemistry | Predictive Value of Tests | Risk Assessment | Environmental Pollutants - pharmacokinetics | Europe | Humans | Fresh Water - chemistry | Environmental Exposure - analysis | Organic Chemicals - analysis | Animals | Organic Chemicals - pharmacokinetics | Models, Biological | Biota - physiology | Crops, Agricultural - chemistry | Environmental Exposure - statistics & numerical data | Environmental Pollutants - analysis | Case studies | Risk assessment | Libraries | Models | Index Medicus | Life Sciences | Toxicology
PBPK | Uncertainty | Exposure | MERLIN-Expo | Multimedia modelling | PHARMACOKINETIC MODEL | ORGANIC-CHEMICALS | INTERINDIVIDUAL VARIABILITY | ENVIRONMENTAL SCIENCES | RATE CONSTANTS | FISH | METABOLIC BIOTRANSFORMATION RATES | SPECIES WEIGHT | ACCUMULATION | EQUILIBRIUM RATIOS | VENICE LAGOON | Multimedia | Milk - chemistry | Predictive Value of Tests | Risk Assessment | Environmental Pollutants - pharmacokinetics | Europe | Humans | Fresh Water - chemistry | Environmental Exposure - analysis | Organic Chemicals - analysis | Animals | Organic Chemicals - pharmacokinetics | Models, Biological | Biota - physiology | Crops, Agricultural - chemistry | Environmental Exposure - statistics & numerical data | Environmental Pollutants - analysis | Case studies | Risk assessment | Libraries | Models | Index Medicus | Life Sciences | Toxicology
Journal Article