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FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article
Cancer, ISSN 0008-543X, 11/2014, Volume 120, Issue 22, pp. 3446 - 3456
The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple... 
mitogen‐activated protein kinase (MAPK) | mitogen‐activated protein kinase‐kinase (MEK) | signaling | colorectal cancer | ovarian cancer | v‐raf murine sarcoma viral oncogene homolog (BRAF) | melanoma | extracellular signal‐regulated kinase (ERK) | Extracellular signal-regulated kinase (ERK) | Signaling | V-raf murine sarcoma viral oncogene homolog (BRAF) | Colorectal cancer | Melanoma | Mitogen-activated protein kinase (MAPK) | Mitogen-activated protein kinase-kinase (MEK) | Ovarian cancer | mitogen-activated protein kinase-kinase (MEK) | mitogen-activated protein kinase (MAPK) | v-raf murine sarcoma viral oncogene homolog (BRAF) | extracellular signal-regulated kinase (ERK) | RNA INTERFERENCE SCREEN | ACTIVATED PROTEIN-KINASE | BRAF(V600E) INHIBITION | ACQUIRED-RESISTANCE | POTENTIAL MECHANISM | TUMOR HETEROGENEITY | CELL LUNG-CANCER | MET AMPLIFICATION | ONCOLOGY | SIGNALING PATHWAY | BRAF MUTATIONS | Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | MAP Kinase Signaling System - physiology | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - physiology | Calcium Signaling | Neoplasms - drug therapy | Care and treatment | Usage | Rapamycin | Protein kinases | Health aspects | Tumors | MEK | BRAF | MAPK | ERK
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e86681
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e81769
During normal cerebellar development, the remarkable expansion of granule cell progenitors (GCPs) generates a population of granule neurons that outnumbers the... 
PRIMITIVE NEUROECTODERMAL TUMORS | SONIC HEDGEHOG | SIGNALING PATHWAY | SPORADIC MEDULLOBLASTOMAS | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | N-MYC | BETA-CATENIN | INT-1 PROTOONCOGENE | BASAL-CELL CARCINOMAS | HUMAN HOMOLOG | Cell Proliferation | Wnt3 Protein - genetics | MAP Kinase Signaling System | Bone Morphogenetic Proteins - metabolism | Medulloblastoma - pathology | Wnt3 Protein - metabolism | Cell Differentiation | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Transgenes | Cerebellar Neoplasms - metabolism | Disease Models, Animal | Gene Expression | Transduction, Genetic | Signal Transduction | Medulloblastoma - metabolism | Cerebellar Neoplasms - genetics | Cell Transformation, Neoplastic - metabolism | Neural Stem Cells - pathology | Mice, Knockout | Animals | Cell Line, Tumor | Mice | Enzyme Activation | Neural Stem Cells - metabolism | Mitogen-Activated Protein Kinases - metabolism | Genetic transcription | Neurons | Protein kinases | Analysis | Medulloblastoma | Genes | Cerebellum | Neurosciences | Animal models | Cerebral cortex | Phosphorylation | Wnt protein | Neurobiology | Kinases | Neurogenesis | Phase transitions | Defects | Proteins | Signal transduction | β-catenin | Pathways | Rodents | Granule cells | Cortex | Extracellular signal-regulated kinase | MAP kinase | Signaling | Inhibitors | Insects | Granular materials | Hedgehog protein | Neural stem cells | Laboratory animals | Tumors
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2004, Volume 572, Issue 1-3, pp. 177 - 183
The multisite phosphorylation of the transcription factor ATF‐2 was investigated using transformed embryonic fibroblasts from wild‐type mice and mice deficient... 
c-Jun N-terminal kinase | Tumour necrosis factor | Epidermal growth factor | p38 | Extracellular signal-regulated protein kinase | PMA, phorbol-12-myristate 13-acetate | CRE, cyclic AMP-response element | E1A, early adenovirus protein 1A | GST, glutathione S-transferase | EGF, epidermal growth factor | TNF, tumour necrosis factor | bZIP, basic region-leucine zipper | AP-1, activating protein 1 | ERK, extracellular signal-regulated protein kinase | HAT, histone acetyl transferase | JNK, c-Jun N-terminal kinase | MAPKAP-K2, MAPK-activated protein kinase 2 | Rb, retinoblastoma protein | ATF-2, activating transcription factor-2 | MAPK, mitogen-activated protein kinase | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMP RESPONSE ELEMENT | FAMILY | CELL BIOLOGY | CREB | BIOPHYSICS | tumour necrosis factor | extracellular signal-regulated protein kinase | epidermal growth factor | C-JUN | CRE-BP1 | BINDING | PROTEIN-KINASE INHIBITORS | ADENOVIRUS-E1A | LEUCINE ZIPPER PROTEINS | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Phosphorylation | Tetradecanoylphorbol Acetate - pharmacology | Embryo, Mammalian | Fibroblasts - physiology | MAP Kinase Kinase 7 | Mitogen-Activated Protein Kinase Kinases - metabolism | p38 Mitogen-Activated Protein Kinases | Phosphopeptides - chemistry | Peptide Fragments - metabolism | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - deficiency | Mice, Knockout | Mitogen-Activated Protein Kinases - deficiency | Transcription Factors - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Peptide Fragments - chemistry | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 8 | Signal Transduction - drug effects | Activating Transcription Factor 2 | Fibroblasts - drug effects | Cyclic AMP Response Element-Binding Protein - metabolism | Phosphopeptides - metabolism | Anisomycin - pharmacology | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Mice | Mitogen-Activated Protein Kinases - metabolism | Cyclic adenylic acid | Glutathione transferase | Mitogens | Protein kinases
Journal Article