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Cerebrovascular Diseases, ISSN 1015-9770, 01/2014, Volume 37, Issue 1, pp. 57 - 63
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2016, Volume 92, pp. 100 - 109
Familial Cerebral Cavernous Malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 gene, and... 
Disease severity | Oxidative stress | Free radicals | Cerebral Cavernous Malformation (CCM) | Familial Cerebral Cavernous Malformation type 1 | Vascular brain lesions | Reactive oxygen species (ROS) | Matrix metalloproteinase (MMP) | Genetic markers set association study | Intracerebral hemorrhage | KRIT1/CCM1 | Inter-individual variability in disease susceptibility and outcome | Cytochrome P450 (CYP) | Cerebrovascular disease | EET epoxyeicosatrienoic acids | 1,25-dihydroxyvitamin D3 | 24-OHC 24(S)-hydroxycholesterol | SNP single nucleotide polymorphism | 25-hydroxyvitamin D3 | AA arachidonic acid | ICH intracerebral hemorrhage | Abbreviations CCM Cerebral Cavernous Malformation | LT leukotrienes | CYP cytochrome P450 | ROS reactive oxygen species | ECM extracellular matrix | 27-OHC 27-hydroxycholesterol | BBB blood-brain barrier | PG prostaglandins | 1,25-OH | NVU neurovascular unit | MMP matrix metalloproteinase | 25-OH-D | CHM common hispanic mutation | VITAMIN-D | SIGNALING PATHWAYS | REDUCES OXIDATIVE STRESS | CEREBROVASCULAR-DISEASE | WHITE-MATTER LESIONS | ENDOCRINOLOGY & METABOLISM | MEDIATED REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | CHOLESTEROL 24-HYDROXYLASE | CORONARY-ARTERY-DISEASE | Brain - diagnostic imaging | Matrix Metalloproteinases - genetics | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Male | Hemangioma, Cavernous, Central Nervous System - genetics | Brain - metabolism | Adult | Female | Multigene Family - genetics | Severity of Illness Index | Hemangioma, Cavernous, Central Nervous System - diagnostic imaging | Oxidative Stress - genetics | Genotype | Proto-Oncogene Proteins - genetics | Magnetic Resonance Imaging | Phenotype | Hemangioma, Cavernous, Central Nervous System - pathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Heterozygote | Aged | Polymorphism, Single Nucleotide | Mutation | Brain | Genetic markers | Analysis | Pharmacy | Cytochrome P-450 | Genetic research | Drugstores | Brain damage | Epidemiology | ECM, extracellular matrix | 27-OHC, 27-hydroxycholesterol | 25-OH-D3, 25-hydroxyvitamin D3 | CHM, common hispanic mutation | NVU, neurovascular unit | ICH, intracerebral hemorrhage | PG, prostaglandins | CCM, Cerebral Cavernous Malformation | KRIT1 | ROS, reactive oxygen species | CYP, cytochrome P450 | EET, epoxyeicosatrienoic acids | LT, leukotrienes | Original Contribution | BBB, blood–brain barrier | SNP, single nucleotide polymorphism | AA, arachidonic acid | 24-OHC, 24(S)-hydroxycholesterol | 1,25-OH2-D3, 1,25-dihydroxyvitamin D3 | CCM1 | MMP, matrix metalloproteinase
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 12/2016, Volume 81, Issue Pt B, pp. 254 - 270
. CCM proteins play pleiotropic roles in distinct redox-sensitive pathways by modulating the fine-tuned crosstalk between redox signaling and autophagy.... 
Cerebral cavernous malformation (CCM) | Oxidative stress | Vascular homeostasis | Inflammation | Redox signaling | Autophagy | Angiogenesis | Antioxidant response | CCM3/PDCD10 | Blood-brain barrier dysfunction | CCM2 | CCM1/KRIT1 | Vascular permeability | Cerebrovascular disease | IMMUNE-RESPONSE | RHO-KINASE | VASCULAR-PERMEABILITY | BETA-CATENIN | CELL BIOLOGY | ENDOTHELIAL-CELLS | SHEAR-STRESS | NF-KAPPA-B | NADPH OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | TO-MESENCHYMAL TRANSITION | Hemangioma, Cavernous, Central Nervous System - physiopathology | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - physiopathology | Oxidative Stress | Humans | Prevention | Proteins | Brain | Medical colleges | Endothelium | Antioxidants | Blood circulation disorders | Medical research | Endothelial growth factors | Medicine, Experimental | Development and progression | Bone morphogenetic proteins | Disease susceptibility | KLF, Kruppel-like factor | COX-2, cycloxygenase-2 | NVU, neurovascular unit | ICH, intracerebral hemorrhage | PDCD10 | KRIT1 | ROS, reactive oxygen species | BMP, bone morphogenetic protein | fCCM, familial form of CCM | EndMT, endothelial-to-mesenchymal transition | VEGF, vascular endothelial growth factor | TGFβ, transforming growth factor beta | AJ, adherens junction | CCM, cerebral cavernous malformation | sCCM, sporadic form of CCM | CCM3 | CCM1
Journal Article
Journal Article
Journal of neurosurgery, ISSN 0022-3085, 2002, Volume 97, Issue 2, pp. 227 - 230
Journal Article
Neurological Sciences, ISSN 1590-1874, 4/2009, Volume 30, Issue 2, pp. 143 - 147
Journal Article
Monatsschrift Kinderheilkunde, ISSN 0026-9298, 12/2007, Volume 155, Issue 12, pp. 1161 - 1165
Familiäre und multiple Kavernome beruhen häufig auf autosomal-dominant vererbten Mutationen, die sich mit einer Penetranz von etwa 60% klinisch manifestieren.... 
Pediatrics | Kavernöses Hämangiom | CCM1 mutation | Familial cavernoma | General Practice / Family Medicine | Cerebral cavernous malformation | Kavernom | CCM1 -Mutation | Genetik | Medicine & Public Health | Cavernoma | Genetics | Familiäre Kavernomatose
Journal Article