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PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e90298
Eosinophils play a central role in asthma. The present study was performed to investigate the effect of tumour necrosis factor-alpha (TNF-alpha) on longevity... 
CELL LIFE | SURVIVAL | IN-VITRO | ACTIVATION | INHIBITION | JNK | MULTIDISCIPLINARY SCIENCES | KINASE | ASTHMA | DEATH | C-JUN | Asthma - metabolism | Eosinophils - metabolism | Phosphorylation | Eosinophils - drug effects | Apoptosis - drug effects | Transcription Factor AP-1 - genetics | Humans | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Transcription Factor AP-1 - metabolism | Pyrrolidines - pharmacology | Quinoxalines - pharmacology | Thiocarbamates - pharmacology | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Eosinophils - pathology | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | Signal Transduction | Gene Expression Regulation | fas Receptor - pharmacology | Imidazoles - pharmacology | I-kappa B Kinase - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Asthma - genetics | Antibodies - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Transcription Factor AP-1 - antagonists & inhibitors | NF-kappa B - genetics | Gliotoxin - pharmacology | Protein Binding | Primary Cell Culture | Asthma - pathology | Retinoids - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Flow cytometry | Transcription factors | Disease | Kinases | Macrophages | Necrosis | Interleukins | DNA fragmentation | Tumor necrosis factor-TNF | Colony-stimulating factor | Chronic obstructive pulmonary disease | Autocrine signalling | Deoxyribonucleic acid--DNA | Gliotoxin | Binding | NF-κB protein | Cell survival | Cytokines | Leukocytes (eosinophilic) | Cloning | c-Jun protein | Pharmacology | Longevity | Tumor necrosis factor-α | Survival | Asthma | Medicine | Cytometry | Hospitals | Inhibitors | TNF inhibitors | Ligands | Leukocytes (granulocytic) | Tumors | Apoptosis | Eosinophils | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 2006, Volume 4, Issue 3, pp. 185 - 198
The etiology of progression from steatosis to steatohepatitis (SH) remains unknown. Using nutritional and genetic models of hepatic steatosis, we show that... 
HUMDISEASE | SIGNALING | HEPATOCYTE APOPTOSIS | TUMOR-NECROSIS-FACTOR | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | NONALCOHOLIC STEATOHEPATITIS | ENDOPLASMIC-RETICULUM STRESS | ELEMENT-BINDING PROTEINS | NF-KAPPA-B | FACTOR-ALPHA | PERMEABILITY TRANSITION | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Oxidative Stress - physiology | Male | Hepatocytes - metabolism | Fatty Liver - chemically induced | Liver - physiopathology | fas Receptor - metabolism | Mitochondrial Membranes - drug effects | Hepatitis - metabolism | Cell Death - drug effects | Glutathione - deficiency | Cell Survival - physiology | Hepatocytes - drug effects | Disease Models, Animal | Cell Survival - drug effects | Fatty Liver - metabolism | Fatty Liver - physiopathology | Liver - metabolism | Cells, Cultured | Rats | fas Receptor - pharmacology | Mice, Transgenic | Mitochondria - metabolism | Cholesterol - metabolism | Rats, Sprague-Dawley | Disease Progression | Mitochondrial Membranes - metabolism | Proteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Animals | Proteins - metabolism | Cell Death - physiology | Hepatitis - physiopathology | Cholesterol - pharmacology | Mice | Oxidative Stress - drug effects | Synthesis | Gastrointestinal agents | Tumor necrosis factor | Analysis | Lipids | Triglycerides | Fatty acids | Cholesterol | Glutathione
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 236 - 250
Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC) and by the inflammasome adaptor ASC.... 
caspase-8 | DED | MC159 | cFLIP | DISC | Fas | death domain | FADD | vFLIP | filament | APOPTOSIS | ACTIVATION | IMMUNE-SYSTEM | INHIBITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | UNIFIED MODEL | EFFECTOR DOMAIN | CELL-DEATH | CELL BIOLOGY | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Caspase 8 - metabolism | Caspase 8 - chemistry | CASP8 and FADD-Like Apoptosis Regulating Protein - chemistry | Death Domain Receptor Signaling Adaptor Proteins - genetics | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Caspase 8 - genetics | Transfection | Cytoskeletal Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Death Effector Domain | Fas-Associated Death Domain Protein - genetics | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Jurkat Cells | Viral Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Viral Proteins - genetics | fas Receptor - pharmacology | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | Fas-Associated Death Domain Protein - chemistry | Cryoelectron Microscopy | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | CARD Signaling Adaptor Proteins | Plasmids - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Autoimmunity | Medical colleges | Skin diseases | Molecular biology | Analysis | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 5, pp. 811 - 823
Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for... 
HUMDISEASE | DEVBIO | SIGNALING | ANDROGEN RECEPTOR | APOPTOSIS | RESORPTION | DISEASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MASS | MECHANISMS | DEFICIENT MICE | OSTEOPETROSIS | EXPRESSION | OSTEOPOROSIS | CELL BIOLOGY | Fas Ligand Protein - metabolism | Male | fas Receptor - metabolism | Bone Remodeling - drug effects | Selective Estrogen Receptor Modulators - therapeutic use | Estrogen Receptor alpha - metabolism | Female | Integrases - metabolism | Mice, Inbred DBA | Cell Differentiation | Estradiol - metabolism | Osteoclasts - pathology | Bone Density | Cathepsin K | Ovariectomy | Signal Transduction | Bone Diseases, Metabolic - prevention & control | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Osteoclasts - metabolism | Estrogen Receptor alpha - deficiency | Mice, Knockout | Bone Diseases, Metabolic - metabolism | Estrogen Receptor alpha - drug effects | Phenotype | Animals | Estrogen Receptor alpha - genetics | Cathepsins - genetics | Cathepsins - metabolism | Tamoxifen - therapeutic use | Tamoxifen - pharmacology | Mice | Bone Diseases, Metabolic - physiopathology | Fas Ligand Protein - genetics | Integrases - genetics | Selective Estrogen Receptor Modulators - pharmacology | Osteoclasts - drug effects | Apoptosis | Cathepsins | Antigens, CD95 | Estradiol | Life Sciences | Estrogen Receptor alpha | Biochemistry, Molecular Biology | Tamoxifen | Bone Diseases, Metabolic | Integrases | Fas Ligand Protein | Selective Estrogen Receptor Modulators | Osteoclasts | Molecular biology | Bone Remodeling
Journal Article
Journal Article
Cell death & disease, ISSN 2041-4889, 04/2016, Volume 7, Issue 4, pp. e2209 - e2209
Glioblastoma (GBM) is one of the most aggressive types of cancer with limited therapeutic options and unfavorable prognosis. Stemness and non-classical... 
Class Ia Phosphatidylinositol 3-Kinase - metabolism | Prognosis | Recombinant Fusion Proteins - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Spheroids, Cellular - pathology | Antineoplastic Agents, Alkylating - pharmacology | Epithelial-Mesenchymal Transition - genetics | Neoplasm Recurrence, Local - mortality | RNA, Messenger - metabolism | fas Receptor - metabolism | Neoplasm Recurrence, Local - pathology | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | fas Receptor - genetics | Immunoglobulin G - pharmacology | Neoplastic Stem Cells - pathology | Glioblastoma - classification | Spheroids, Cellular - drug effects | Brain Neoplasms - mortality | Class Ia Phosphatidylinositol 3-Kinase - genetics | Signal Transduction | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Brain Neoplasms - genetics | fas Receptor - pharmacology | Neoplasm Recurrence, Local - classification | Drug Synergism | Brain Neoplasms - classification | Glioblastoma - pathology | Survival Analysis | Neoplasm Recurrence, Local - genetics | Primary Cell Culture | Temozolomide | Glioblastoma - mortality | Drug Combinations | Biomarkers | Ligands | Cancer therapies | Cancer | Tumors | Original
Journal Article