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Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 16, pp. 10447 - 10459
Background: Mechanisms whereby local bone-derived factors regulate FGF-23 are unclear. Results: Low and high molecular weight FGF-2 stimulated FGF-23 promoter... 
TRANSCRIPTION FACTORS | CELLS | KLOTHO | Fibroblast Growth Factor (FGF) | VITAMIN-D METABOLISM | Calcineurin | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cyclic AMP (cAMP) | HYPOPHOSPHATEMIC RICKETS | PHOSPHATE HOMEOSTASIS | Osteoblast | GENE-EXPRESSION | MICE | BONE | Fibroblast Growth Factor Receptor (FGFR) | SIGNALING MODULE | Molecular Weight | Humans | Fibroblast Growth Factor 2 - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Fibroblast Growth Factors - metabolism | Calcineurin - genetics | Protein Isoforms - metabolism | Phospholipase C gamma - genetics | Fibroblast Growth Factor 2 - metabolism | Transcription, Genetic | Cell Differentiation | Osteoblasts - cytology | Cyclic AMP - metabolism | Cell Line | Promoter Regions, Genetic | Phospholipase C gamma - metabolism | Signal Transduction | NFATC Transcription Factors - metabolism | Osteoblasts - drug effects | Gene Expression Regulation | Protein Isoforms - pharmacology | Cyclic AMP Response Element-Binding Protein - genetics | Fibroblast Growth Factor 2 - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Protein c-ets-1 | Osteoblasts - metabolism | Calcineurin - metabolism | Mitogen-Activated Protein Kinases - metabolism | NFATC Transcription Factors - genetics | Protein Isoforms - genetics | Index Medicus | Gene Regulation
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2017, Volume 16, Issue 8, pp. 1717 - 1726
Journal Article
Journal Article
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 10/2016, Volume 16, Issue 9, pp. 1142 - 1154
Lung cancer is still the leading cause of cancer related death worldwide. Fibroblast growth factor receptor (FGFR) is a tirosine-kinase receptor that is seen... 
Amplification | Targeted inhibitors | Non-small-cell lung cancer (NSCLC) | Tumorigenic role | Fifbroblast growth factor receptor (FGFR) | Prognostic role | XENOGRAFT MODELS | CHEMISTRY, MEDICINAL | prognostic role | targeted inhibitors | non-small-cell lung cancer (NSCLC) | tumorigenic role | PROOF-OF-CONCEPT | amplification | BIBF 1120 | SELECTIVE INHIBITOR | ONCOLOGY | TRIPLE ANGIOKINASE INHIBITOR | POTENT ANTITUMOR | TYROSINE KINASE INHIBITOR | GENE AMPLIFICATION | fifbroblast growth factor receptor (FGFR) | ANGIOGENESIS INHIBITOR | PHASE-I | Lung Neoplasms - drug therapy | Small Molecule Libraries - pharmacology | Humans | Lung Neoplasms - metabolism | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Receptors, Fibroblast Growth Factor - genetics | Antineoplastic Agents - pharmacology | Lung - metabolism | Molecular Targeted Therapy - methods | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung - pathology | Carcinoma, Non-Small-Cell Lung - genetics | Antibodies, Monoclonal - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Small Molecule Libraries - therapeutic use | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Lung - drug effects | Receptors, Fibroblast Growth Factor - metabolism | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2017, Volume 135, pp. 531 - 543
A series of 2-oxo-3, 4-dihydropyrimido[4,5- ]-pyrimidinyl derivatives were designed and synthesized as new irreversible inhibitors of the FGFR family. One of... 
FGFR | Irreversible inhibitor | 2-Oxo-3,4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives | CHEMISTRY, MEDICINAL | DISCOVERY | FAMILY | AZD4547 | 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives | SELECTIVE INHIBITOR | POTENT | PATHWAY | REACTIVATION | RESISTANCE | TYROSINE KINASE INHIBITOR | TARGETING FGFR | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Structure-Activity Relationship | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Drug Screening Assays, Antitumor | Fibroblast growth factors | Enzyme inhibitors | Drug discovery | Lung cancer, Non-small cell | Derivatives (Financial instruments) | Resveratrol
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2018, Volume 154, pp. 9 - 28
Starting from the phase II clinical FGFR inhibitor lucitanib ( ), we conducted a medicinal chemistry approach by opening the central quinoline skeleton coupled... 
VEGFR | Synergistic effect | Lucitanib | FGFR | Tumor growth inhibition | CHEMISTRY, MEDICINAL | METASTASIS | SOLID TUMORS | ANGIOGENESIS | TYROSINE KINASE | PANCREATIC-CANCER | DISCOVERY | BREAST-CANCER | SELECTIVE INHIBITOR | AMPLIFICATION | THERAPEUTIC TARGET | Quinoline | Alkaloids | Fibroblast growth factors | Pyridine | Vascular endothelial growth factor | Analysis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2016, Volume 59, Issue 23, pp. 10586 - 10600
Journal Article
Journal Article
Journal Article