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PloS one, ISSN 1932-6203, 11/2010, Volume 5, Issue 11, pp. e14117 - e14117
Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression... 
Fibroblast Growth Factor 7 - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Coculture Techniques | Humans | Lung Neoplasms - metabolism | Fibroblast Growth Factor 2 - pharmacology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Fibroblasts - cytology | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Tyrosine | Phenols | Fibroblast growth factors | RNA | Analysis | Luciferase | Fibroblast growth factor | Biotechnology | Transcription | Gene regulation | Lung cancer | Biology | Kinases | Cell adhesion & migration | Morphogenesis | Epidermal growth factor | Fibroblast growth factor receptor 7 | Gefitinib | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Fibroblast growth factor 2 | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | Gene expression | Src protein | Self sufficiency | Pulmonary hypertension | Studies | Signaling | Inhibitors | Monoclonal antibodies | Ligands | Mutation | Tumors | Fibroblast growth factor receptors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Index Medicus | Biological Sciences | kinase inhibitor | structure-based drug design | cancer drug resistance | PNAS Plus | drug discovery
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33870 - e33870
Background: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Diabetes Mellitus - genetics | Membrane Proteins - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Diabetes Mellitus - metabolism | Fibroblast Growth Factors - genetics | Multiprotein Complexes - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Adipose Tissue | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Type 2 diabetes | Physiological aspects | Obesity | Cellular signal transduction | Fibroblast growth factors | Liver | Adipose tissue | Body fat | Laboratories | Dietary minerals | Science | Homeostasis | Biology | Adipocytes | Metabolic syndrome | Angiogenesis | Signal transduction | Rodents | Animal tissues | Fibroblast growth factor receptor 4 | Fibroblasts | Physiology | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Binding | Heparan sulfate | Fibroblast growth factor 1 | Fasting | Diabetes mellitus | Melanoma | Gene expression | Metabolism | Ablation | Musculoskeletal system | Signaling | Proteomics | Stem cells | Affinity | Insulin resistance | Diabetes | Kinetics | Nanotechnology | Cancer | Fibroblast growth factor receptors | Index Medicus
Journal Article
The FEBS journal, ISSN 1742-4658, 04/2016, Volume 283, Issue 9, pp. 1653 - 1668
Regeneration of skeletal muscles is required throughout life to ensure optimal performance. Therefore, a better understanding of the resident cells involved in... 
fibro/adipocytes | adipogenesis | fibroblast growth factor receptor | adipogenic differentiation | βKlotho | αKlotho | PiggyBac transposon | FAPs | FGF21 | satellite cells | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Adipocytes - cytology | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Adipogenesis - genetics | Fibroblasts - metabolism | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Satellite Cells, Skeletal Muscle - cytology | Gene Expression Regulation | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | Lipid Droplets | Animals | Adipocytes - metabolism | Fibroblasts - cytology | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus | Piggybac transposon | Fibro | Adipogenic differentiation | Satellite cells | adipocytes | Fibroblast growth factor receptors | Adipogenesis
Journal Article
Journal Article