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1. Full Text Targeting folate receptor alpha for cancer treatment
by Cheung, Anthony and Bax, Heather J and Josephs, Debra H and Ilieva, Kristina M and Pellizzari, Giulia and Opzoomer, James and Bloomfield, Jacinta and Fittall, Matthew and Grigoriadis, Anita and Figini, Mariangela and Canevari, Silvana and Spicer, James F and Tutt, Andrew N and Karagiannis, Sophia N
Oncotarget, ISSN 1949-2553, 08/2016, Volume 7, Issue 32, pp. 52553 - 52574
Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer... 
Monoclonal antibodies | Biomarker | Folate receptor alpha | Immunotherapy | Cancer | PEGYLATED LIPOSOMAL DOXORUBICIN | FLOW-CYTOMETRIC METHOD | OVARIAN-CARCINOMA PATIENTS | SOLID TUMORS | THYMIDYLATE SYNTHASE INHIBITOR | folate receptor alpha | MALIGNANT PLEURAL MESOTHELIOMA | biomarker | NEGATIVE BREAST-CANCER | CELL BIOLOGY | CELL LUNG-CANCER | MONOCLONAL-ANTIBODY MOV18 | immunotherapy | cancer | PHASE-I | monoclonal antibodies | Neoplasms - metabolism | Folate Receptor 1 - metabolism | Humans
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2. Full Text Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results
by van Dam, Gooitzen M and Themelis, George and Crane, Lucia M. A and Harlaar, Niels J and Pleijhuis, Rick G and Kelder, Wendy and Sarantopoulos, Athanasios and de Jong, Johannes S and Arts, Henriette J. G and van der Zee, Ate G. J and Bart, Joost and Low, Philip S and Ntziachristos, Vasilis
Nature Medicine, ISSN 1078-8956, 09/2011, Volume 17, Issue 10, pp. 1315 - U202
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in... 
BREAST-CANCER | SURGERY | SURVIVAL | MANAGEMENT | TISSUE | FUTURE | MODEL | EXPRESSION | STRATEGIES | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Diagnostic Imaging - methods | Fluorescein-5-isothiocyanate - chemistry | Microscopy, Fluorescence - methods | Folate Receptor 1 - metabolism | Humans | Middle Aged | Ovarian Neoplasms - pathology | Monitoring, Intraoperative - methods | Female | Aged | Molecular Structure
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3. Full Text Folate receptor alpha as a tumor target in epithelial ovarian cancer
by Kalli, Kimberly R and Oberg, Ann L and Keeney, Gary L and Christianson, Teresa J.H and Low, Philip S and Knutson, Keith L and Hartmann, Lynn C
Gynecologic Oncology, ISSN 0090-8258, 2007, Volume 108, Issue 3, pp. 619 - 626
Abstract Objectives. Folate receptor α (FRα) is a folate-binding protein overexpressed on ovarian and several other epithelial malignancies that can be used as... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Folate receptor | Ovarian cancer | 5-METHYLTETRAHYDROFOLATE | VIVO | ovarian cancer | BINDING-PROTEIN | folate receptor | CELL-GROWTH | OBSTETRICS & GYNECOLOGY | BREAST-CANCER | IN-VITRO | ONCOLOGY | TISSUES | IMAGING AGENTS | EXPRESSION | CARCINOMA | Immunohistochemistry | Folate Receptors, GPI-Anchored | Adenocarcinoma, Mucinous - pathology | Adenocarcinoma, Clear Cell - mortality | Humans | Middle Aged | Cystadenocarcinoma, Serous - metabolism | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | Cystadenocarcinoma, Serous - genetics | Ovarian Neoplasms - mortality | Cystadenocarcinoma, Serous - pathology | Neoplasm Recurrence, Local - mortality | Cystadenocarcinoma, Serous - drug therapy | Carcinoma, Endometrioid - metabolism | Neoplasm Recurrence, Local - pathology | Ovarian Neoplasms - genetics | Neoplasm Metastasis | Female | Ovarian Neoplasms - metabolism | Retrospective Studies | Adenocarcinoma, Mucinous - drug therapy | Ovarian Neoplasms - drug therapy | Carcinoma, Endometrioid - genetics | Neoplasm Recurrence, Local - metabolism | Adenocarcinoma, Clear Cell - metabolism | Medical Records | Receptors, Cell Surface - metabolism | Minnesota | Carcinoma, Endometrioid - drug therapy | Adenocarcinoma, Mucinous - mortality | Carrier Proteins - genetics | Disease-Free Survival | Carrier Proteins - metabolism | Carcinoma, Endometrioid - mortality | Adenocarcinoma, Mucinous - metabolism | Survival Analysis | Cystadenocarcinoma, Serous - mortality | Neoplasm Recurrence, Local - genetics | Adenocarcinoma, Clear Cell - pathology | Adenocarcinoma, Mucinous - genetics | Adenocarcinoma, Clear Cell - genetics | Carcinoma, Endometrioid - pathology | Adenocarcinoma, Clear Cell - drug therapy | Receptors, Cell Surface - genetics | Folic acid
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4. Full Text Folate receptor alpha expression in lung cancer: Diagnostic and prognostic significance
by O'Shannessy, Daniel J and Yu, Gordon and Smale, Robert and Fu, Yao-Shi and Singhal, Sunil and Thiel, Robert P and Somers, Elizabeth B and Vachani, Anil
Oncotarget, ISSN 1949-2553, 2012, Volume 3, Issue 4, pp. 414 - 425
Adenocarcinoma | Immunohistochemistry | Prognosis | FRA | Folate receptor alpha | Non-small cell lung cancer
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5. Full Text IMGN853, a folate receptor-α (FRα)-targeting antibody-drug conjugate, exhibits potent targeted antitumor activity against FRα-expressing tumors
by Ab, Olga and Whiteman, Kathleen R and Bartle, Laura M and Sun, Xiuxia and Singh, Rajeeva and Tavares, Daniel and La Belle, Alyssa and Payne, Gillian and Lutz, Robert J and Pinkas, Jan and Goldmacher, Victor S and Chittenden, Thomas and Lambert, John M
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2015, Volume 14, Issue 7, pp. 1605 - 1613
A majority of ovarian and non-small cell lung adenocarcinoma cancers overexpress folate receptor alpha (FR alpha). Here, we report the development of an... 
BREAST-CANCER | HODGKINS-LYMPHOMA | ONCOLOGY | BRENTUXIMAB VEDOTIN | PHASE-II | OVARIAN-CANCER | MONOCLONAL-ANTIBODIES | BINDING | TRASTUZUMAB EMTANSINE | EPITHELIAL OVARIAN | LINKER | Neoplasms - metabolism | Folate Receptor 1 - immunology | Humans | Maytansine - pharmacology | Immunoconjugates - immunology | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Female | Cytotoxicity, Immunologic - drug effects | Antibodies, Monoclonal - immunology | Molecular Targeted Therapy - methods | Maytansine - analogs & derivatives | Antibodies, Monoclonal - pharmacology | Folate Receptor 1 - antagonists & inhibitors | Treatment Outcome | Mice, SCID | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Bystander Effect - drug effects | Tumor Burden - drug effects | Mice, Nude | Neoplasms - immunology | Cell Line, Tumor | Antibodies, Monoclonal, Humanized - immunology | Maytansine - immunology | Tumor Burden - immunology
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6. Full Text Safety and activity of mirvetuximab soravtansine (IMGN853), a folate receptor alpha-targeting antibody-drug conjugate, in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer: A phase i expansion study
by Moore, Kathleen N and Martin, Lainie P and O'Malley, David M and Matulonis, Ursula A and Konner, Jason A and Perez, Raymond P and Bauer, Todd M and Ruiz-Soto, Rodrigo and Birrer, Michael J
Journal of Clinical Oncology, ISSN 0732-183X, 04/2017, Volume 35, Issue 10, pp. 1112 - 1118
Purpose This phase I expansion cohort study evaluated the safety and clinical activity of mirvetuximab soravtansine (IMGN853), an antibody-drug conjugate... 
PEGYLATED LIPOSOMAL DOXORUBICIN | CARBOPLATIN | THERAPY | MECHANISM | ONCOLOGY | EXPRESSION | CARCINOMA | TUMORS | CHEMOTHERAPY | DELIVERY | Nausea - chemically induced | Humans | Middle Aged | Drug Resistance, Neoplasm | Response Evaluation Criteria in Solid Tumors | Antineoplastic Agents - therapeutic use | Fatigue - chemically induced | Diarrhea - chemically induced | Peritoneal Neoplasms - chemistry | Platinum Compounds - therapeutic use | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - chemistry | Antineoplastic Agents - adverse effects | Vision Disorders - chemically induced | Aged, 80 and over | Immunoconjugates - therapeutic use | Adult | Female | Ovarian Neoplasms - drug therapy | Fallopian Tube Neoplasms - drug therapy | Immunoconjugates - adverse effects | Antibodies, Monoclonal, Humanized - adverse effects | Maytansine - adverse effects | Ovarian Neoplasms - chemistry | Antibodies, Monoclonal, Humanized - therapeutic use | Maytansine - analogs & derivatives | Folate Receptor 1 - antagonists & inhibitors | Hypotension - chemically induced | Maytansine - therapeutic use | Folate Receptor 1 - analysis | Disease-Free Survival | Retreatment | Aged | Index Medicus | Phase I and Clinical Pharmacology | Chemotherapy | Gynecologic | Translational Oncology | ORIGINAL REPORTS
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7. Full Text Folate receptor alpha peptide vaccine generates immunity in breast and ovarian cancer patients
by Kalli, Kimberly R and Block, Matthew S and Kasi, Pashtoon M and Erskine, Courtney L and Hobday, Timothy J and Dietz, Allan and Padley, Douglas and Gustafson, Michael P and Shreeder, Barath and Puglisi-Knutson, Danell and Visscher, Dan W and Mangskau, Toni K and Wilson, Glynn and Knutson, Keith L
Clinical Cancer Research, ISSN 1078-0432, 07/2018, Volume 24, Issue 13, pp. 3014 - 3025
Purpose: Folate receptor alpha (FR) is overexpressed in several cancers. Endogenous immunity to the FR has been demonstrated in patients and suggests the... 
TUMOR-INFILTRATING LYMPHOCYTES | DOSE CYCLOPHOSPHAMIDE | SURVIVAL | GROUP-STUDY I-01 | ONCOLOGY | GM-CSF | IMMUNOTHERAPY | E75 VACCINE | REGULATORY T-CELLS | INTRACELLULAR DOMAIN | ADJUVANT | Antigens | Immune response | Ovarian carcinoma | Medical treatment | Vaccination | Feasibility studies | Breast cancer | Lymphocytes T | Vaccines | Epitopes | Patients | Immunity | Folic acid | CD4 antigen | Ovarian cancer | Cyclophosphamide | Immunogenicity | Lymphocytes | Histocompatibility antigen HLA | Tetanus | Safety | Genotypes | Cancer | Tumors | folate receptor | breast cancer | antibodies | T cells | cancer vaccine | ovarian cancer
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8. Full Text High Expression of Folate Receptor Alpha in Lung Cancer Correlates with Adenocarcinoma Histology and Mutation
by Nunez, Maria Ines and Behrens, Carmen and Woods, Denise M and Lin, Heather and Suraokar, Milind and Kadara, Humam and Hofstetter, Wayne and Kalhor, Neda and Lee, J. Jack and Franklin, Wilbur and Stewart, David J and Wistuba, MD, Ignacio I
Journal of Thoracic Oncology, ISSN 1556-0864, 05/2012, Volume 7, Issue 5, pp. 833 - 840
Folate receptor alpha (FRα) and reduced folate carrier-1 (RFC1) regulate uptake of folate molecules inside the cell. FRα is a potential biomarker of tumors... 
Non−small-cell lung carcinoma | membrane transporter | Folate receptor alpha | Reduced folate carrier-1 | Epidermal growth factor receptor | Membrane transporter | Non-small-cell lung carcinoma | FARLETUZUMAB | THYMIDYLATE SYNTHASE | ANTIFOLATE | CHEMOTHERAPY | LY231514 | CARRIER | GROWTH-FACTOR RECEPTOR | ONCOLOGY | RESPIRATORY SYSTEM | GENE-EXPRESSION | CARCINOMA
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9. Full Text Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17
by Tummers, Quirijn R.J.G and Hoogstins, Charlotte E.S and Gaarenstroom, Katja N and de Kroon, Cor D and van Poelgeest, Mariette I.E and Vuyk, Jaap and Bosse, Tjalling and Smit, Vincent T.H.B.M and van de Velde, Cornelis J.H and Cohen, Adam F and Low, Philip S and Burggraaf, Jacobus and Vahrmeijer, Alexander L
Oncotarget, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 32144 - 32155
Introduction: Intraoperative fluorescence imaging of the folate-receptor alpha (FR alpha) could support completeness of resection in cancer surgery.... 
Fluorescence | Breast cancer | Folate-receptor alpha | Image-guided surgery | Ovarian cancer | image-guided surgery | folate-receptor alpha | breast cancer | fluorescence | ovarian cancer | CELL BIOLOGY | Breast Neoplasms - surgery | Fluorescent Dyes - pharmacokinetics | Predictive Value of Tests | Fluorescein-5-isothiocyanate - pharmacokinetics | Folic Acid - adverse effects | Humans | Middle Aged | Ovarian Neoplasms - pathology | Fluorescent Dyes - adverse effects | Luminescent Measurements | False Positive Reactions | Folic Acid - administration & dosage | Feasibility Studies | Breast Neoplasms - chemistry | Netherlands | Adult | Female | Fluorescent Dyes - administration & dosage | Optical Imaging - methods | Ovarian Neoplasms - chemistry | Reproducibility of Results | Folic Acid - analogs & derivatives | Biomarkers, Tumor - analysis | Fluorescein-5-isothiocyanate - administration & dosage | Folic Acid - pharmacokinetics | Folate Receptor 1 - analysis | Administration, Intravenous | Breast Neoplasms - pathology | Intraoperative Care | Fluorescein-5-isothiocyanate - adverse effects | Aged | Ovarian Neoplasms - surgery
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10. Full Text Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression
by Kurosaki, Akira and Hasegawa, Kosei and Kato, Tomomi and Abe, Kenji and Hanaoka, Tatsuya and Miyara, Akiko and O'Shannessy, Daniel J and Somers, Elizabeth B and Yasuda, Masanori and Sekino, Tetsuo and Fujiwara, Keiichi
International Journal of Cancer, ISSN 0020-7136, 04/2016, Volume 138, Issue 8, pp. 1994 - 2002
Folate receptor alpha (FRA) is a GPI‐anchored glycoprotein and encoded by the FOLR1 gene. High expression of FRA is observed in specific malignant tumors of... 
diagnostic | FRA | ovarian cancer | serum biomarker | folate receptor alpha | FARLETUZUMAB | BINDING-PROTEIN | VINTAFOLIDE | PHASE-II | MONOCLONAL-ANTIBODY | ENDOMETRIOSIS | ONCOLOGY | CA125 | PRECLINICAL EVALUATION | ASSOCIATION | EC145 | Folate Receptor 1 - blood | Immunohistochemistry | Prognosis | Prospective Studies | Area Under Curve | Humans | Middle Aged | Ovarian Neoplasms - mortality | Young Adult | Neoplasms, Glandular and Epithelial - blood | Neoplasms, Glandular and Epithelial - mortality | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Neoplasms, Glandular and Epithelial - diagnosis | Enzyme-Linked Immunosorbent Assay | Ovarian Neoplasms - diagnosis | Kaplan-Meier Estimate | Ovarian Neoplasms - blood | Biomarkers, Tumor - blood | Disease-Free Survival | Carcinoma, Ovarian Epithelial | ROC Curve | Aged | Analysis | Colorectal cancer | Diagnosis | Folic acid | Ovarian cancer | Cancer | Biomarkers | Metastasis | Medical prognosis | Tumors
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11. Full Text Folate Receptor Alpha Defect Causes Cerebral Folate Transport Deficiency: A Treatable Neurodegenerative Disorder Associated with Disturbed Myelin Metabolism
by Steinfeld, Robert and Grapp, Marcel and Kraetzner, Ralph and Dreha-Kulaczewski, Steffi and Helms, Gunther and Dechent, Peter and Wevers, Ron and Grosso, Salvatore and Gärtner, Jutta and Medicinsk strålningsfysik, Lund and Medical Radiation Physics, Lund and Lund University and Lunds universitet
The American Journal of Human Genetics, ISSN 0002-9297, 2009, Volume 85, Issue 3, pp. 354 - 363
Sufficient folate supplementation is essential for a multitude of biological processes and diverse organ systems. At least five distinct inherited disorders of... 
HOMOCYSTEINE | SPECTROSCOPY | CLONING | DNA | KINETICS | GENETICS & HEREDITY | REDUCTASE | IDENTIFICATION | MOLECULAR-BASIS | MICE LACKING | METHIONINE | Folate Receptors, GPI-Anchored | Humans | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | RNA, Messenger - metabolism | Myelin Sheath - metabolism | Brain - metabolism | Biological Transport | DNA Mutational Analysis | Membrane Transport Proteins - genetics | Carrier Proteins - chemistry | Female | Membrane Transport Proteins - metabolism | Receptors, Cell Surface - chemistry | Amino Acid Sequence | Folate Receptor 1 | RNA, Messenger - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - therapy | Mutation - genetics | Organ Specificity | Carrier Proteins - genetics | Carrier Proteins - metabolism | Models, Biological | Brain - pathology | Brain Mapping | Folic Acid - metabolism | Receptors, Cell Surface - genetics | Myelination | Gene mutations | Analysis | Nutritional aspects | Causes of | Nervous system | Genetic aspects | Degeneration | Health aspects | Folic acid | Clinical Medicine | Medicinsk genetik | Basic Medicine | Medical Genetics | Pediatrics | Radiologi och bildbehandling | Medical and Health Sciences | Medicin och hälsovetenskap | Pediatrik | Medicinska och farmaceutiska grundvetenskaper | Radiology, Nuclear Medicine and Medical Imaging | Klinisk medicin
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12. Full Text Folate and folate receptor alpha antagonists mechanism of action in ovarian cancer
by Walters, Christen L and Arend, Rebecca C and Armstrong, Deborah K and Naumann, R. Wendel and Alvarez, Ronald D
Gynecologic Oncology, ISSN 0090-8258, 2013, Volume 131, Issue 2, pp. 493 - 498
Abstract Objective The goal of this report is to review the activity of promising antifolate and folate receptor agents being developed for ovarian cancer... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Antifolate receptor antibodies | Folate-chemotherapy conjugates | Thymidylate synthase inhibitors | PERSISTENT | PLATINUM-RESISTANT OVARIAN | BEVACIZUMAB | OBSTETRICS & GYNECOLOGY | PHASE-II TRIAL | CARCINOGENESIS | ONCOLOGY | RECURRENT | HUMANIZED MONOCLONAL-ANTIBODY | CULTURED KB CELLS | CARCINOMA | EXPRESSION | Clinical Trials, Phase III as Topic | Animals | Antibodies, Monoclonal, Humanized - therapeutic use | Folate Receptor 1 - metabolism | Humans | Folate Receptor 1 - antagonists & inhibitors | Folic Acid - metabolism | Female | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Clinical Trials, Phase II as Topic | Chemotherapy | Folic acid | Cancer | Ovarian cancer | Index Medicus
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13. Full Text Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha
by Hansen, Mariann F and Greibe, Eva and Skovbjerg, Signe and Rohde, Sarah and Kristensen, Anders C.M and Jensen, Trine R and Stentoft, Charlotte and Kjær, Karina H and Kronborg, Camilla S and Martensen, Pia M
Cellular Signalling, ISSN 0898-6568, 07/2015, Volume 27, Issue 7, pp. 1356 - 1368
The signal transducer and activator of transcription 3 (STAT3) is a well-described pro-oncogene found constitutively activated in several cancer types. Folates... 
Vitamin B9 | gp130 | Folate Receptor | Folic acid | STAT3 | Gp130 | HUMAN OVARIAN | BINDING-PROTEIN | PROLIFERATION | CANCER-THERAPY | CELL BIOLOGY | BREAST-CANCER | FOLBP1 | NEURAL STEM-CELLS | Vitamin 89 | PATHWAY | INFLAMMATION | EXPRESSION | Folic Acid - pharmacology | Humans | Transcriptional Activation - drug effects | Folate Receptor 1 - antagonists & inhibitors | Janus Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Cyclin A2 - metabolism | Interleukin-6 - pharmacology | RNA Interference | Signal Transduction - drug effects | Folate Receptor 1 - genetics | Folate Receptor 1 - metabolism | HEK293 Cells | Cyclin A2 - genetics | Cell Proliferation - drug effects | HeLa Cells | Phosphorylation - drug effects | Leucovorin - pharmacology | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | RNA, Small Interfering - metabolism | Cellular signal transduction | Genetic aspects | Leucovorin | Vascular endothelial growth factor | Epidermal growth factor | Endothelial growth factors | Interferon
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14. Full Text Folate receptor α associated with triple-negative breast cancer and poor prognosis
by Zhang, Zhang and Wang, Jianmin and Tacha, David E and Li, Pamela and Bremer, Ryan E and Chen, Huijiao and Wei, Bing and Xiao, Xiuli and Da, Jiping and Skinner, Kristin and Hicks, David G and Bu, Hong and Tang, Ping
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 2014, Volume 138, Issue 7, pp. 890 - 895
Context.-Folate receptor alpha (FRA) has been shown to be selectively expressed in several types of human cancer, including breast cancer. Currently, several... 
TARGETED THERAPY | MEDICINE, RESEARCH & EXPERIMENTAL | FARLETUZUMAB | ISOFORMS | BINDING-PROTEIN | PATHOLOGY | EPITHELIAL OVARIAN-CANCER | OVEREXPRESSION | GENE | HUMANIZED MONOCLONAL-ANTIBODY | MEDICAL LABORATORY TECHNOLOGY | EXPRESSION | CARCINOMA | Immunohistochemistry | Receptors, Estrogen - metabolism | Prognosis | Humans | Middle Aged | Kaplan-Meier Estimate | Receptor, ErbB-2 - metabolism | Receptors, Progesterone - metabolism | Disease-Free Survival | Triple Negative Breast Neoplasms - metabolism | Folate Receptor 1 - metabolism | Triple Negative Breast Neoplasms - pathology | Adult | Carcinoma, Ductal, Breast - pathology | Female | Aged | Retrospective Studies | Carcinoma, Ductal, Breast - metabolism | Cohort Studies
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15. Full Text Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha
by Alam, C and Aufreiter, S and Georgiou, CJ and Hoque, MT and Finnell, RH and O'Connor, DL and Goldman, ID and Bendayan, R
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2019, Volume 116, Issue 35, pp. 17531 - 17540
Folates are critical for central nervous system function. Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate... 
blood-brain barrier | AUTOANTIBODIES | DEFECTS | TRANSPORTER | RAT | MULTIDISCIPLINARY SCIENCES | BARRIER | DEFICIENCY | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | P-GLYCOPROTEIN | brain folate transport | ENZYMES | vitamin D receptor | MALABSORPTION | Ethylenediaminetetraacetic acid | Calcifediol | Nervous system diseases | Alfacalcidol | Vitamin D | Folic acid | Choroid plexus | Brain | Central nervous system | Disorders | Calcitriol | Cerebrospinal fluid | Inactivation | Transportation systems | Receptors | Dihydroxyvitamin D3 | Blood-brain barrier | Vitamin B | Pretreatment | Children | 25-Hydroxyvitamin D | Deactivation | Neurodegenerative diseases | Nuclear receptors | Calciferol | Ligands | Mice | In vivo methods and tests | Vitamin D receptors | Transport | Transporter | Metabolic disorders
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