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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23293
HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of... 
REPLICATION | PHOSPHORYLATION | TAT | MULTIDISCIPLINARY SCIENCES | KINASE | IMMUNODEFICIENCY-VIRUS TYPE-1 | SH3 DOMAINS | SHORT LINEAR MOTIFS | BINDING | VIRAL-INFECTION | NEF | rev Gene Products, Human Immunodeficiency Virus - chemistry | Humans | env Gene Products, Human Immunodeficiency Virus - metabolism | rev Gene Products, Human Immunodeficiency Virus - metabolism | nef Gene Products, Human Immunodeficiency Virus - chemistry | tat Gene Products, Human Immunodeficiency Virus - chemistry | CREB-Binding Protein - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | env Gene Products, Human Immunodeficiency Virus - genetics | Human Immunodeficiency Virus Proteins - chemistry | Databases, Protein | nef Gene Products, Human Immunodeficiency Virus - metabolism | gag Gene Products, Human Immunodeficiency Virus - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Calmodulin - metabolism | Protein Structure, Secondary | tat Gene Products, Human Immunodeficiency Virus - genetics | Models, Molecular | gag Gene Products, Human Immunodeficiency Virus - chemistry | Binding Sites - genetics | Human Immunodeficiency Virus Proteins - metabolism | Proteins - genetics | Protein Interaction Mapping - methods | Proteins - metabolism | nef Gene Products, Human Immunodeficiency Virus - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Human Immunodeficiency Virus Proteins - genetics | rev Gene Products, Human Immunodeficiency Virus - genetics | Amino Acid Motifs - genetics | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Casein Kinase II - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Physiological aspects | Viral proteins | HIV (Viruses) | Genomics | Protein binding | Phenotypes | Phosphorylation | Hot spots | Crosstalk | Amino acid sequence | Viruses | Genomes | Kinases | Proteins | Conserved sequence | Human immunodeficiency virus--HIV | Computer applications | Mutation | Proteomes | Localization | Bioinformatics | Binding sites | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e21225
Background: The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a... 
RESPONSES | IMMUNITY | ASSAY | SAFETY | MULTIDISCIPLINARY SCIENCES | ANTIBODY | IMMUNOGENICITY EVALUATION | CANDIDATE | INFECTION | STEP | MEMORY T-CELLS | env Gene Products, Human Immunodeficiency Virus - immunology | Immunization, Secondary - adverse effects | Immunoglobulin G - blood | Human Immunodeficiency Virus Proteins - immunology | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Male | Antibodies, Viral - blood | Vaccines, DNA - administration & dosage | Young Adult | env Gene Products, Human Immunodeficiency Virus - genetics | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Adenoviridae - genetics | Adult | Female | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Immunization - adverse effects | Enzyme-Linked Immunosorbent Assay | Immunization - methods | Anemia - chemically induced | Immunization, Secondary - methods | HIV-1 - genetics | HIV-1 - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | Interferon-gamma - immunology | Adolescent | Antibodies, Viral - immunology | Human Immunodeficiency Virus Proteins - genetics | T-Lymphocytes - immunology | AIDS Vaccines - administration & dosage | gag Gene Products, Human Immunodeficiency Virus - immunology | Interferon-gamma - blood | Cohort Studies | Oligomers | AIDS vaccines | Adenoviruses | Immunotherapy | DNA | Clinical trials | Product development | Interferon | Biological response modifiers | T cells | HIV (Viruses) | Antigenic determinants | Health care | CD8 antigen | Antibodies | Lymphocytes T | Infections | Vaccines | Epidemiology | Randomization | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Inserts | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Recombinant | Binding | Medical research | Immunoglobulins | Cytokines | Epitopes | Immune response (humoral) | CD4 antigen | Disease prevention | Hospitals | Infectious diseases | Immunogenicity | γ-Interferon | Adults | Cancer | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e34723
HIV-1 candidate vaccines expressing an artificial polyprotein comprising Gag, Pol and Nef (GPN) and a secreted envelope protein (Env) were shown in recent... 
AIDS RESEARCH | IMMUNIZATION | T-CELL RESPONSES | VIRUS | PHASE-I TRIAL | IMMUNE-RESPONSES | BIOLOGY | ENVELOPE PROTEIN | INFECTION | NYVAC-C | EXPRESSION | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Vaccines, Synthetic - immunology | Vaccines, DNA - administration & dosage | Clinical Trials, Phase III as Topic | env Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - biosynthesis | HEK293 Cells | Female | pol Gene Products, Human Immunodeficiency Virus - genetics | Gene Products, gag - immunology | Gene Products, gag - genetics | Vaccines, Synthetic - genetics | nef Gene Products, Human Immunodeficiency Virus - biosynthesis | HIV-1 - genetics | Gene Products, gag - biosynthesis | HIV-1 - immunology | Animals | env Gene Products, Human Immunodeficiency Virus - biosynthesis | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | Vaccines, Virus-Like Particle - immunology | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | AIDS vaccines | Viral proteins | Vaccination | DNA | Amino acids | T cells | HIV (Viruses) | Antigenic determinants | Competition | CD8 antigen | Clinical trials | Viruses | Lymphocytes T | DNA vaccines | Histocompatibility antigen H-2 | Vaccines | Virus-like particles | Proteins | Clonal deletion | Gag protein | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Combined vaccines | Deoxyribonucleic acid--DNA | Medical research | Cytomegalovirus | Envelope protein | Gene expression | Nef protein | Immunogenicity | γ-Interferon | Budding | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2007, Volume 13, Issue 1, pp. 100 - 106
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2017, Volume 13, Issue 7, p. e1006529
The ability to control lentivirus replication may be determined, in part, by the extent to which individual viral proteins are targeted by the immune system.... 
env Gene Products, Human Immunodeficiency Virus - immunology | SAIDS Vaccines - administration & dosage | HIV Infections - virology | Humans | Macaca mulatta | Rectum - immunology | HIV-1 - genetics | Rectum - virology | HIV Infections - immunology | SAIDS Vaccines - genetics | HIV-1 - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Simian Immunodeficiency Virus - genetics | env Gene Products, Human Immunodeficiency Virus - genetics | Animals | HIV-1 - physiology | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Virus Replication | Antibodies, Viral - immunology | gag Gene Products, Human Immunodeficiency Virus - genetics | gag Gene Products, Human Immunodeficiency Virus - immunology | Disease Models, Animal | Simian Immunodeficiency Virus - immunology | PROTECTION | CORRELATES ANALYSIS | MICROBIOLOGY | T-CELL RESPONSES | HIGHLY PATHOGENIC SIV | VIROLOGY | HIV | ENVELOPE | INFECTED-CELLS | VESICULAR STOMATITIS-VIRUS | DISCORDANT ASSOCIATIONS | NEUTRALIZATION | PARASITOLOGY | Rhesus monkey | Control | AIDS vaccines | Usage | Immune response | Genetic aspects | Research | Simian immunodeficiency virus | Laboratories | Viremia | Funding | Chronic infection | Viruses | Infections | Vaccines | Loads (forces) | Proteins | Immunology | Gag protein | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Primates | Inserts | Localization | Supervision | Immune system | Antigens | Medical research | Statistical analysis | Stability | Monkeys & apes | Pathology | Tat protein | Nef protein | Replication | Neutralization | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus
Journal Article
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e108631
Background: Elevated risk of HIV-1 infection among recipients of an adenovirus serotype 5 (Ad5)-vectored HIV-1 vaccine was previously reported in the Step... 
RESPONSES | WOMEN | MULTIDISCIPLINARY SCIENCES | CELL-MEDIATED-IMMUNITY | ACQUISITION | DOUBLE-BLIND | STEP TRIAL | GAG/POL/NEF VACCINE | PARTICIPANTS | EXPOSURE | DESIGNS | HIV Infections - prevention & control | Immunoassay | Leukocytes, Mononuclear - metabolism | Follow-Up Studies | Leukocytes, Mononuclear - secretion | Humans | AIDS Vaccines - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Male | Risk | pol Gene Products, Human Immunodeficiency Virus - metabolism | Interferon-gamma - metabolism | Recombinant Proteins - biosynthesis | CD4-Positive T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - pathology | Leukocytes, Mononuclear - immunology | CD8-Positive T-Lymphocytes - metabolism | nef Gene Products, Human Immunodeficiency Virus - metabolism | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Interleukin-2 - metabolism | HIV-1 - metabolism | Lymphocyte Activation | Interferon-gamma - secretion | CD4-Positive T-Lymphocytes - metabolism | Proportional Hazards Models | Recombinant Proteins - genetics | CD4-Positive T-Lymphocytes - secretion | Recombinant Proteins - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | CD8-Positive T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | Interleukin-2 - secretion | Cohort Studies | Flow cytometry | Laboratories | CD8 antigen | Interleukin | Vaccination | Antibodies | Clinical trials | Stimulation | Leukocytes (mononuclear) | Infections | Activation | Lymphocytes T | Vaccines | Assaying | Cell activation | Immunology | Interleukin 2 | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Enzyme-linked immunosorbent assay | Public health | Medical research | Immune response | Sampling designs | Health risks | Hazards | T cell receptors | CD4 antigen | Infectious diseases | Statistical models | Womens health | Correlation analysis | Adenoviruses | γ-Interferon | Interferon | Cancer | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2015, Volume 23, Issue 3, pp. 591 - 601
This study evaluated the safety and immunogenicity of PENNVAX-B in 12 HIV infected individuals. PENNVAX-B is a combination of three optimized synthetic... 
MEDICINE, RESEARCH & EXPERIMENTAL | ELECTROPORATION | RESERVOIR | ELIMINATION | ANTIRETROVIRAL THERAPY | CD8(+) T-CELLS | REPLICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LYMPHOID-TISSUE | GENETICS & HEREDITY | FULL REPERTOIRE | EXPRESSION | LYMPHOCYTES | Consensus Sequence | Perforin - genetics | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | Middle Aged | Vaccination | AIDS Vaccines - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Male | Granzymes - genetics | Leukocytes, Mononuclear - virology | HIV Infections - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV Infections - pathology | Leukocytes, Mononuclear - immunology | Adult | Female | Granzymes - biosynthesis | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | HIV Infections - virology | Interferon-gamma - secretion | gag Gene Products, Human Immunodeficiency Virus - chemistry | pol Gene Products, Human Immunodeficiency Virus - chemistry | Enzyme-Linked Immunospot Assay | AIDS Vaccines - chemistry | Antiretroviral Therapy, Highly Active | Leukocytes, Mononuclear - pathology | HIV-1 - immunology | HIV Infections - therapy | Vaccines, Synthetic | AIDS Vaccines - genetics | AIDS Vaccines - administration & dosage | gag Gene Products, Human Immunodeficiency Virus - immunology | Immunity, Cellular | Interferon-gamma - biosynthesis | Perforin - biosynthesis | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 16
Background: We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector... 
IMMUNITY | NEUTRALIZING ANTIBODIES | ASSAY | REPLICATION | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | PHASE-1 SAFETY | CANDIDATE | INFECTION | GAG | T-CELLS | HIV Infections - prevention & control | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Genetic Vectors - adverse effects | Male | AIDS Vaccines - adverse effects | Young Adult | HIV Infections - immunology | Immunization, Secondary | Drug-Related Side Effects and Adverse Reactions | Adenoviridae - genetics | Adult | gag Gene Products, Human Immunodeficiency Virus - genetics | Adenoviridae - immunology | pol Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - adverse effects | Double-Blind Method | Genetic Vectors - immunology | HIV Infections - virology | HIV-1 - genetics | Genetic Vectors - genetics | HIV-1 - classification | HIV-1 - immunology | Vaccines, DNA - adverse effects | Adolescent | gag Gene Products, Human Immunodeficiency Virus - adverse effects | Antibodies, Viral - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | HIV antigens | Medical research | AIDS vaccines | Safety and security measures | Biological response modifiers | HIV (Viruses) | Adenoviruses | DNA | Medicine, Experimental | Genetic research | Interferon | Health aspects | HIV infection | Laboratories | Antibodies | Infections | DNA vaccines | Vaccines | Dosage | Immunity | Epidemiology | Proteins | Randomization | Immunology | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Safety | Public health | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Recombinant | Immune system | Antigens | Immunoglobulins | Immune response | Priming | Immune response (humoral) | Infectious diseases | Nef protein | Immunogenicity | γ-Interferon | Adults | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article