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1. Full Text Construction of 4-substituted 2-(pyrrolidine-3-yl)acetic acid derivatives as cyclic γ-aminobutyric acid analogues employing intermolecular [2+2]-photocycloaddition as key steps
by Petz, Susanne and Allmendinger, Lars and Mayer, Peter and Wanner, Klaus T
Tetrahedron, ISSN 0040-4020, 05/2019, Volume 75, Issue 19, pp. 2755 - 2762
The synthesis of new 2-(pyrrolidine-3-yl)acetic acid derivatives as cyclic γ-aminobutyric acid analogues, which are additionally substituted at the 4-position,... 
GABA | Pyrrolidines | Cyclic γ-aminobutyric acid analogues | [2+2]-photocycloaddition | de Mayo reaction | REAGENT | METHYLATION | 1,3-DIOXIN-4-ONES | CHEMISTRY, ORGANIC | Cyclic gamma-aminobutyric acid analogues | TRIMETHYLSILYLDIAZOMETHANE | GABA UPTAKE
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2. Full Text Misuse of the γ‐aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK
by Kapil, Vikas and Green, Jody L and Le Lait, Marie‐Claire and Wood, David M and Dargan, Paul I
British Journal of Clinical Pharmacology, ISSN 0306-5251, 07/2014, Volume 78, Issue 1, pp. 190 - 191
PHARMACOLOGY & PHARMACY | WITHDRAWAL | Gabapentin | Baclofen - administration & dosage | Humans | Middle Aged | Cyclohexanecarboxylic Acids - administration & dosage | Male | gamma-Aminobutyric Acid - administration & dosage | Pregabalin | Street Drugs - adverse effects | Young Adult | Prescription Drug Misuse - statistics & numerical data | Health Surveys | Adolescent | Amines - administration & dosage | Adult | Female | gamma-Aminobutyric Acid - analogs & derivatives | United Kingdom - epidemiology | Letters to the Editors
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3. Full Text Pregabalin: A novel γ-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders
by Tassone, Daniel M., PharmD and Boyce, Eric, PharmD and Guyer, Jennifer, PharmD and Nuzum, Donald, PharmD
Clinical Therapeutics, ISSN 0149-2918, 2007, Volume 29, Issue 1, pp. 26 - 48
Abstract Background: The US Food and Drug Administration (FDA) approved pregabalin in December 2004 for the treatment of neuropathic pain associated with... 
Internal Medicine | Medical Education | epilepsy | diabetic peripheral neuropathy | partial-onset seizures | neuropathic pain | generalized anxiety disorder | social anxiety disorder | postherpetic neuralgia | pregabalin | Lyrica | ADD-ON TREATMENT | REFRACTORY EPILEPSY | AMERICAN-ACADEMY | DOSE-RESPONSE | QUALITY-STANDARDS-SUBCOMMITTEE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | ANTIEPILEPTIC DRUGS | Analgesics - pharmacology | Analgesics - therapeutic use | Anticonvulsants - pharmacokinetics | Epilepsies, Partial - drug therapy | Humans | Anticonvulsants - therapeutic use | gamma-Aminobutyric Acid - pharmacology | Anticonvulsants - administration & dosage | Analgesics - pharmacokinetics | Clinical Trials as Topic | Pregabalin | Anticonvulsants - pharmacology | Neuralgia - drug therapy | Anticonvulsants - adverse effects | Drug Interactions | gamma-Aminobutyric Acid - therapeutic use | Anxiety Disorders - drug therapy | gamma-Aminobutyric Acid - analogs & derivatives | Analgesics - adverse effects | gamma-Aminobutyric Acid - adverse effects | gamma-Aminobutyric Acid - pharmacokinetics
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4. Full Text Determination of Therapeutic γ-Aminobutyric Acid Analogs in Forensic Whole Blood by Hydrophilic Interaction Liquid Chromatography-Electrospray Tandem Mass Spectrometry
by Sørensen, Lambert K and Hasselstrøm, Jørgen B
Journal of Analytical Toxicology, ISSN 0146-4760, 5/2014, Volume 38, Issue 4, pp. 177 - 183
Vigabatrin, pregabalin, gabapentin and baclofen are γ-aminobutyric acid analogs that are used in the treatment of epileptic seizures (vigabatrin, pregabalin... 
CHEMISTRY, ANALYTICAL | PREGABALIN | HUMAN PLASMA | BACLOFEN INTOXICATION | OVERDOSE | FLUORESCENCE DETECTION | TOXICOLOGY | MIMICKING BRAIN-DEATH | HUMAN SERUM | ANTIEPILEPTIC DRUGS | VIGABATRIN | GABAPENTIN | Tandem Mass Spectrometry - instrumentation | Limit of Detection | Reproducibility of Results | Humans | Forensic Toxicology - instrumentation | Chromatography, Liquid - instrumentation | Calibration | Spectrometry, Mass, Electrospray Ionization - instrumentation | Reference Standards | gamma-Aminobutyric Acid - blood | Spectrometry, Mass, Electrospray Ionization - methods | Hydrophobic and Hydrophilic Interactions | Forensic Toxicology - methods | Chromatography, Liquid - methods | gamma-Aminobutyric Acid - analogs & derivatives | Postmortem Changes | Tandem Mass Spectrometry - methods | Index Medicus
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5. Full Text Stereodivergent synthesis of cyclic γ-aminobutyric acid – GABA analogues
by Ďuriš, Andrej and Berkeš, Dušan and Jakubec, Pavol
Tetrahedron Letters, ISSN 0040-4039, 02/2019, Volume 60, Issue 6, pp. 480 - 484
A novel synthetic route towards two series of enantiomerically pure cyclic analogues of 2,3- - and 2,3- -γ-aminobutyric acid (GABA) was developed. The route is... 
Michael addition | GABA analogue | γ-Aminobutyric acid | Stereodivergent | Stereoselective synthesis | gamma-Aminobutyric acid | ASYMMETRIC TRANSFORMATION CIAT | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | STEREOSELECTIVE-SYNTHESIS | EFFICIENT
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6. Full Text Synthesis of γ-aminobutyric acid analogs based on carbohydrate scaffolds
by Zhong, Ming and Meng, Xiang-Bao and Li, Zhong-Jun
Carbohydrate Research, ISSN 0008-6215, 2010, Volume 345, Issue 9, pp. 1099 - 1106
γ-Aminobutyric acid analogs based on sugar scaffolds were prepared in six to nine steps starting from -glucal and -galactal. The key step in the synthesis is... 
Glycal | Vilsmeier–Haack reaction | GABA analogs | Sugar amino acids | Vilsmeier-Haack reaction | DESIGN | MIMETICS | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | GLYCALS | AMINOTRANSFERASE | SUGAR AMINO-ACIDS | TARGETS | LACTAMS | CHEMISTRY, APPLIED | gamma-Aminobutyric Acid - chemical synthesis | Carbohydrates - chemistry | gamma-Aminobutyric Acid - analogs & derivatives | Stereoisomerism | gamma-Aminobutyric Acid - chemistry
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7. Full Text Carboxylic acids as A traceless activation group for conjugate additions: A three-step synthesis of (±)-pregabalin
by Chu, Lingling and Ohta, Chisa and Zuo, Zhiwei and MacMillan, David W. C
Journal of the American Chemical Society, ISSN 0002-7863, 08/2014, Volume 136, Issue 31, pp. 10886 - 10889
The direct application of carboxylic acids as a traceless activation group for radical Michael additions has been accomplished via visible light-mediated... 
DNA CROSS-LINKING | PREGABALIN | RADICAL-CHAIN CHEMISTRY | PYRROLIZIDINE ALKALOIDS | INVENTION | CARBON-CARBON BONDS | DECARBOXYLATION | HOMOLOGATION | AUXILIARY | CHEMISTRY, MULTIDISCIPLINARY | CATALYSTS | gamma-Aminobutyric Acid - chemical synthesis | Chemistry Techniques, Synthetic | Pregabalin | gamma-Aminobutyric Acid - analogs & derivatives | Carboxylic Acids - chemistry | gamma-Aminobutyric Acid - chemistry | Photons | Carboxylic acids | Chemical properties | Analysis | Carbon dioxide | Conjugates | Trade names | Synthesis | Strategy | Activation | Arrays | Radicals | Communication
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8. Full Text Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists
by Froestl, Wolfgang and Froestl, Wolfgang and Mickel, Stuart J and Mickel, Stuart J and Hall, Roger G and Hall, Roger G and von Sprecher, Georg and Von Sprecher, Georg and Strub, Dietrich and Strub, Dietrich and Baumann, Peter A and Baumann, Peter A and Brugger, Felix and Brugger, Felix and Gentsch, Conrad and Gentsch, Conrad and Jaekel, Joachim and Jaekel, Joachim and Olpe, Hans-Rudolf and Olpe, Hans-Rudolf and Rihs, Grety and Rihs, Grety and Vassout, Annick and Vassout, Annick and Waldmeier, Peter C and Waldmeier, Peter C and Bittiger, Helmut and Bittiger, Helmut
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/1995, Volume 38, Issue 17, pp. 3297 - 3312
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABAB receptors. For many years efforts to... 
Cats | Magnetic Resonance Spectroscopy | Stereoisomerism | Rats | gamma-Aminobutyric Acid - pharmacology | Crystallography, X-Ray | Male | Structure-Activity Relationship | Rats, Sprague-Dawley | Organophosphonates - pharmacology | Animals | Organophosphonates - chemistry | GABA-B Receptor Agonists | Protein Binding | Behavior, Animal - drug effects | In Vitro Techniques | gamma-Aminobutyric Acid - analogs & derivatives | Receptors, GABA-B - metabolism
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9. Full Text Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists
by Froestl, Wolfgang and Froestl, Wolfgang and Mickel, Stuart J and Mickel, Stuart J and von Sprecher, Georg and Von Sprecher, Georg and Diel, Peter J and Diel, Peter J and Hall, Roger G and Hall, Roger G and Maier, Ludwig and Maier, Ludwig and Strub, Dietrich and Strub, Dietrich and Melillo, Vito and Melillo, Vito and Baumann, Peter A and Baumann, Peter A and Bernasconi, Raymond and Bernasconi, Raymond and Gentsch, Conrad and Gentsch, Conrad and Hauser, Kathleen and Hauser, Kathleen and Jaekel, Joachim and Jaekel, Joachim and Karlsson, Goeril and Karlsson, Goeril and Klebs, Klaus and Klebs, Klaus and Maître, Laurent and Maître, Laurent and Marescaux, Christian and Marescaux, Christian and Pozza, Mario F and Pozza, Mario F and Schmutz, Markus and Schmutz, Markus and Steinmann, Martin W and Steinmann, Martin W and van Riezen, Henk and Van Riezen, Henk and Vassout, Annick and Vassout, Annick and Mondadori, Cesare and Mondadori, Cesare and Olpe, Hans-Rudolf and Olpe, Hans-Rudolf and Waldmeier, Peter C and Waldmeier, Peter C and Bittiger, Helmut and Bittiger, Helmut
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/1995, Volume 38, Issue 17, pp. 3313 - 3331
In 1987, 25 years after the synthesis of the potent and selective GABAB agonist baclofen (1), Kerr et al. described the first GABAB antagonist phaclofen 2.... 
Phosphinic Acids - chemistry | Magnetic Resonance Spectroscopy | Administration, Oral | GABA-B Receptor Antagonists | Learning - drug effects | Rats | gamma-Aminobutyric Acid - pharmacology | gamma-Aminobutyric Acid - administration & dosage | Structure-Activity Relationship | Hippocampus - drug effects | Amnesia - drug therapy | Animals | Long-Term Potentiation - drug effects | Phosphinic Acids - pharmacology | Protein Binding | Cerebral Cortex - physiology | Cerebral Cortex - drug effects | Radioligand Assay | Hippocampus - physiology | In Vitro Techniques | gamma-Aminobutyric Acid - analogs & derivatives | Receptors, GABA-B - metabolism
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10. Full Text Synthesis of new fluorinated analogs of GABA, Pregabalin bioisosteres, and their effects on [3H]GABA uptake by rat brain nerve terminals
by Borisova, T and Pozdnyakova, N and Shaitanova, E and Gerus, I and Dudarenko, M and Mironets, R and Haufe, G and Kukhar, V
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2015, Volume 23, Issue 15, pp. 4316 - 4323
Influence of new fluorinated analogs of Pregabalin on [ H]GABA uptake by brain nerve terminals. Fluorinated analogs of natural substances take an essential... 
[3H]GABA uptake | Rat brain nerve terminals | Fluorinated analogs of γ-aminobutyric acid (β-polyfluoroalkyl-GABAs) | Pregabalin | Lyrica | Abbreviations GABA γ-aminobutyric acid | FGABAs fluorinated analogs of γ-aminobutyric acid | HEPES N-2-hydroxyethylpiperazine-n-2-ethanesulfonic acid | CHEMISTRY, MEDICINAL | TRANSPORTERS | ENANTIOMERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPOCAMPAL | HIGH-AFFINITY | CHEMISTRY, ORGANIC | RELEASE | DISCOVERY | GLUTAMATE | PHARMACOLOGY | CONFORMATIONALLY RESTRICTED ANALOGS | INHIBITORS | Fluorinated analogs of gamma-aminobutyric acid (beta-polyfluoroalkyl-GABAs) | [H-3]GABA uptake | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Pregabalin - metabolism | Rats | Male | gamma-Aminobutyric Acid - chemical synthesis | Tritium - chemistry | Synaptosomes - metabolism | Brain - metabolism | Animals | GABA Plasma Membrane Transport Proteins - metabolism | Pregabalin - chemistry | gamma-Aminobutyric Acid - analogs & derivatives | Fluorine - chemistry | GABA Plasma Membrane Transport Proteins - chemistry | GABA | Brain
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11. Full Text Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews
by Wiffen, Philip J and Wiffen, Philip J and Derry, Sheena and Derry, Sheena and Moore, R. Andrew and Moore, R Andrew and Aldington, Dominic and Aldington, Dominic and Cole, Peter and Cole, Peter and Rice, Andrew S.C and Rice, Andrew S C and Lunn, Michael P T and Lunn, Michael P.T and Hamunen, Katri and Hamunen, Katri and Haanpaa, Maija and Haanpaa, Maija and Kalso, Eija A and Kalso, Eija A
The Cochrane database of systematic reviews, ISSN 1469-493X, 2013, Volume 11, Issue 11, p. CD010567
Background Antiepileptic drugs have been used for treating different types of neuropathic pain, and sometimes fibromyalgia. Our understanding of quality... 
EXPERT PANEL RECOMMENDATIONS | MEDICINE, GENERAL & INTERNAL | PREGABALIN | EFFICACY | GUIDELINES | CLINICAL-TRIAL DESIGN | PHARMACOLOGICAL MANAGEMENT | TRIGEMINAL NEURALGIA | ENRICHED ENROLLMENT | QUALITY-OF-LIFE | EPIDEMIOLOGY | Cyclohexanecarboxylic Acids - therapeutic use | Gabapentin | Humans | Anticonvulsants - therapeutic use | Patient Dropouts | Pregabalin | Neuralgia - drug therapy | Review Literature as Topic | Fibromyalgia - drug therapy | Amines - therapeutic use | Intention to Treat Analysis | gamma-Aminobutyric Acid - therapeutic use | Pain Measurement | gamma-Aminobutyric Acid - analogs & derivatives
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12. Full Text Phosphonic acid analogs of GABA through reductive dealkylation of phosphonic diesters with lithium trialkylborohydrides
by Chowdhury, Sarwat and Muni, Niraj J and Greenwood, Nicholas P and Pepperberg, David R and Standaert, Robert F
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 13, pp. 3745 - 3748
Lithium trialkylborohydrides were found to mono-dealkylate dialkylphosphonates rapidly (rate of cleavage Me, Bn > 1°). The reaction was applied to the... 
Lithium trialkylborohydrides | GABA antagonists | Dealkylation | GABA C receptors | Phosphonate esters | GABA | receptors | CHEMISTRY, MEDICINAL | RECEPTOR ANTAGONISTS | TRIPHOSPHATE ANALOGS | CHEMISTRY, ORGANIC | DIALKYL PHOSPHONATES | phosphonate esters | GABA(C) receptors | SODIUM BIS(2-METHOXYETHOXY)ALUMINUM HYDRIDE | lithium trialkylborohydrides | PHARMACOLOGY | ESTERS | dealkylation | DI-P-NITROBENZYL | SELECTIVE CLEAVAGE | XENOPUS OOCYTES | GAMMA-AMINOBUTYRIC-ACID | Chemistry, Pharmaceutical - methods | Magnetic Resonance Spectroscopy | Models, Chemical | Oocytes - metabolism | Xenopus laevis | gamma-Aminobutyric Acid - chemistry | Lithium | Dose-Response Relationship, Drug | Neurotransmitter Agents | Organophosphonates - chemical synthesis | Animals | Borohydrides - chemistry | Esters - chemistry | Drug Design | Organophosphonates - chemistry | Inhibitory Concentration 50 | gamma-Aminobutyric Acid - analogs & derivatives
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13. Full Text Combination pharmacotherapy for the treatment of neuropathic pain in adults
by Chaparro, Luis Enrique and Chaparro, Luis Enrique and Wiffen, Philip J and Wiffen, Philip J and Moore, R Andrew and Moore, R Andrew and Gilron, Ian and Gilron, Ian
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2012, Volume 7, Issue 6, p. CD008943
Background Pharmacotherapy remains an important modality for the treatment of neuropathic pain. However, as monotherapy current drugs are associated with... 
MEDICINE, GENERAL & INTERNAL | POSTHERPETIC NEURALGIA | DIABETIC PERIPHERAL NEUROPATHY | SPINAL-CORD-INJURY | CANCER PAIN | RANDOMIZED CONTROLLED-TRIAL | PLACEBO-CONTROLLED TRIAL | QUALITY-OF-LIFE | DOUBLE-BLIND CROSSOVER | LIDOCAINE MEDICATED PLASTER | CHRONIC NONCANCER PAIN | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Gabapentin | Humans | Phenylurea Compounds - therapeutic use | Pregabalin | N-Methylaspartate - antagonists & inhibitors | Neuralgia - drug therapy | Nortriptyline - therapeutic use | Tramadol - therapeutic use | Drug Therapy, Combination - methods | Antidepressive Agents, Tricyclic - therapeutic use | Amines - therapeutic use | Adult | gamma-Aminobutyric Acid - therapeutic use | Acetaminophen - therapeutic use | gamma-Aminobutyric Acid - analogs & derivatives | Benzodiazepinones - therapeutic use | Morphine - therapeutic use | Thioctic Acid - therapeutic use
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14. Full Text The importance of Green Chemistry in Process Research and Development
by Dunn, Peter J
Chemical Society Reviews, ISSN 0306-0012, 02/2012, Volume 41, Issue 4, pp. 1452 - 1461
Green Chemistry or Sustainable Chemistry is defined by the Environmental Protection Agency as "the design of chemical products that reduce or eliminate the use... 
ORGANIC-SYNTHESIS | ALDOLASE | ASYMMETRIC-SYNTHESIS | ACID | METALS | STOCKS | DIRECTED EVOLUTION | CHEMISTRY, MULTIDISCIPLINARY | KEY | SOLVENT | Green Chemistry Technology | Biocatalysis | Solvents - chemistry | Rosuvastatin Calcium | Fluorobenzenes | Pyrazines - metabolism | Lipase - metabolism | Pregabalin | Pyrimidines - biosynthesis | Pharmaceutical Preparations - chemical synthesis | Triazoles - metabolism | Pharmaceutical Preparations - metabolism | gamma-Aminobutyric Acid - biosynthesis | Sulfonamides | Transaminases - metabolism | Sitagliptin Phosphate | gamma-Aminobutyric Acid - analogs & derivatives
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15. Full Text A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra
by Rae, Caroline D
Neurochemical Research, ISSN 0364-3190, 1/2014, Volume 39, Issue 1, pp. 1 - 36
The current knowledge of the normal biochemistry of compounds that give rise to resonances in human brain proton magnetic resonance spectra measureable at... 
Neurochemistry | Biochemistry, general | Neurology | Neurosciences | γ-Aminobutyric acid | Biomedicine | Lactate | Choline | Creatine | Cell Biology | N -acetylaspartate | myo-inositol | N-acetylaspartate | Brain - metabolism | Choline - metabolism | Protons | Magnetic Resonance Spectroscopy | Metabolic Networks and Pathways | Inositol - metabolism | gamma-Aminobutyric Acid - metabolism | Humans | Lactic Acid - metabolism |