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1. Full Text Pregabalin: A novel γ-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders
by Tassone, Daniel M., PharmD and Boyce, Eric, PharmD and Guyer, Jennifer, PharmD and Nuzum, Donald, PharmD
Clinical therapeutics, ISSN 0149-2918, 2007, Volume 29, Issue 1, pp. 26 - 48
Internal Medicine | Medical Education | epilepsy | diabetic peripheral neuropathy | partial-onset seizures | neuropathic pain | generalized anxiety disorder | social anxiety disorder | postherpetic neuralgia | pregabalin | Lyrica | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neurology | Diabetes. Impaired glucose tolerance | Pharmacology. Drug treatments | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Nervous system (semeiology, syndromes) | Analgesics - pharmacology | Analgesics - therapeutic use | Anticonvulsants - pharmacokinetics | Epilepsies, Partial - drug therapy | Humans | Anticonvulsants - therapeutic use | gamma-Aminobutyric Acid - pharmacology | Anticonvulsants - administration & dosage | Analgesics - pharmacokinetics | Clinical Trials as Topic | Pregabalin | Anticonvulsants - pharmacology | Neuralgia - drug therapy | Anticonvulsants - adverse effects | Drug Interactions | gamma-Aminobutyric Acid - therapeutic use | Anxiety Disorders - drug therapy | gamma-Aminobutyric Acid - analogs & derivatives | Analgesics - adverse effects | gamma-Aminobutyric Acid - adverse effects | gamma-Aminobutyric Acid - pharmacokinetics | Index Medicus
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2. Full Text Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy
by Ma, Celena and Pejo, Ervin and McGrath, Megan and Jayakar, Selwyn S and Zhou, Xiaojuan and Miller, Keith W and Cohen, Jonathan B and Raines, Douglas E
Anesthesiology (Philadelphia), ISSN 0003-3022, 08/2017, Volume 127, Issue 5, pp. 824 - 837
Life Sciences & Biomedicine | Anesthesiology | Science & Technology | GABA Antagonists - metabolism | Naphthalenes - chemistry | Binding, Competitive - physiology | gamma-Aminobutyric Acid - metabolism | Xenopus laevis | gamma-Aminobutyric Acid - pharmacology | Treatment Outcome | Etomidate - metabolism | Oocytes | Etomidate - analogs & derivatives | GABA Antagonists - pharmacology | Naphthalenes - pharmacology | Binding, Competitive - drug effects | Dose-Response Relationship, Drug | Animals | Etomidate - pharmacology | Female | Receptors, GABA-A - metabolism | Naphthalenes - metabolism | Index Medicus | Abridged Index Medicus
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3. Full Text Synthesis of new fluorinated analogs of GABA, Pregabalin bioisosteres, and their effects on [3H]GABA uptake by rat brain nerve terminals
by Borisova, T and Pozdnyakova, N and Shaitanova, E and Gerus, I and Dudarenko, M and Mironets, R and Haufe, G and Kukhar, V
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2015, Volume 23, Issue 15, pp. 4316 - 4323
[3H]GABA uptake | Rat brain nerve terminals | Fluorinated analogs of γ-aminobutyric acid (β-polyfluoroalkyl-GABAs) | Pregabalin | Lyrica | Abbreviations GABA γ-aminobutyric acid | FGABAs fluorinated analogs of γ-aminobutyric acid | HEPES N-2-hydroxyethylpiperazine-n-2-ethanesulfonic acid | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Pregabalin - metabolism | Rats | Male | gamma-Aminobutyric Acid - chemical synthesis | Tritium - chemistry | Synaptosomes - metabolism | Brain - metabolism | Animals | GABA Plasma Membrane Transport Proteins - metabolism | Pregabalin - chemistry | gamma-Aminobutyric Acid - analogs & derivatives | Fluorine - chemistry | GABA Plasma Membrane Transport Proteins - chemistry | GABA | Brain | Index Medicus
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4. Full Text Determination of Therapeutic γ-Aminobutyric Acid Analogs in Forensic Whole Blood by Hydrophilic Interaction Liquid Chromatography-Electrospray Tandem Mass Spectrometry
by Sørensen, Lambert K and Hasselstrøm, Jørgen B
Journal of analytical toxicology, ISSN 0146-4760, 5/2014, Volume 38, Issue 4, pp. 177 - 183
Physical Sciences | Toxicology | Chemistry | Chemistry, Analytical | Life Sciences & Biomedicine | Science & Technology | Tandem Mass Spectrometry - instrumentation | Limit of Detection | Reproducibility of Results | Humans | Forensic Toxicology - instrumentation | Chromatography, Liquid - instrumentation | Calibration | Spectrometry, Mass, Electrospray Ionization - instrumentation | Reference Standards | gamma-Aminobutyric Acid - blood | Spectrometry, Mass, Electrospray Ionization - methods | Hydrophobic and Hydrophilic Interactions | Forensic Toxicology - methods | Chromatography, Liquid - methods | gamma-Aminobutyric Acid - analogs & derivatives | Postmortem Changes | Tandem Mass Spectrometry - methods | Index Medicus
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5. Full Text Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids
by Johnston, Graham A. R and Johnston, Graham A. R
Neurochemical research, ISSN 0364-3190, 3/2016, Volume 41, Issue 3, pp. 476 - 480
Neurochemistry | Biochemistry, general | Neurology | Neurosciences | Biomedicine | GABA A receptors | GABA | trans -4-Aminocrotonic acid | 4-Aminotetrolic acid | cis -4-Aminocrotonic acid | GABA C receptors | Cell Biology | cis-4-Aminocrotonic acid | trans-4-Aminocrotonic acid | receptors | Biochemistry & Molecular Biology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Crotonates - chemistry | GABA Agonists - chemistry | Stereoisomerism | Aminobutyrates - chemistry | Humans | gamma-Aminobutyric Acid - chemistry | Crotonates - pharmacology | gamma-Aminobutyric Acid - pharmacology | Aminobutyrates - pharmacology | GABA Antagonists - pharmacology | Neurotransmitter Agents - chemistry | Animals | Neurotransmitter Agents - pharmacology | GABA Agonists - pharmacology | Receptors, GABA - metabolism | Receptors, GABA-A - metabolism | gamma-Aminobutyric Acid - analogs & derivatives | GABA Antagonists - chemistry | Chemical properties | Bonds | Analysis | Index Medicus
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6. A role of GABA analogues in the treatment of neurological diseases
by Gajcy, K and Lochyński, S and Librowski, T
Current medicinal chemistry, ISSN 0929-8673, 2010, Volume 17, Issue 22, pp. 2338 - 2347
Neurological diseases | GABAergic receptors | Cyclopropane derivatives | GABA analogues | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Animals | Humans | Nervous System Diseases - drug therapy | gamma-Aminobutyric Acid - chemistry | gamma-Aminobutyric Acid - pharmacology | gamma-Aminobutyric Acid - therapeutic use | gamma-Aminobutyric Acid - analogs & derivatives | Drugs | Brain | gamma -Aminobutyric acid | Parkinson's disease | Mental disorders | Neurodegenerative diseases | Chorea | Central nervous system | Depression | Anticonvulsants | Neurotransmitters | Pain | Affective disorders | Polarity | Anxiety | Convulsions | Alzheimer's disease | Movement disorders
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7. Full Text Protective effect of N,N′-dialkylated analogs of 4,4′-diaminodiphenylsulfone in a model of intrastriatal quinolinic acid induced-excitotoxicity
by Tristán-López, Luis and Pérez-Álvarez, Víctor and Pérez-Severiano, Francisca and Montes, Sergio and Pérez-Neri, Iván and Rivera-Espinosa, Liliana and Ríos, Camilo
Neuroscience letters, ISSN 0304-3940, 10/2012, Volume 528, Issue 1, pp. 1 - 5
Analogs | Dapsone | Neuroprotection | Methemoglobin | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Rats, Wistar | Rats | Male | Neuroprotective Agents - metabolism | Dapsone - metabolism | Brain - drug effects | Brain - metabolism | Animals | Neuroprotective Agents - pharmacology | Behavior, Animal - drug effects | Methemoglobin - metabolism | Dapsone - pharmacology | Quinolinic Acid - toxicity | Dapsone - analogs & derivatives | gamma-Aminobutyric Acid - analysis | Methemoglobin - analysis | GABA | Analysis | Index Medicus | Indexing in process
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8. Full Text Synthesis, Conformation and Biological Evaluation of the Enantiomers of 3‐Fluoro‐γ‐Aminobutyric Acid ((R)‐ and (S)‐3F‐GABA): An Analogue of the Neurotransmitter GABA
by Deniau, Gildas and Slawin, Alexandra M. Z and Lebl, Tomas and Chorki, Fatima and Issberner, Jon P and van Mourik, Tanja and Heygate, Judith M and Lambert, Jeremy J and Etherington, Lori‐An and Sillar, Keith T and O'Hagan, David
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 12/2007, Volume 8, Issue 18, pp. 2265 - 2274
GABA | density functional calculations | NMR spectroscopy | neurotransmitters | fluorine | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Xenopus laevis - embryology | Stereoisomerism | Humans | Drug Evaluation | gamma-Aminobutyric Acid - chemistry | gamma-Aminobutyric Acid - pharmacology | gamma-Aminobutyric Acid - chemical synthesis | GABA Agents - chemical synthesis | GABA Agents - pharmacology | Animals | GABA Agents - chemistry | Models, Biological | Biological Assay | Molecular Structure | gamma-Aminobutyric Acid - analogs & derivatives | Index Medicus
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9. Full Text Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin
by Juncosa, Jose I and Groves, Andrew P and Xia, Guoyao and Silverman, Richard B
Bioorganic & medicinal chemistry, ISSN 0968-0896, 02/2013, Volume 21, Issue 4, pp. 903 - 911
Enzyme inhibition | Molecular dynamics | γ-Aminobutyric acid aminotransferase | Vigabatrin | 4-Amino-5-fluoropentanoic acid | 4-Amino-5- fluoropentanoic acid | 4-Aminobutyrate Transaminase - metabolism | Catalytic Domain | Anticonvulsants - chemical synthesis | Anticonvulsants - chemistry | gamma-Aminobutyric Acid - chemistry | Vigabatrin - chemistry | Molecular Docking Simulation | Vigabatrin - chemical synthesis | 4-Aminobutyrate Transaminase - chemistry | Binding Sites | Fluorine - chemistry | Index Medicus | enzyme inhibition | 4-amino-5-fluoropentanoic acid
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10. Full Text Combination pharmacotherapy for the treatment of neuropathic pain in adults
by Gilron, Ian and Chaparro, Luis Enrique and Wiffen, Philip J and Moore, R Andrew and Gilron, Ian
Cochrane library, ISSN 1469-493X, 2012, Volume 2020, Issue 7, pp. CD008943 - CD008943
gamma-Aminobutyric Acid | Nortriptyline | Amines | Chronic non-cancer pain | Gabapentin | Morphine | Phenylurea Compounds | Pregabalin | Pain & anaesthesia | 2019 3. Chronic pain | 2019 3.1 Neuropathic pain | Analgesics | Acetaminophen | Antidepressive Agents, Tricyclic | Thioctic Acid | Tramadol | Benzodiazepinones | Cyclohexanecarboxylic Acids | N-Methylaspartate | Neuralgia | Pharmacological therapies | Drug Therapy, Combination | Medicine General & Introductory Medical Sciences | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Humans | Phenylurea Compounds - therapeutic use | N-Methylaspartate - antagonists & inhibitors | Neuralgia - drug therapy | Nortriptyline - therapeutic use | Tramadol - therapeutic use | Drug Therapy, Combination - methods | Antidepressive Agents, Tricyclic - therapeutic use | Amines - therapeutic use | Adult | gamma-Aminobutyric Acid - therapeutic use | Acetaminophen - therapeutic use | gamma-Aminobutyric Acid - analogs & derivatives | Benzodiazepinones - therapeutic use | Morphine - therapeutic use | Thioctic Acid - therapeutic use | Index Medicus
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