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Biological Psychiatry, ISSN 0006-3223, 2010, Volume 67, Issue 9, pp. 831 - 839
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 10/2010, Volume 49, Issue 10, pp. 661 - 669
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4654 - 4666
Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SUBSTANTIA-GELATINOSA NEURONS | INDUCED EPILEPTIFORM ACTIVITY | ENTORHINAL CORTEX | INHERITED MYOCLONUS | CARDIAC-SURGERY | SODIUM-CHANNELS | GABAERGIC TONIC INHIBITION | GABA(A) RECEPTORS | HIPPOCAMPAL-NEURONS | FLUID DRAINAGE | Isoflurane - pharmacology | Humans | Middle Aged | Tranexamic Acid - pharmacology | Propofol - pharmacology | Mice, 129 Strain | Anticonvulsants - pharmacology | Receptors, Glycine - antagonists & inhibitors | Seizures - chemically induced | Young Adult | Aprotinin - pharmacology | Spinal Cord - pathology | Neurons - physiology | Aged, 80 and over | Inhibitory Concentration 50 | Adult | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | GABA-A Receptor Antagonists - pharmacology | Binding, Competitive | Membrane Potentials - drug effects | Aminocaproic Acid - adverse effects | GABA-A Receptor Antagonists - pharmacokinetics | Mice, Inbred C57BL | Cells, Cultured | gamma-Aminobutyric Acid - pharmacology | GABA-A Receptor Antagonists - adverse effects | Tranexamic Acid - adverse effects | Aminocaproic Acid - pharmacology | Patch-Clamp Techniques | Animals | Glycine - pharmacology | Protein Binding | Tranexamic Acid - pharmacokinetics | Aged | Mice | Receptors, GABA-A - metabolism | In Vitro Techniques | Inhibitory Postsynaptic Potentials - drug effects | Dose-response relationship (Biochemistry) | Complications and side effects | Care and treatment | Glycine receptors | Tranexamic acid | Research | Seizures (Medicine) | Diagnosis | Properties
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 6, pp. 803 - 815
Hippocampal activity influences neurogenesis in the adult dentate gyrus; however, little is known about the involvement of the hippocampal circuitry in this... 
RAT DENTATE GYRUS | TEMPORAL-LOBE EPILEPSY | POSTNATAL MOUSE-BRAIN | PROLIFERATING CELLS | GENERATED GRANULE CELLS | CORTICAL CIRCUIT FORMATION | BEHAVING RAT | GAMMA OSCILLATIONS | PSA-NCAM | PRECURSOR CELLS | NEUROSCIENCES | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Ki-67 Antigen - metabolism | N-Methylaspartate - pharmacology | Calbindins | Drug Interactions | Neurons - ultrastructure | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neurons - metabolism | Tetrodotoxin - pharmacology | Microscopy, Immunoelectron - methods | Nickel - pharmacology | 4-Aminopyridine - pharmacology | Potassium Channel Blockers - pharmacology | Membrane Potentials - drug effects | Sialic Acids - metabolism | gamma-Aminobutyric Acid - pharmacology | Mice, Transgenic | Excitatory Amino Acid Agonists - pharmacology | Bicuculline - pharmacology | GABA Antagonists - pharmacology | Immunohistochemistry - methods | Vesicular Inhibitory Amino Acid Transport Proteins - metabolism | Glycine - pharmacology | Green Fluorescent Proteins - biosynthesis | Mice | Nestin | Phosphopyruvate Hydratase - metabolism | Sodium-Potassium-Chloride Symporters - metabolism | Patch-Clamp Techniques - methods | Neurons - classification | Intermediate Filament Proteins - genetics | Bromodeoxyuridine - metabolism | Neural Cell Adhesion Molecule L1 - metabolism | Neurons - drug effects | Cell Differentiation - physiology | Electric Stimulation - methods | History, Ancient | Hippocampus - cytology | Membrane Potentials - physiology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | S100 Calcium Binding Protein G - metabolism | Animals | Cell Count - methods | Solute Carrier Family 12, Member 2 | Cell Differentiation - drug effects | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Stem Cells - drug effects | In Vitro Techniques | GABA | Neurons | Cell research | Studies | Brain | Neurotransmitters | Microscopy | Neurogenesis | Rodents
Journal Article
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2007, Volume 82, Issue 1, pp. 21 - 32
The low productivity and escalating costs of drug development have been well documented over the past several years. Less than 10% of new compounds that enter... 
TRIPTANS SEROTONIN | METAANALYSIS | PAIN | DOSE-RESPONSE | INTEGRATION | 5-HT1B/1D AGONISTS | CLINICAL-TRIALS | DISEASE | PHARMACOLOGY & PHARMACY | SIMULATION | MIGRAINE | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 592 - 600
When chronic alterations in neuronal activity occur, network gain is maintained by global homeostatic scaling of synaptic strength, but the stability of... 
MOUSE-BRAIN | HIPPOCAMPAL SLICE CULTURES | AXON TERMINALS | GAIN-CONTROL | SYNAPTIC-TRANSMISSION | GABA RELEASE | CB1 CANNABINOID RECEPTOR | RAT HIPPOCAMPUS | EXPRESSION | NEUROSCIENCES | PLASTICITY | Cannabinoid Receptor Modulators - metabolism | Cannabinoid Receptor Modulators - pharmacology | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Nerve Net - physiology | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Neural Inhibition - physiology | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Neurons - physiology | Benzamides - pharmacology | Homeostasis - drug effects | Tetrodotoxin - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | Synapses - drug effects | Synapses - physiology | Enzyme Inhibitors - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Morpholines - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Calcium Channel Blockers - pharmacology | Down-Regulation - drug effects | Hippocampus - cytology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Agatoxins | Conotoxins - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Polyamines - pharmacology | Animals | Homeostasis - physiology | Benzoxazines - pharmacology | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Brain | Physiological aspects | Homeostasis | Research | Synapses | Injuries
Journal Article
Journal Article