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Diabetes, ISSN 0012-1797, 06/2006, Volume 55, Issue 6, pp. 1554 - 1561
Journal Article
by Peng, JH and Cui, T and Huang, F and Chen, L and Zhao, Y and Xu, L and Xu, LL and Feng, Q and Hu, YY
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 646 - 654
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined... 
HEPATITIS | LIPOPOLYSACCHARIDE-BINDING PROTEIN | DISEASE | BARRIER | FATTY LIVER | RATS | ETHANOL | PHARMACOLOGY & PHARMACY | MICE | KAPPA-B | INTESTINAL PERMEABILITY | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Tight Junctions - genetics | Isoflavones - pharmacology | Male | Alanine Transaminase - blood | Alcohol-Related Disorders - genetics | Antigens, CD - genetics | Receptors, Immunologic - antagonists & inhibitors | Antigens, CD - metabolism | Liver Diseases, Alcoholic - drug therapy | Zonula Occludens-1 Protein - metabolism | Neutrophil Infiltration - drug effects | Disease Models, Animal | Tight Junctions - drug effects | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Fatty Liver - metabolism | Portal Vein - metabolism | Liver - metabolism | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 2 - metabolism | Neutrophil Infiltration - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Fatty Liver - drug therapy | Triglycerides - metabolism | Microvilli - genetics | Aspartate Aminotransferases - blood | Diet | Microvilli - metabolism | Receptors, Immunologic - genetics | Intestines - drug effects | Tumor Necrosis Factor-alpha - metabolism | Liver - enzymology | Intestines - metabolism | Acute-Phase Proteins - genetics | Alcohol-Related Disorders - drug therapy | Lipopolysaccharide Receptors - metabolism | Alcohol-Related Disorders - metabolism | Liver Diseases, Alcoholic - genetics | Receptors, Immunologic - biosynthesis | Kupffer Cells - metabolism | Endotoxins - metabolism | Fatty Liver - genetics | Portal Vein - drug effects | Acute-Phase Proteins - metabolism | Endotoxins - genetics | gamma-Glutamyltransferase - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Liver Diseases, Alcoholic - metabolism | Kupffer Cells - drug effects | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Microvilli - drug effects | Endotoxins - antagonists & inhibitors | Animals | Carrier Proteins - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Lipopolysaccharide Receptors - genetics | Receptors, Immunologic - metabolism
Journal Article
Nature Medicine, ISSN 1078-8956, 2012, Volume 18, Issue 4, pp. 572 - 579
Nat Med. 2012 Mar 4;18(4):572-9. doi: 10.1038/nm.2667. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN JAGGED1 | CELL BIOLOGY | ALAGILLE-SYNDROME | BILE-DUCT DEVELOPMENT | REGULATES FORMATION | MOUSE MODEL | CHOLINE-DEFICIENT | GENE-EXPRESSION | NUMB | OVAL CELLS | DIFFERENTIATION | Wnt3A Protein - metabolism | Ethionine - administration & dosage | Keratins, Hair-Specific - genetics | Receptors, Notch - metabolism | Humans | Middle Aged | Liver Diseases - pathology | Cell Communication - physiology | Male | RNA, Messenger - metabolism | Young Adult | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Liver Regeneration - genetics | Biliary Tract - metabolism | Serrate-Jagged Proteins | Adult | Antigens, Differentiation - metabolism | Female | Membrane Proteins - metabolism | Cell Differentiation - physiology | Hepatocytes - physiology | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation - physiology | Mice, Transgenic | gamma-Glutamyltransferase - metabolism | Biliary Tract - physiopathology | Cell Communication - genetics | Liver Regeneration - physiology | beta Catenin - genetics | Biliary Tract - pathology | Nerve Tissue Proteins - metabolism | Macrophages - metabolism | Animals | Creatine Kinase - metabolism | Signal Transduction - physiology | Stem Cell Niche - physiology | Stem Cells - physiology | Aged | Mice | Chronic Disease | Liver diseases | Physiological aspects | Development and progression | Genetic aspects | Research | Macrophages | Cell differentiation | Wnt proteins | Signal transduction | Cellular biology | Gene expression
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2012, Volume 53, Issue 10, pp. 1857 - 1867
Huntington's disease (HD) is a CAG repeat disorder affecting the HD gene, which encodes for huntingtin (Htt) and is characterized by prominent cell death in... 
Striatal cells | Oxidative stress | Reactive oxygen species | Huntingtin | Huntington disease | MRP1 | PROTEIN | INCREASED OXIDATIVE DAMAGE | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | GENE | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | MITOCHONDRIAL DYSFUNCTION | STRESS | BRAIN | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Glutathione Reductase - metabolism | Huntington Disease - pathology | Caspase 3 - metabolism | RNA, Messenger - metabolism | Corpus Striatum - cytology | Corpus Striatum - metabolism | Glutathione - pharmacology | Biological Transport | Multidrug Resistance-Associated Proteins - genetics | Neostriatum - metabolism | Glutamate-Cysteine Ligase - metabolism | Glutathione Synthase - metabolism | Nuclear Proteins - genetics | Glutathione Peroxidase - metabolism | Glutathione - analogs & derivatives | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Glutathione Transferase - metabolism | Nuclear Proteins - metabolism | gamma-Glutamyltransferase - metabolism | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Gene Knock-In Techniques | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Huntington Disease - genetics | Mice | Mutation | Multidrug Resistance-Associated Proteins - metabolism | Antioxidants | Drug resistance in microorganisms | Messenger RNA | Thiols | Huntington's chorea | Ligases | Glutathione transferase | Cell death | Analysis | Peroxidase | Cells
Journal Article
Diabetes Care, ISSN 0149-5992, 04/2016, Volume 39, Issue 4, pp. 572 - 581
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179036
As a catadromous species, salinity is a key parameter that affects gonadal development of Chinese mitten crab Eriocheir sinensis during reproductive migration.... 
ANIMAL-TISSUES | NA+/K+-ATPASE ACTIVITY | IONIC REGULATION | K+-ATPASE | MULTIDISCIPLINARY SCIENCES | SEAWATER ACCLIMATION | LITOPENAEUS-VANNAMEI | FREE AMINO-ACIDS | GILLS | CARCINUS-MAENAS | FRESH-WATER | Malondialdehyde - metabolism | Sodium-Potassium-Exchanging ATPase - genetics | Uric Acid - metabolism | Gonads - drug effects | Lipoproteins, HDL - metabolism | Brachyura - growth & development | Hemolymph - metabolism | Gills - metabolism | Male | gamma-Glutamyltransferase - metabolism | Osmoregulation - drug effects | RNA, Messenger - metabolism | Fatty Acids, Omega-6 - metabolism | Amino Acids - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Brachyura - metabolism | Gills - drug effects | Gonads - metabolism | Salts - pharmacology | Animals | Gonads - growth & development | Glucose - metabolism | Hemolymph - chemistry | Fatty Acids - metabolism | Physiological aspects | Research | Crabs | Salinity | Taurine | Science education | Physiological effects | Polyunsaturated fatty acids | Migration | Zoology | Estuaries | Amino acids | Glucose | Physiological responses | Crustaceans | Arginine | Salinity effects | Physiology | Magnesium | Catadromous species | Malonaldehyde | Enzymes | Alanine | Nutrition | Phenylalanine | Threonine | Gills | Tryptophan | Hemolymph | Osmoregulation | Marine biology | Gender differences | Ecology | Uric acid | Permeability | Brackish water | Metabolism | Gene expression | Na+/K+-exchanging ATPase | Fatty acids | Cholesterol | Studies | Ammonia | Lysine | Ornithine | Females | Aquaculture
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 10/2010, Volume 299, Issue 4, pp. 584 - 592
Liver fat represents a balance between input, secretion, and oxidation of fatty acids. As humans spend the majority of a 24-h period in a postprandial state,... 
Abdominal obesity | Oxidation | Postprandial metabolism | Stable isotopes | Very low-density lipoprotein | Desaturation | stable isotopes | PHYSIOLOGY | LIPID-METABOLISM | ACETATE RECOVERY FACTOR | DE-NOVO LIPOGENESIS | oxidation | desaturation | SKELETAL-MUSCLE | POSTPRANDIAL LIPEMIA | KETONE-BODIES | abdominal obesity | INSULIN-RESISTANCE | very low-density lipoprotein | ENDOCRINOLOGY & METABOLISM | FAMILIAL COMBINED HYPERLIPIDEMIA | postprandial metabolism | ADIPOSE-TISSUE | STEAROYL-COENZYME | Dietary Fats - metabolism | Apolipoproteins B - metabolism | Area Under Curve | gamma-Glutamyltransferase - blood | Humans | Middle Aged | Male | Alanine Transaminase - blood | Apolipoproteins B - blood | Insulin - blood | Young Adult | Fatty Acids, Nonesterified - metabolism | C-Reactive Protein - metabolism | Lipoproteins - metabolism | Postprandial Period | Adult | Fatty Acids, Nonesterified - blood | C-Reactive Protein - analysis | Fatty Liver - metabolism | 3-Hydroxybutyric Acid - blood | gamma-Glutamyltransferase - metabolism | Lipoproteins - blood | Obesity - metabolism | Triglycerides - metabolism | Insulin - metabolism | Lipoproteins, VLDL - blood | 3-Hydroxybutyric Acid - metabolism | Lipoproteins, VLDL - metabolism | Triglycerides - blood | Alanine Transaminase - metabolism | Prevention | Obesity | Fat metabolism | Liver | Physiological aspects | Oxidation-reduction reaction | Health aspects
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 24 - 35
Bile acid transporters and the nuclear factor erythroid 2-related factor (Nrf-2)-mediated adaptive response play important roles in the development of... 
HepG2 cells | Rifampicin | Bile acid transporters | Nrf2 | TUDCA | Adaptive response | DRUG | SALT EXPORT PUMP | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | RIFAMYCIN SV | INDUCED LIVER-INJURY | CHOLESTATIC RAT-LIVER | INHIBITION | ENDOCRINOLOGY & METABOLISM | CANALICULAR MEMBRANES | INDUCED HEPATOTOXICITY | Adaptation, Physiological | Aspartate Aminotransferases - genetics | L-Lactate Dehydrogenase - metabolism | RNA, Small Interfering - genetics | ATP Binding Cassette Subfamily B Member 11 - antagonists & inhibitors | Humans | Alkaline Phosphatase - metabolism | Stress, Physiological | Rifampin - antagonists & inhibitors | NF-E2-Related Factor 2 - agonists | Adenosine Triphosphate | Bilirubin | Organic Anion Transporters, Sodium-Dependent - genetics | Taurochenodeoxycholic Acid - pharmacology | Alanine Transaminase - genetics | ATP Binding Cassette Subfamily B Member 11 - metabolism | ATP Binding Cassette Transporter, Sub-Family B - agonists | Membrane Transport Proteins - genetics | ATP Binding Cassette Subfamily B Member 11 - agonists | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | NF-E2-Related Factor 2 - genetics | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics | Alkaline Phosphatase - genetics | Signal Transduction | Gene Expression Regulation | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | gamma-Glutamyltransferase - metabolism | Antibiotics, Antitubercular - pharmacology | Symporters - metabolism | Aspartate Aminotransferases - metabolism | Hep G2 Cells | gamma-Glutamyltransferase - genetics | L-Lactate Dehydrogenase - genetics | NF-E2-Related Factor 2 - metabolism | Solute Carrier Organic Anion Transporter Family Member 1b1 - metabolism | Symporters - genetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Multidrug Resistance-Associated Proteins - agonists | Alanine Transaminase - metabolism | Rifampin - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP Binding Cassette Subfamily B Member 11 - genetics | RNA, Small Interfering - metabolism | Drug resistance in microorganisms | Phosphatases | Liver | Muscle proteins | Rifampin | Adenosine triphosphate | Deoxycholic acid | Proteins | Liver diseases
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 05/2012, Volume 79, pp. 189 - 198
Journal Article
Scandinavian Journal of Gastroenterology, ISSN 0036-5521, 04/2011, Volume 46, Issue 4, pp. 485 - 494
Abstract Objective. Lipopolysaccharide (LPS) is suspected to trigger primary biliary cirrhosis (PBC) in susceptible individuals, yet the precise mechanism of... 
Lipopolysaccharide | primary biliary cirrhosis | pro-inflammatory cytokines | Toll-like receptor 4 | RECOGNITION | INNATE IMMUNE-RESPONSE | ENDOTOXEMIA | CUTTING EDGE | PATHOGENESIS | INFECTIOUS-DISEASE | LIVER-INJURY | TOLL-LIKE RECEPTORS | STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | INTESTINAL PERMEABILITY | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | Epithelial Cells - metabolism | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | gamma-Glutamyltransferase - blood | Humans | Middle Aged | NF-kappa B - immunology | Lipopolysaccharides - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Monocytes - immunology | Hepatitis, Autoimmune - metabolism | Lipopolysaccharides - immunology | Antigens, CD - metabolism | Lipopolysaccharide Receptors - metabolism | Immunoglobulins - metabolism | Inflammation - metabolism | Liver Cirrhosis, Biliary - immunology | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Liver Cirrhosis, Biliary - etiology | Adult | Female | Interleukin-8 - metabolism | Membrane Glycoproteins - immunology | Toll-Like Receptors - metabolism | Interleukin-6 - metabolism | Alkaline Phosphatase - blood | Antigens, Differentiation, Myelomonocytic - immunology | Hepatitis B, Chronic - metabolism | Cross-Sectional Studies | Toll-Like Receptors - immunology | Cells, Cultured | Interleukin-1beta - immunology | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 4 - metabolism | Liver Diseases, Alcoholic - metabolism | Bilirubin - blood | Antigens, Differentiation, Myelomonocytic - metabolism | Epithelial Cells - immunology | Interleukin-6 - immunology | Interleukin-8 - immunology | Liver Cirrhosis, Biliary - metabolism
Journal Article