X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (4389) 4389
Book Review (1136) 1136
Publication (656) 656
Book Chapter (83) 83
Conference Proceeding (23) 23
Dissertation (9) 9
Book / eBook (1) 1
Government Document (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (3423) 3423
humans (2568) 2568
gamma-secretase (2299) 2299
animals (2197) 2197
alzheimer's disease (1717) 1717
amyloid precursor protein (1372) 1372
neurosciences (1296) 1296
alzheimers-disease (1262) 1262
biochemistry & molecular biology (1202) 1202
mice (1151) 1151
cell biology (757) 757
amyloid precursor protein secretases - metabolism (732) 732
alzheimer disease - metabolism (704) 704
amyloid beta-peptides - metabolism (630) 630
amyloid beta-protein precursor - metabolism (602) 602
gamma-secretase activity (597) 597
in-vivo (596) 596
γ-secretase (573) 573
a-beta (567) 567
presenilin (565) 565
gamma-secretase inhibitor (543) 543
notch (537) 537
signal transduction (514) 514
membrane proteins - metabolism (459) 459
male (437) 437
gamma-secretase inhibitors (432) 432
alzheimer disease - genetics (431) 431
female (424) 424
proteins (424) 424
article (414) 414
presenilin-1 (411) 411
intracellular domain (400) 400
transgenic mice (399) 399
amyloid precursor protein secretases - antagonists & inhibitors (396) 396
pharmacology & pharmacy (393) 393
mutation (389) 389
precursor protein (386) 386
expression (379) 379
alzheimer disease - pathology (377) 377
amyloid beta-protein (371) 371
brain (359) 359
alzheimer disease - drug therapy (350) 350
cells, cultured (345) 345
cell line (343) 343
mice, transgenic (336) 336
amyloid precursor protein secretases (334) 334
amyloid beta-protein precursor - genetics (330) 330
oncology (328) 328
alzheimer’s disease (320) 320
cell line, tumor (319) 319
app (317) 317
membrane proteins - genetics (310) 310
alzheimers disease (308) 308
research (306) 306
proteolysis (304) 304
cleavage (301) 301
disease models, animal (296) 296
brain - metabolism (295) 295
mouse model (293) 293
familial alzheimers-disease (291) 291
receptors, notch - metabolism (289) 289
clinical neurology (282) 282
secretase (275) 275
neurons - metabolism (271) 271
rats (265) 265
chemistry, medicinal (264) 264
amyloid-beta (261) 261
apoptosis (261) 261
amyloid (258) 258
multidisciplinary sciences (253) 253
alzheimer disease (251) 251
neurology (251) 251
analysis (250) 250
activation (249) 249
beta-secretase (249) 249
amino acid sequence (247) 247
endopeptidases - metabolism (243) 243
cancer (241) 241
peptides (239) 239
molecular sequence data (234) 234
amyloid precursor protein secretases - genetics (232) 232
cells (231) 231
mental disorders (229) 229
peptide fragments - metabolism (228) 228
nicastrin (227) 227
protein structure, tertiary (226) 226
neurons (225) 225
mice, inbred c57bl (221) 221
oxidative stress (219) 219
enzyme inhibitors - pharmacology (215) 215
neurodegenerative diseases (214) 214
protein binding (210) 210
alzheimer disease - physiopathology (209) 209
presenilin-1 - genetics (209) 209
in-vitro (207) 207
signal transduction - physiology (206) 206
mice, knockout (204) 204
genetic aspects (199) 199
models, biological (198) 198
aspartic acid endopeptidases (196) 196
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (4406) 4406
French (9) 9
Spanish (9) 9
Chinese (8) 8
Japanese (8) 8
Polish (5) 5
German (3) 3
Czech (1) 1
Korean (1) 1
Persian (1) 1
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


11/2012
γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptide (Aβ), the principal component of amyloid plaques present in Alzheimer’s... 
Gamma-secretase | Alzheimer's Disease | Proteomics | Amyloid beta peptide | 0317
Dissertation
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 06/2016, Volume 8, Issue 6, pp. 595 - 608
Despite continuing debate about the amyloid -protein (or A hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that... 
MEDICINE, RESEARCH & EXPERIMENTAL | treatment | NEURITIC DEGENERATION | TAU PATHOLOGY | Alzheimer | APOLIPOPROTEIN-E | genetics | cell biology | IN-VIVO | BETA-SECRETASE BACE1 | A-BETA | PRECURSOR PROTEIN | TRANSGENIC MOUSE MODEL | GAMMA-SECRETASE | GENOME-WIDE ASSOCIATION
Journal Article
Organic Letters, ISSN 1523-7060, 07/2017, Volume 19, Issue 13, pp. 3438 - 3441
Two efficient, modular, step- and pot-economic strategies to access various 5,6,7,12-tetrahydrobenzo[2,3]-azepino[4,5-b]indoles and... 
GOLD | ROUTE | GAMMA-SECRETASE INHIBITOR | HETEROARENES | INDOLE | CHEMISTRY, ORGANIC | BOND FORMATION | ALKYNES | HYDROARYLATION
Journal Article
NATURE NEUROSCIENCE, ISSN 1097-6256, 08/2011, Volume 14, Issue 8, pp. 1023 - U120
The amyloid-beta peptide A beta 42 is known to be a primary amyloidogenic and pathogenic agent in Alzheimer's disease. However, the role of A beta 43, which is... 
ALZHEIMERS-DISEASE | IN-VIVO | DISEASE-LIKE PATHOLOGY | A-BETA | AMYLOID-BETA-PROTEIN | GAMMA-SECRETASE ACTIVITY | PRESENILIN MUTATIONS | TERMINAL FRAGMENT | PRECURSOR PROTEIN | NEUROSCIENCES | SENILE PLAQUES
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 10/2010, Volume 29, Issue 19, pp. 3408 - 3420
The amyloid peptides A beta(40) and A beta(42) of Alzheimer's disease are thought to contribute differentially to the disease process. Although A beta(42)... 
LONG-TERM | BIOCHEMISTRY & MOLECULAR BIOLOGY | oligomer | TERMINAL FRAGMENT | AMYLOID PRECURSOR PROTEIN | SYNAPTIC PLASTICITY | OLIGOMERS | CELL BIOLOGY | microelectrode array | neurotoxicity | IN-VIVO | MUTATIONS | beta-amyloid peptides | Alzheimer's disease | GAMMA-SECRETASE | MOLECULAR-BASIS | AGGREGATION
Journal Article
Bulletin du Cancer, ISSN 0007-4551, 10/2017, Volume 104, Issue 10, pp. 883 - 891
The Notch pathway plays an essential role during embryonal development and tissue in adults. Notch signaling occurs through transmembrane receptors which... 
Targeted therapy | Notch | Gamma-secretase inhibitor | Cancer
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 07/2019, Volume 58, Issue 28, pp. 3065 - 3068
Intramembrane proteases typically cleave multiple substrates within their transmembrane domains (TMDs). Because substrate TMDs lack a consensus sequence around... 
DOMAIN | INTRAMEMBRANE PROTEOLYSIS | MECHANISM | SEQUENTIAL CLEAVAGE | DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | GAMMA-SECRETASE
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 07/2011, Volume 3, Issue 7
Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in... 
BETA-PEPTIDE DEPOSITION | PAIRED HELICAL FILAMENTS | A-BETA | AMYLOID-PRECURSOR-PROTEIN | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | GAMMA-SECRETASE | APOLIPOPROTEIN-E | TRANSGENIC MICE | SENILE PLAQUES | CELL BIOLOGY
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 07/2019, Volume 18, Issue 7, pp. 1230 - 1242
Prostate cancer remains among the leading causes of cancer-related deaths in men. Patients with aggressive disease typically undergo hormone deprivation... 
GAMMA-SECRETASE INHIBITOR | SOLID TUMORS | ONCOLOGY | PATHWAY | INCREASED SURVIVAL | COMBINATION | PHASE-I | EXPRESSION | DOCETAXEL | RO4929097 | ENZALUTAMIDE
Journal Article
Molecular and Cellular Neuroscience, ISSN 1044-7431, 10/2019, Volume 100, pp. 103392 - 103392
In drug discovery, as well as in the study of disease biology, it is fundamental to develop models that recapitulate aspects of a disorder, in order to... 
Tau | Gamma secretase modulator | Amyloid | Drug discovery | Alzheimer's disease | iPSC | Index Medicus
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2019, Volume 139, Issue 1, pp. 124 - 134
Nicastrin ( ) mutations are associated with familial acne inversa (AI), and emerging evidence suggests that microRNAs (miRNAs) are involved in various skin... 
GROWTH-FACTOR RECEPTOR | NCSTN | HOMEOSTASIS | INFLAMMATION | NOTCH | PROLIFERATION | GAMMA-SECRETASE | HIDRADENITIS SUPPURATIVA | EXPRESSION | NICASTRIN MUTATIONS | DERMATOLOGY
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 3/2016, Volume 136, Issue 6, pp. 1246 - 1258
The γ-secretase complex is composed of at least four components: presenilin (PS1 or PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin... 
nicastrin | APP | Alzheimer’s disease | Aph-1 | gamma-secretase
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 09/2006, Volume 12, Issue 9, pp. 1005 - 1015
Alzheimer disease is a progressive dementia with unknown etiology that affects a growing number of the aging population. Increased expression of inflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | OSTEOPETROTIC OP/OP MICE | AMYLOID PRECURSOR PROTEIN | CELL BIOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | MARROW-DERIVED CELLS | TARGET GAMMA-SECRETASE | IN-VIVO | A-BETA | GENE-EXPRESSION | CENTRAL-NERVOUS-SYSTEM | TRANSGENIC MICE
Journal Article
JOURNAL OF ALZHEIMERS DISEASE, ISSN 1387-2877, 2010, Volume 19, Issue 1, pp. 311 - 323
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production and deposition of the amyloid-beta peptide (A beta). For many years,... 
INSULIN-DEGRADING ENZYME | oligomer | amyloid-beta protein precursor | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | PITTSBURGH COMPOUND-B | PLAQUE CORE PROTEIN | SENILE PLAQUES | APP TRANSGENIC MICE | fibril | POSITRON-EMISSION-TOMOGRAPHY | A-BETA | GAMMA-SECRETASE ACTIVITY | PRECURSOR PROTEIN | Amyloid-beta
Journal Article
by Sun, LF and Zhou, R and Yang, GH and Shi, YG
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2017, Volume 114, Issue 4, pp. E476 - E485
A hallmark of Alzheimer's disease (AD) is the aggregation of gamma-amyloid peptides (A beta) into amyloid plaques in patient brain. Cleavage of amyloid... 
cleavage activity | APP | DEMENTIA | MECHANISM | MULTIDISCIPLINARY SCIENCES | gamma-secretase | PLAQUES | A beta peptides | AGE-OF-ONSET | amyloid hypothesis | AMYLOID CASCADE HYPOTHESIS | CALCIUM | A-BETA | FAMILIAL ALZHEIMERS-DISEASE | PROTEIN-PRECURSOR | Alzheimer's disease
Journal Article
Journal of Nutrition, ISSN 0022-3166, 10/2009, Volume 139, Issue 10, pp. 1987 - 1993
Alzheimer's disease (AD) is characterized by the extracellular deposition of beta-amyloid peptide (A beta) in cerebral plaques. A beta is derived from the... 
SIGNALING PATHWAYS | NUTRITION & DIETETICS | ALZHEIMERS-DISEASE | MAP KINASE | NECROSIS-FACTOR-ALPHA | PRECURSOR PROTEIN | BRAIN INJURY | TRANSGENIC MOUSE MODEL | GAMMA-SECRETASE | BACE1 PROMOTER | POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 37, pp. 6280 - 6283
A unique two-carbon ring expansion of isatin has been achieved to conveniently construct the functionalized dibenzo[b,d]azepin-6-one scaffold in moderate to... 
ONE-POT SYNTHESIS | 7-MEMBERED RINGS | EFFICIENT SYNTHESIS | GAMMA-SECRETASE INHIBITORS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | ARYLAMINES | Bromides | Construction | Scaffolds | Carbon
Journal Article
by Zhou, XL and Fang, YH and Wan, L and Xu, QR and Huang, H and Zhu, RR and Wu, QC and Liu, JC
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 06/2019, Volume 234, Issue 6, pp. 8834 - 8845
Purpose During myocardial infarction (MI), cardiac fibroblasts (CFs) transform into myofibroblast (CMT). This study aimed to investigate the crosstalk of... 
FIBROSIS | TARGET | GAMMA-SECRETASE INHIBITOR | PHYSIOLOGY | MYOCARDIAL-INFARCTION | cardiac fibroblasts | myofibroblast | Notch1 | TGF-beta 1 | INJURY | myocardial fibrosis | CELL BIOLOGY
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 12/2017, Volume 82, Issue 23, pp. 12791 - 12797
We present an operationally simple lactone-to-lactam transformation utilizing diverse amine nucleophiles. The key steps of amidation, alcohol activation, and... 
CHEMISTRY, ORGANIC | GAMMA-SECRETASE MODULATORS | DERIVATIVES | DISCOVERY | ESTERS | LACTAMIZATION | Chemical properties | Chemical synthesis | Analysis | Pyridazine | Lactones
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.