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EMBO JOURNAL, ISSN 0261-4189, 05/2019, Volume 38, Issue 10
Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase-1, caspase-4, caspase-5 and caspase-11. These caspases cleave and activate... 
GSDMD | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | pannexin-1 | gasdermin | RELEASE | CLEAVAGE | CELL BIOLOGY | pyroptosis | GASDERMIN D | PORE | NLRP3 | 1 CHANNELS | CASPASE-11 | INHIBITOR
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 11/2018, Volume 25, Issue 9, pp. 2339 - 2353.e4
Intrinsic apoptosis resulting from BAX/BAK-mediated mitochondrial membrane damage is regarded as immunologically silent. We show here that in macrophages,... 
caspase-8 | BCL-XL | mitochondria | MCL-1 | Gasdermin | BAX | NLRP3 | IAPs | BAK | caspase-1 | GASDERMIN D | B-CELL | INTERLEUKIN-1-BETA | XIAP | ANTITUMOR-ACTIVITY | INHIBITOR | PROTEINS | CLEAVAGE | CELL-DEATH | CUTTING EDGE | CELL BIOLOGY
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 14128 - 14128
Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged,... 
GSDMD | MEMBRANE ATTACK | GASDERMIN D | NECROSIS | GENE | MECHANISM | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | GENOME-WIDE | PORE FORMATION | PYROPTOSIS
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 10/2018, Volume 82, pp. 79 - 85
Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. The caspase members of this clan... 
Gasdermin | Pyroptosis | Protease | Regulated cell death | Apoptosis | ACTIVATION | MICE DEFICIENT | NONCANONICAL INFLAMMASOME | DEVELOPMENTAL BIOLOGY | CELL-DEATH | CELL BIOLOGY | APOPTOSOME | GASDERMIN D | INFLAMMATORY CASPASES | UNIFIED MODEL | Humans | Caspases - metabolism | Oligomers | Enzymes | Cell death | Aspartic proteinases | Melanoma | regulated cell death | protease | pyroptosis | gasdermin
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 01/2018, Volume 430, Issue 2, pp. 207 - 216
Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation... 
caspase-11 | gasdermin D | inflammasome | LPS | outer-membrane vesicles | CASPASE-11 ACTIVATION | UNCONVENTIONAL PROTEIN SECRETION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOPLASMIC LPS | NLRP3 INFLAMMASOME | PYROPTOTIC CELL-DEATH | BACTERIAL PATHOGENS | INTRACELLULAR LPS | GASDERMIN-D | INNATE IMMUNITY
Journal Article
Immunopharmacology and Immunotoxicology, ISSN 0892-3973, 09/2019, Volume 41, Issue 5, pp. 538 - 548
Background: The pharmacological application of kaempferol, a natural flavonol present in different plant species, has been demonstrated to have extensive... 
pyroptosis | Splenic lymphocytes | kaempferol | gasdermin D | inflammation
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 09/2019, Volume 106, Issue 3, pp. 553 - 562
The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms... 
gasdermin‐D | NLRP3 | caspase‐11 | K+ efflux | AIM2 INFLAMMASOME | K plus efflux | GASTROINTESTINAL-TRACT | caspase-11 | gasdermin-D | NLRP3 INFLAMMASOME | PYROPTOSIS | IMMUNOLOGY | INTERLEUKIN-1-BETA MATURATION | PLASMA-MEMBRANE | NEUTROPHIL RECRUITMENT | CELL BIOLOGY | INDUCED GTPASES | HEMATOLOGY
Journal Article