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European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 11/2012, Volume 47, Issue 4, pp. 652 - 660
Journal Article
Journal Article
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 01/2019, Volume 109, pp. 563 - 572
[Display omitted] •Ginkgolide B enhanced gemcitabine sensitivity in pancreatic cancer cell lines.•Ginkgolide B suppressed cell proliferation and increase... 
Nuclear factor kappa b (NF-кB) | Ginkgolide B (GB) | Platelet-activating factor receptor (PAFR) | Pancreatic cancer | Gemcitabine sensitivity
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 12/2017, Volume 96, pp. 792 - 797
•Recombinant α-Syn caused cytotoxicity to SH-SY5Y cell in a concentration-dependent manner.•SH-SY5Y cell was more susceptible to α-Syn aggregates.•α-Syn... 
Bilobalide | α-Synuclein | Aggregates | Ginkgolide B | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | GENE | MUTATION | PHARMACOLOGY & PHARMACY | MICE | alpha-Synuclein | PARKINSONS-DISEASE | EXTRACT
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 5/2015, Volume 75, Issue 5, pp. 949 - 959
Cisplatin is a widely used chemotherapeutic drug for the treatment of various cancers. However, the ototoxicity severely limited its maximum dose. The present... 
Medicine & Public Health | NADPH oxidase | Oncology | Cancer Research | Akt | Pharmacology/Toxicology | Ginkgolide B | Cisplatin | Ototoxicity | Nrf2/HO-1 | APOPTOSIS | BILOBA EXTRACT EGB-761 | MECHANISMS | CELL-DEATH | HEARING-LOSS | ONCOLOGY | PHARMACOLOGY & PHARMACY | Heme Oxygenase-1 - metabolism | Ginkgolides - pharmacology | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - biosynthesis | NADPH Oxidases - metabolism | Male | Membrane Potential, Mitochondrial - drug effects | Lactones - pharmacology | Cochlear Diseases - metabolism | Hearing Loss - metabolism | Cisplatin - toxicity | Membrane Glycoproteins - antagonists & inhibitors | Cochlea - metabolism | Cochlear Diseases - prevention & control | Membrane Proteins - metabolism | NADPH Oxidases - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Hearing Loss - chemically induced | Cell Line | NADPH Oxidases - antagonists & inhibitors | Rats | Cochlea - cytology | Random Allocation | Enzyme Activation - drug effects | NADPH Oxidase 2 | Rats, Sprague-Dawley | Reactive Oxygen Species - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Cochlea - drug effects | Cochlear Diseases - chemically induced | NF-E2-Related Factor 2 - metabolism | Mice | Hearing Loss - prevention & control | Oxidases | Antimitotic agents | Chemotherapy | Antineoplastic agents | Cancer
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 10/2011, Volume 137, Issue 3, pp. 1462 - 1468
Ginkgolide B (GB) is one of the ginkgolides that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba L. (Ginkgoaceae), and is a... 
Nuclear factor kappa-B | Inflammatory cytokine | Intracerebral hemorrhage | Ginkgolide B | Toll-like receptor 4 | Neuronal cell apoptosis | CHEMISTRY, MEDICINAL | BILOBA EXTRACT | RANDOMIZED CLINICAL-TRIAL | MEMORY IMPAIRMENT | LOW-DENSITY-LIPOPROTEIN | INNATE IMMUNE-RESPONSE | 5-YEAR DOUBLE-BLIND | ELDERLY-PEOPLE | PLANT SCIENCES | EXPERIMENTAL INTRACEREBRAL HEMORRHAGE | ISCHEMIA-REPERFUSION INJURY | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | VASCULAR ENDOTHELIAL-CELLS | Tumor Necrosis Factor-alpha - metabolism | Cerebral Hemorrhage - metabolism | Neurons - pathology | Ginkgolides - pharmacology | Rats, Wistar | Apoptosis - drug effects | Male | NF-kappa B - metabolism | Lactones - pharmacology | Brain - metabolism | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Time Factors | Interleukin-1beta - metabolism | Lactones - administration & dosage | Inflammation Mediators - metabolism | Neurons - metabolism | Neurons - drug effects | Neuroprotective Agents - administration & dosage | Interleukin-6 - metabolism | Disease Models, Animal | Cerebral Hemorrhage - drug therapy | Toll-Like Receptor 4 - drug effects | Injections, Intraperitoneal | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - metabolism | Brain - drug effects | Ginkgo biloba | Animals | NF-kappa B - genetics | Signal Transduction - drug effects | Ginkgolides - administration & dosage | Brain - pathology | Cerebral Hemorrhage - pathology | Plants, Medicinal | Brain | Neurons | Apoptosis | Transcription factors | Astrocytes | Roots | Bark | beta -Amyloid | Inflammation | TLR4 protein | Gene expression | Hemorrhage | Interleukin 6 | Leaves | NF- Kappa B protein | Reperfusion | Ischemia | Toll-like receptors | ginkgolides | Tumor necrosis factor- alpha
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36237
Aims: To investigate whether ginkgolide B (a platelet-activating factor inhibitor) affects vascular inflammation in atherosclerosis-prone apolipoprotein... 
ADHESION | ACTIVATION | PLATELETS | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | KINASE | LOW-DENSITY-LIPOPROTEIN | P-SELECTIN | ATHEROSCLEROSIS | DEFICIENT MICE | APOLIPOPROTEIN-E | Ginkgolides - pharmacology | Apolipoproteins E - deficiency | P-Selectin - metabolism | Atherosclerosis - genetics | Humans | Male | Phosphatidylinositol 3-Kinases - metabolism | Aorta - metabolism | Lactones - pharmacology | Chemokine CCL5 - blood | Vasculitis - genetics | CD40 Ligand - metabolism | Lactones - administration & dosage | Lipids - blood | Chemokine CCL5 - metabolism | Platelet Aggregation - drug effects | Phosphorylation - drug effects | Blood Platelets - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Atherosclerosis - drug therapy | Plaque, Atherosclerotic - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Mice, Knockout | Aorta - pathology | Macrophages - metabolism | Animals | Ginkgolides - administration & dosage | Platelet Activation | Apolipoproteins E - genetics | Vasculitis - drug therapy | Macrophages - drug effects | Mice | Platelet Factor 4 - blood | Platelet Factor 4 - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Immunohistochemistry | Heart | RANTES | Thrombin | AKT protein | CD40L protein | Proteins | Platelet factor 4 | Cell activation | Blood-brain barrier | Cell adhesion | Aorta | Inhibition | Scanning electron microscopy | Immunoglobulins | Platelet aggregation | Electron microscopy | Apolipoproteins | 1-Phosphatidylinositol 3-kinase | Androgens | Arteriosclerosis | Ligands | Transduction | Geriatrics | Atherogenesis | Phosphorylation | Platelet-activating factor | Lymphocytes T | Agglomeration | Activation | Kinases | Macrophages | Experiments | Blood platelets | Apolipoprotein E | Rodents | Atherosclerosis | Tumor necrosis factor-TNF | Lesions | Enzyme-linked immunosorbent assay | Aspirin | Endocrine therapy | Inflammation | Cholesterol | Collagen | Coronary vessels | Laboratory animals | Platelets | Chemokines | P-selectin
Journal Article
Phytotherapy Research, ISSN 0951-418X, 12/2018, Volume 32, Issue 12, pp. 2417 - 2427
The current study was undertaken to delineate the protective effect of Ginkgolide B, a phyto‐constituent from Ginkgo biloba, on oxidized (ox)‐LDL‐induced... 
atherosclerosis | ox‐LDL | inflammation | Ginkgolide B | LOX‐1 | ROS | ox-LDL | LOX-1 | OXIDATIVE STRESS | ACTIVATION | ATHEROGENESIS | CHEMISTRY, MEDICINAL | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | CELL-CYCLE ARREST | ADHESION | LYCOPENE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | RECEPTOR-1 | Inflammation - chemically induced | Vascular Diseases - prevention & control | Ginkgolides - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Plant Extracts - pharmacology | Humans | Lactones - pharmacology | Inflammation - metabolism | Inflammation - drug therapy | Vascular Diseases - drug therapy | Ginkgolides - therapeutic use | Atherosclerosis - drug therapy | Human Umbilical Vein Endothelial Cells - drug effects | Atherosclerosis - chemically induced | Cells, Cultured | Down-Regulation - drug effects | Vascular Diseases - chemically induced | Lactones - therapeutic use | Scavenger Receptors, Class E - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Macrophages - metabolism | NADPH Oxidase 4 - metabolism | Animals | Signal Transduction - drug effects | Macrophages - drug effects | RAW 264.7 Cells | Inflammation - prevention & control | Mice | Plant Extracts - therapeutic use | Atherosclerosis - prevention & control | Lipoproteins, LDL | Oxidases | Lectins | Low density lipoproteins | Atherosclerosis | Endothelium | Lipoproteins (low density) | Transcription | Oxidase | Matrix metalloproteinase | Macrophages | NAD(P)H oxidase | Cell adhesion molecules | Cell adhesion & migration | Prostaglandin endoperoxide synthase | Proteins | NOX4 protein | Cascades | Cell adhesion | Attenuation | Metalloproteinase | Cytokines | Pharmacology | Inflammation | Chemical compounds | Adhesion | Cholesterol | Endothelial cells | Monocytes | Lymphocytes B | Liquid oxygen | Arteriosclerosis | Umbilical vein
Journal Article