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Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 01/2018, Volume 20, Issue 1, pp. 157 - 164
... nmol/kg (n = 8). Each volunteer underwent 2 hyperinsulinaemic‐euglycaemic clamps where the basal level of glucose infusion rate (GIR... 
apelin/APJ system | type 2 diabetes | adipokine | hyperinsulinaemic‐euglycaemic clamp | insulin resistance | hyperinsulinaemic-euglycaemic clamp | apelin | APJ system | HEART-FAILURE | ENDOCRINOLOGY & METABOLISM | RESISTANT MICE | AGONIST | Apelin - analogs & derivatives | Overweight - drug therapy | Humans | Anti-Obesity Agents - adverse effects | Male | Apelin Receptors - agonists | Anti-Obesity Agents - therapeutic use | Apelin - blood | Dose-Response Relationship, Drug | Young Adult | Overweight - metabolism | Intercellular Signaling Peptides and Proteins - pharmacokinetics | Hypoglycemic Agents - administration & dosage | Adult | Intercellular Signaling Peptides and Proteins - administration & dosage | Body Mass Index | Hypoglycemic Agents - therapeutic use | Anti-Obesity Agents - administration & dosage | Double-Blind Method | Apelin - adverse effects | Peptide Fragments - administration & dosage | Insulin Resistance | Peptide Fragments - pharmacokinetics | Apelin - therapeutic use | Proof of Concept Study | Cross-Over Studies | Apelin Receptors - metabolism | Overweight - blood | Adolescent | Intercellular Signaling Peptides and Proteins - therapeutic use | Peptide Fragments - adverse effects | Peptide Fragments - therapeutic use | Glucose Clamp Technique | Infusions, Intravenous | Hypoglycemic Agents - adverse effects | Intercellular Signaling Peptides and Proteins - adverse effects | Type 2 diabetes | Obesity | Diabetics | Analysis | Insulin resistance | Glucose | Insulin | Dextrose | Glucose tolerance | Animal models | Intravenous administration | Diabetes mellitus | Rodents | Body weight
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 02/2018, Volume 20, Issue 2, pp. 400 - 408
.... Two euglycaemic clamp studies, 1 in subjects with type 1 diabetes (T1D) and 1 in healthy subjects, were conducted to demonstrate pharmacokinetic (PK... 
pharmacokinetics | biosimilar insulin | type 1 diabetes | glycaemic control | insulin analogues | pharmacodynamics | SUBCUTANEOUS INJECTION | METABOLITES | NPH INSULIN | BIOTRANSFORMATION | ULTRALENTE | ENDOCRINOLOGY & METABOLISM | EXPOSURE | United States | Humans | Male | Insulin Glargine - pharmacokinetics | Patient Dropouts | Hypoglycemia - prevention & control | Young Adult | Hypoglycemic Agents - blood | Insulin Glargine - blood | Biotransformation | Biosimilar Pharmaceuticals - pharmacokinetics | Adult | Female | Hypoglycemia - chemically induced | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Biosimilar Pharmaceuticals - therapeutic use | Hypoglycemic Agents - pharmacokinetics | Insulin Glargine - adverse effects | Blood Glucose - analysis | Double-Blind Method | Insulin Glargine - therapeutic use | Biosimilar Pharmaceuticals - blood | Biosimilar Pharmaceuticals - adverse effects | Diabetes Mellitus, Type 1 - drug therapy | Cross-Over Studies | Insulin Glargine - analogs & derivatives | European Union | Diabetes Mellitus, Type 1 - blood | Glucose Clamp Technique | Hypoglycemic Agents - adverse effects | Medical research | Metabolites | Type 1 diabetes | Analysis | Medicine, Experimental | Amino acids | Dosage and administration | Research | Insulin | Studies | Amino acid sequence | Diabetes mellitus (insulin dependent) | Diabetes | Diabetes mellitus | Original
Journal Article
Diabetes Care, ISSN 0149-5992, 07/2012, Volume 35, Issue 7, pp. 1605 - 1610
OBJECTIVE-This study was designed to determine a cutoff point for identifying insulin resistance from hyperinsulinemic-euglycemic clamp studies performed at 120 mU/m(2... 
SENSITIVITY | AREA | INVIVO | GLUCOSE | ENDOCRINOLOGY & METABOLISM | Body Mass Index | Models, Biological | Humans | Middle Aged | Insulin Resistance | Adult | Glucose Clamp Technique - methods | Reference Values | Aged | Decision Trees | Insulin - blood | Medical research | Medicine, Experimental | Insulin resistance | Research | Diabetes | Glucose | Dextrose | Studies | Hyperglycemia | Insulin | Original Research
Journal Article
Diabetes Care, ISSN 0149-5992, 06/2013, Volume 36, Issue 6, pp. 1607 - 1612
...), calculated from two clamps (2cDI, insulin sensitivity from the hyperinsulinemic-euglycemic clamp and first-phase insulin from the hyperglycemic clamp... 
CLEARANCE | GLUCOSE-TOLERANCE TEST | ENDOCRINOLOGY & METABOLISM | RESISTANCE | SECRETION | SPECTRUM | OBESE YOUTH | AFRICAN-AMERICAN | ORAL DISPOSITION INDEX | Insulin-Secreting Cells - physiology | Insulin Resistance - physiology | Humans | Adolescent | Female | Glucose Clamp Technique - methods | Male | Insulin - blood | Child | Original Research
Journal Article