Biotechnology Progress, ISSN 8756-7938, 2014, Volume 30, Issue 3, pp. 681 - 688
Amino acids (AAs) derived from hydrolysis of protein rest streams are interesting feedstocks for the chemical industry due to their functionality. However,...
biorefinery | alginate | biomass | immobilization | chromatography | electrodialysis | nitrogen-containing chemicals | bulk chemicals | isolation | industrial chemical | enzymatic modification | Industrial chemical | Isolation | Biomass | Enzymatic modification | Electrodialysis | Enzymes, Immobilized - chemistry | Glutamate Decarboxylase - chemistry | Escherichia coli - enzymology | Glutamic Acid - isolation & purification | gamma-Aminobutyric Acid - chemistry | Aspartic Acid - chemistry | Aspartic Acid - isolation & purification | Glutamic Acid - chemistry | Hydrolysis | Enzymes | Usage | GABA | Aspartate | Glutamate decarboxylase | Glutamate
biorefinery | alginate | biomass | immobilization | chromatography | electrodialysis | nitrogen-containing chemicals | bulk chemicals | isolation | industrial chemical | enzymatic modification | Industrial chemical | Isolation | Biomass | Enzymatic modification | Electrodialysis | Enzymes, Immobilized - chemistry | Glutamate Decarboxylase - chemistry | Escherichia coli - enzymology | Glutamic Acid - isolation & purification | gamma-Aminobutyric Acid - chemistry | Aspartic Acid - chemistry | Aspartic Acid - isolation & purification | Glutamic Acid - chemistry | Hydrolysis | Enzymes | Usage | GABA | Aspartate | Glutamate decarboxylase | Glutamate
Journal Article
Journal of Biotechnology, ISSN 0168-1656, 01/2014, Volume 169, Issue 1, pp. 112 - 120
The goal of this work was to develop an immobilized whole-cell biocatalytic process for the environment-friendly synthesis of α-ketoglutaric acid (α-KG) from...
Whole-cell biocatalyst | Glutamic acid | α-Ketoglutaric acid | Proteus mirabilis | Bacillus subtilis | SECRETION STRESS | ESCHERICHIA-COLI | TOPOLOGY PREDICTION | CITRIC ACIDS | BACILLUS-STEAROTHERMOPHILUS | YEAST | METABOLISM | MEMBRANE-VESICLES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ETHANOL | YARROWIA-LIPOLYTICA WSH-Z06 | alpha Ketoglutaric acid | Recombinant Proteins - metabolism | Biocatalysis | Gene Expression - genetics | Cells, Immobilized - metabolism | Bacillus subtilis - genetics | Proteus mirabilis - enzymology | Escherichia coli - genetics | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Glutamic Acid - metabolism | D-Amino-Acid Oxidase - metabolism | Ketoglutaric Acids - metabolism | Bacillus subtilis - metabolism
Whole-cell biocatalyst | Glutamic acid | α-Ketoglutaric acid | Proteus mirabilis | Bacillus subtilis | SECRETION STRESS | ESCHERICHIA-COLI | TOPOLOGY PREDICTION | CITRIC ACIDS | BACILLUS-STEAROTHERMOPHILUS | YEAST | METABOLISM | MEMBRANE-VESICLES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ETHANOL | YARROWIA-LIPOLYTICA WSH-Z06 | alpha Ketoglutaric acid | Recombinant Proteins - metabolism | Biocatalysis | Gene Expression - genetics | Cells, Immobilized - metabolism | Bacillus subtilis - genetics | Proteus mirabilis - enzymology | Escherichia coli - genetics | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Glutamic Acid - metabolism | D-Amino-Acid Oxidase - metabolism | Ketoglutaric Acids - metabolism | Bacillus subtilis - metabolism
Journal Article
International Journal of Food Science & Technology, ISSN 0950-5423, 02/2019, Volume 54, Issue 2, pp. 361 - 367
Summary Beer contains only limited amounts of readily fermentable carbohydrates and amino acids. Beer spoilage lactic acid bacteria have to come up with...
Amino acid | iso‐α‐acid | organic acid | off‐flavour compound | biogenic amine | hop‐resistance | carbohydrate | hop-resistance | iso-α-acid | off-flavour compound | BACTERIA | FOOD SCIENCE & TECHNOLOGY | IDENTIFICATION | iso-alpha-acid | BEER-SPOILAGE ABILITY | RESISTANCE | LINDNERI | Glutamic acid | Carbohydrates | Lactic acid bacteria | Amines | Flavor compounds | Hops | Amino acids | Carbohydrate metabolism | Bitter acids | Maltose | Metabolism | Glyoxylic acid | Organic acids | Aroma compounds | Glucose metabolism | Metabolites | Arginine | Off flavor | Spoilage | Nutrient content | Bacteria | Malic acid | Lactic acid | Biogenic amines
Amino acid | iso‐α‐acid | organic acid | off‐flavour compound | biogenic amine | hop‐resistance | carbohydrate | hop-resistance | iso-α-acid | off-flavour compound | BACTERIA | FOOD SCIENCE & TECHNOLOGY | IDENTIFICATION | iso-alpha-acid | BEER-SPOILAGE ABILITY | RESISTANCE | LINDNERI | Glutamic acid | Carbohydrates | Lactic acid bacteria | Amines | Flavor compounds | Hops | Amino acids | Carbohydrate metabolism | Bitter acids | Maltose | Metabolism | Glyoxylic acid | Organic acids | Aroma compounds | Glucose metabolism | Metabolites | Arginine | Off flavor | Spoilage | Nutrient content | Bacteria | Malic acid | Lactic acid | Biogenic amines
Journal Article
Carbohydrate Polymers, ISSN 0144-8617, 01/2018, Volume 179, pp. 100 - 109
Injectable hydrogels have great potential in minimally invasive delivery. In this work, novel injectable hydrogels were prepared self-crosslinking of aldehyde...
Poly (γ-glutamic acid) | Protein delivery | Hyaluronic acid | Injectable hydrogel | POLYMER SCIENCE | COMPOSITE HYDROGELS | Poly (gamma-glutamic acid) | PREVENTION | CHEMISTRY, ORGANIC | CONTROLLED DRUG-RELEASE | MECHANISMS | L-LYSINE | TEMPERATURE | BACILLUS-SUBTILIS | POLY(L-GLUTAMIC ACID) | CROSS-LINKING HYDROGELS | CHEMISTRY, APPLIED | SOLUTE RELEASE | Viscosity | Cell Survival - drug effects | NIH 3T3 Cells | Shear Strength | Rheology | Biocompatible Materials - chemistry | Hyaluronic Acid - chemistry | Elasticity | Biocompatible Materials - pharmacology | Hydrogels - chemical synthesis | Drug Delivery Systems | Biocompatible Materials - chemical synthesis | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Injections | Animals | Serum Albumin, Bovine - chemistry | Mice | Hydrogels - pharmacology | Hydrogels - chemistry | Aldehydes - chemistry | Glutamate | Crosslinked polymers | Biological products | Analysis | Mechanical properties | Albumin | Amino acids
Poly (γ-glutamic acid) | Protein delivery | Hyaluronic acid | Injectable hydrogel | POLYMER SCIENCE | COMPOSITE HYDROGELS | Poly (gamma-glutamic acid) | PREVENTION | CHEMISTRY, ORGANIC | CONTROLLED DRUG-RELEASE | MECHANISMS | L-LYSINE | TEMPERATURE | BACILLUS-SUBTILIS | POLY(L-GLUTAMIC ACID) | CROSS-LINKING HYDROGELS | CHEMISTRY, APPLIED | SOLUTE RELEASE | Viscosity | Cell Survival - drug effects | NIH 3T3 Cells | Shear Strength | Rheology | Biocompatible Materials - chemistry | Hyaluronic Acid - chemistry | Elasticity | Biocompatible Materials - pharmacology | Hydrogels - chemical synthesis | Drug Delivery Systems | Biocompatible Materials - chemical synthesis | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Injections | Animals | Serum Albumin, Bovine - chemistry | Mice | Hydrogels - pharmacology | Hydrogels - chemistry | Aldehydes - chemistry | Glutamate | Crosslinked polymers | Biological products | Analysis | Mechanical properties | Albumin | Amino acids
Journal Article
Psychiatry Research: Neuroimaging, ISSN 0925-4927, 2010, Volume 191, Issue 2, pp. 122 - 127
Abstract The NMDA receptor antagonist ketamine can induce a rapid improvement in depressive symptoms that often endures for days after a single intravenous...
Radiology | Psychiatry | NMDA antagonist | Magnetic resonance spectroscopy | Amino acid neurotransmitter | Major depressive disorder | ACTIVATION | DEPRESSED-PATIENTS | PSYCHIATRY | D-ASPARTATE ANTAGONIST | MAJOR DEPRESSION | NMDA ANTAGONISTS | NEUROIMAGING | PREFRONTAL CORTEX | CLINICAL NEUROLOGY | NEUROGENESIS | GABA CONCENTRATIONS | RAT HIPPOCAMPUS | DENTATE GYRUS | Protons | Single-Blind Method | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Male | Statistics as Topic | Young Adult | Heart Rate - drug effects | Dissociative Disorders - chemically induced | Psychiatric Status Rating Scales | Time Factors | Adult | Female | Antidepressive Agents - pharmacology | Blood Pressure - drug effects | Ketamine - therapeutic use | Retrospective Studies | Occipital Lobe - drug effects | Depressive Disorder, Major - drug therapy | Occipital Lobe - metabolism | Depressive Disorder, Major - pathology | Magnetic Resonance Spectroscopy | Psychometrics | Antidepressive Agents - therapeutic use | Aged | Glutamic Acid - metabolism | Ketamine - pharmacology | magnetic resonance spectroscopy | major depressive disorder | amino acid neurotransmitter
Radiology | Psychiatry | NMDA antagonist | Magnetic resonance spectroscopy | Amino acid neurotransmitter | Major depressive disorder | ACTIVATION | DEPRESSED-PATIENTS | PSYCHIATRY | D-ASPARTATE ANTAGONIST | MAJOR DEPRESSION | NMDA ANTAGONISTS | NEUROIMAGING | PREFRONTAL CORTEX | CLINICAL NEUROLOGY | NEUROGENESIS | GABA CONCENTRATIONS | RAT HIPPOCAMPUS | DENTATE GYRUS | Protons | Single-Blind Method | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Male | Statistics as Topic | Young Adult | Heart Rate - drug effects | Dissociative Disorders - chemically induced | Psychiatric Status Rating Scales | Time Factors | Adult | Female | Antidepressive Agents - pharmacology | Blood Pressure - drug effects | Ketamine - therapeutic use | Retrospective Studies | Occipital Lobe - drug effects | Depressive Disorder, Major - drug therapy | Occipital Lobe - metabolism | Depressive Disorder, Major - pathology | Magnetic Resonance Spectroscopy | Psychometrics | Antidepressive Agents - therapeutic use | Aged | Glutamic Acid - metabolism | Ketamine - pharmacology | magnetic resonance spectroscopy | major depressive disorder | amino acid neurotransmitter
Journal Article
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2002, Volume 54, Issue 5, pp. 695 - 713
Chemotherapy has had limited success in the treatment of cancer over the years, due, in part, to the untoward toxicity of the therapeutic agent to normal...
Anticancer drugs | Drug targeting | Poly( l-glutamic acid) | Polymer–drug conjugates | Enhanced permeability and retention effect | Poly(L-glutamic acid) | Polymer-drug conjugates | ACID)-PACLITAXEL CONJUGATE | EFFICACY | enhanced permeability and retention effect | POLYMERIC CARRIERS | MACROMOLECULAR DRUGS | ANTITUMOR-ACTIVITY | anticancer drugs | PACLITAXEL | drug targeting | FACILE SYNTHESIS | poly(L-glutamic acid) | polymer-drug conjugates | OVARIAN OCA-1 TUMOR | PHARMACOLOGY & PHARMACY | MICE | WATER | Camptothecin - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Antineoplastic Agents - administration & dosage | DNA - metabolism | Antimetabolites - therapeutic use | Paclitaxel - therapeutic use | Polyglutamic Acid - chemical synthesis | Drug Carriers | Drug Delivery Systems | Neoplasms - drug therapy | Antimetabolites - administration & dosage | Antineoplastic Agents - metabolism | Polyglutamic Acid - pharmacokinetics | Anthracyclines - administration & dosage | Camptothecin - administration & dosage | Anthracyclines - therapeutic use | Paclitaxel - administration & dosage
Anticancer drugs | Drug targeting | Poly( l-glutamic acid) | Polymer–drug conjugates | Enhanced permeability and retention effect | Poly(L-glutamic acid) | Polymer-drug conjugates | ACID)-PACLITAXEL CONJUGATE | EFFICACY | enhanced permeability and retention effect | POLYMERIC CARRIERS | MACROMOLECULAR DRUGS | ANTITUMOR-ACTIVITY | anticancer drugs | PACLITAXEL | drug targeting | FACILE SYNTHESIS | poly(L-glutamic acid) | polymer-drug conjugates | OVARIAN OCA-1 TUMOR | PHARMACOLOGY & PHARMACY | MICE | WATER | Camptothecin - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Antineoplastic Agents - administration & dosage | DNA - metabolism | Antimetabolites - therapeutic use | Paclitaxel - therapeutic use | Polyglutamic Acid - chemical synthesis | Drug Carriers | Drug Delivery Systems | Neoplasms - drug therapy | Antimetabolites - administration & dosage | Antineoplastic Agents - metabolism | Polyglutamic Acid - pharmacokinetics | Anthracyclines - administration & dosage | Camptothecin - administration & dosage | Anthracyclines - therapeutic use | Paclitaxel - administration & dosage
Journal Article
International Journal of Food Science & Technology, ISSN 0950-5423, 10/2017, Volume 52, Issue 10, pp. 2191 - 2200
Summary Chemical, nutritional and antiradical properties of juice and shoot powder from wheatgrass and pulses were evaluated. Wheatgrass powder (WP) showed...
pulses | minerals | Amino acids | wheatgrass | phenolics | ANTIOXIDANT ACTIVITY | ACIDS | GRASS JUICE | FOOD SCIENCE & TECHNOLOGY | TRITICUM-AESTIVUM | SPROUTS | GERMINATION | PROTEIN-CHARACTERISTICS | IN-VITRO | INHIBITION | CHLOROPHYLL | Chlorophyll | Legumes | Beans | Histidine | GABA | Glutamate | Saturated fatty acids | Mimosaceae | Glutamic acid | Threonine | Gallic acid | Scavenging | Free form | Sinapic acid | p-Coumaric acid | Leucine | Citrulline | Phenolic compounds | Protocatechuic acid | Powder | Butyric acid | Ferulic acid | Coumaric acid | γ-Aminobutyric acid | Acids | Arginine | Phenols | Vanillic acid | Shoots
pulses | minerals | Amino acids | wheatgrass | phenolics | ANTIOXIDANT ACTIVITY | ACIDS | GRASS JUICE | FOOD SCIENCE & TECHNOLOGY | TRITICUM-AESTIVUM | SPROUTS | GERMINATION | PROTEIN-CHARACTERISTICS | IN-VITRO | INHIBITION | CHLOROPHYLL | Chlorophyll | Legumes | Beans | Histidine | GABA | Glutamate | Saturated fatty acids | Mimosaceae | Glutamic acid | Threonine | Gallic acid | Scavenging | Free form | Sinapic acid | p-Coumaric acid | Leucine | Citrulline | Phenolic compounds | Protocatechuic acid | Powder | Butyric acid | Ferulic acid | Coumaric acid | γ-Aminobutyric acid | Acids | Arginine | Phenols | Vanillic acid | Shoots
Journal Article
Microbiology, ISSN 1350-0872, 03/2009, Volume 155, Issue 3, pp. 805 - 812
1 Swine Odor and Manure Management Research Unit, USDA, ARS, National Soil Tilth Laboratory, NSRIC-2103, Ames, IA 50011, USA 2 Department of Biotechnology,...
K-12 | CATABOLISM | RPOS | THIOREDOXIN | GENES | MICROBIOLOGY | HYDROGEN-PEROXIDE | MECHANISMS | Escherichia coli O157 - genetics | Oxidative Stress | Escherichia coli O157 - metabolism | Escherichia coli Proteins - metabolism | Diamide - metabolism | Hydrogen Peroxide - metabolism | Escherichia coli O157 - drug effects | Carboxy-Lyases - metabolism | Glutamic Acid - metabolism | Membrane Proteins - metabolism | Mutation | Gene Expression Regulation, Bacterial | Acids - pharmacology | Arginine - metabolism | Hydrogen-Ion Concentration | Oxidative stress | Control | Escherichia coli | Physiological aspects | Genetic aspects | Research | Glutamate | Health aspects | Risk factors
K-12 | CATABOLISM | RPOS | THIOREDOXIN | GENES | MICROBIOLOGY | HYDROGEN-PEROXIDE | MECHANISMS | Escherichia coli O157 - genetics | Oxidative Stress | Escherichia coli O157 - metabolism | Escherichia coli Proteins - metabolism | Diamide - metabolism | Hydrogen Peroxide - metabolism | Escherichia coli O157 - drug effects | Carboxy-Lyases - metabolism | Glutamic Acid - metabolism | Membrane Proteins - metabolism | Mutation | Gene Expression Regulation, Bacterial | Acids - pharmacology | Arginine - metabolism | Hydrogen-Ion Concentration | Oxidative stress | Control | Escherichia coli | Physiological aspects | Genetic aspects | Research | Glutamate | Health aspects | Risk factors
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0163265
The biosynthesis of carboxylic acids including fatty acids from biomass is central in envisaged biorefinery concepts. The productivities are often, however,...
PLANT OILS | BAEYER-VILLIGER MONOOXYGENASE | AMINOCARBOXYLIC ACIDS | MEMBRANE INTEGRITY | MULTIDISCIPLINARY SCIENCES | METABOLIC FLUX ANALYSIS | MICROBIAL SYNTHESIS | H-NS | RICINOLEIC ACID | SACCHAROMYCES-CEREVISIAE | CARBOXYLIC-ACIDS | Amino acids | Glutamate | Fatty acids | Escherichia coli | Protons | Glutamic acid | Growth rate | Toxicity | Ricinoleic acid | Baeyer-Villiger monooxygenase | Activation | Biosynthesis | Biomass | Alcohol dehydrogenase | Food science | Biocatalysts | Alcohols | Proteins | Engineering | Cell growth | E coli | Metabolites | Drug tolerance | Biotransformation | Acid resistance | Bacteria | Pseudomonas putida | Recombinant | Enzymes | Glycerol | Linear programming | Carboxylic acids | RNA polymerase | Metabolism | Gene expression | Strain | Decarboxylation
PLANT OILS | BAEYER-VILLIGER MONOOXYGENASE | AMINOCARBOXYLIC ACIDS | MEMBRANE INTEGRITY | MULTIDISCIPLINARY SCIENCES | METABOLIC FLUX ANALYSIS | MICROBIAL SYNTHESIS | H-NS | RICINOLEIC ACID | SACCHAROMYCES-CEREVISIAE | CARBOXYLIC-ACIDS | Amino acids | Glutamate | Fatty acids | Escherichia coli | Protons | Glutamic acid | Growth rate | Toxicity | Ricinoleic acid | Baeyer-Villiger monooxygenase | Activation | Biosynthesis | Biomass | Alcohol dehydrogenase | Food science | Biocatalysts | Alcohols | Proteins | Engineering | Cell growth | E coli | Metabolites | Drug tolerance | Biotransformation | Acid resistance | Bacteria | Pseudomonas putida | Recombinant | Enzymes | Glycerol | Linear programming | Carboxylic acids | RNA polymerase | Metabolism | Gene expression | Strain | Decarboxylation
Journal Article
Journal of Materials Science: Materials in Medicine, ISSN 0957-4530, 1/2017, Volume 28, Issue 1, pp. 1 - 17
Intervertebral disc (IVD) degeneration often leads to low back pain, which is one of the major causes of disability worldwide, affecting more than 80% of the...
Biomedical Engineering | Polymer Sciences | Nanoparticles | Materials Science | Regenerative Medicine/Tissue Engineering | Intervertebral disc | Organ culture | Poly( γ -glutamic acid) | Chitosan | Ceramics, Glass, Composites, Natural Materials | Surfaces and Interfaces, Thin Films | Biomaterials | Poly(γ-glutamic acid) | PROGENITOR CELLS | MATERIALS SCIENCE, BIOMATERIALS | GAMMA-GLUTAMIC ACID | ENGINEERING, BIOMEDICAL | Poly(gamma-glutamic acid) | MESENCHYMAL STEM-CELLS | CELLULAR UPTAKE | IN-VITRO | POLYELECTROLYTE COMPLEX | NUCLEUS PULPOSUS CELLS | BIOMEDICAL APPLICATIONS | MOLECULAR THERAPY | GROWTH-FACTOR | Amino acids | Glutamate | Backache | Collagen | Stem cells | Biomedical engineering | Nanomaterials | Biomedical materials | Bone diseases | Polymers | Spine
Biomedical Engineering | Polymer Sciences | Nanoparticles | Materials Science | Regenerative Medicine/Tissue Engineering | Intervertebral disc | Organ culture | Poly( γ -glutamic acid) | Chitosan | Ceramics, Glass, Composites, Natural Materials | Surfaces and Interfaces, Thin Films | Biomaterials | Poly(γ-glutamic acid) | PROGENITOR CELLS | MATERIALS SCIENCE, BIOMATERIALS | GAMMA-GLUTAMIC ACID | ENGINEERING, BIOMEDICAL | Poly(gamma-glutamic acid) | MESENCHYMAL STEM-CELLS | CELLULAR UPTAKE | IN-VITRO | POLYELECTROLYTE COMPLEX | NUCLEUS PULPOSUS CELLS | BIOMEDICAL APPLICATIONS | MOLECULAR THERAPY | GROWTH-FACTOR | Amino acids | Glutamate | Backache | Collagen | Stem cells | Biomedical engineering | Nanomaterials | Biomedical materials | Bone diseases | Polymers | Spine
Journal Article
Materials Science & Engineering C, ISSN 0928-4931, 07/2017, Volume 76, pp. 743 - 751
A novel targeted drug delivery nanoparticle system based on poly(D,L-lactide- -glycolide) acid (PLGA) for delivery of doxorubicin (DOX) was developed. DOX-PLGA...
Multimeric FA nanoparticles | Targeted drug delivery | Sustained-release system | PLGA nanoparticles | Folic acid | CANCER-CELLS | SYSTEM | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES | RELEASE | THERAPY | IN-VITRO DEGRADATION | ACID)-FUNCTIONALIZED GOLD NANOPARTICLES | CYTOTOXICITY | Folic Acid | Glutamic Acid | Nanoparticles | Lactic Acid | Humans | Polyglycolic Acid | Spectroscopy, Fourier Transform Infrared | Doxorubicin | Drug Carriers
Multimeric FA nanoparticles | Targeted drug delivery | Sustained-release system | PLGA nanoparticles | Folic acid | CANCER-CELLS | SYSTEM | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES | RELEASE | THERAPY | IN-VITRO DEGRADATION | ACID)-FUNCTIONALIZED GOLD NANOPARTICLES | CYTOTOXICITY | Folic Acid | Glutamic Acid | Nanoparticles | Lactic Acid | Humans | Polyglycolic Acid | Spectroscopy, Fourier Transform Infrared | Doxorubicin | Drug Carriers
Journal Article