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Journal Article
Neoplasia, ISSN 1476-5586, 02/2019, Volume 21, Issue 2, pp. 230 - 238
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71115
Renal cell carcinoma (RCC) is the sixth most common cancer in the US. While RCC is highly metastatic, there are few therapeutics options available for patients... 
ACTIVATED-RECEPTOR-ALPHA | THERAPY | METABOLISM | MECHANISM | MULTIDISCIPLINARY SCIENCES | C-MYC | IDENTIFICATION | PEROXISOME PROLIFERATORS | CARCINOMA | EPIDEMIOLOGY | PROGRESSION | Immunohistochemistry | Tyrosine - pharmacology | Cyclin D1 - metabolism | Kidney Neoplasms - genetics | Apoptosis - drug effects | Humans | Carcinoma, Renal Cell - genetics | Cell Survival - genetics | Apoptosis - genetics | Immunoblotting | Kidney Neoplasms - metabolism | G1 Phase - drug effects | Glycolysis - drug effects | Tyrosine - analogs & derivatives | Glycolysis - genetics | Glycolysis - physiology | RNA Interference | Deoxyglucose - pharmacology | Cell Cycle Checkpoints - genetics | G1 Phase - genetics | Cell Survival - physiology | Cell Line | Cell Survival - drug effects | PPAR alpha - antagonists & inhibitors | Carcinoma, Renal Cell - pathology | Cell Cycle Checkpoints - physiology | PPAR alpha - genetics | Glucose - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | G1 Phase - physiology | Proto-Oncogene Proteins c-myc - metabolism | Carcinoma, Renal Cell - metabolism | Resting Phase, Cell Cycle - genetics | Cell Cycle Checkpoints - drug effects | Resting Phase, Cell Cycle - physiology | Cell Line, Tumor | Glucose - metabolism | Kidney Neoplasms - pathology | Resting Phase, Cell Cycle - drug effects | Oxazoles - pharmacology | Apoptosis - physiology | PPAR alpha - metabolism | Metabolomics | Energy metabolism | Nephrology | Syngeneic grafts | Toxicity | c-Myc protein | Cytotoxicity | Myc protein | Cyclin D1 | Cancer therapies | Cyclin-dependent kinase 4 | Metastases | Proteins | Allografts | Cell cycle | Xenografts | Oxidation | Inhibition | Internal medicine | siRNA | Metabolism | Patients | Fatty acids | Pathology | MicroRNAs | Kidney cancer | Proteomics | Glycolysis | VHL protein | Regulatory proteins | Clear cell-type renal cell carcinoma | Cancer | Apoptosis | Kidney transplantation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 28, pp. 10209 - 10214
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2019, Volume 58, Issue 14, pp. 4638 - 4643
Cancer cells usually adapt metabolic phenotypes to chemotherapeutics. A defensive strategy against this flexibility is to modulate signaling pathways relevant... 
platinum | metabolism | mitochondria | thioredoxin reductase | antitumor agents | SYSTEM | CISPLATIN | ANTIOXIDANTS | CHEMISTRY, MULTIDISCIPLINARY | Thioredoxin | Cancer cells | Cancer | Ovarian cancer | Phenotypes | Reactive oxygen species | Ovarian carcinoma | Toxicity | Caspase | Cytotoxicity | Metabolism | Cisplatin | Mitochondria | Bioenergetics | Platinum | Morphology | Glycolysis | Inhibition | Reductase
Journal Article
The FEBS Journal, ISSN 1742-464X, 12/2018, Volume 285, Issue 23, pp. 4413 - 4423
Hydrolysis of ATP by the mitochondrial F‐ATPase is inhibited by a protein called IF1. In the parasitic flagellate, Trypanosoma brucei, this protein, known as... 
ATP synthase | Trypanosoma brucei | enzyme inhibitor | trypanosome | TbIF1 | IF 1 | F1Fo‐ATPase | F‐ATPase | F-ATPase | ATPase | TbIF | Enzyme inhibitors | Analysis | Adenosine triphosphatase | Blood proteins | Protons | Yeast | Amino acids | pH effects | Drug development | Monomers | Proteins | Mitochondria | Glycolysis | Dimers | Membrane potential | Inhibition | Electron transport | Dimerization | ATP | Recombinant
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2293 - 2306
Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a... 
CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | KIDNEY-TYPE GLUTAMINASE | PHOSPHATE-ACTIVATED GLUTAMINASE | MITOCHONDRIAL METABOLISM | AEROBIC GLYCOLYSIS | GROWTH | C-MYC | ACUTE MYELOID-LEUKEMIA | 2-HYDROXYGLUTARATE LEVELS | EXPRESSION | Neoplasm Transplantation | Humans | Gene Expression Regulation, Neoplastic | Mutation, Missense | Carcinoma, Hepatocellular - drug therapy | Heterografts | Cell Transformation, Neoplastic - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Sulfides - pharmacology | Thiadiazoles - pharmacology | Glutaminase - biosynthesis | Mice, Transgenic | Carcinoma, Hepatocellular - enzymology | Cell Transformation, Neoplastic - metabolism | Glutaminase - antagonists & inhibitors | Gene Expression Regulation, Enzymologic | Animals | Liver Neoplasms, Experimental - drug therapy | Carcinoma, Hepatocellular - pathology | Liver Neoplasms, Experimental - enzymology | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Glutaminase - genetics | Amino Acid Substitution | Medical research | Enzymes | Colleges & universities | Grants | Glucose | Metabolism | Fatty acids | Proteins | Survival analysis | Cell growth | Software | Lymphomas | Tumorigenesis | Infrared imaging systems | Laboratory animals | Tumors | Cancer | Crystal structure | Index Medicus | Abridged Index Medicus | Oncology | Hepatology
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 11/2017, Volume 95, Issue 11, pp. 2195 - 2206
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 48, pp. 41600 - 41615
Journal Article