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Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 04/2012, Volume 20, Issue 7, pp. 2290 - 2303
An association between α -adrenoceptor affinities, hERG K -antagonistic properties and antiarrhythmic activities for a series of phenylpiperazine derivatives... 
hERG | Phenylpiperazine | Antiarrhythmic activity | Hydantoin
Journal Article
Progress in biophysics and molecular biology, ISSN 0079-6107, 02/2019
The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current I . I... 
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2017, Volume 595, Issue 14, pp. 4695 - 4723
This study represents a first step toward predicting mechanisms of sex‐based arrhythmias that may lead to important developments in risk stratification and may... 
TdP | arrhythmias | hERG mutation | long‐QT | computational model | sex‐differences | dofetilide | sex-differences | long-QT | MENSTRUAL-CYCLE | PHYSIOLOGY | DRUG-BINDING | CARDIAC ION CHANNELS | LONG-QT SYNDROME | NEUROSCIENCES | VENTRICULAR REPOLARIZATION | FORCE-FIELD | HERG POTASSIUM CHANNEL | MOLECULAR-DYNAMICS SIMULATIONS | RABBIT HEARTS | AUTONOMIC NERVOUS-SYSTEM | Guinea Pigs | Phenethylamines - pharmacology | Anti-Arrhythmia Agents - pharmacology | Adrenergic beta-Agonists - pharmacology | Male | Sex Characteristics | Sulfonamides - pharmacology | Arrhythmias, Cardiac - physiopathology | Arousal - physiology | Animals | Models, Biological | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Female | Ether-A-Go-Go Potassium Channels - physiology | Molecular Docking Simulation | Estradiol - pharmacology | Medical research | Computer-generated environments | Arrhythmia | Computer simulation | Estrogen | Medicine, Experimental | Progesterone | Risk factors | Cardiac arrhythmia | HERG protein | Molecular structure | Sex | Risk | Stimulation | Nervous system | Myocytes | Drug development | Arousal | Potassium channels (voltage-gated) | Mathematical models | Sexual behavior | Sympathetic nervous system | Patients | Discharge | Testosterone | Screening | Molecular modelling | Computer applications | Ventricle | Mutation | Females | Binding sites | Structure-function relationships | Cardiovascular | Research Paper
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 10/2019, Volume 135, pp. 22 - 30
Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder associated with respiratory abnormalities and, in up to ~40% of patients, with prolongation of... 
KCNH2 | Long QT syndrome | hERG | Rett Syndrome | Sarizotan
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 09/2014, Volume 24, Issue 18, pp. 4598 - 4602
The synthesis and pharmacological data of some new and potent hydrophilic 5-HT receptor antagonists are described. Propanediol derivative 25 was identified as... 
hERG | receptor antagonists | 5-HT | Pharmacokinetic
Journal Article
Toxicological Sciences, ISSN 1096-6080, 04/2019, Volume 168, Issue 2, pp. 365 - 380
Abstract The proarrhythmic potency of drugs is usually attributed to the IKr current block. During safety pharmacology testing analysis of IKr in... 
hERG | safety pharmacology | cardiac action potential | proarrhythmia | I Kr
Journal Article
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, ISSN 0277-0008, 03/2018, Volume 38, Issue 3, pp. 341 - 348
Journal Article
Bioscience Reports, ISSN 0144-8463, 09/2018, Volume 38, Issue 5, p. BSR20171269
Journal Article
Cardiovascular Research, ISSN 0008-6363, 08/2005, Volume 67, Issue 3, pp. 498 - 509
Objective: Short QT syndrome (SQTS) is characterized by ventricular arrhythmias and sudden death. One form of SQTS is caused by mutation N588K in human... 
HERG | Short QT | Purkinje | Potassium channel | Arrhythmias
Journal Article
The Journal of Physiology, ISSN 0022-3751, 05/2018, Volume 596, Issue 10, pp. 1783 - 1784
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2017, Volume 12, Issue 16, pp. 1254 - 1260
This Minireview describes a presentation made at the XXIV National Meeting in Medicinal Chemistry (NMMC) held in Perugia (Italy), September 11–14, 2016. It... 
antagonists | hERG | dopamine D | receptors | medicinal chemistry
Journal Article