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halohydrins (194) 194
chemistry, organic (165) 165
epoxides (137) 137
halohydrin dehalogenase (85) 85
chemistry, multidisciplinary (71) 71
alcohols (67) 67
conversion (61) 61
kinetic resolution (46) 46
epoxide (44) 44
cleavage (41) 41
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beta-halohydrins (33) 33
chemistry (33) 33
halides (32) 32
ketones (32) 32
oxiranes (32) 32
haloalcohol dehalogenase (31) 31
halohydrin (31) 31
mechanism (31) 31
biochemistry & molecular biology (29) 29
stereoisomerism (29) 29
hydrolases - metabolism (28) 28
regioselective conversion (28) 28
bromohydrins (27) 27
enantiomers (27) 27
olefins (26) 26
chemistry, applied (25) 25
hydrolysis (23) 23
lithium halides (22) 22
metal-halides (22) 22
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acid (19) 19
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ethers (19) 19
biotechnology (18) 18
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iodine (18) 18
synthesis (18) 18
analysis (17) 17
epoxide hydrolase (17) 17
hydrolases - chemistry (17) 17
oxidation (17) 17
research (17) 17
agrobacterium-radiobacter ad1 (16) 16
halohydrin dehalogenases (16) 16
mild (16) 16
purification (16) 16
ring opening (16) 16
catalysts (15) 15
chemistry, inorganic & nuclear (15) 15
directed evolution (15) 15
enantioselective synthesis (15) 15
escherichia coli (15) 15
bromide (14) 14
escherichia-coli (14) 14
hydrolases - genetics (14) 14
kinetics (14) 14
molecular structure (14) 14
organic-synthesis (14) 14
reduction (14) 14
regioselectivity (14) 14
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vic-halohydrins (14) 14
enzym (13) 13
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halohydrine (13) 13
organic chemistry (13) 13
reagent (13) 13
biocatalysts (12) 12
biosynthesis (12) 12
carbonyl reductase (12) 12
carbonyl-compounds (12) 12
dehalogenation (12) 12
enantio-selectivity (12) 12
enantioselektivität (12) 12
epoxy compounds - chemistry (12) 12
gene (12) 12
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agrobacterium-radiobacter (11) 11
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chemoenzymatic synthesis (11) 11
chloride (11) 11
cyanide (11) 11
highly regioselective conversion (11) 11
iodohydrins (11) 11
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Synlett, ISSN 0936-5214, 03/2019, Volume 30, Issue 4, pp. 437 - 441
Abstract β-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical... 
letter | oxidation | alcohols | halogenation | dimethyl sulfoxide | halohydrins
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2014, Volume 136, Issue 1, pp. 48 - 51
Epoxides are versatile intermediates in organic synthesis, but have rarely been employed in cross-coupling reactions. We report that bipyridine-ligated nickel... 
NUCLEOPHILES | HALOHYDRINS | ALDEHYDES | RADICALS | CHEMISTRY, MULTIDISCIPLINARY | WATER
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 06/2018, Volume 360, Issue 11, pp. 2119 - 2124
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 06/2016, Volume 358, Issue 12, pp. 1886 - 1891
The highly regioselective organocatalytic chlorosilylation of oxirane derivatives using bulky silyl reagents such as (tert‐butyl)diphenylsilyl chloride... 
organocatalysis | regioselectivity | amine N‐oxides | silicon | amine N-oxides | AMMONIUM HALIDES | CONVERSION | 1,2-EPOXIDES | CHEMISTRY, ORGANIC | CATALYST | CLEAVAGE | EPOXIDES | 2,3-EPOXY ALCOHOLS | BETA-HALOHYDRINS | CHEMISTRY, APPLIED | RING OPENINGS | EFFICIENT | Oxides | Ethylene oxide | Catalysis | Chemical tests and reagents | Sulfates | Synthesis | Chlorides | Reagents | Insertion | Oxirane | Chemical reactions | Derivatives
Journal Article
Catalysis Letters, ISSN 1011-372X, 02/2019, Volume 149, Issue 2, pp. 629 - 637
A gene encoding halohydrin dehalogenase from an alphaproteobacterium (AbHHDH) was identified, cloned and over-expressed in Escherichia coli. AbHHDH was able to... 
Biocatalysis | Halohydrins | Enantioselectivity | Epoxides | Halohydrin dehalogenase | (S)-2,3-DICHLORO-1-PROPANOL | RECOMBINANT ESCHERICHIA-COLI | EPOXIDE HYDROLASE | HYDROLYSIS | CHEMISTRY, PHYSICAL | IDENTIFICATION | AGROBACTERIUM-RADIOBACTER AD1 | GENE | KINETIC RESOLUTION | ENZYMES | PURIFICATION | Enantiomers | Escherichia coli | Stereoselectivity | Optical activity | E coli | Substrates
Journal Article
Green chemistry : an international journal and green chemistry resource : GC, ISSN 1463-9270, 2010, Volume 12, Issue 1, pp. 81 - 86
The development of a green-by-design, two-step, three-enzyme process for the synthesis of a key intermediate in the manufacture of atorvastatin, the active... 
ORGANIC-SYNTHESIS | EPOXIDES | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | IN-VITRO | EVOLUTION | CATALYTIC FUNCTION | EXPLORATION | RESOLUTION | HALOHYDRIN DEHALOGENASE | CHEMISTRY, MULTIDISCIPLINARY | ECONOMY
Journal Article
Green chemistry : an international journal and green chemistry resource : GC, ISSN 1463-9262, 2010, Volume 12, Issue 1, pp. 81 - 86
The development of a green-by-design, two-step, three-enzyme process for the synthesis of a key intermediate in the manufacture of atorvastatin, the active... 
Drugs
Journal Article
European journal of organic chemistry, ISSN 1434-193X, 2018, Volume 2018, Issue 18, pp. 2110 - 2116
A straightforward chemoenzymatic synthesis of luliconazole has been developed. The key step involved the preparation of the enantiomerically pure β‐halohydrin... 
Synthetic methods | Biocatalysis | Synthesis design | Enzyme catalysis | Chemoenzymatic synthesis | Kinetic resolution | ENANTIOSELECTIVE SYNTHESIS | EFFICIENT ROUTE | PROTOCOL | CHEMISTRY, ORGANIC | ALCOHOLS | THERAPY | HALOHYDRINS | Lipase
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2018, Volume 140, Issue 16, pp. 5500 - 5515
The kinetics of epoxide formation by Darzens condensation of aliphatic ketones 1 with arylsulfonyl-substituted chloromethyl anions 2 (ArSO2CHCl–) have been... 
SODIUM-BOROHYDRIDE | STERIC STRAINS | MOLECULAR-ORBITAL METHODS | NUCLEOPHILIC-ADDITION REACTIONS | REACTIVITY | ION | ALDEHYDES | PARAMETERS | BASIS-SET | CHEMISTRY, MULTIDISCIPLINARY | GENERAL-METHOD | Chemical reactions | Chemical properties | Dynamics | Chemical compounds | Analysis
Journal Article
Chemical and Biochemical Engineering Quarterly, ISSN 0352-9568, 2017, Volume 31, Issue 3, pp. 233 - 240
The biodegradation of two halohydrins (1,3-dichloro-2-propanol and 3-chloro-1,2-propanediol) by P. putida DSM 437 was investigated. Intact cells of previously... 
Biodegradation | Halohydrins | P. Putida | Kinetics | Whole cells | Cell-free extracts | halohydrins | biodegradation | HALOALCOHOL DEHALOGENASE | whole cells | ENGINEERING, CHEMICAL | REMOVAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 1,3-DICHLORO-2-PROPANOL | cell-free extracts | P. putida | kinetics | EPICHLOROHYDRIN | CULTURES | BINDING | Epoxy resins
Journal Article
Advanced synthesis & catalysis, ISSN 1615-4150, 2018, Volume 360, Issue 3, pp. 568 - 574
A practical method for the asymmetric transfer hydrogenation of α‐substituted ketones was developed utilizing oxo‐tethered N‐sulfonyldiamine‐ruthenium... 
asymmetric transfer hydrogenation | ruthenium | α-haloketones | asymmetric catalysis | halohydrins | CONVENIENT SYNTHESIS | PRACTICAL SYNTHESIS | SCALE-UP | ENANTIOSELECTIVE SYNTHESIS | AQUEOUS-MEDIA | CHEMISTRY, ORGANIC | PROCHIRAL KETONES | DYNAMIC KINETIC RESOLUTION | BETA-AMINO ALCOHOLS | REDUCTION | alpha-haloketones | CHEMISTRY, APPLIED
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2016, Volume 2016, Issue 21, pp. 3584 - 3591
A method has been developed for the conversion of primary, secondary, and tertiary alcohols, and phenol, into the corresponding esters at room temperature. The... 
Titanium | Esters | Halohydrins | Radical reactions | Acylation | TI-III | REAGENT | MECHANISM | CHEMISTRY, ORGANIC | SOLVENT | FREE-RADICAL CHEMISTRY | ELECTRON-TRANSFER | KINETIC RESOLUTION | RECYCLABLE CATALYST | DERIVATIVES | Phenols | Full Paper | Full Papers
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 02/2015, Volume 11, Issue 1, pp. 242 - 248
beta-Haloalkoxysulfonium ions generated by the reaction of electrogenerated Br+ and I+ ions stabilized by dimethyl sulfoxide (DMSO) reacted with sodium... 
Electrosynthesis | Halohydrins | Epoxides | DMSO | Halogen cations | ALKENES | halogen cations | electrosynthesis | MECHANISM | INTEGRATION | halohydrins | CHEMISTRY, ORGANIC | IODINATION | epoxides | POOLS | CHEMICAL OXIDATION
Journal Article