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1. Full Text Molecular pathways: Fumarate Hydratase-deficient kidney cancer - Targeting the warburg effect in cancer
by Linehan, W. Marston and Rouault, Tracey A
Clinical Cancer Research, ISSN 1078-0432, 07/2013, Volume 19, Issue 13, pp. 3345 - 3352
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a hereditary cancer syndrome in which affected individuals are at risk for development of... 
MET PROTOONCOGENE | INHIBITION | HIF | ONCOLOGY | HEREDITARY LEIOMYOMATOSIS | HLRCC SYNDROME | MUTATIONS | UTERINE LEIOMYOMAS | TUMORS | RENAL-CELL CARCINOMA | Uterine Neoplasms - genetics | AMP-Activated Protein Kinases - metabolism | Uterine Neoplasms - metabolism | Skin Neoplasms - drug therapy | Humans | Translational Medical Research | Leiomyomatosis - metabolism | Antineoplastic Agents - therapeutic use | Fumarate Hydratase - deficiency | Fumarate Hydratase - genetics | Molecular Targeted Therapy | Neoplastic Syndromes, Hereditary | Skin Neoplasms - metabolism | Fumarate Hydratase - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Signal Transduction - drug effects | Leiomyomatosis - drug therapy | Skin Neoplasms - genetics | Uterine Neoplasms - drug therapy | Antineoplastic Agents - pharmacology | Leiomyomatosis - genetics
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2. Full Text Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome: Part I. The Utility of Immunohistochemistry
by Shia, Jinru
Journal of Molecular Diagnostics, ISSN 1525-1578, 07/2008, Volume 10, Issue 4, pp. 293 - 300
The utility of immunohistochemical detection of DNA mismatch repair (MMR) protein in screening colorectal tumors for hereditary nonpolyposis colorectal cancer... 
COLON-CANCER | GENE-MUTATIONS | LYNCH-SYNDROME | HMSH2 | EXPRESSION ANALYSIS | MSH2 | REVISED BETHESDA GUIDELINES | TUMOR-CELLS | DNA MISMATCH-REPAIR | PATHOLOGY | IDENTIFICATION | Microsatellite Instability | Humans | Risk Factors | Mass Screening - methods | Colorectal Neoplasms - diagnosis | Syndrome | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | Immunohistochemistry - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Sensitivity and Specificity | Colorectal Neoplasms - complications | Colorectal Neoplasms, Hereditary Nonpolyposis - etiology | Colorectal Neoplasms - metabolism | Counterpoint | Point
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3. Full Text Hereditary colorectal cancer syndromes: American society of clinical oncology clinical practice guideline endorsement of familial risk-colorectal cancer: European Society for medical oncology clinical practice guidelines
by Stoffel, Elena M and Mangu, Pamela B and Gruber, Stephen B and Hamilton, Stanley R and Kalady, Matthew F and Lau, Michelle Wan Yee and Lu, Karen H and Roach, Nancy and Limburg, Paul J and European Society of Clinical Oncology and American Society of Clinical Oncology
Journal of Clinical Oncology, ISSN 0732-183X, 10/2015, Volume 33, Issue 2, pp. 209 - 217
Purpose To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC)... 
LYNCH-SYNDROME | MULTICENTER | MANAGEMENT | ONCOLOGY | PHENOTYPE | REVISED BETHESDA GUIDELINES | IDENTIFICATION | MLH1 | MSH2 MUTATION CARRIERS | ADENOMATOUS POLYPOSIS | ENDOMETRIAL CANCER | Medical History Taking | Microsatellite Instability | Genetic Testing | Sigmoidoscopy | Early Detection of Cancer - methods | Adenomatous Polyposis Coli - prevention & control | Humans | Genetic Counseling | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | Colorectal Neoplasms, Hereditary Nonpolyposis - therapy | Anticarcinogenic Agents - administration & dosage | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Colonoscopy | DNA Mismatch Repair | Germ-Line Mutation | Adenomatous Polyposis Coli - therapy | Adenomatous Polyposis Coli - genetics | Population Surveillance - methods | Adenomatous Polyposis Coli Protein - genetics | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | DNA Glycosylases - genetics | Heterozygote | Adenomatous Polyposis Coli - diagnosis | Chemoprevention - methods | Gic2 | To4 | ASCO Special | Gic1 | To8 | Gdln1
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4. Hereditary gynecologic cancer
: risk, prevention, and management
by Lu, Karen H
2008, ISBN 9781420052879, xv, 285
Hereditary Gynecologic Cancer: Risk, Prevention and Management fills the need that exists for a book addressing highly relevant clinical issues associated with... 
genetics | therapy | Genital Neoplasms, Female | Genes, BRCA2 | Genetic aspects | Genes, BRCA1 | prevention & control | Generative organs, Female | Neoplastic Syndromes, Hereditary | Cancer | Clinical & internal medicine | Gynecology & Women's Health | Medical Genetics | Oncology | Obstetrics | Genital Neoplasms, Female - prevention & control
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5. Inherited cancer syndromes
: current clinical management
by Ellis, C. Neal
2011, 2nd ed., ISBN 9781441968203, viii, 204
The second edition of "Inherited Cancer Syndromes" incorporates new genetic markers data with the clinical utility and practicality of the first edition.... 
Genetic aspects | Genetic disorders | genetics | Cancer | Neoplastic Syndromes, Hereditary | Clinical & internal medicine | Neoplastic Syndromes, Hereditary - therapy | Human Genetics | Oncology | Cancer Research | Medicine & Public Health | General Surgery | Surgical Oncology
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6. Full Text Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment
by Menko, Fred H and Maher, Eamonn R and Schmidt, Laura S and Middelton, Lindsay A and Aittomäki, Kristiina and Tomlinson, Ian and Richard, Stéphane and Linehan, W Marston
Familial Cancer, ISSN 1389-9600, 12/2014, Volume 13, Issue 4, pp. 637 - 644
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant condition in which susceptible individuals are at risk for the development of... 
Human Genetics | Tricarboxylic acid cycle | Fumarate hydratase | Biomedicine | Surveillance | Nephrectomy | Targeted therapy | Hereditary leiomyomatosis and renal cell cancer | Cancer Research | Type 2 papillary renal cell cancer | Epidemiology | Biomedicine general | FUMARATE-HYDRATASE GENE | FH MUTATIONS | AGGRESSIVE FORM | TUMOR SYNDROME | ONCOLOGY | UTERINE FIBROIDS | GENETICS & HEREDITY | GERMLINE MUTATIONS | MISSENSE MUTATION | PARENCHYMAL SPARING SURGERY | CARCINOMA | KIDNEY CANCER | Kidney Neoplasms - genetics | Early Detection of Cancer - methods | Humans | Middle Aged | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - diagnosis | Neoplastic Syndromes, Hereditary | Skin Neoplasms - complications | Leiomyomatosis - complications | Carcinoma, Renal Cell - diagnosis | Uterine Neoplasms - complications | Female | Enzymes | Medical genetics | Genetic aspects | Health aspects | Population genetics | Risk factors | Cancer | targeted therapy | tricarboxylic acid cycle | fumarate hydratase | nephrectomy | surveillance | hereditary leiomyomatosis and renal cell cancer | papillary type 2 renal cancer
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7. Colorectal cancer
by Ponz de Leon, M. (Maurizio)
2002, ISBN 3540430474, xv, 303
Colon (Anatomy) -- Cancer | Rectum -- Cancer
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8. Full Text A study of over 35,000 women with breast cancer tested with a 25‐gene panel of hereditary cancer genes
by Buys, Saundra S and Sandbach, John F and Gammon, Amanda and Patel, Gayle and Kidd, John and Brown, Krystal L and Sharma, Lavania and Saam, Jennifer and Lancaster, Johnathan and Daly, Mary B
Cancer, ISSN 0008-543X, 05/2017, Volume 123, Issue 10, pp. 1721 - 1730
BACKGROUND As panel testing becomes more common in clinical practice, it is important to understand the prevalence and trends associated with the pathogenic... 
breast cancer type 1 (BRCA1) | panel testing | hereditary breast and ovarian cancer | BRCA2 | triple‐negative breast cancer | triple-negative breast cancer | POPULATION | BRCA2 MUTATIONS | METAANALYSIS | VARIANTS | RISK | PREVALENCE | FAMILY-HISTORY | SUSCEPTIBILITY GENES | COWDEN-SYNDROME | ONCOLOGY | DIFFUSE GASTRIC-CANCER | Genetic Testing | Age Factors | Humans | Middle Aged | Young Adult | Checkpoint Kinase 2 - genetics | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Genes, BRCA2 | Adult | Female | RNA Helicases - genetics | Lynch Syndrome II - genetics | Neoplastic Syndromes, Hereditary - genetics | Genes, BRCA1 | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Hereditary Breast and Ovarian Cancer Syndrome - genetics | DNA-Binding Proteins - genetics | Fanconi Anemia Complementation Group Proteins | Breast Neoplasms - genetics | Triple Negative Breast Neoplasms - genetics | Aged | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Women | Breast cancer | Genetic aspects | Diagnosis | Research | Health aspects | Oncogenes | BRCA2 protein | CHK2 protein | Threonine | BRCA1 protein | Genes | Health risks | Protein C | Genetic screening | DNA helicase | Men | Breast | Ataxia | Ataxia telangiectasia mutated protein | Protein-serine/threonine kinase | Mutation | Health risk assessment | Age | Cancer
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9. Full Text Immunohistochemistry versus Microsatellite Instability Testing for Screening Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome: Part II. The Utility of Microsatellite Instability Testing
by Zhang, Liying
Journal of Molecular Diagnostics, ISSN 1525-1578, 07/2008, Volume 10, Issue 4, pp. 301 - 307
Germline mutations in the mismatch repair genes mutL homolog 1 (MLH1) and mutS homolog 2 (MSH2), MSH6, and postmeiotic segregation increased 2 (PMS2) lead to... 
MSH6 | LYNCH-SYNDROME | GENE | BRAF MUTATION | GERMLINE EPIMUTATION | REVISED BETHESDA GUIDELINES | MISMATCH-REPAIR | COLON | PATHOLOGY | MLH1 | TUMORS | Microsatellite Instability | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Risk Factors | Mass Screening - methods | Colorectal Neoplasms - diagnosis | Syndrome | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | Immunohistochemistry - methods | Sensitivity and Specificity | Colorectal Neoplasms - complications | Colorectal Neoplasms, Hereditary Nonpolyposis - etiology | Counterpoint | Point
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10. Full Text Lower Cancer Incidence in Amsterdam-I Criteria Families Without Mismatch Repair Deficiency: Familial Colorectal Cancer Type X
by Lindor, Noralane M and Rabe, Kari and Petersen, Gloria M and Haile, Robert and Casey, Graham and Baron, John and Gallinger, Steve and Bapat, Bharati and Aronson, Melyssa and Hopper, John and Jass, Jeremy and LeMarchand, Loic and Grove, John and Potter, John and Newcomb, Polly and Terdiman, Jonathan P and Conrad, Peggy and Moslein, Gabriella and Goldberg, Richard and Ziogas, Argyrios and Anton-Culver, Hoda and de Andrade, Mariza and Siegmund, Kim and Thibodeau, Stephen N and Boardman, Lisa A and Seminara, Daniela
JAMA, ISSN 0098-7484, 04/2005, Volume 293, Issue 16, pp. 1979 - 1985
CONTEXT Approximately 60% of families that meet the Amsterdam-I criteria (AC-I) for hereditary nonpolyposis colorectal cancer (HNPCC) have a hereditary... 
MEDICINE, GENERAL & INTERNAL | KINDREDS | MICROSATELLITE INSTABILITY | MUTATION CARRIERS | GENES | Colorectal Neoplasms, Hereditary Nonpolyposis - classification | MutL Protein Homolog 1 | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | DNA Repair - genetics | Base Pair Mismatch - genetics | Neoplastic Syndromes, Hereditary - epidemiology | Neoplasms - genetics | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Neoplasm Proteins - genetics | Chromosomal Instability | Microsatellite Repeats | Carrier Proteins | Colorectal Neoplasms - epidemiology | SEER Program | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Proto-Oncogene Proteins - genetics | Colorectal Neoplasms - classification | MutS Homolog 2 Protein | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins | Adaptor Proteins, Signal Transducing | Mass Screening | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Pedigree | Heterozygote | Aged | Neoplastic Syndromes, Hereditary - classification | Neoplasms - epidemiology | Heredity | Health risk assessment | Genes | Deoxyribonucleic acid--DNA | Colorectal cancer
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11. Full Text Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer
by Ricketts, Christopher J and Shuch, Brian and Vocke, Cathy D and Metwalli, Adam R and Bratslavsky, Gennady and Middelton, Lindsay and Yang, Youfeng and Wei, Ming-Hui and Pautler, Stephen E and Peterson, James and Stolle, Catherine A and Zbar, Berton and Merino, Maria J and Schmidt, Laura S and Pinto, Peter A and Srinivasan, Ramaprasad and Pacak, Karel and Linehan, W. Marston
Journal of Urology, The, ISSN 0022-5347, 2012, Volume 188, Issue 6, pp. 2063 - 2071
Purpose Recently, a new renal cell cancer syndrome has been linked to germline mutation of multiple subunits ( SDHB / C / D ) of the Krebs cycle enzyme,... 
Urology | kidney | citric acid cycle | germ-line mutation | carcinoma, renal cell | succinate dehydrogenase | TYPE-3 | VARIANTS | HEREDITARY LEIOMYOMATOSIS | PARAGANGLIOMA | germline mutation | SDHB | TUMORS | RENAL-CELL CARCINOMA | renal cell | PHEOCHROMOCYTOMA | carcinoma | B GENE | GERMLINE MUTATIONS | UROLOGY & NEPHROLOGY | Kidney Neoplasms - genetics | Genetic Testing | Humans | Middle Aged | Genetic Diseases, Inborn - genetics | Carcinoma, Renal Cell - genetics | Carcinoma, Renal Cell - surgery | Male | Disease Progression | Kidney Neoplasms - diagnosis | Young Adult | Kidney Neoplasms - surgery | Succinate Dehydrogenase - genetics | Pedigree | Carcinoma, Renal Cell - diagnosis | Adolescent | Germ-Line Mutation | Adult | Female | Genetic Diseases, Inborn - surgery | Genetic Diseases, Inborn - diagnosis | Enzymes | Gene mutations | Oncology, Experimental | Kidney cancer | Research | Citric acid | Cancer | Succinate dehydrogenase | Krebs cycle | renal cell cancer (RCC) | hereditary kidney cancer
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12. Full Text Is there a role for programmed death ligand-1 testing and immunotherapy in colorectal cancer with microsatellite instability?: Part I-Colorectal Cancer: Microsatellite Instability, Testing, and Clinical Implications
by Marginean, Esmeralda Celia and Melosky, Barbara
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 01/2018, Volume 142, Issue 1, pp. 17 - 25
Context.-Colorectal cancer (CRC) represents the third most-common cancer in developed countries and is a leading cause of cancer deaths worldwide. Two... 
ADJUVANT CHEMOTHERAPY | MEDICINE, RESEARCH & EXPERIMENTAL | LYNCH-SYNDROME | CLASSIFICATION | RISK | COLON | PATHOLOGY | TUMORS | BETHESDA GUIDELINES | HEREDITARY | PREDICT | CARCINOMAS | MEDICAL LABORATORY TECHNOLOGY | Microsatellite Instability | Antibodies, Monoclonal, Humanized - therapeutic use | Genetic Testing | Prognosis | Colorectal Neoplasms - genetics | Humans | B7-H1 Antigen - metabolism | Colorectal Neoplasms - therapy | Algorithms | B7-H1 Antigen - antagonists & inhibitors | Antineoplastic Agents, Immunological - therapeutic use | DNA Mismatch Repair | Immunotherapy | DNA, Neoplasm - genetics | Mutation | Colorectal Neoplasms - metabolism | Polymerase chain reaction | Usage | Care and treatment | Colorectal cancer | Genetic aspects | Research | Gene expression | Risk factors | Apoptosis | DNA polymerase | Accounting | Colorectal carcinoma | Genomics | Systematic review | Genomes | Microsatellite instability | Metabolism | Cancer therapies | Consortia | Chemotherapy | Medical prognosis | Classification | DNA methylation | Ligands | Genetic testing | Deoxyribonucleic acid--DNA | Tumors
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13. Full Text International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
by Canto, Marcia Irene and Harinck, Femme and Hruban, Ralph H and Offerhaus, George Johan and Poley, Jan-Werner and Kamel, Ihab and Nio, Yung and Schulick, Richard S and Bassi, Claudio and Kluijt, Irma and Levy, Michael J and Chak, Amitabh and Fockens, Paul and Goggins, Michael and Bruno, Marco and Int Canc Pancreas Screening and International Cancer of Pancreas Screening (CAPS) Consortium
Gut, ISSN 0017-5749, 03/2013, Volume 62, Issue 3, pp. 339 - 347
Background Screening individuals at increased risk for pancreatic cancer (PC) detects early, potentially curable, pancreatic neoplasia. Objective To develop... 
CONSENSUS GUIDELINES | BRCA2 MUTATIONS | HEREDITARY PANCREATITIS | K-RAS | GERMLINE MUTATIONS | CYSTIC NEOPLASMS | FOLLOW-UP | PAPILLARY-MUCINOUS NEOPLASMS | PALB2 MUTATIONS | INTRAEPITHELIAL NEOPLASIA | GASTROENTEROLOGY & HEPATOLOGY | Genetic Predisposition to Disease | Age Factors | Endosonography | Follow-Up Studies | Early Detection of Cancer | Pancreatectomy - standards | Pancreatic Neoplasms - diagnosis | Carcinoma - surgery | Humans | Pancreatic Neoplasms - surgery | Risk Factors | Carcinoma - diagnosis | Pancreatic Neoplasms - genetics | Treatment Outcome | Mutation - genetics | Neoplasm Grading | Pedigree | Carcinoma - genetics | Cholangiopancreatography, Magnetic Resonance | Practice guidelines (Medicine) | Reports | Care and treatment | Pancreatic cancer | Risk factors | Studies | Consortia | Surveillance | Family medical history | Endoscopy | Tumors | Screening | Family Cancer | Pancreatic Cancer | Endoscopic Ultrasonography | 1506 | Guidelines
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14. Full Text Childhood cancer predisposition syndromes—A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology
by Ripperger, Tim and Bielack, Stefan S and Borkhardt, Arndt and Brecht, Ines B and Burkhardt, Birgit and Calaminus, Gabriele and Debatin, Klaus‐Michael and Deubzer, Hedwig and Dirksen, Uta and Eckert, Cornelia and Eggert, Angelika and Erlacher, Miriam and Fleischhack, Gudrun and