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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
Aim/Hypothesis: Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is... 
3T3-L1 ADIPOCYTES | SUBCUTANEOUS FAT-CELLS | BETA-ADRENERGIC STIMULATION | WEIGHT-REDUCTION | TISSUE | ENDOCRINOLOGY & METABOLISM | UPPER-BODY OBESITY | PPAR-GAMMA | SKELETAL-MUSCLE METABOLISM | TNF-ALPHA | LIPOPROTEIN-LIPASE | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2019, Volume 120, Issue 8, pp. 13706 - 13716
Journal Article
Journal Article
Journal Article
Progress in Lipid Research, ISSN 0163-7827, 01/2011, Volume 50, Issue 1, pp. 14 - 27
Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG) stored in cellular lipid droplets. The hydrolytic cleavage of TAG... 
Neutral lipid storage disease | Triacylglycerol | Lipase | Lipolysis | Fat stores | ADIPOSE TRIGLYCERIDE LIPASE | HORMONE-SENSITIVE LIPASE | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RETINOL-BINDING-PROTEIN | CHANARIN-DORFMAN-SYNDROME | DIET-INDUCED OBESITY | GENE IDENTIFICATION-58 CGI-58 | LIPID STORAGE DISEASE | SKELETAL-MUSCLE | NUTRITION & DIETETICS | INSULIN-RESISTANCE | Adipose Tissue - metabolism | Adipose Tissue - enzymology | Animals | Physiological Phenomena | Humans | ARF1, ADP-ribosylation factor 1 | STS, steroid sulfatase | MGL, monoglyceride lipase | TNF-α, tumor necrosis factor alpha | FoxO1, forkhead box O1 | MAG, monoacylglycerol | Review | NEFA, non-esterified fatty acid | γ, peroxisome proliferator-activated receptor-alpha | CGI-58, comparative-gene-identification 58 | RE, retinylester | CE, cholesterylester | COPI, coat protein complex-I | G0S2, G0 | LPAAT, lysophosphatidic acid acyltransferase | 2-AG, 2-arachidonoyl glycerol | β hydrolase domain containing protein 1–15 | PNPLA1-5, patatin-like phospholipase domain containing protein 1–5 | PPRE, PPAR-response element | cPLA2, cytosolic phospholipase A2 | ATGL, adipose triglyceride lipase | NLSD, neutral lipid storage disease | CDS, Chanarin-Dorfman syndrome | mTor, mammalian target of rapamycin | BAT, brown adipose tissue | DAG, diacylglycerol | PPARα | TAG, triacylglycerol | WAT, white adipose tissue | TGH, triglyceride hydrolase | BiFC, bimolecular fluorescence complementation | HSL, hormone-sensitive lipase | RBP4, retinol-binding protein 4 | ABHD1-15, α | LD, lipid droplet | NLSDI, NLSD with ichthyosis | GS2, gene sequence 2 | ER, endoplasmic reticulum | G1 Switch Protein 2 | NLSDM, NLSD with myopathy | PKA, protein kinase A | gamma
Journal Article
DIABETES, ISSN 0012-1797, 01/2006, Volume 55, Issue 1, pp. 148 - 157
Adipose triglyceride lipase (ATGL) is a recently described adipose-enriched protein with triglyceride-specific lipase activity. ATGL shares the greatest... 
HORMONE-SENSITIVE LIPASE | POTATO | ADIPOCYTES | MESSENGER-RNA EXPRESSION | PATATIN | TISSUE | PURIFICATION | ENDOCRINOLOGY & METABOLISM | ACYL-HYDROLASE | TUBER PROTEIN | FAMILY | Hydrolysis | Care and treatment | Metabolic diseases | Research | Diabetes | Diagnosis | Risk factors
Journal Article