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New England Journal of Medicine, ISSN 0028-4793, 10/2019, Volume 381, Issue 14, pp. 1398 - 1398
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 108 - 111
Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and... 
PATHOGENESIS | CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | MACHADO-JOSEPH-DISEASE | MUTANT HUNTINGTIN | ATAXIN-3 | INTRANUCLEAR INCLUSIONS | LC3 | MOUSE MODELS | AGGREGATION | Humans | Ubiquitin - metabolism | Male | Neurons - cytology | Autophagy | Brain - metabolism | Peptides - metabolism | Protein Domains | Ataxin-3 - chemistry | Female | Food Deprivation | Neurons - metabolism | Protein Stability | Ataxin-3 - metabolism | Disease Models, Animal | Binding, Competitive | Cell Line | Ataxin-3 - deficiency | Huntingtin Protein - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Cells, Cultured | Mutant Proteins - genetics | Exons - genetics | Mutant Proteins - metabolism | Huntington Disease - metabolism | Huntingtin Protein - chemistry | Animals | Mutant Proteins - chemistry | Brain - pathology | Huntington Disease - genetics | Protein Binding | Mice | Huntingtin Protein - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | Beclin-1 - metabolism | Ataxin-3 - genetics | Physiological aspects | Autophagy (Cytology) | Neural circuitry | Observations | Huntingtons disease | Competition | Biotechnology | Huntingtin | Toxicity | Pathogenesis | Impairment | Biosynthesis | Kinases | Experiments | Degradation | Proteins | Scholarships & fellowships | Ataxin | Rodents | Spinocerebellar ataxia | Ataxia | Biocompatibility | Trinucleotide repeat diseases | Medical research | Starvation | Neurodegenerative diseases | Polyglutamine diseases | Huntington's disease | Neurological diseases | Machado-Joseph disease | Cell lines | Scientific imaging | Mass spectrometry | Phagocytosis | Index Medicus
Journal Article
Journal Article
Cell, ISSN 0092-8674, 09/2017, Volume 171, Issue 1, pp. 179 - 187.e10
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 6, pp. 2366 - 2370
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3734 - 3746
Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range of neurotoxic aggregates that are associated with Huntington's... 
EXON-1 PROTEIN | L-PROLINE BINDING | PROTEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | POLYMER PHYSICS | LIQUID DROPLETS | POLYGLUTAMINE AGGREGATION | INCLUSION-BODY FORMATION | NEURODEGENERATIVE DISEASES | STRUCTURAL FEATURES | Humans | Fluorescence | Tryptophan - chemistry | Thermodynamics | Huntingtin Protein - ultrastructure | Protein Aggregation, Pathological - pathology | Profilins - genetics | Protein Aggregation, Pathological - prevention & control | Protein Stability | Binding Sites | Peptide Fragments - genetics | Peptide Fragments - ultrastructure | Recombinant Proteins - metabolism | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Polyglutamic Acid - metabolism | Recombinant Proteins - ultrastructure | Huntingtin Protein - metabolism | Solubility | Models, Molecular | Recombinant Proteins - chemistry | Scattering, Small Angle | Negative Staining | Polyglutamic Acid - genetics | Huntingtin Protein - chemistry | Polyglutamic Acid - chemistry | Proline-Rich Protein Domains | Peptide Fragments - chemistry | Image Processing, Computer-Assisted | Profilins - chemistry | Ligands | Huntingtin Protein - genetics | Mutation | Profilins - metabolism | Profilins - ultrastructure | Protein Aggregation, Pathological - metabolism | Amino Acid Substitution | Index Medicus | neurodegenerative disease | Molecular Biophysics | protein aggregation | Huntington disease | phase transitions | polyglutamine | biophysics
Journal Article