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10/2011
The current study investigates the antihyperhomocysteinemic and antihyperlipidemic effect of chloroform and methanol extracts of the leaves of Trichilia... 
Hyperhomocysteinemia | Methionine-induced hyperhomocysteinemia | Trichilia connaroides
Web Resource
American Journal of Pathology, The, ISSN 0002-9440, 2007, Volume 170, Issue 2, pp. 667 - 679
Journal Article
Circulation Research, ISSN 0009-7330, 06/2012, Volume 111, Issue 1, pp. 37 - 49
RATIONALE:Hyperhomocysteinemia (HHcy) accelerates atherosclerosis and increases inflammatory monocytes (MC) in peripheral tissues. However, its causative role... 
atherosclerosis | hyperhomocysteinemia | HOMOCYSTEINE | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | STROKE PREVENTION | inflammatory monocyte | CYSTATHIONINE BETA-SYNTHASE | RANDOMIZED CONTROLLED-TRIAL | ACCELERATES ATHEROSCLEROSIS | FOLIC-ACID | VASCULAR-DISEASE | DENSITY-LIPOPROTEIN | PERIPHERAL VASCULAR DISEASE | CHEMOATTRACTANT PROTEIN-1 | HEMATOLOGY | Oxidative Stress | Atherosclerosis - genetics | Tumor Necrosis Factor-alpha - blood | Male | Green Fluorescent Proteins - genetics | Inflammation - blood | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Cell Differentiation | Disease Models, Animal | Hyperlipidemias - immunology | Hyperhomocysteinemia - enzymology | Atherosclerosis - pathology | Aorta - immunology | Mice, Transgenic | Chemokine CCL2 - blood | Inflammation - etiology | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Atherosclerosis - blood | Green Fluorescent Proteins - biosynthesis | Mice | Hyperhomocysteinemia - complications | Inflammation - enzymology | Lyases - deficiency | Bone Marrow Cells - enzymology | Hyperlipidemias - enzymology | Atherosclerosis - etiology | Atherosclerosis - enzymology | Hyperhomocysteinemia - immunology | Interleukin-6 - blood | Lipids - blood | Receptors, LDL - deficiency | Superoxides - metabolism | Bone Marrow Cells - drug effects | Lyases - genetics | Aorta - enzymology | Hyperlipidemias - complications | Macrophages - immunology | Severity of Illness Index | Receptors, LDL - genetics | Hyperhomocysteinemia - blood | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Inflammation Mediators - blood | Inflammation - immunology | Antioxidants - pharmacology | Vitamin B Complex - pharmacology | Animals | Hyperhomocysteinemia - genetics | Macrophages - drug effects
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3998 - 4009
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy... 
DNA methylation | Foam cell | Homocysteine | Atherosclerosis | Fatty acid-binding protein 4 | atherosclerosis | homocysteine | free Cholesterol | DNMT1 | S-adenosylhomocysteine | AZC | azacytidine | S-adenosylmethionine | | FABP4 | fatty acid-binding protein 4 | DNA methyltransferases 1 | HHcy | Hyperhomocysteinemia | ApoE | SAH | total Cholesterol | apolipoprotein E knockout | Cholesteryl Ester | SAM | Hcy | HYPERHOMOCYSTEINEMIA | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN 4 | ADIPOGENESIS | CELL BIOLOGY | BIOPHYSICS | DISEASE | PPAR-GAMMA | DIFFERENTIATION | EXPRESSION | Diet - adverse effects | Cholesterol - blood | Humans | Hyperhomocysteinemia - metabolism | Male | Monocytes - metabolism | Aorta - metabolism | Fatty Acid-Binding Proteins - metabolism | Apolipoproteins E - metabolism | Atherosclerosis - etiology | DNA Methylation | Hyperhomocysteinemia - physiopathology | Monocytes - pathology | Foam Cells - pathology | Aorta - enzymology | Foam Cells - metabolism | Genes, Reporter | Repressor Proteins - metabolism | Methionine - poisoning | Promoter Regions, Genetic | Hyperhomocysteinemia - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Repressor Proteins - genetics | Foam Cells - enzymology | Cholesterol - metabolism | Hyperhomocysteinemia - etiology | Fatty Acid-Binding Proteins - genetics | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Monocytes - enzymology | Animals | Apolipoproteins E - genetics | Cell Line, Tumor
Journal Article
Annual Review of Nutrition, ISSN 0199-9885, 7/2016, Volume 36, Issue 1, pp. 211 - 239
Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated... 
clinical trial | dementia | folate | cobalamin (vitamin B12) | cognition | Alzheimer's disease | PLASMA TOTAL HOMOCYSTEINE | BRAIN ATROPHY | ALZHEIMERS-DISEASE | FATTY-ACID-METABOLISM | RANDOMIZED CONTROLLED-TRIAL | NUTRITION & DIETETICS | SMALL-VESSEL DISEASE | MEDIAL TEMPORAL-LOBE | WHITE-MATTER HYPERINTENSITIES | PLACEBO-CONTROLLED TRIAL | TRANSIENT CEREBRAL-ISCHEMIA | Hyperhomocysteinemia - epidemiology | Folic Acid - therapeutic use | Folic Acid - adverse effects | Neurodegenerative Diseases - etiology | Nootropic Agents - metabolism | Humans | Neurodegenerative Diseases - prevention & control | Hyperhomocysteinemia - metabolism | Vitamin B 12 - adverse effects | Homocysteine - metabolism | Vitamin B 12 - therapeutic use | Cognitive Dysfunction - prevention & control | Hyperhomocysteinemia - physiopathology | Cognition Disorders - prevention & control | Cognition Disorders - etiology | Cognitive Dysfunction - epidemiology | Aging | Nutritional Status | Dietary Supplements - adverse effects | Vitamin B 6 - metabolism | Risk Factors | Homocysteine - blood | Nootropic Agents - therapeutic use | Cerebrovascular Circulation | Cognitive Dysfunction - etiology | Evidence-Based Medicine | Nootropic Agents - adverse effects | Animals | Neurodegenerative Diseases - physiopathology | Vitamin B 6 - adverse effects | Vitamin B 6 - therapeutic use | Biomarkers | Folic Acid - metabolism | Hyperhomocysteinemia - diet therapy | Cognition Disorders - epidemiology | Neurodegenerative Diseases - epidemiology | Vitamin B 12 - metabolism | Practice Guidelines as Topic | Physiological aspects | Homocysteine | Health aspects | Dementia
Journal Article
05/2010
Background: Hyperhomocysteinemia (hhcy) has been considered as a risk factor for several obstetrical complications such as early pregnancy loss, pre-eclampsia... 
Subfertility | Female infertility | Hyperhomocysteinemia
Web Resource
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 5, pp. 1012 - 1023.e14
Background & Aims Hyperhomocysteinemia is often associated with liver and metabolic diseases. We studied nuclear receptors that mediate oscillatory control of... 
Gastroenterology and Hepatology | Nuclear Receptor | Liver Disease Model | Metabolism | Circadian Regulation | PATHWAYS | SMALL HETERODIMER PARTNER | TRIGLYCERIDE | TRANSCRIPTION | ENDOPLASMIC-RETICULUM STRESS | LIVER-DISEASE | FARNESOID X RECEPTOR | FATTY LIVER | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Glucose Intolerance - metabolism | Receptors, Cytoplasmic and Nuclear - deficiency | Transcriptional Activation | Homeostasis | Hyperhomocysteinemia - metabolism | Cystathionine gamma-Lyase - metabolism | Homocysteine - metabolism | RNA, Messenger - metabolism | Glucose Intolerance - blood | Time Factors | Hyperhomocysteinemia - prevention & control | Diet, High-Fat | Cholic Acid | Cholestyramine Resin | Cystathionine gamma-Lyase - genetics | Betaine-Homocysteine S-Methyltransferase - metabolism | Disease Models, Animal | Hyperhomocysteinemia - blood | Ethanol | Liver - metabolism | Homocysteine - blood | Receptors, Cytoplasmic and Nuclear - genetics | Circadian Rhythm | Hepatocyte Nuclear Factor 3-alpha - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Hyperhomocysteinemia - genetics | Blood Glucose - metabolism | Hyperhomocysteinemia - chemically induced | Betaine-Homocysteine S-Methyltransferase - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Homocysteine | Pharmacy | Neurophysiology | Index Medicus | Abridged Index Medicus | Nuclear receptor | liver disease model | metabolism | circadian regulation
Journal Article