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MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 08/2011, Volume 66, Issue 2, pp. 505 - 519
Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of magnetic resonance imaging and spectroscopy, particularly for low-gamma... 
SELECTIVE EXCITATION | INTERMEDIARY METABOLISM | NMR-SPECTROSCOPY | PULSE DESIGN ALGORITHM | KINETIC-PROPERTIES | dynamic nuclear polarization | imaging | pyruvate | hyperpolarized carbon-13 | SINGLET-STATE | PARAMETER RELATIONS | tumor | IN-VIVO | TREATMENT RESPONSE | metabolism | MR SPECTROSCOPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 12/2014, Volume 72, Issue 6, pp. 1599 - 1609
PurposeTo demonstrate simultaneous hyperpolarization and imaging of three C-13-labeled perfusion MRI contrast agents with dissimilar molecular structures... 
hyperpolarized | EXCITATION | TIMES | permeability | DNP | MOUSE | BLOOD-FLOW | CANCER | perfusion imaging | prostate cancer | C-13 | INJECTION | IN-VIVO | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | UREA
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 05/2008, Volume 59, Issue 5, pp. 1005 - 1013
Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO2 in equilibrium with HCO3-. The aim of this... 
CORONARY-ARTERY DISEASE | cardiac metabolism | VENTRICULAR-FUNCTION | hyperpolarized C-13 | pyruvate | PERFUSED RAT-HEART | COMPUTED-TOMOGRAPHY | REPERFUSED MYOCARDIAL-INFARCTION | NMR | ANGIOGRAPHY | SPECTROSCOPY | ENHANCEMENT | metabolic imaging | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 10/2014, Volume 55, Issue 10, pp. 1567 - 1572
Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity... 
CARCINOMA-CELLS | GLUTAMINE | PET/MR imaging | hyperpolarized C-13 | CHEMOTHERAPY | prostate cancer | PET/MRI | C-13-magnetic resonance | IN-VIVO | LACTATE | prostate | metabolism | RADIOTHERAPY | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
JOURNAL OF PHYSICAL CHEMISTRY C, ISSN 1932-7447, 04/2018, Volume 122, Issue 13, pp. 7432 - 7443
Hyperpolarization via dissolution dynamic nuclear polarization (dDNP) is crucial to significantly increasing the magnetic resonance imaging (MRI) sensitivity,... 
HYPERPOLARIZED C-13 | SPECTRAL DIFFUSION | MATERIALS SCIENCE, MULTIDISCIPLINARY | AQUEOUS PYRUVIC-ACID | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | ALPHA-KETO ACIDS | DISSOLUTION-DNP | NMR | DYNAMIC NUCLEAR-POLARIZATION | METABOLISM | MAGNETIC-RESONANCE | PHOTOCHEMISTRY
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2015, Volume 6
The advent of nuclear spins hyperpolarization techniques represents a breakthrough in the field of medical diagnoses by magnetic resonance imaging. Dynamic... 
HYPERPOLARIZED C-13 | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | LACTATE | PASADENA HYPERPOLARIZATION | SPIN ORDER | MAGNETIC-FIELD | EXCHANGE | CANCER | TUMORS
Journal Article
EUROPEAN RADIOLOGY, ISSN 0938-7994, 01/2006, Volume 16, Issue 1, pp. 57 - 67
The evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical... 
PARA-HYDROGEN | NOBLE-GAS MRI | NUCLEAR-MAGNETIC-RESONANCE | hyperpolarized C-13 | new imaging applications | magnetic resonance imaging (MRI) | IN-VITRO | SPECTROSCOPY | REGIONAL VENTILATION | metabolic imaging | POLARIZATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PERFUSION ASSESSMENT | REAL-TIME
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2018, Volume 115, Issue 10, pp. E2429 - E2436
Placental functions, including transport and metabolism, play essential roles in pregnancy. This study assesses such processes in vivo, from a hyperpolarized... 
DIFFUSION-WEIGHTED MRI | preeclamptic models | FETAL FLUID BALANCE | VIVO | MULTIDISCIPLINARY SCIENCES | pregnancy | WAVE-FORMS | dissolution DNP | RAT MODEL | hyperpolarized C-13 MR | 0.5 T | METABOLISM | placental physiology | UREA TRANSPORT | PART 1 | INTRAUTERINE GROWTH RESTRICTION
Journal Article
NMR IN BIOMEDICINE, ISSN 0952-3480, 05/2018, Volume 31, Issue 5
Measurements of hyperpolarized C-13 label exchange between injected [1-C-13]pyruvate and the endogenous tumor lactate pool can give an apparent first-order... 
CELLS | MRI | NMR-SPECTROSCOPY | hyperpolarized C-13 | pyruvate | CANCER | TRANSPORT | BIOPHYSICS | SPECTROSCOPY | tumor | HYPERPOLARIZED PYRUVATE | MAGNETIC-RESONANCE | metabolism | DIFFUSION | lactate | EXCHANGE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
by Lee, H and Song, JE and Shin, J and Joe, E and Joo, CG and Choi, YS and Song, HT and Kim, DH
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 08/2018, Volume 80, Issue 2, pp. 703 - 710
PurposeTo test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial... 
HEART | EXCITATION | SPECTRAL LOCALIZATION | ACQUISITION | SPICE | hyperpolarized C-13 | pyruvate | partially separable model | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | high resolution spectroscopic imaging | PULSES | EPI
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 10/2009, Volume 106, Issue 43, pp. 18131 - 18136
Metabolic fluxes can serve as specific biomarkers for detecting malignant transformations, tumor progression, and response to microenvironmental changes and... 
PYRUVATE | CARCINOMA CELLS | hyperpolarized NMR | MULTIDISCIPLINARY SCIENCES | FLUX | pyruvate/lactate conversion | FAMILY | breast cancer metabolism | C-13 MAGNETIC-RESONANCE | NMR | SPECTROSCOPY | ERYTHROCYTES | monocarboxylate transporters | IN-VIVO | LACTATE | metabolic fluxes
Journal Article
NMR IN BIOMEDICINE, ISSN 0952-3480, 02/2019, Volume 32, Issue 2
Vorinostat is a histone deacetylase (HDAC) inhibitor that inhibits cell proliferation and induces apoptosis in solid tumors, and is in clinical trials for the... 
PYRUVATE | SUBEROYLANILIDE HYDROXAMIC ACID | IMAGING DATA | ADJUVANT TEMOZOLOMIDE | IN-VITRO | glioblastoma | MAGNETIC-RESONANCE-SPECTROSCOPY | BIOPHYSICS | METABOLISM | SPECTROSCOPY | LACTATE | HDAC inhibitor | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | hyperpolarized C-13 MRSI | HISTONE DEACETYLASE | BRAIN
Journal Article
NEURO-ONCOLOGY, ISSN 1522-8517, 02/2010, Volume 12, Issue 2, pp. 133 - 144
In order to compare in vivo metabolism between malignant gliomas and normal brain, C-13 magnetic resonance (MR) spectroscopic imaging data were acquired from... 
DIAGNOSIS | EXCITATION | PYRUVATE | brain tumor | HYPOXIA | CANCER | CLINICAL NEUROLOGY | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | IN-VIVO | LACTATE | human glioblastoma xenograft | hyperpolarized carbon-13 metabolic imaging | H-1 MR SPECTROSCOPY | dynamic nuclear polarization (DNP) | XENOGRAFTS
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 05/2015, Volume 73, Issue 5, pp. 1726 - 1732
PurposeThere is great potential for real-time investigation of metabolism with MRS and hyperpolarized (HP) C-13 agents. Unfortunately, HP technology has high... 
SYSTEM | hyperpolarized | colon cancer | TO-NOISE RATIO | multiple-mouse | spectroscopy | IN-VIVO | metabolism | throughput | C-13 pyruvate | MULTIPLE-MOUSE MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | multianimal
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 10/2016, Volume 76, Issue 4, pp. 1033 - 1038
Purpose: Chemical shift imaging (CSI) has long been considered the gold standard method for in vivo hyperpolarized C-13 metabolite imaging because of its high... 
hyperpolarized C-13 MRI | compressed sensing | MRI | RECONSTRUCTION | in-vivo MRI | chemical shift imaging (CSI) | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 05/2015, Volume 73, Issue 5, pp. 1713 - 1717
PurposeFast dynamic imaging of hyperpolarized C-13-labeled pyruvate and its downstream metabolites shows great potential for probing metabolic changes in the... 
HEART | PYRUVATE | SPECTRAL-SPATIAL EXCITATION | MRI | multiecho | hyperpolarized C-13 | SEPARATION | spectral-spatial | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | cardiac metabolic imaging | PULSES
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 11/2010, Volume 64, Issue 5, pp. 1323 - 1331
Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a method to non-invasively study real-time metabolic rocesses occurring... 
RF pulses | cardiac metabolism | pyruvate | OFF-RESONANCE CORRECTION | hyperpolarized 13C | METABOLISM | SPECTROSCOPY | IN-VIVO | MAGNETIC-RESONANCE | bicarbonate | metabolic imaging | pulse sequences | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
JOURNAL OF MAGNETIC RESONANCE, ISSN 1090-7807, 01/2010, Volume 202, Issue 1, pp. 85 - 92
Purpose: To investigate metabolic exchange between C-13(1)-pyruvate, C-13(1)-lactate, and C-13(1)-alanine in preclinical model systems using kinetic modeling... 
EPSI | CELLS | TRAMP | Lactate | BIOCHEMICAL RESEARCH METHODS | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | Pyruvate | Dynamic spectroscopy | Metabolism | Modeling | TUMORS | DEHYDROGENASE | NMR | C-13 | SPECTROSCOPY | ALANINE | PROSTATE-CANCER | Hyperpolarized C-13
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2017, Volume 114, Issue 33, pp. E6982 - E6991
Proinflammatory mononuclear phagocytes (MPs) play a crucial role in the progression of multiple sclerosis (MS) and other neurodegenerative diseases. Despite... 
WHITE-MATTER | multiple sclerosis | MULTIDISCIPLINARY SCIENCES | hyperpolarized C-13 MR spectroscopy | CEREBROSPINAL-FLUID | PYRUVATE-DEHYDROGENASE KINASES | macrophages | SPECTROSCOPY | neuroinflammation | MICROGLIA | INFLAMMATION | MOUSE MODEL | REMYELINATION | metabolism | CUPRIZONE-INDUCED DEMYELINATION | PIVOTAL ROLE
Journal Article
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