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hypothiocyanous acid (53) 53
index medicus (47) 47
biochemistry & molecular biology (42) 42
myeloperoxidase (42) 42
hypochlorous acid (39) 39
humans (29) 29
animals (25) 25
peroxidase - metabolism (24) 24
thiocyanates - metabolism (23) 23
thiocyanate (21) 21
hydrogen-peroxide (20) 20
oxidation-reduction (19) 19
thiocyanates - pharmacology (18) 18
absolute rate constants (16) 16
hypobromous acid (15) 15
peroxidase (15) 15
eosinophil peroxidase (14) 14
hypochlorous acid - metabolism (14) 14
protein oxidation (14) 14
hydrogen peroxide (13) 13
oxidants - metabolism (13) 13
thiols (13) 13
atherosclerosis (12) 12
endocrinology & metabolism (12) 12
enzymes (12) 12
kinetics (12) 12
myeloperoxidase-derived oxidants (12) 12
oxidation (12) 12
inflammation (11) 11
cell line (10) 10
free radicals (10) 10
low-density-lipoprotein (10) 10
oxidative stress (10) 10
hypochlorous acid - pharmacology (9) 9
male (9) 9
proteins (9) 9
sulfhydryl compounds - metabolism (9) 9
thiocyanates - chemistry (9) 9
young-people (9) 9
catalyzed oxidation (8) 8
cells, cultured (8) 8
glutathione - metabolism (8) 8
human atherosclerotic lesions (8) 8
lactoperoxidase (8) 8
hypochlorous acid - chemistry (7) 7
mice (7) 7
mpo, myeloperoxidase (7) 7
oxidation-reduction reaction (7) 7
thiol oxidation (7) 7
amino-acids (6) 6
apoptosis (6) 6
endothelial cells - metabolism (6) 6
endothelium (6) 6
health aspects (6) 6
hydrogen peroxide - metabolism (6) 6
oxidants (6) 6
peroxidase - chemistry (6) 6
smoking (6) 6
analysis (5) 5
endothelial cells - drug effects (5) 5
female (5) 5
hydrogen-ion concentration (5) 5
hypothiocyanite (5) 5
macrophages (5) 5
oxidants - chemistry (5) 5
oxidants - pharmacology (5) 5
oxidation-reduction - drug effects (5) 5
physiological aspects (5) 5
protein (5) 5
rats (5) 5
research article (5) 5
signal transduction (5) 5
acids (4) 4
bromates - metabolism (4) 4
calcium (4) 4
cell death (4) 4
cells (4) 4
cysteine (4) 4
cystic-fibrosis (4) 4
extracellular matrix (4) 4
hocl, hypochlorous acid (4) 4
hoscn, hypothiocyanous acid (4) 4
host-defense (4) 4
hypothiocyanous acid hoscn (4) 4
lactoperoxidase-catalyzed oxidation (4) 4
macrophages - drug effects (4) 4
macrophages - metabolism (4) 4
medicine (4) 4
molecular structure (4) 4
nf-kappa-b (4) 4
nitric-oxide (4) 4
nitrogen-centered radicals (4) 4
sulfhydryl compounds - chemistry (4) 4
superoxide (4) 4
thioredoxin-disulfide reductase - metabolism (4) 4
tnb, 5-thio-2-nitrobenzoic acid (4) 4
albumin (3) 3
amino acids (3) 3
anti-bacterial agents - pharmacology (3) 3
apolipoprotein-a-i (3) 3
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Biochemical journal, ISSN 0264-6021, 2013, Volume 449, Issue 2, pp. 531 - 542
.... Although it has been established that HOCI (hypochlorous acid) produced by MPO targets apoA-I (apolipoprotein... 
Myeloperoxidase | Protein oxidation | High-density lipoprotein | Atherosclerosis | Hypothiocyanous acid | Cholesterol efflux | atherosclerosis | PROTEIN | SITE-SPECIFIC OXIDATION | CATALYZED OXIDATION | high-density lipoprotein | BIOCHEMISTRY & MOLECULAR BIOLOGY | hypothiocyanous acid | ABCA1-DEPENDENT CHOLESTEROL TRANSPORT | myeloperoxidase | HUMAN ATHEROSCLEROTIC LESIONS | METHIONINE OXIDATION | THIOCYANATE LEVELS | protein oxidation | YOUNG-PEOPLE | cholesterol efflux | CORONARY-ARTERY-DISEASE | CHLORINATION | Apolipoprotein A-I - pharmacology | Endothelium, Vascular - cytology | Thiocyanates - metabolism | Humans | Lipoproteins, HDL - metabolism | Oxidants - metabolism | Molecular Sequence Data | Endothelium, Vascular - drug effects | Male | Lipoproteins, HDL - pharmacology | Flow Cytometry | Peptides - metabolism | Oxidation-Reduction - drug effects | Thiocyanates - pharmacology | Female | Biological Transport - drug effects | Apolipoprotein A-I - chemistry | Amino Acid Sequence | Cell Line | Peptides - chemistry | Cells, Cultured | E-Selectin - metabolism | Apolipoprotein A-I - metabolism | Macrophages - cytology | Cholesterol - metabolism | Peptides - pharmacology | Hypochlorous Acid - pharmacology | Intercellular Adhesion Molecule-1 - metabolism | Macrophages - metabolism | Endothelium, Vascular - metabolism | Macrophages - drug effects | Vascular Cell Adhesion Molecule-1 - metabolism | Hypochlorous Acid - metabolism | Peroxidase - metabolism
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 305 - 316
.... MPO catalyses the oxidation of Cl-, Br- and SCN- by H2O2 to generate the powerful oxidants hypochlorous acid (HOCI), hypobromous acid (HOBr... 
Glutathione peroxidase | Eosinophil peroxidase | Myeloperoxidase (MPO) | Thiocyanate | Selenium | Hypothiocyanous acid (HOSCN) | Thioredoxin reductase | eosinophil peroxidase | MAMMALIAN THIOREDOXIN | PROTEIN | HYPOBROMOUS ACID | PEROXYNITRITE | HYPOCHLOROUS ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUTATHIONE-PEROXIDASE | THIOCYANATE ION | thiocyanate | thioredoxin reductase | myeloperoxidase (MPO) | selenium | EBSELEN | hypothiocyanous acid (HOSCN) | glutathione peroxidase | PEROXIDASE-LIKE ACTIVITY | Glutathione Peroxidase - metabolism | Selenium - chemistry | Thiocyanates - metabolism | Oxidation-Reduction | Humans | Amino Acids - chemistry | Male | Erythrocytes - chemistry | Peroxidase - chemistry | Thiocyanates - chemistry | Amino Acids - metabolism | Thioredoxin-Disulfide Reductase - metabolism | Erythrocytes - metabolism | Molecular Structure | Kinetics | Peroxidase - metabolism | UPLC, ultra-performance liquid chromatography | RBC, red blood cell | t-BOOH, t-butyl hydroperoxide | Fmoc, fluoren-9-ylmethoxycarbonyl | MetSeO, methionine selenoxide | MPO, myeloperoxidase | SeMet, selenomethionine | TNB, 5-thio-2-nitrobenzoic acid | DTT, dithiothreitol | Sec, selenocysteine | GR, glutathione reductase | TrxR, thioredoxin reductase | DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid) | GPx, glutathione peroxidase | LPO, lactoperoxidase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2010, Volume 430, Issue 1, pp. 161 - 169
MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by hydrogen peroxide to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN... 
Cell signalling | Thiol | p38 | Protein tyrosine phosphatase | Mitogen-activated protein kinase (MAPK) | Myeloperoxidase | Hypothiocyanous acid (HOSCN) | thiol | HYPOBROMOUS ACID | SULFENIC ACID | protein tyrosine phosphatase | HUMAN SERUM-ALBUMIN | HYPOCHLOROUS ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | SITE CYSTEINE | THIOCYANATE ION | HYPOTHIOCYANOUS ACID | myeloperoxidase | cell signalling | RATE CONSTANTS | YOUNG-PEOPLE | HYDROGEN-PEROXIDE | hypothiocyanous acid (HOSCN) | Cell Line | Thiocyanates - metabolism | Phosphorylation | Antioxidants - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Transcription Factors - biosynthesis | Antioxidants - pharmacology | MAP Kinase Signaling System | Protein Tyrosine Phosphatases - antagonists & inhibitors | Macrophages - metabolism | Animals | Mitogen-Activated Protein Kinase 14 - metabolism | Thiocyanates - pharmacology | Macrophages - drug effects | Mice | Apoptosis | Mitogen-Activated Protein Kinase 1 - metabolism | Peroxidase - metabolism | Protein kinase A | Cysteine | Hydrogen peroxide | Thiols | Hypochlorous acid | sulfenic acid | Oxidizing agents | Macrophages | Western blotting | Signal transduction | Chloride | Oxidants | Phosphoproteins | Oxidation | Peroxidase | Catalysis | Dithiothreitol | Adducts | Enzymes | bromides | Leukocytes (eosinophilic) | protein thiols | Extracellular signal-regulated kinase | Data processing | Ions | MAP kinase | Plasma levels | Protein-tyrosine-phosphatase | MKK, MAPK kinase | MPO, myeloperoxidase | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | ECL, enhanced chemiluminescence | HOCl, hypochlorous acid | HOSCN, hypothiocyanous acid | HOBr, hypobromous acid | LPO, lactoperoxidase | MAPK, mitogen-activated protein kinase | PTP, protein tyrosine phosphatase
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2006, Volume 399, Issue 1, pp. 161 - 168
GSH is rapidly oxidized by HOCl (hypochlorous acid), which is produced physiologically by the neutrophil enzyme myeloperoxidase... 
Biomarker | Peroxynitrite | Glutathione sulfonamide | Hypochlorous acid | Dehydroglutathione | Myeloperoxidase | Glutathione | hypochlorous acid | peroxynitrite | CATALYZED OXIDATION | glutathione | BIOCHEMISTRY & MOLECULAR BIOLOGY | REDUCED GLUTATHIONE | myeloperoxidase | biomarker | ACID-ASSISTED OXIDATION | AMINO-ACIDS | 3-CHLOROTYROSINE | glutathione sulfonamide | HYDROGEN-PEROXIDE | dehydroglutathione | CARBON-DIOXIDE | RADICAL-ANION | CHLORIDE | Oxidants - chemistry | Glutathione - analogs & derivatives | Oxidation-Reduction | Glutathione - metabolism | Oxidants - metabolism | Sulfones - metabolism | Glutathione Disulfide - metabolism | Peroxidase - chemistry | Glutathione - analysis | Sulfones - chemistry | Glutathione - chemistry | Molecular Structure | Glutathione Disulfide - chemistry | Hypochlorous Acid - chemistry | Sulfones - analysis | Chromatography, Liquid - methods | Mass Spectrometry - methods | Peroxidase - metabolism | NEM, N-ethylmaleimide, NH2Cl, ammonia monochloramine | TauNCl, taurine chloramine | LC–MS | MPO, myeloperoxidase | TNB, 5-thio-2-nitrobenzoic acid | HOI, hypoiodous acid | HOCl, hypochlorous acid | HOSCN, hypothiocyanous acid | DTNB, 5,5-dithiobis-2-nitrobenzoic acid | LC–ESI–MS, liquid chromatography–electrospray ionization–MS | HOBr, hypobromous acid | MS, liquid chromatography-tandem MS | GSA, glutathione sulfonamide
Journal Article
Free Radical Research, ISSN 1071-5762, 01/2009, Volume 43, Issue 12, pp. 1147 - 1158
Journal Article