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Journal of Experimental Medicine, ISSN 0022-1007, 12/2012, Volume 209, Issue 13, pp. 2441 - 2453
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8(+) cytolytic T cell (CTL) fate. In some cell systems,... 
MAMMALIAN TARGET | RAPAMYCIN | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | L-SELECTIN | ACTIVATION | KINASE | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Phosphatidylinositol 3-Kinases - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Cell Movement - physiology | Hypoxia-Inducible Factor 1 - genetics | Mechanistic Target of Rapamycin Complex 1 | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Receptors, Antigen, T-Cell - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphatidylinositol 3-Kinases - genetics | Animals | Proteins - metabolism | Glucose - metabolism | Glycolysis | Interleukin-2 - pharmacology | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Chemokines - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 19857 - 19857
Through both gain-and loss-of-TTF-1 expression strategies, we show that TTF-1 positively regulates vascular endothelial growth factor (VEGF) and that the VEGF... 
SURVIVAL | MORPHOGENESIS | EPITHELIAL-CELLS | GM-CSF | VEGF | MULTIDISCIPLINARY SCIENCES | LUNG ADENOCARCINOMA | GENE-EXPRESSION | NKX2-1 | CANCER | ENDOTHELIAL GROWTH-FACTOR | Exosomes - metabolism | Angiogenic Proteins - genetics | Neovascularization, Physiologic - drug effects | Thyroid Nuclear Factor 1 | TOR Serine-Threonine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Culture Media, Conditioned - pharmacology | Lung Neoplasms - pathology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - immunology | Vascular Endothelial Growth Factor A - genetics | Cell Hypoxia | Transcription Factors - secretion | Nuclear Proteins - secretion | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Lung Neoplasms - blood supply | A549 Cells | Promoter Regions, Genetic | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Cell Survival | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Indoles - toxicity | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Vascular Endothelial Growth Factor A - analysis | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Blotting, Western | Antibodies - pharmacology | Transcription Factors - metabolism | Up-Regulation - drug effects | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Pyrroles - toxicity | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Angiogenic Proteins - metabolism | RNA, Small Interfering - metabolism | TOR protein | Statistical analysis | Granulocyte-macrophage colony-stimulating factor | Lung | Lung cancer | Media | Rapamycin | Secretome | Exosomes | Macrophages | Angiogenesis | Hypoxia | Colony-stimulating factor | Vascular endothelial growth factor | Thyroid transcription factor 1 | Thyroid | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 29, pp. 21197 - 21207
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2003, Volume 95, Issue 7, pp. 516 - 525
Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells able to survive and grow under hypoxic... 
Intercellular Signaling Peptides and Proteins - analysis | Neoplasms - metabolism | Vascular Endothelial Growth Factor A | G(M1) Ganglioside - analysis | Vascular Endothelial Growth Factors | Humans | Immunoblotting | Male | Transplantation, Heterologous | Hypoxia-Inducible Factor 1, alpha Subunit | Transcription Factors - drug effects | Endothelial Growth Factors - analysis | Carcinoma, Hepatocellular - drug therapy | Female | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Carcinoma - drug therapy | Cell Hypoxia - drug effects | Enzyme-Linked Immunosorbent Assay | Liver Neoplasms - drug therapy | Angiogenesis Inhibitors - pharmacology | Platelet Endothelial Cell Adhesion Molecule-1 - analysis | Rats | Neoplasms - blood supply | Uterine Cervical Neoplasms - drug therapy | Stomach Neoplasms - drug therapy | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Precipitin Tests | Neoplasms - drug therapy | Indazoles - pharmacology | Transcription Factors - metabolism | Culture Media, Conditioned | Animals | Lymphokines - analysis | Neuroblastoma - drug therapy | Killer Cells, Natural - drug effects | Mice | Neovascularization, Pathologic - metabolism | Killer Cells, Natural - metabolism | Kidney Neoplasms - drug therapy | Antimitotic agents | Antineoplastic agents | Evaluation | Drug therapy | Medical treatment | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17462 - 17467
Both preclinical and clinical studies suggest that brief cycles of ischemia and reperfusion in the arm or leg may protect the heart against injury following... 
Heart | Femoral artery | Phosphorylation | Messenger RNA | Reperfusion | Ischemia | Genes | Antibodies | Hypoxia | Ischemic preconditioning | Myocardial infarction | Cardioprotection | Cardiac surgery | Coronary heart disease | ARTERY-BYPASS SURGERY | COACTIVATOR | PROTECTION | LIMB ISCHEMIA | MULTIDISCIPLINARY SCIENCES | myocardial infarction | REPERFUSION INJURY | KINASE | FACTOR-I | HIF-1 | INTERMITTENT HYPOXIA | cardioprotection | cardiac surgery | coronary heart disease | Myocardial Infarction - genetics | Interleukin-10 - blood | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Immunoblotting | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia-Inducible Factor 1 - genetics | Cell Hypoxia | Myoblasts, Skeletal - cytology | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myocardium - metabolism | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Myoblasts, Skeletal - metabolism | Acriflavine - pharmacology | Cell Line | Aryl Hydrocarbon Receptor Nuclear Translocator - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Myocardium - pathology | Myocardial Infarction - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Interleukin-10 - genetics | Protein Binding | Ischemic Preconditioning, Myocardial - methods | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Myocardial Infarction - prevention & control | Myoblasts, Skeletal - drug effects | Hypoxia-Inducible Factor 1 - antagonists & inhibitors | Physiological aspects | Heart attack | Plasma | Chromatin | Heart attacks | Cytokines | Coronary vessels | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43543 - 43556
Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the alpha 2... 
CANCER GROWTH | COLON CARCINOMA-CELLS | DOMAIN-III | ANGIOSTATIC ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERLECAN PROTEIN CORE | VEGF RECEPTOR-2 | HEPARAN-SULFATE PROTEOGLYCAN | BASEMENT-MEMBRANE PROTEOGLYCANS | TUMOR-GROWTH | ALPHA-2-BETA-1 INTEGRIN | Protein Kinase C - genetics | MAP Kinase Signaling System - physiology | Human Umbilical Vein Endothelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Active Transport, Cell Nucleus - physiology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Proto-Oncogene Proteins c-akt - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Cell Nucleus - metabolism | MAP Kinase Kinase 4 - metabolism | TOR Serine-Threonine Kinases - genetics | Heparan Sulfate Proteoglycans - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Kinase C - metabolism | Swine | Human Umbilical Vein Endothelial Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Peptide Fragments - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | NFATC Transcription Factors - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Neovascularization, Physiologic - physiology | Transcription, Genetic - physiology | Animals | Cell Nucleus - genetics | Heparan Sulfate Proteoglycans - metabolism | MAP Kinase Kinase 4 - genetics | NFATC Transcription Factors - genetics | Index Medicus | Proteoglycan | Angiogenesis | Vascular Endothelial Growth Factor (VEGF) | AP1 | VEGF Receptor 2 | Vascular Biology | Calcineurin | Perlecan | Glycobiology and Extracellular Matrices | Endothelial Cell | NFAT1
Journal Article
Journal Article