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Molecular Pharmacology, ISSN 0026-895X, 11/2006, Volume 70, Issue 5, pp. 1469 - 1480
Journal Article
by Wang, D and Zhang, J and Lu, YP and Luo, QQ and Zhu, L
IUBMB LIFE, ISSN 1521-6543, 09/2016, Volume 68, Issue 9, pp. 748 - 755
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis. Under hypoxia, the active HIF1- subunits are mainly regulated through increased... 
CELLS | MITOCHONDRIAL BIOGENESIS | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | gene transcription regulation | nuclear respiratory factor-1 | FACTOR-1-ALPHA | hypoxia-inducible factor 1 | HIF-1-ALPHA | NF-KAPPA-B | TRANSCRIPTIONAL REGULATION | EXPRESSION | Analysis | Luciferase | Genetic transcription
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 03/2005, Volume 111, Issue 8, pp. 1054 - 1062
Background - Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular... 
Angiogenesis | Angiomatosis, bacillary | Hypoxia | Bartonella henselae | HIF-1 protein | hypoxia | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | angiogenesis | FACTOR EXPRESSION | angiomatosis, bacillary | MESSENGER-RNA STABILITY | BARTONELLA-HENSELAE | FACTOR 1-ALPHA | KAPOSIS-SARCOMA | CELL RESPONSE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | ENDOTHELIAL GROWTH-FACTOR | Endothelium, Vascular - cytology | Macrophages - chemistry | Cell Hypoxia - physiology | Humans | HeLa Cells - metabolism | Histiocytes - pathology | Bartonella henselae - isolation & purification | Hypoxia-Inducible Factor 1, alpha Subunit | DNA-Binding Proteins - metabolism | Endothelial Cells - microbiology | Histiocytes - chemistry | Adenosine Triphosphate - metabolism | Up-Regulation - physiology | Transcription Factors - immunology | Umbilical Veins - cytology | Neovascularization, Pathologic - microbiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Bartonella henselae - pathogenicity | DNA-Binding Proteins - immunology | Hypoxia-Inducible Factor 1 | Macrophages - pathology | Nuclear Proteins - metabolism | HeLa Cells - microbiology | Nuclear Proteins - immunology | Immunohistochemistry - methods | Transcription Factors - metabolism | HeLa Cells - chemistry | Fimbriae, Bacterial - physiology | Nuclear Proteins - physiology | Angiomatosis, Bacillary - pathology | Fimbriae, Bacterial - metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 36, Issue 11, pp. 2158 - 2162
OBJECTIVE—The purpose of this study was to determine the role of smooth muscle cell–derived hypoxia-inducible factor-1α (Hif-1α) in the pathogenesis of aortic... 
aneurysm | hypoxia | angiotensin II | smooth muscle | vascular remodeling | elastin | extracellular matrix | WALL | ANGIOTENSIN-II | INACTIVATION | GENE | DISSECTION | LEADS | PERIPHERAL VASCULAR DISEASE | MICE | HIF-1-ALPHA | HEMATOLOGY | Aminopropionitrile | Aortic Aneurysm, Abdominal - chemically induced | Vascular Remodeling | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Male | Aortic Aneurysm, Thoracic - chemically induced | Aortic Aneurysm, Abdominal - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Elastic Tissue - metabolism | Aortic Aneurysm, Thoracic - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tropoelastin - metabolism | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Genetic Predisposition to Disease | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Aorta, Thoracic - metabolism | Mice, Knockout | Elastic Tissue - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Tropoelastin - genetics | Aortic Aneurysm, Thoracic - metabolism | Protein-Lysine 6-Oxidase - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112470
Celastrol, a tripterine derived from the traditional Chinese medicine plant Tripterygium wilfordii Hook F. ("Thunder of God Vine''), has been reported to have... 
HUMAN PROSTATE-CANCER | ACTIVATION | BNIP3 | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | AUTOPHAGY | HIF-1-ALPHA | INDUCTION | UP-REGULATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Neoplasms - metabolism | Cell Line | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Humans | Vascular Endothelial Growth Factor A - genetics | Hep G2 Cells | Cell Nucleus - metabolism | Glucose Transporter Type 1 - genetics | MCF-7 Cells | Neoplasms - genetics | Signal Transduction - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Proto-Oncogene Proteins c-akt - metabolism | Hsp90 protein | Transcription factors | Hypoxia-inducible factor 1 | Toxicity | Liver | Mental health | Science | Cytotoxicity | AKT protein | Activation | Biochemistry | Metastasis | Kinases | Autophagy | Stomach cancer | Accumulation | Proteins | Angiogenesis | Signal transduction | Cell growth | Rodents | Transcription activation | Cell cycle | Inhibition | Vascular endothelial growth factor | Hypoxia-inducible factors | Medicinal plants | Medical research | Neurodegenerative diseases | Tumor cells | Traditional Chinese medicine | Protein biosynthesis | JNK protein | Breast cancer | Tumor cell lines | Metabolism | Gene expression | BNIP3 protein | Neurological diseases | Signaling | Hepatocytes | Protein synthesis | Hypoxia | Molecular biology | Phagocytosis | Apoptosis | Cancer
Journal Article
Clinical and Experimental Metastasis, ISSN 0262-0898, 02/2018, Volume 35, Issue 1-2, pp. 37 - 51
HIF-1 alpha is a transcriptional regulator that functions in the adaptation of cells to hypoxic conditions; it strongly impacts the prognosis of patients with... 
Pancreatic adenocarcinoma | Ascorbate | Metastasis | Hypoxia inducible factor | Vitamin C | CELLS | ANGIOGENESIS | INDUCTION | BREAST-CANCER | HIF-2-ALPHA | ONCOLOGY | DEGRADATION | INDUCED CYTOTOXICITY | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | FACTOR-I ALPHA
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2007, Volume 6, Issue 1, pp. 220 - 226
Chrysin is a natural flavonoid and has been shown recently to have anticancer effects. However, the mechanisms that chrysin inhibits cancers are not well... 
Angiogenesis | Hypoxia-inducible factor 1 | Chrysin | Vascular endothelial growth factor | Cancer | HUMAN PROSTATE-CANCER | FACTOR 1-ALPHA | HIF-1-ALPHA PROTEIN | IN-VITRO | ONCOLOGY | CELL-PROLIFERATION | TRANSCRIPTION FACTOR | TUMOR-GROWTH | FACTOR VEGF EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | FACTOR-ALPHA
Journal Article
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2014, Volume 73, Issue 2, pp. 343 - 348
Journal Article