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Pharmacology and Therapeutics, ISSN 0163-7258, 03/2018, Volume 183, pp. 127 - 136
Preclinical drug screens are not based on human physiology, possibly complicating predictions on cardiotoxicity. Drug screening can be humanised with assays... 
Arrhythmia | iPSC-CMs | Safety pharmacology | IK1 | Cardiac electrophysiology | CiPA | IPSC-CMs | Pharmacology (medical) | Pharmacology | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 10/2019, Volume 597, Issue 20, pp. 5047 - 5048
Journal Article
Toxicological Sciences, ISSN 1096-6080, 07/2019, Volume 170, Issue 1, pp. 167 - 179
Abstract Cardiac side-effects are one of the major reasons for failure of drugs during preclinical development. Induced pluripotent stem cell-derived... 
LATE SODIUM CURRENT | pacing | iPSC-CMs | CiPA | optogenetics | MEA | RISK | PROLONGATION | AGENTS | TOXICOLOGY | proarrhythmia | ANTIARRHYTHMIC-DRUGS
Journal Article
Progress in Biophysics and Molecular Biology, ISSN 0079-6107, 12/2019, Volume 149, pp. 86 - 98
The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current I . I... 
hERG | Safety pharmacology | iPSC-CMs | Isoforms | Biophysics | Molecular Biology
Journal Article
Toxicological Sciences, ISSN 1096-6080, 02/2019, Volume 167, Issue 2, pp. 360 - 374
Abstract Numerous drugs have the potential to prolong the QT interval and may cause accidental cardiac arrest (torsades de pointes [TdP]). Women are at a... 
INTERVAL | STIMULATION | RISK | CELL-DERIVED CARDIOMYOCYTES | I-KS | WOMEN | ELECTROPHYSIOLOGY | GENDER | TOXICOLOGY | HEALTH | drug-induced QT prolongation and torsades de pointes | sex differences | DURATION | human iPSC-CMs
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1733, pp. 127 - 136
Myocardial infarction is the leading cause of morbidity and mortality worldwide. Recent advances in cardiac regenerative therapy have allowed for novel... 
Heart | microRNA | Exosomes | iPSC-CMs | Stem cell | Exosomes - metabolism | Cell Differentiation - genetics | Regeneration | Myocytes, Cardiac - cytology | Humans | Myocardium - metabolism | Myocytes, Cardiac - metabolism | Culture Media, Conditioned - pharmacology | Data Mining | MicroRNAs - genetics | Induced Pluripotent Stem Cells - cytology
Journal Article
Toxicological Sciences, ISSN 1096-6080, 03/2017, Volume 156, Issue 1, pp. 25 - 38
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-induced cardiotoxicity in... 
Drug-induced proarrhythmia | iPSC-CMs | Batch variations | ACTION-POTENTIALS | TORSADES-DE-POINTES | DOFETILIDE | CONTRACTILITY | drug-induced proarrhythmia | PROLONGATION | LONG-QT SYNDROME | VENTRICULAR MYOCYTES | MATURATION | IMPEDANCE | TOXICOLOGY | batch variations | RISK-ASSESSMENT | Arrhythmias, Cardiac - chemically induced | Drug Evaluation, Preclinical - economics | Calcium Channel Blockers - adverse effects | Anti-Arrhythmia Agents - pharmacology | Humans | Potassium Channel Blockers - antagonists & inhibitors | Toxicity Tests, Acute - methods | Potassium Channel Blockers - adverse effects | Arrhythmias, Cardiac - pathology | Shal Potassium Channels - genetics | Kv1.5 Potassium Channel - genetics | Toxicity Tests, Acute - economics | Induced Pluripotent Stem Cells - cytology | Voltage-Gated Sodium Channel Blockers - adverse effects | Potassium Channel Blockers - pharmacology | Induced Pluripotent Stem Cells - metabolism | Arrhythmias, Cardiac - metabolism | Induced Pluripotent Stem Cells - pathology | Cell Line | Drug Evaluation, Preclinical - methods | Reproducibility of Results | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Antioxidants - pharmacology | Calcium Channel Blockers - pharmacology | Gene Expression Regulation - drug effects | Myocytes, Cardiac - pathology | Shal Potassium Channels - metabolism | Calcium Channels, L-Type - genetics | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Kv1.5 Potassium Channel - metabolism | Calcium Channel Blockers - chemistry | Myocytes, Cardiac - metabolism | Voltage-Gated Sodium Channel Blockers - pharmacology | Calcium Channels, L-Type - metabolism | Kinetics | Electrophysiological Phenomena - drug effects
Journal Article
Journal of cardiovascular development and disease, ISSN 2308-3425, 05/2018, Volume 5, Issue 2, p. 25
3′-5′-cyclic adenosine monophosphate (cAMP) is a signaling messenger produced in response to the stimulation of cellular receptors, and has a myriad of... 
development | iPSC-CMs | ventricle | FRET | T-tubule | phosphodiesterase | atrial | cAMP | caveolae
Journal Article
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