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immune tolerance - immunology (4) 4
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interleukin 10 (4) 4
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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 607 - 620.e15
Background Patients with heterozygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experience autoimmunity and lymphoid... 
Allergy and Immunology | PHTS | autoimmunity | immunologic synapse | PTEN | Regulatory T cells | phosphatases | phosphoinositide 3-kinase | PH domain leucine-rich repeat protein phosphatase | HOMEOSTASIS | PROTEIN | KINASE | PROMOTER MUTATIONS | RILEY-RUVALCABA-SYNDROME | IMMUNOLOGY | ALLERGY | RESOLUTION MELTING ANALYSIS | AKT-MTOR | LYMPHOID HYPERPLASIA | EXPRESSION | Autoimmunity | Humans | Hyperplasia | Middle Aged | Phosphoprotein Phosphatases - metabolism | Male | Immunological Synapses - metabolism | Young Adult | Forkhead Transcription Factors - metabolism | Membrane Potential, Mitochondrial | Adult | Child | Hamartoma Syndrome, Multiple - immunology | Lymphocyte Subsets - physiology | T-Lymphocytes, Regulatory - physiology | PTEN Phosphohydrolase - genetics | Hamartoma Syndrome, Multiple - genetics | Signal Transduction | Cells, Cultured | B-Lymphocytes - physiology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Mutation - genetics | Protein Transport | Adolescent | Protein Binding | Aged | Medical colleges | Care and treatment | Phosphatases | Gene mutations | Analysis | Children's hospitals | Genomics | Medical genetics | Genetic research | T cells | Tumors | Hamartoma | Proteins | Blood & organ donations | Hematology | Biopsy | Lymphocytes | T cell receptors | Mutation | Kinases | Metabolism | Phosphatase | FACS, Fluorescence-activated cell sorting | TCR, T-cell receptor | mTOR complex 1 | NHERF1, Na+ | H+-exchanger 3 regulatory factor | MALT, Mucosa-associated lymphoid tissue | APC, Allophycocyanin | SHIP, Src homology domain 2–containing inositol phosphatase | HRM, High Resolution DNA Melting | FITC, Fluorescein isothiocyanate | PP2A, Protein phosphatase 2A | mTORC1, PTEN | PHTS, PTEN hamartoma tumor syndrome | PerCP, Peridinin-chlorophyll-protein complex | CS, Cowden syndrome | POD, Peroxidase | Tmem, Memory T | TMRE, Tetramethylrhodamine-ethylester | Immune Deficiencies, Infection, and Systemic Immune Disorders | IC50, Inhibitory concentration of 50 | CTLA-4, Cytotoxic T lymphocyte–associated antigen 4 | PHLPP, PH domain leucine-rich repeat protein phosphatase | AKT | DLG1, Scaffold protein discs, large homolog 1 | FOXP3, Forkhead box P3 | ICAM-1, Intercellular adhesion molecule 1 | iTreg, In vitro induced regulatory T | PE, Phycoerythrin | PI3K, Phosphoinositide 3-kinase | mTOR, Mammalian target of rapamycin | PTEN, Phosphatase and tensin homologue deleted on chromosome 10
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 02/2019, Volume 26, Issue 7, pp. 1869 - 1879.e3
Journal Article
Cellular and Molecular Immunology, ISSN 1672-7681, 03/2012, Volume 9, Issue 2, pp. 136 - 146
Journal Article
Molecular Immunology, ISSN 0161-5890, 11/2018, Volume 103, pp. 251 - 256
Previous studies demonstrate that the number of induced regulatory T cells (iTregs) increases in aged mice. However, these studies do not characterize iTregs... 
IRI | iTregs | Foxp3 | Age | ACTIVATION | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALS | IMMUNOLOGY | HEPATIC ISCHEMIA/REPERFUSION INJURY | PATHOGENESIS | KUPFFER CELLS | MICE | INFLAMMATORY RESPONSE | Medical research | Liver diseases | Interleukins | Analysis | Immunotherapy | Liver | Medicine, Experimental | Interferon | Biological response modifiers | T cells | Reperfusion injury
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4290 - 4300
Purpose: We study CD38 levels in immunosuppressive CD4(+)CD25(high)Foxp3(+) regulatory T cells (Treg) and further define immunomodulating effects of a... 
IN-VITRO | MICROENVIRONMENT | ONCOLOGY | IMMUNOTHERAPY | LENALIDOMIDE | DARATUMUMAB MONOTHERAPY | PERIPHERAL-BLOOD | PROLIFERATION | ANTITUMOR-ACTIVITY | CARCINOMA | CANCER | Leukocytes, Mononuclear - drug effects | Immunosuppression - methods | Cell Count | Humans | Interleukin-10 - blood | Multiple Myeloma - immunology | Immunologic Memory - drug effects | Transforming Growth Factor beta - blood | ADP-ribosyl Cyclase 1 - blood | T-Lymphocytes, Regulatory - immunology | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | T-Lymphocytes, Regulatory - drug effects | Antibodies, Monoclonal - administration & dosage | Immunosuppressive Agents - immunology | ADP-ribosyl Cyclase 1 - immunology | Cell Line, Tumor | Female | Gene Expression Regulation, Neoplastic - drug effects | Immunosuppressive Agents - administration & dosage | Immune Tolerance - drug effects | Multiple Myeloma - blood | Plasma | CD8 antigen | Multiple myeloma | Bone marrow transplantation | Recovery of function | Leukocytes (mononuclear) | Lymphocytes T | Immunosuppressive agents | Killer cells | Lymphocytes | CD38 antigen | Interleukin 1 | Bone marrow | Peripheral blood mononuclear cells | CD25 antigen | Foxp3 protein | Inhibition | Natural killer cells | Immunoregulation | Patients | CD4 antigen | Immunosuppression | Experimental design | Interleukin 10 | Lysis | Monoclonal antibodies | Health risk assessment | Cancer | IFNγ | CD107a | bone marrow stromal cells (BMSCs) | natural occurring Tregs (nTregs) | regulatory T (Treg) | CD38 | Isatuximab (Isa) (SAR650984) | PD1 | multiple myeloma (MM) | conventional T (Tcon) | tumor-induced Treg (iTregs)
Journal Article
Bone Marrow Transplantation, ISSN 0268-3369, 12/2018, Volume 53, Issue 12, pp. 1568 - 1577
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 06/2017, Volume 8, p. 748
Regulatory T cells (Tregs) are critical for the maintenance of immune homeostasis and self-tolerance and can be therapeutically used for prevention of unwanted... 
Allo-iTregs | Demethylation | Transplantation | Foxp3 | Vitamin C | DENDRITIC CELLS | 5-METHYLCYTOSINE | vitamin C | CONVERSION | IMMUNOLOGY | VERSUS-HOST-DISEASE | EPIGENETIC CHANGES | DNA DEMETHYLATION | demethylation | allo-iTregs | transplantation | IN-VIVO | GENE-EXPRESSION | 5-HYDROXYMETHYLCYTOSINE | MODULATION
Journal Article