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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2017, Volume 8, Issue 5, pp. 486 - 491
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure... 
Epacadostat | data-centric medicinal chemistry | immuno-oncology | INCB24360 | IDO1
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2018, Volume 158, pp. 286 - 297
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1481 - 1488
Indoleamine 2,3-dioxygenase 1 (IDO1), a tryptophan catabolising enzyme, is known as a tumour cell survival factor that causes immune escape in several types of... 
flavonoid | Sophora flavescens | IDO1 inhibitor | Indoleamine 2,3-dioxygenase 1 (IDO1) | Indoleamine 2 | GAMMA | CHEMISTRY, MEDICINAL | IDO | BIOCHEMISTRY & MOLECULAR BIOLOGY | ROOTS | RECEPTOR | 3-dioxygenase 1 (IDO1)
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 03/2018, Volume 39, Issue 3, pp. 307 - 325
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) catalyze the commitment step of the kynurenine (KYN) metabolic pathway.... 
KYN | AhR | immuno-oncology | TDO2 | KYNase | IDO1 | MALIGNANT GLIOMA | ARYL-HYDROCARBON RECEPTOR | DENDRITIC CELL IMMUNOGENICITY | INDOLEAMINE 2,3-DIOXYGENASE | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | INHIBITOR | EXPRESSION | 2,3-DIOXYGENASE 1 IDO1 | TRYPTOPHAN CATABOLISM | CUTTING EDGE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 13, pp. 3249 - 3254
For cancer cells to survive and proliferate, they must escape normal immune destruction. One mechanism by which this is accomplished is through immune... 
Kynurenine | Heme | Cancer | IDO1 | MECHANISM | heme | MULTIDISCIPLINARY SCIENCES | kynurenine | CELL-PROLIFERATION | TRYPTOPHAN CATABOLISM | DISCOVERY | 1 IDO1 INHIBITORS | SOLUBLE GUANYLYL CYCLASE | INFLAMMATION | DIOXYGENASE | cancer | BINDING | Immune response | Metabolites | Oncology, Experimental | Cancer cells | Physiological aspects | Oxidoreductases | Research | Biological Sciences | Physical Sciences
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2016, Volume 300, pp. 13 - 24
Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated. We showed... 
Aryl hydrocarbon receptor | Obesity | TLR2/TGFβ/PI3K/NF-κB/IDO1/AHR axis | α-Naphthoflavone and CH-223191 | Liver steatosis | TOLL-LIKE-RECEPTORS | METABOLIC SYNDROME | DENDRITIC CELLS | INDOLEAMINE 2,3-DIOXYGENASE | LOW-DENSITY-LIPOPROTEIN | DIOXIN RECEPTOR | TLR2/TGF beta/PI3K/NF-kappa B/IDO1/AHR axis | alpha-Naphthoflavone and CH-223191 | REGULATORY T-CELLS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NF-KAPPA-B | ADIPOSE-TISSUE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Signal Transduction | Kynurenine - biosynthesis | Mice, Inbred C57BL | Fatty Liver - prevention & control | Male | Toll-Like Receptor 2 - metabolism | Animals | Adiposity | Benzoflavones - pharmacology | Lipids - blood | Obesity - prevention & control | Intra-Abdominal Fat - drug effects | Mice | Azo Compounds - pharmacology | Diet, Western | Transforming Growth Factor beta - metabolism | Hepatocytes - drug effects | Lipoproteins, LDL | Pyrazoles - pharmacology | Index Medicus | KYNURENINE | TRYPTOPHAN | METABOLITES | QUINOLINES | 60 APPLIED LIFE SCIENCES | LUCIFERASE | GROWTH FACTORS | HYDROXY COMPOUNDS | INHIBITION | DIET | LIGANDS | METABOLISM | LIVER | LIVER CELLS | MICE | METABOLIC DISEASES | RECEPTORS | LIPOPROTEINS | Aryl Hydrocarbon Receptor | NF-κB | PI3K | TGFβ | AHR axis | TLR2 | IDO1
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2018, Volume 140, Issue 44, pp. 14538 - 14541
Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an important heme-containing enzyme that is a key drug target for cancer immunotherapy. Several hIDO1 inhibitors... 
CRYSTAL-STRUCTURES | MECHANISM | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | IDO1
Journal Article
Applied Immunohistochemistry and Molecular Morphology, ISSN 1541-2016, 2019, p. 1
Developments in genomic pathology have led to novel molecular classification schemes in gastric cancers. Two of these new subtypes, Epstein-Barr virus... 
WARS | gastric cancer | molecular subtype | IDO1
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
Journal Article
Phytomedicine, ISSN 0944-7113, 10/2019, Volume 63, p. 153055
Indoleamine 2,3-dioxygenase 1 (IDO1), an important intracellular rate-limiting enzyme in the development of Hepatic fibrosis (HF), and has been proposed as a... 
Hepatic fibrosis | Danshensu | JAK2-STAT3 signaling | IDO1
Journal Article
Immunity, ISSN 1074-7613, 02/2017, Volume 46, Issue 2, pp. 233 - 244
Journal Article
The FEBS Journal, ISSN 1742-464X, 01/2017, Volume 284, Issue 2, pp. 222 - 236
Influenza A viruses (IAVs) remain serious threats to public health because of the shortage of effective means of control. Developing more effective virus... 
influenza virus | innate immunity | interferon | indoleamine‐pyrrole 2,3‐dioxygenase (IDO1) | host–pathogen interaction | indoleamine-pyrrole 2,3-dioxygenase (IDO1) | host-pathogen interaction | CELLS | HUMAN MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | A VIRUS | RESPONSES | NS1 PROTEIN | INHIBITION | REPLICATION | SALIPHENYLHALAMIDE | EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Humans | Kynurenine - biosynthesis | Transcriptome | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Interferons - immunology | Influenza A Virus, H1N1 Subtype - growth & development | Tryptophan - metabolism | Lung - virology | Macrophages - virology | Metabolic Networks and Pathways - immunology | Female | Interferons - genetics | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Orthomyxoviridae Infections - drug therapy | Antiviral Agents - pharmacology | Orthomyxoviridae Infections - pathology | Gene Expression Regulation | Viral Nonstructural Proteins - genetics | Influenza A Virus, H1N1 Subtype - drug effects | Sulfonamides - pharmacology | Host-Pathogen Interactions | Metabolic Networks and Pathways - genetics | Pyrroles - pharmacology | Animals | Virus Replication | Kynurenine - antagonists & inhibitors | Lung - drug effects | Oximes - pharmacology | Macrophages - drug effects | Viral Nonstructural Proteins - metabolism | Mice | Mice, Inbred BALB C | Oxazoles - pharmacology | Thiazoles - pharmacology | Metabolic Networks and Pathways - drug effects | Primary Cell Culture | Orthomyxoviridae Infections - virology | Immunologic Factors - pharmacology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Lung - immunology | Orthomyxoviridae Infections - immunology | Influenza viruses | Influenza | Physiological aspects | Interferon | Biological response modifiers | T cells | Health aspects | Antibacterial agents | Viruses | Infections | Biosynthesis | Drugs | Lymphocytes T | Drug development | Macrophages | Antiinfectives and antibacterials | Lipopolysaccharides | Control | Pain | Bacteria | Attenuation | Inhibition | Public health | Antiviral agents | Dioxygenase | Pathogens | Hypersensitivity | Host-pathogen interactions | Replication | NS1 protein | Stimuli
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 11/2019, Volume 352, Issue 11, pp. e1900165 - n/a
A series of imidazole derivatives were designed following rational drug design, and synthesized through microwave‐assisted one‐pot multicomponent reactions.... 
imidazole | IDO1 inhibitors | microwave | one‐pot | one-pot | CHEMISTRY, MEDICINAL | INDOLEAMINE 2,3-DIOXYGENASE | CRYSTAL-STRUCTURES | PHARMACOLOGY & PHARMACY | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | 2,3-DIOXYGENASE 1 IDO1 | DISCOVERY
Journal Article
Oncotarget, ISSN 1949-2553, 07/2019, Volume 10, Issue 44, p. 4546
Treatment options and risk stratification for esophageal adenocarcinomas (EAC) currently rely on pathological criteria such as tumor staging. However, with... 
Journal Article