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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2001, Volume 276, Issue 30, pp. 28451 - 28458
Activation of the transcription factor NF-kappaB is necessary for full expression of tumor necrosis factor alpha (TNF-alpha)-inducible endothelial chemokines... 
ZINC FINGER PROTEIN | ADHESION | TRANSCRIPTIONAL ACTIVATION | INHIBITION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | E-SELECTIN | IKK-ALPHA | BETA | A20 | EPSILON | IKK2 protein | monocyte chemoattractant protein 1 | IKK1 protein
Journal Article
Journal of Computational and Theoretical Nanoscience, ISSN 1546-1955, 05/2016, Volume 13, Issue 5, pp. 2805 - 2810
Long non-coding RNAs (lncRNAs) form the largest class of non-protein coding genes in the human genome. While a small subset of well-characterized lncRNAs has... 
NF-κb | IKK1 | IKK2 | LncRNAs | Proteins | Binding | Ribonucleic acids | Computation | Mathematical analysis | Mathematical models | Nanostructure | Bioinformatics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2005, Volume 102, Issue 44, pp. 15977 - 15982
Repeated-epilation (Er) mutation in the mouse is inherited as an autosomal and semidominant mutation. Major defects in heterozygous adults and homozygous... 
Proteins | Biological Sciences | Epidermal cells | Genes | Genomics | Keratinocytes | Epidermis | Skin | Mice | Genetic mutation | Embryos | Genetics | Epidermal development | IKK1 | Stratifin | stratifin | epidermal development | genetics
Journal Article
by Li, QT and Lu, QX and Estepa, G and Verma, IM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 11/2005, Volume 102, Issue 44, pp. 15977 - 15982
Repeated-epilation (Er) mutation in the mouse is inherited as an autosomal and semidominant mutation. Major defects in heterozygous adults and homozygous... 
stratifin | SPECIFICITY | LENTIVIRUS VECTOR | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | epidermal development | IKK1 | FIBROBLASTS | genetics | STRUCTURAL BASIS | MICE | PROTEINS | EXPRESSION | EPIDERMAL MORPHOGENESIS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2002, Volume 277, Issue 13, pp. 10842 - 10851
Journal Article
Journal of visualized experiments : JoVE, ISSN 1940-087X, 11/2018, Issue 141
A class of extracellular stimuli requires activation of IKK1/alpha to induce generation of an NF-kappa B subunit, p52, through processing of its precursor... 
ACTIVATION | PHOSPHORYLATION | NF-KAPPA-B2 | MULTIDISCIPLINARY SCIENCES | Biochemistry | IKK-ALPHA | CRYSTALLOGRAPHY | molecular replacement | BETA | UBIQUITINATION | KINASE COMPLEX | IKK1/alpha | NF-kappa B | inhibitor | crystal structure | GENE-EXPRESSION | Serine-Threonine protein Kinase | Issue 141 | NF-KAPPA-B | Animals | Transfection | I-kappa B Kinase - chemistry | Humans | Insecta | Crystallization | Index Medicus
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 07/2000, Volume 14, Issue 14, pp. 1729 - 1733
NF-kappa B activity is induced by cytokines, stress, and pathogens. IKK1 and IKK2 are critical I kappa B kinases in NF-kappa B activation. In this study mice... 
IKK | NF-κB | Knockout | Apoptosis | Endothelium | NTD | knockout | endothelium | ACTIVATION | PHOSPHORYLATION | apoptosis | ALPHA | DEVELOPMENTAL BIOLOGY | BETA | KINASE COMPLEX | NF-kappa B | DISSOCIATION | GENETICS & HEREDITY | EMBRYONIC LETHALITY | COMPONENT | SKIN | SUBUNIT | IKK2 protein | lacZ gene | IKK1 protein | NF-^kB protein | Research Communication
Journal Article
Oncogene, ISSN 0950-9232, 03/2013, Volume 32, Issue 10, pp. 1223 - 1232
Kaposi's sarcoma-associated herpesvirus (KSHV) K13/vFLIP (viral Flice-inhibitory protein) induces transcription of numerous genes through NF-kappa B... 
AIDS | endothelial cells | KSHV | Kaposi's sarcoma | NF-kB | vFLIP/K13 | KSHV VFLIP | IKK-GAMMA | ENZYME A20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT GENE-EXPRESSION | A20 INTERACTS | CELL BIOLOGY | KINASE COMPLEX | UBIQUITIN CHAINS | NF-kappa B | ONCOLOGY | ENDOTHELIAL-CELLS | GENETICS & HEREDITY | ZINC-FINGER PROTEIN | TRANSCRIPTION FACTOR | Sarcoma, Kaposi - metabolism | Humans | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Viral Proteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Herpesvirus 8, Human - metabolism | Nuclear Proteins - biosynthesis | Tumor Necrosis Factor alpha-Induced Protein 3 | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | NF-kappa B - antagonists & inhibitors | Transduction, Genetic | Endothelial Cells - metabolism | Viral Proteins - genetics | Herpesvirus 8, Human - genetics | Nuclear Proteins - metabolism | Viral Proteins - antagonists & inhibitors | Sarcoma, Kaposi - virology | DNA-Binding Proteins - genetics | Intracellular Signaling Peptides and Proteins - biosynthesis | Sarcoma, Kaposi - pathology | Proteins - genetics | Animals | Proteins - metabolism | NF-kappa B - genetics | Endothelial Cells - cytology | Chemokine CXCL10 - secretion | Mice | Chemokine CXCL10 - metabolism | DNA-Binding Proteins - biosynthesis | Sarcoma, Kaposi - genetics | Index Medicus | Cell proliferation | Cytokines | Transcription | Inflammation | regulatory proteins | IKK1 protein | Endothelial cells | FLICE-inhibitory protein | NF- Kappa B protein | Transcription activation | IP-10 protein | Chemokines | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2003, Volume 278, Issue 52, pp. 52406 - 52411
The human herpes virus 8 (HHV8)-encoded viral FLICE inhibitory protein (vFLIP), also known as K13, is known to activate the NF-kappaB pathway, a property not... 
KINASE COMPLEX | APOPTOSIS | NUCLEAR-FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOMA-ASSOCIATED HERPESVIRUS | SEVERE LIVER DEGENERATION | INCONTINENTIA PIGMENTI | IKK-ALPHA | GAMMA-DEFICIENT MICE | PROTEASOME INHIBITOR | T-CELLS | NEMO protein | IKK2 protein | IKK1 protein | vFLIP protein
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2000, Volume 165, Issue 5, pp. 2719 - 2728
TNF-ru induced a dose- and time-dependent increase in cyclooxygenase-2 (COX-2) expression and PGE, formation in human NCI-H292 epithelial cells.... 
RESPONSE ELEMENT | GRANULOSA-CELLS | GENE | IKK-BETA SUBUNIT | NUCLEAR-FACTOR | PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE-2 | ENDOTHELIAL-CELLS | G/H SYNTHASE | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | TRANSCRIPTIONAL REGULATION | Prostaglandin-Endoperoxide Synthases - biosynthesis | Humans | Lung - enzymology | Protein-Tyrosine Kinases - physiology | Cell Nucleus - metabolism | Thiocarbamates - pharmacology | Protein Kinase C - metabolism | Estrenes - pharmacology | Phospholipase C gamma | NF-kappa B - antagonists & inhibitors | Protein Kinase C - physiology | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Benzoquinones | Membrane Proteins | Protein-Serine-Threonine Kinases - biosynthesis | Signal Transduction - drug effects | NF-kappa B - biosynthesis | Lung - drug effects | Epithelial Cells - enzymology | Tumor Necrosis Factor-alpha - physiology | Enzyme Activation - genetics | Staurosporine - pharmacology | Type C Phospholipases - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors | Epithelial Cells - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Cyclooxygenase 2 | Epithelial Cells - drug effects | Rifabutin - analogs & derivatives | Phosphatidylinositol Diacylglycerol-Lyase | Enzyme Induction - immunology | Type C Phospholipases - antagonists & inhibitors | Enzyme Activation - immunology | Pyrrolidines - pharmacology | Lactams, Macrocyclic | Signal Transduction - immunology | Isoenzymes - metabolism | Pyrrolidinones - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Lung - metabolism