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Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1019 - 1031
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major... 
C-REACTIVE PROTEIN | INFLAMMATORY-RESPONSE | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis | of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across | INTERLEUKIN-6 | RESPIRATORY-DISTRESS-SYNDROME | PREDICTION | species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI | ACUTE-PHASE RESPONSE | ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-kappa B induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation | BLOCKADE | INHIBITOR | SEVERITY | Phosphorylation | Humans | NF-kappa B - metabolism | Pancreatitis - complications | Receptors, Interleukin-8B - antagonists & inhibitors | Benzenesulfonates - pharmacology | Interleukin-6 - physiology | Pancreatitis - immunology | Acute Lung Injury - metabolism | Chemokine CXCL1 - metabolism | STAT3 Transcription Factor - metabolism | Acinar Cells - metabolism | Aminosalicylic Acids - pharmacology | Signal Transduction | Mice, Inbred C57BL | Pancreas - pathology | Mice, Transgenic | Acute Lung Injury - pathology | Interleukin-6 - secretion | Animals | Myeloid Cells - secretion | Receptors, Interleukin-8B - metabolism | Myeloid Cells - metabolism | Acute Lung Injury - immunology | Pancreatitis - pathology | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | Pancreatitis - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Acute Lung Injury - etiology | Receptors, Interleukin-6 - metabolism | Lung diseases | Pancreatitis | Genetic aspects | Research | Health aspects | Risk factors | Interleukin-6 | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
Gastroenterological Endoscopy, ISSN 0387-1207, 2015, Volume 57, Issue 4, pp. 1191 - 1196
Journal Article
Evaluation of the prognostic role of inflammatory markers: Tumor necrosis factor (TNF-a) and interleukin-6 (IL-6) - in patients with acute pancreatitis, 12/2003
Acute pancreatitis is one of the poorly understood common acute digestive tract disorders. It is not just difficult to diagnose, even the severity of the... 
Acute pancreatitis, IL-6, TNF-a
Journal
International Journal of Biological Sciences, ISSN 1449-2288, 2012, Volume 8, Issue 9, pp. 1237 - 1247
Journal Article
International Immunology, ISSN 0953-8178, 12/2007, Volume 19, Issue 12, pp. 1431 - 1440
Naive CD4+ T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for... 
IL-6 | Colitis
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 11/2019, Volume 82, pp. 145 - 159
Alzheimer’s disease (AD) is the most commonly diagnosed dementia but its underlying pathological mechanisms still unclear. Neuroinflammation and secretion of... 
IL-6 trans-signaling | Amyloidosis | Behavior | Alzheimer’s disease | Survival | IL-6
Journal Article
Pakistan Journal of Medical and Health Sciences, ISSN 1996-7195, 07/2018, Volume 12, Issue 3, pp. 1340 - 1342
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 05/2017, Volume 312, Issue 5, pp. E447 - E459
Cachexia is a debilitating condition that occurs with chronic disease, including cancer; our research has shown that some regulation of cancer cachexia... 
Inflammation | Ovariectomy | Apc | IL-6 | Cancer | cancer | inflammation | IL-6, ovariectomy | ApcMin
Journal Article
Journal Article
by Lokau and Schoeder and Haybaeck and Garbers
Cancers, ISSN 2072-6694, 11/2019, Volume 11, Issue 11, p. 1704
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It can be caused by chronic liver cell injury with resulting sustained... 
hcc | jak1 | stat3 | il-6
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 9/2017, Volume 16, Issue 9, pp. 1898 - 1908
Inflammation mediated by activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling is a major cause of chemotherapy... 
Stat3 | IL-6 receptor | pancreatic cancer | chemoresistance | IL-6
Journal Article
by Liang, Q and Liu, ZY and Zhu, C and Wang, B and Liu, XK and Yang, YA and Lv, X and Mu, HY and Wang, KJ
HEPATOLOGY, ISSN 0270-9139, 11/2018, Volume 68, Issue 5, pp. 1977 - 1990
T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T-cell receptor (TCR) immune repertoire is closely associated... 
GAMMA | PARTIAL-HEPATECTOMY | ACTIVATION | MECHANISM | REGIONS | STAT3 | IL-6/STAT3 | ALPHA | DEFICIENT MICE | GASTROENTEROLOGY & HEPATOLOGY | IL-6
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 2019, Volume 20, Issue 18
Our previous study suggested that the interleukin (IL)-6 and IL-10 could serve as good biomarkers for chronic inflammatory disease. We previously established... 
luciferase | anti-inflammation | IL-10 | IL-6
Journal Article
FASEB Journal, ISSN 0892-6638, 2015, Volume 29, Issue 5, pp. 1615 - 1628
Regular exercise reduces the risk for numerous chronic diseases. Exercise not only impacts the contracting skeletal muscle but also elicits systemic changes.... 
Myokines | CCL2 | ANGPTL4 | IL-6
Journal Article