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Journal of thoracic oncology, ISSN 1556-0864, 11/2018, Volume 13, Issue 11, pp. 1771 - 1775
Checkpoint inhibitors augment the immune system’s natural surveillance mechanisms and have increasing applications in NSCLC. Immunosuppressive corticosteroids... 
immuno-oncology | NSCLC | nivolumab | corticosteroids | Respiratory System | Oncology | Life Sciences & Biomedicine | Science & Technology
Journal Article
Annals of oncology, ISSN 0923-7534, 01/2018, Volume 29, Issue 1, pp. 84 - 91
Abstract Advances from immuno-oncology (IO) are changing the standard of care of many types of cancer, and the paradigm of cancer treatments and drug... 
Landscape analysis | Clinical trials | Cancer immunotherapy | Immuno-oncology | Tumor immunology | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - therapy | Clinical Trials as Topic | Antineoplastic Agents, Immunological - therapeutic use | Neoplasms - immunology | Humans | Index Medicus
Journal Article
by Gibbs, David L and Brown, Scott D and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Plaisier, Christopher L and Ziv, Elad and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Jianfang and Dhankani, Varsha and Reynolds, Sheila M and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Rao, Arvind and Hu, Hai and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Lamb, Andrew and Zhou, Wanding and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Rabkin, Charles S and Lazar, Alexander J and Serody, Jonathan S and Vincent, Benjamin G and Demchok, John A and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Lawrence, Michael S and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Chambwe, Nyasha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Kanchi, Rupa S and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Ryan, Michael and Zhang, Jiexin and Abeshouse, Adam and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gross, Benjamin E and Heins, Zachary J and La, Konnor and Ladanyi, Marc and Ochoa, Angelica and Phillips, Sarah M and Reznik, Ed and Sander, Chris and Sumer, S. Onur and Wang, Jioajiao and Zhang, Hongxin and Anur, Pavana and Stuart, Joshua M and Wong, Christopher K and Hayes, D. Neil and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity (Cambridge, Mass.), ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | Life Sciences & Biomedicine | Science & Technology | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | miRNA | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Index Medicus | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article
Oncotarget, ISSN 1949-2553, 02/2018, Volume 9, Issue 17, pp. 13593 - 13611
The adenosine receptor (AR) subtypes A2A and A2B are rhodopsin-like Gs protein-coupled receptors whose expression is highly regulated under pathological, e.g.... 
Receptor heteromerization | G protein-coupled receptor (GPCR) | Adenosine receptors (ARs) | Pharmacology | Immuno-oncology
Journal Article
Current oncology (Toronto), ISSN 1198-0052, 10/2018, Volume 25, Issue 5, pp. e373 - e384
Immunotherapy has emerged as a new standard of care, showing survival benefit for solid tumours in multiple disease sites and indications. The survival... 
Immuno-oncology | Life Sciences & Biomedicine | Oncology | Science & Technology | Original
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 10, Issue 2, pp. 209 - 215
Non-Small Cell Lung Cancer (NSCLC) patients with Epidermal Growth Factor Receptor (EGFR) mutation benefit from a first line of treatment with tyrosine kinase... 
EGFR mutation | Chemotherapy | NSCLC | Immuno-oncology | Immunotherapy
Journal Article
Annals of oncology, ISSN 0923-7534, 04/2018, Volume 29, Issue 4, pp. 812 - 824
Journal Article
Annals of oncology, ISSN 0923-7534, 12/2017, Volume 28, Issue 12, pp. 2977 - 2984
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 05/2017, Volume 8, Issue 5, pp. 486 - 491
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure... 
Epacadostat | data-centric medicinal chemistry | immuno-oncology | INCB24360 | IDO1
Journal Article
Oncoimmunology, ISSN 2162-402X, 05/2015, Volume 4, Issue 6, pp. e1008842 - e1008842
Melanoma is responsible for most skin cancer-related deaths and is one of the most common cancers diagnosed in young adults. In melanoma, tumors can become... 
melanoma | immuno-oncology | biomarker | Electrochemotherapy | ipilimumab | Biomarker | Immuno-oncology | Ipilimumab | Melanoma | Oncology | Immunology | Life Sciences & Biomedicine | Science & Technology
Journal Article
by Gupta, Rajarsi and Singh, Pankaj and Shroyer, Kenneth R and Zhao, Tianhao and Batiste, Rebecca and Rao, Arvind U.K and Lazar, Alexander J and Sharma, Ashish and Thorsson, Vésteinn and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Kim, Jaegil and Lawrence, Michael S and Meier, Sam and Noble, Michael S and Voet, Doug and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Reynolds, Sheila and Thorsson, Vesteinn and Akbani, Rehan and Broom, Bradley M and Kanchi, Rupa S and Korkut, Anil and Liang, Han and Ling, Shiyun and Lu, Yiling and Ng, Kwok-Shing and Ryan, Michael and Wang, Jing and Weinstein, John N and Zhang, Jiexin and Abeshouse, Adam and Armenia, Joshua and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Jianjiong and Gross, Benjamin E and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Nissan, Moriah G and Ochoa, Angelica and Reznik, Ed and Sanchez-Vega, Francisco and Schultz, Nikolaus and Sheridan, Robert and Sun, Yichao and Taylor, Barry S and Wang, Jioajiao and Benz, Christopher and Wong, Christopher K and Hayes, D. Neil and Parker, Joel S and Wilkerson, Matthew D and Chuah, Eric and Dhalla, Noreen and Lee, Darlene and Marra, Marco A and Moore, Richard A and Mungall, Andrew J and Mungall, Karen and Robertson, A. Gordon and Schein, Jacqueline E and Tam, Angela and Thiessen, Nina and Tse, Kane and Wong, Tina and Beroukhim, Rameen and Cherniack, Andrew D and Cibulskis, Carrie and Gao, Galen F and Ha, Gavin and Meyerson, Matthew and Schumacher, Steven E and Shih, Juliann and Kucherlapati, Raju S and Baylin, Stephen and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell reports (Cambridge), ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 181 - 193.e7
Journal Article