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Blood, ISSN 0006-4971, 03/2006, Volume 107, Issue 6, pp. 2409 - 2414
Abstract Interleukin-2 (IL-2) is historically known as a T-cell growth factor. Accumulating evidence from knockout mice suggests that IL-2 is crucial for the... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 09/2010, Volume 116, Issue 10, pp. 1726 - 1733
Abstract Natural killer (NK) cells are innate effector lymphocytes that control the growth of major histocompatibility complex class I negative tumors. We show... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 17, pp. 4008 - 4010
Abstract Considerable functional heterogeneity within human natural killer (NK) cells has been revealed through the characterization of distinct NK-cell... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 10, pp. 2752 - 2762
Abstract Type 17 programmed CD161hiCD8α+ T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 2, pp. 653 - 660
Abstract Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established by an encounter with... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 11/2007, Volume 110, Issue 9, pp. 3263 - 3270
Abstract Cysteinyl leukotrienes (cys-LTs) induce inflammation through 2 G protein–coupled receptors (GPCRs), CysLT1 and CysLT2, which are coexpressed by most... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 3, pp. 564 - 571
Abstract The Tec kinase Itk is critical for the development of αβ T cells as well as differentiation of CD4+ T cells into Th2 cells. Itk null mice have defects... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 12/2009, Volume 114, Issue 25, pp. 5182 - 5190
Abstract Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer cell functions. KIR genes are highly... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 02/2011, Volume 117, Issue 7, pp. 2189 - 2199
Abstract HIV infection can result in depletion of total CD4+ T cells and naive CD8+ T cells, and in the generation of dysfunctional effector CD8+ T cells. In... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 11/2017, Volume 130, Issue 21, pp. 2307 - 2316
Key Points Leniolisib, a novel, potent, selective oral PI3Kδ inhibitor was tested in patients with gain-of-function pathogenic variants in PIK3CD. Treatment... 
100 | Immunobiology and Immunotherapy
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 14, pp. 2669 - 2677
Key Points Mutations in GATA2 are a cause of human NK cell deficiency. GATA2 is required for human NK cell maturation, specifically maintenance of the... 
Immunobiology
Journal Article
Journal of Toxicologic Pathology, ISSN 0914-9198, 2017, Volume 30, Issue 2, pp. 111 - 123
[Abstract] : While an understanding of the structure and function of a generically described immune system is essential in contemporary biomedicine, it is... 
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 25, pp. 6361 - 6371
Abstract Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 04/2008, Volume 111, Issue 8, pp. 4273 - 4282
Abstract E3 ubiquitin ligases determine which intracellular proteins are targets of the ubiquitin conjugation pathway and thus play a key role in determining... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 02/2006, Volume 107, Issue 3, pp. 1063 - 1069
Bullous pemphigoid (BP) is an autoimmune disease associated with autoantibodies directed against the hemidesmosomal antigens anti-BP230 and anti-B180. Neonatal... 
Immunobiology
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 14, pp. 2818 - 2826
Abstract We analyzed the involvement of Wiskott-Aldrich syndrome protein (WASp), a critical regulator of actin cytoskeleton remodeling, in the control of... 
Immunobiology
Journal Article
1990, North and South American English-language ed., ISBN 0134561384, 168 p., [6] p. of plates
Book