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1. Full Text IL-2 administration increases CD4+CD25hi Foxp3 + regulatory T cells in cancer patients
by Ahmadzadeh, Mojgan and Rosenberg, Steven A
Blood, ISSN 0006-4971, 03/2006, Volume 107, Issue 6, pp. 2409 - 2414
Abstract Interleukin-2 (IL-2) is historically known as a T-cell growth factor. Accumulating evidence from knockout mice suggests that IL-2 is crucial for the... 
Immunobiology
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2. Full Text Human γδ T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement
by Maniar, Amudhan and Zhang, Xiaoyu and Lin, Wei and Gastman, Brian R and Pauza, C. David and Strome, Scott E and Chapoval, Andrei I
Blood, ISSN 0006-4971, 09/2010, Volume 116, Issue 10, pp. 1726 - 1733
Abstract Natural killer (NK) cells are innate effector lymphocytes that control the growth of major histocompatibility complex class I negative tumors. We show... 
Immunobiology
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3. Full Text Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22
by Hughes, Tiffany and Becknell, Brian and McClory, Susan and Briercheck, Edward and Freud, Aharon G and Zhang, Xiaoli and Mao, Hsiaoyin and Nuovo, Gerard and Yu, Jianhua and Caligiuri, Michael A
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 17, pp. 4008 - 4010
Abstract Considerable functional heterogeneity within human natural killer (NK) cells has been revealed through the characterization of distinct NK-cell... 
Immunobiology
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4. Full Text Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8α+ semi-invariant T cells
by Turtle, Cameron J and Delrow, Jeff and Joslyn, Rochelle C and Swanson, Hillary M and Basom, Ryan and Tabellini, Laura and Delaney, Colleen and Heimfeld, Shelly and Hansen, John A and Riddell, Stanley R
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 10, pp. 2752 - 2762
Abstract Type 17 programmed CD161hiCD8α+ T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces... 
Immunobiology
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5. Full Text Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-κB activation in dendritic cells
by Sen, Pradip and Wallet, Mark A and Yi, Zuoan and Huang, Yingsu and Henderson, Michael and Mathews, Clayton E and Earp, H. Shelton and Matsushima, Glenn and Baldwin Jr, Albert S and Tisch, Roland M
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 2, pp. 653 - 660
Abstract Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established by an encounter with... 
Immunobiology
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6. Full Text CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene-dependent mitogenic responses of mast cells
by Jiang, Yongfeng and Borrelli, Laura A and Kanaoka, Yoshihide and Bacskai, Brian J and Boyce, Joshua A
Blood, ISSN 0006-4971, 11/2007, Volume 110, Issue 9, pp. 3263 - 3270
Abstract Cysteinyl leukotrienes (cys-LTs) induce inflammation through 2 G protein–coupled receptors (GPCRs), CysLT1 and CysLT2, which are coexpressed by most... 
Immunobiology
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7. Full Text Enhanced development of CD4 + γδ T cells in the absence of Itk results in elevated IgE production
by Qi, Qian and Xia, Mingcan and Hu, Jianfang and Hicks, Elizabeth and Iyer, Archana and Xiong, Na and August, Avery
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 3, pp. 564 - 571
Abstract The Tec kinase Itk is critical for the development of αβ T cells as well as differentiation of CD4+ T cells into Th2 cells. Itk null mice have defects... 
Immunobiology
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8. Full Text Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine245
by Bari, Rafijul and Bell, Teresa and Leung, Wai-Hang and Vong, Queenie P and Chan, Wing Keung and Das Gupta, Neha and Holladay, Martha and Rooney, Barbara and Leung, Wing
Blood, ISSN 0006-4971, 12/2009, Volume 114, Issue 25, pp. 5182 - 5190
Abstract Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer cell functions. KIR genes are highly... 
Immunobiology
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9. Full Text mTORC2 deficiency in cutaneous dendritic cells potentiates CD8 + effector T cell responses and accelerates skin graft rejection
by Watson, Alicia R and Dai, Helong and Diaz-Perez, Julio A and Killeen, Meaghan E and Mathers, Alicia R and Thomson, Angus W
American Journal of Transplantation, ISSN 1600-6135, 03/2019, Volume 19, Issue 3, pp. 646 - 661
dermatology | immunosuppressant - mechanistic target of rapamycin (mTOR) | antigen presentation/recognition | cellular biology | immunobiology | dendritic cell | basic (laboratory) research/science
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10. Full Text Blockade of Extracellular HMGB1 Suppresses Xenoreactive B Cell Responses and Delays Acute Vascular Xenogeneic Rejection
by Li, J.-H and Zhao, B and Zhu, X.-H and Wang, L and Zou, H.-J and Chen, S and Guo, H and Ruan, Y.-L and Zheng, F and Xiang, Y and Ming, C.-S and Gong, F.-L and Chen, G
American Journal of Transplantation, ISSN 1600-6135, 08/2015, Volume 15, Issue 8, pp. 2062 - 2074
rejection: vascular | xenoantibody | innate immunity | Animal models: murine | immunobiology | xenotransplantation | basic (laboratory) research/science, heart transplantation/cardiology
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11. Full Text HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells
by Favre, David and Stoddart, Cheryl A and Emu, Brinda and Hoh, Rebecca and Martin, Jeffrey N and Hecht, Frederick M and Deeks, Steven G and McCune, Joseph M
Blood, ISSN 0006-4971, 02/2011, Volume 117, Issue 7, pp. 2189 - 2199
Abstract HIV infection can result in depletion of total CD4+ T cells and naive CD8+ T cells, and in the generation of dysfunctional effector CD8+ T cells. In... 
Immunobiology
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12. Full Text Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib
by Rao, V. Koneti and Webster, Sharon and Dalm, Virgil A. S. H and Šedivá, Anna and Van Hagen, P. Martin and Holland, Steven and Rosenzweig, Sergio D and Christ, Andreas D and Sloth, Birgitte and Cabanski, Maciej and Joshi, Aniket D and De Buck, Stefan and Doucet, Julie and Guerini, Danilo and Kalis, Christoph and Pylvaenaeinen, Ilona and Soldermann, Nicolas and Kashyap, Anuj and Uzel, Gulbu and Lenardo, Michael J and Patel, Dhavalkumar D and Lucas, Carrie L and Burkhart, Christoph
Blood, ISSN 0006-4971, 11/2017, Volume 130, Issue 21, pp. 2307 - 2316
Key Points Leniolisib, a novel, potent, selective oral PI3Kδ inhibitor was tested in patients with gain-of-function pathogenic variants in PIK3CD. Treatment... 
100 | Immunobiology and Immunotherapy
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13. Full Text Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset
by Mace, Emily M and Hsu, Amy P and Monaco-Shawver, Linda and Makedonas, George and Rosen, Joshua B and Dropulic, Lesia and Cohen, Jeffrey I and Frenkel, Eugene P and Bagwell, John C and Sullivan, John L and Biron, Christine A and Spalding, Christine and Zerbe, Christa S and Uzel, Gulbu and Holland, Steven M and Orange, Jordan S
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 14, pp. 2669 - 2677
Key Points Mutations in GATA2 are a cause of human NK cell deficiency. GATA2 is required for human NK cell maturation, specifically maintenance of the... 
Immunobiology
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14. Full Text The lymphoid system : a review of species differences
by Patrick J. Haley and Independent Consultant specializing in Immunotoxicology and Immunopathology
Journal of Toxicologic Pathology, ISSN 0914-9198, 2017, Volume 30, Issue 2, pp. 111 - 123
[Abstract] : While an understanding of the structure and function of a generically described immune system is essential in contemporary biomedicine, it is... 
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15. Full Text IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and γδ T cells in vivo
by Do, Jeong-Su and Min, Booki
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 25, pp. 6361 - 6371
Abstract Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under... 
Immunobiology
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16. Full Text Itch-/- αβ and γδ T cells independently contribute to autoimmunity in Itchy mice
by Parravicini, Valentino and Field, Anne-Christine and Tomlinson, Peter D and Basson, M. Albert and Zamoyska, Rose
Blood, ISSN 0006-4971, 04/2008, Volume 111, Issue 8, pp. 4273 - 4282
Abstract E3 ubiquitin ligases determine which intracellular proteins are targets of the ubiquitin conjugation pathway and thus play a key role in determining... 
Immunobiology
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17. Full Text Differential roles for β2 integrins in experimental autoimmune bullous pemphigoid
by Liu, Zhi and Zhao, Minglang and Li, Ning and Diaz, Luis A and Mayadas, Tanya N
Blood, ISSN 0006-4971, 02/2006, Volume 107, Issue 3, pp. 1063 - 1069
Bullous pemphigoid (BP) is an autoimmune disease associated with autoantibodies directed against the hemidesmosomal antigens anti-BP230 and anti-B180. Neonatal... 
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18. Full Text Impaired NK-cell migration in WAS/XLT patients: Role of Cdc42/WASp pathway in the control of chemokine-induced β2 integrin high-affinity state
by Stabile, Helena and Carlino, Claudia and Mazza, Cinzia and Giliani, Silvia and Morrone, Stefania and Notarangelo, Lucia D and Notarangelo, Luigi D and Santoni, Angela and Gismondi, Angela
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 14, pp. 2818 - 2826
Abstract We analyzed the involvement of Wiskott-Aldrich syndrome protein (WASp), a critical regulator of actin cytoskeleton remodeling, in the control of... 
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19. Immunology
: a foundation text
by Davey, Basiro and Open University
1990, North and South American English-language ed., ISBN 0134561384, 168 p., [6] p. of plates
physiology | Immunity | Immunology
Book