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Gynecologic Oncology, ISSN 0090-8258, 09/2017, Volume 146, Issue 3, pp. 484 - 490
Indoleamine 2,3-dioxygenase-1 (IDO1) is a key regulator of immune tolerance in ovarian cancer. This study investigated efficacy and safety of the IDO1 enzyme... 
Epacadostat | IDO1 enzyme inhibitor | Tamoxifen | Ca-125 | Ovarian cancer | SURVIVAL | DIAGNOSIS | PROTEIN | PROGNOSIS | INDOLEAMINE 2,3-DIOXYGENASE | OBSTETRICS & GYNECOLOGY | ONCOLOGY | IMMUNOTHERAPY | EXPRESSION | T-CELLS | Recurrence | Neoplasms, Glandular and Epithelial - chemistry | Oximes - pharmacokinetics | Oximes - adverse effects | Peritoneal Neoplasms - blood | Humans | Middle Aged | Oximes - therapeutic use | Response Evaluation Criteria in Solid Tumors | Fatigue - chemically induced | Peritoneal Neoplasms - chemistry | Antineoplastic Agents, Hormonal - adverse effects | Early Termination of Clinical Trials | Fallopian Tube Neoplasms - blood | Neoplasms, Glandular and Epithelial - blood | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - chemistry | Exanthema - chemically induced | Antineoplastic Agents, Hormonal - therapeutic use | Adult | Female | Ovarian Neoplasms - drug therapy | Pruritus - chemically induced | Fallopian Tube Neoplasms - drug therapy | Drug Eruptions - etiology | Ovarian Neoplasms - chemistry | CA-125 Antigen - blood | Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis | Ovarian Neoplasms - blood | Survival Rate | Sulfonamides - pharmacokinetics | Disease-Free Survival | Sulfonamides - therapeutic use | Tamoxifen - therapeutic use | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Sulfonamides - adverse effects | Aged | Tamoxifen - adverse effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Care and treatment | Chemotherapy | Enzyme inhibitors | Cancer | Medical research | Medicine, Experimental
Journal Article
Immunology, ISSN 0019-2805, 10/2015, Volume 146, Issue 2, pp. 292 - 300
Summary Indoleamine 2,3‐dioxygenase (IDO) is expressed in antigen‐presenting cells and exerts immunosuppressive effects on CD4+ T cells. One mechanism is... 
fatty acid | indoleamine 2,3‐dioxygenase | general control non‐derepressible 2 kinase | acetyl coenzyme A carboxylase 1 | T cells | ATP‐citrate lyase | Indoleamine 2,3-dioxygenase | Acetyl coenzyme A carboxylase 1 | Fatty acid | ATP-citrate lyase | General control non-derepressible 2 kinase | SURVIVAL | GCN2 | TOLERANCE | INDUCTION | IMMUNOLOGY | GLYCOLYSIS | AMINO-ACID | INHIBITION | METABOLISM | ARYL-HYDROCARBON RECEPTOR | general control non-derepressible 2 kinase | indoleamine 2,3-dioxygenase | EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Cell Proliferation | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Lymphocyte Activation | Down-Regulation | Humans | Cells, Cultured | CD4-Positive T-Lymphocytes - enzymology | Lymphocyte Culture Test, Mixed | Mechanistic Target of Rapamycin Complex 1 | CD4-Positive T-Lymphocytes - immunology | Gene Expression Regulation, Enzymologic | Multiprotein Complexes - metabolism | Tryptophan - deficiency | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Differentiation | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Fatty Acids - biosynthesis | Enzymes | Cell growth | T cell receptors | Dehydrogenases | Kinases | Lymphocytes | Original
Journal Article
Scientific Reports, 12/2016, Volume 6, p. 38308
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0118562 - e0118562
Dendritic cells (DC) interact with naive T cells to regulate the delicate balance between immunity and tolerance required to maintain immunological... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IN-VITRO | NOD MICE | INHIBITION | ARYL-HYDROCARBON RECEPTOR | NONOBESE DIABETIC MICE | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | 2,3-DIOXYGENASE | TRYPTOPHAN CATABOLISM | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Signal Transduction | Monocytes - cytology | Vaccines, Subunit - genetics | Dendritic Cells - immunology | Humans | Monocytes - metabolism | NF-kappa B - metabolism | Proinsulin - genetics | Proteome | Gene Expression Profiling | Vaccines, Subunit - immunology | Cholera Toxin - genetics | Proteomics | Cholera Toxin - immunology | Cell Differentiation | Dendritic Cells - cytology | Dendritic Cells - metabolism | Cluster Analysis | Proinsulin - immunology | Autoimmunity | Enzymes | Dendritic cells | Type 1 diabetes | Vaccination | Physiological aspects | Tryptophan | Protein biosynthesis | Cholera | Vaccines | Cholera toxin | T cells | Disease | Mucosa | Bar codes | Hydrocarbons | Biochemistry | Immunity | Proteins | Hyperglycemia | Inhibition | Fusion protein | Public health | Cholera toxin B subunit | NF-κB protein | Dioxygenase | Antigens | Cytokines | Toxin b | Insulin | Immunological tolerance | Immunosuppression | Protein synthesis | Water-borne diseases | Homeostasis | Lymphocytes T | Diabetes mellitus (insulin dependent) | Infections | Biosynthesis | Kinases | Inoculation | Immunology | Lymphocytes | Pancreas | Immune system | Degradation products | Maturation | Therapeutic applications | Diabetes mellitus | Inflammation | Pharmacology | Medicine | Monocytes | Diabetes | Autoimmune diseases | Dendritic structure | Health disparities | Index Medicus
Journal Article
Microbiology and Immunology, ISSN 0385-5600, 02/2018, Volume 62, Issue 2, pp. 71 - 79
Journal Article