Journal of Reproductive Immunology, ISSN 0165-0378, 2017, Volume 119, pp. 54 - 60
Highlights • Decrease expression of IDO on the endothelial cells was associated with preeclampsia. • Lower IDO expression was correlated with hypertension or...
Obstetrics and Gynecology | Indoleamine 2 | 3-Dioxygenase | Placenta | Preeclampsia | Fetal growth restriction | PREVENTION | IMMUNOLOGY | TRYPTOPHAN CATABOLISM | RECURRENT SPONTANEOUS-ABORTION | REPRODUCTIVE BIOLOGY | ALLOGENEIC FETAL REJECTION | INTERFERON-GAMMA | IDO | INFLAMMATION | GROWTH-FACTOR | 2,3-DIOXYGENASE | RECEPTOR-1 | Hypertension | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Trophoblasts - metabolism | Endothelial Cells - metabolism | Down-Regulation | Humans | Stromal Cells - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Chorionic Villi - metabolism | Fetal Growth Retardation - immunology | Pregnancy | Endothelial Cells - ultrastructure | Stromal Cells - ultrastructure | Placenta - pathology | Adult | Female | Retrospective Studies | Pre-Eclampsia - immunology | Proteinuria | Endothelium | Tyrosine | Enzymes | Growth | Tryptophan | Fetus
Obstetrics and Gynecology | Indoleamine 2 | 3-Dioxygenase | Placenta | Preeclampsia | Fetal growth restriction | PREVENTION | IMMUNOLOGY | TRYPTOPHAN CATABOLISM | RECURRENT SPONTANEOUS-ABORTION | REPRODUCTIVE BIOLOGY | ALLOGENEIC FETAL REJECTION | INTERFERON-GAMMA | IDO | INFLAMMATION | GROWTH-FACTOR | 2,3-DIOXYGENASE | RECEPTOR-1 | Hypertension | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Trophoblasts - metabolism | Endothelial Cells - metabolism | Down-Regulation | Humans | Stromal Cells - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Chorionic Villi - metabolism | Fetal Growth Retardation - immunology | Pregnancy | Endothelial Cells - ultrastructure | Stromal Cells - ultrastructure | Placenta - pathology | Adult | Female | Retrospective Studies | Pre-Eclampsia - immunology | Proteinuria | Endothelium | Tyrosine | Enzymes | Growth | Tryptophan | Fetus
Journal Article
Pathology - Research and Practice, ISSN 0344-0338, 09/2018, Volume 214, Issue 9, pp. 1309 - 1314
This study was to test hypotheses that indoleamine 2, 3-dioxygenase and B7-H1 expressions can be used as prognostic markers in human pancreatic carcinoma (PC)....
Human | B7-H1 | Pancreatic carcinoma | Prognosis | IDO | MECHANISM | INDUCE | PATHOLOGY | SUPPRESSION | TUMORS | IMMUNE EVASION | COLORECTAL-CANCER | GROWTH | 2,3-DIOXYGENASE | T-CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Follow-Up Studies | Biomarkers, Tumor - analysis | Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Young Adult | B7-H1 Antigen - biosynthesis | Adolescent | Adult | Female | Aged | B7-H1 Antigen - analysis | Pancreatic Neoplasms - mortality | Retrospective Studies | Immunohistochemistry | Carcinoma | Diabetes | Pancreatic cancer | Analysis | Cancer
Human | B7-H1 | Pancreatic carcinoma | Prognosis | IDO | MECHANISM | INDUCE | PATHOLOGY | SUPPRESSION | TUMORS | IMMUNE EVASION | COLORECTAL-CANCER | GROWTH | 2,3-DIOXYGENASE | T-CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Follow-Up Studies | Biomarkers, Tumor - analysis | Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Young Adult | B7-H1 Antigen - biosynthesis | Adolescent | Adult | Female | Aged | B7-H1 Antigen - analysis | Pancreatic Neoplasms - mortality | Retrospective Studies | Immunohistochemistry | Carcinoma | Diabetes | Pancreatic cancer | Analysis | Cancer
Journal Article
CARCINOGENESIS, ISSN 0143-3334, 01/2013, Volume 34, Issue 1, pp. 163 - 169
Cyclooxygenase 2 (COX2) is overexpressed in 80% of colon adenocarcinomas. However, the mechanism leading to aberrant COX2 expression in tumors is unclear....
CYCLOOXYGENASE-2 GENE-EXPRESSION | TRANSCRIPTIONAL ACTIVITY | ONCOLOGY | PROSTAGLANDIN-E SYNTHASE-1 | INDOLEAMINE 2,3-DIOXYGENASE | INTESTINAL TUMORIGENESIS | VASCULAR ENDOTHELIAL-CELLS | COX-2 INHIBITORS | UP-REGULATION | NF-KAPPA B | HUMAN COLORECTAL-CANCER
CYCLOOXYGENASE-2 GENE-EXPRESSION | TRANSCRIPTIONAL ACTIVITY | ONCOLOGY | PROSTAGLANDIN-E SYNTHASE-1 | INDOLEAMINE 2,3-DIOXYGENASE | INTESTINAL TUMORIGENESIS | VASCULAR ENDOTHELIAL-CELLS | COX-2 INHIBITORS | UP-REGULATION | NF-KAPPA B | HUMAN COLORECTAL-CANCER
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2009, Volume 123, Issue 1, pp. 239 - 248
Background Indoleamine 2, 3-dioxygenase (IDO), a tryptophan-degrading enzyme in dendritic cells (DCs), mediates an immunosuppressive effect on activated T...
Allergy and Immunology | asthma | dendritic cells | Der p 1 | IDO | T H2 cells | 2 cells | GAMMA | TH2 RESPONSES | T(H)2 cells | TRANSPLANT TOLERANCE | ALLERGEN | DERMATOPHAGOIDES-PTERONYSSINUS | IMMUNOLOGY | IN-VITRO | ALLERGY | REGULATORY T-CELLS | 2,3-DIOXYGENASE GENE | EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Cysteine Endopeptidases | Gene Expression Regulation, Enzymologic - drug effects | Asthma - enzymology | Dendritic Cells - immunology | Humans | Cells, Cultured | Male | Antigens, Dermatophagoides - pharmacology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Up-Regulation - drug effects | Antigens, Dermatophagoides - immunology | Interleukin-4 - immunology | Arthropod Proteins | Up-Regulation - immunology | Dendritic Cells - enzymology | T-Lymphocytes, Helper-Inducer - immunology | Interferon-gamma - immunology | T-Lymphocytes, Helper-Inducer - enzymology | Asthma - immunology | Tumor Necrosis Factor-alpha - immunology | Female | Gene Expression Regulation, Enzymologic - immunology | Enzymes | Antitubercular agents | Universities and colleges | Dendritic cells | T cells | Asthma | Studies | Cytokines | Lymphocytes | Cloning | Experiments | Allergies
Allergy and Immunology | asthma | dendritic cells | Der p 1 | IDO | T H2 cells | 2 cells | GAMMA | TH2 RESPONSES | T(H)2 cells | TRANSPLANT TOLERANCE | ALLERGEN | DERMATOPHAGOIDES-PTERONYSSINUS | IMMUNOLOGY | IN-VITRO | ALLERGY | REGULATORY T-CELLS | 2,3-DIOXYGENASE GENE | EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Cysteine Endopeptidases | Gene Expression Regulation, Enzymologic - drug effects | Asthma - enzymology | Dendritic Cells - immunology | Humans | Cells, Cultured | Male | Antigens, Dermatophagoides - pharmacology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Up-Regulation - drug effects | Antigens, Dermatophagoides - immunology | Interleukin-4 - immunology | Arthropod Proteins | Up-Regulation - immunology | Dendritic Cells - enzymology | T-Lymphocytes, Helper-Inducer - immunology | Interferon-gamma - immunology | T-Lymphocytes, Helper-Inducer - enzymology | Asthma - immunology | Tumor Necrosis Factor-alpha - immunology | Female | Gene Expression Regulation, Enzymologic - immunology | Enzymes | Antitubercular agents | Universities and colleges | Dendritic cells | T cells | Asthma | Studies | Cytokines | Lymphocytes | Cloning | Experiments | Allergies
Journal Article
Journal of Experimental and Clinical Cancer Research, 02/2019, Volume 38, Issue 1
Journal Article
Journal of Cancer, ISSN 1837-9664, 2019, Volume 10, Issue 1, pp. 267 - 276
Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in tryptophan (Trp) metabolism, is generally considered to be an immunosuppressive molecule....
Indoleamine 2 | Prognosis | Radical resection | Lung cancer | 3-dioxygenase | KYNURENINE | CELLS | 2,3-DIOXYGENASE EXPRESSION | ANTITUMOR-ACTIVITY | prognosis | lung cancer | INHIBITION | ONCOLOGY | ARYL-HYDROCARBON RECEPTOR | COLORECTAL-CANCER | radical resection | Indoleamine 2,3-dioxygenase | TRYPTOPHAN DEGRADATION | DISEASE PROGRESSION
Indoleamine 2 | Prognosis | Radical resection | Lung cancer | 3-dioxygenase | KYNURENINE | CELLS | 2,3-DIOXYGENASE EXPRESSION | ANTITUMOR-ACTIVITY | prognosis | lung cancer | INHIBITION | ONCOLOGY | ARYL-HYDROCARBON RECEPTOR | COLORECTAL-CANCER | radical resection | Indoleamine 2,3-dioxygenase | TRYPTOPHAN DEGRADATION | DISEASE PROGRESSION
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2016, Volume 305, pp. 167 - 171
Abstract Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection that may affect the brain. We investigated the role...
Neurology | Allergy and Immunology | Sepsis | Indoleamine 2,3-dioxygenase 1/2 | Energetic metabolism | Cognitive impairment | TRYPTOPHAN | OXIDATIVE STRESS | MOUSE | MODEL | IMMUNOLOGY | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | ENCEPHALOPATHY | CECAL LIGATION | INFLAMMATION | BRAIN | PERFORATION | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Sepsis - etiology | Rats, Wistar | Sympathomimetics - pharmacology | Cognition Disorders - metabolism | Male | Sepsis - complications | Hippocampus - drug effects | p-Hydroxyamphetamine - therapeutic use | Cognition Disorders - prevention & control | Cognition Disorders - etiology | Exploratory Behavior - drug effects | Statistics, Nonparametric | Energy Metabolism - physiology | Histocompatibility Antigens - metabolism | Disease Models, Animal | Inhibition (Psychology) | Sympathomimetics - therapeutic use | Rats | p-Hydroxyamphetamine - pharmacology | Hippocampus - metabolism | Animals | Injections, Intra-Articular | Avoidance Learning - drug effects | Energy Metabolism - drug effects | Sepsis - microbiology | Physiological aspects | Brain
Neurology | Allergy and Immunology | Sepsis | Indoleamine 2,3-dioxygenase 1/2 | Energetic metabolism | Cognitive impairment | TRYPTOPHAN | OXIDATIVE STRESS | MOUSE | MODEL | IMMUNOLOGY | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | ENCEPHALOPATHY | CECAL LIGATION | INFLAMMATION | BRAIN | PERFORATION | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Sepsis - etiology | Rats, Wistar | Sympathomimetics - pharmacology | Cognition Disorders - metabolism | Male | Sepsis - complications | Hippocampus - drug effects | p-Hydroxyamphetamine - therapeutic use | Cognition Disorders - prevention & control | Cognition Disorders - etiology | Exploratory Behavior - drug effects | Statistics, Nonparametric | Energy Metabolism - physiology | Histocompatibility Antigens - metabolism | Disease Models, Animal | Inhibition (Psychology) | Sympathomimetics - therapeutic use | Rats | p-Hydroxyamphetamine - pharmacology | Hippocampus - metabolism | Animals | Injections, Intra-Articular | Avoidance Learning - drug effects | Energy Metabolism - drug effects | Sepsis - microbiology | Physiological aspects | Brain
Journal Article
Bioscience, Biotechnology and Biochemistry, ISSN 0916-8451, 2017, Volume 81, Issue 5, pp. 966 - 971
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2018, Volume 13, Issue 3, p. e0193737
Aims Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated...
CELLS | ABDOMINAL AORTIC-ANEURYSMS | MODELS | ELASTASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ATHEROSCLEROSIS | EXPRESSION | LESIONS | Aortic Aneurysm, Abdominal - chemically induced | Myocytes, Smooth Muscle - pathology | Diet, High-Fat - adverse effects | Male | Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency | Receptors, LDL - deficiency | Angiotensin II - adverse effects | T-Lymphocytes - pathology | Myocytes, Smooth Muscle - cytology | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Macrophages - pathology | Cell Survival | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Macrophages - cytology | Muscle, Smooth, Vascular - cytology | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | T-Lymphocytes - cytology | T-Lymphocytes - immunology | Mice | Apoptosis | Proteolipids | Lipoproteins | Rattus | Rats | Physiological aspects | Aortic aneurysms | Genetic aspects | Research | Blood lipoproteins | Health aspects | Ketogenic diet
CELLS | ABDOMINAL AORTIC-ANEURYSMS | MODELS | ELASTASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ATHEROSCLEROSIS | EXPRESSION | LESIONS | Aortic Aneurysm, Abdominal - chemically induced | Myocytes, Smooth Muscle - pathology | Diet, High-Fat - adverse effects | Male | Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency | Receptors, LDL - deficiency | Angiotensin II - adverse effects | T-Lymphocytes - pathology | Myocytes, Smooth Muscle - cytology | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Macrophages - pathology | Cell Survival | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Macrophages - cytology | Muscle, Smooth, Vascular - cytology | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | T-Lymphocytes - cytology | T-Lymphocytes - immunology | Mice | Apoptosis | Proteolipids | Lipoproteins | Rattus | Rats | Physiological aspects | Aortic aneurysms | Genetic aspects | Research | Blood lipoproteins | Health aspects | Ketogenic diet
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1
gamma delta T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human gamma delta T lymphocytes...
ENCEPHALOMYELITIS | RESPONSES | CYTOKINE ANALYSIS | INHIBITION | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | DELTA T-CELLS | STROMAL CELLS | CYTOTOXICITY | LYMPHOCYTE-PROLIFERATION
ENCEPHALOMYELITIS | RESPONSES | CYTOKINE ANALYSIS | INHIBITION | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | DELTA T-CELLS | STROMAL CELLS | CYTOTOXICITY | LYMPHOCYTE-PROLIFERATION
Journal Article
BioImpacts, ISSN 2228-5652, 2019, Volume 9, Issue 1, pp. 1 - 3
Trafficking of macromolecular immunotherapy agent into the tumor microenvironment (TME) is a challenging issue. In the TME, cancer cells exploit indoleamine 2,...
Indoleamine 2 | IDO inhibitor | Cancer therapy | Immunotherapy | Kynurenine | Solid tumors | 3-dioxygenase | Indoleamine 2, 3-dioxygenase
Indoleamine 2 | IDO inhibitor | Cancer therapy | Immunotherapy | Kynurenine | Solid tumors | 3-dioxygenase | Indoleamine 2, 3-dioxygenase
Journal Article
Molecular medicine reports, 04/2018, Volume 17, Issue 4, p. 4867
Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the degradation pathway of the essential amino acid tryptophan and is...
Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Neoplasms - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - chemistry | Disease Susceptibility | Neoplasms - etiology | Signal Transduction | Immunomodulation | Humans | Gene Expression Regulation | Immune Tolerance | Molecular Targeted Therapy | Immunity | Neoplasms - drug therapy | Animals | Enzyme Activation | Neoplasms - pathology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors
Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Neoplasms - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - chemistry | Disease Susceptibility | Neoplasms - etiology | Signal Transduction | Immunomodulation | Humans | Gene Expression Regulation | Immune Tolerance | Molecular Targeted Therapy | Immunity | Neoplasms - drug therapy | Animals | Enzyme Activation | Neoplasms - pathology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors
Journal Article
Cancer Science, ISSN 1347-9032, 06/2007, Volume 98, Issue 6, pp. 874 - 881
Foxp3+ CD4+CD25+ regulatory T (Treg) cells and immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) play an important role in immunoregulation....
DENDRITIC-CELLS | INTERFERON-GAMMA | ONCOLOGY | POOR-PROGNOSIS | TRANSCRIPTION FACTOR FOXP3 | OVARIAN-CANCER | 2,3-DIOXYGENASE EXPRESSION | PROGNOSTIC VALUE | TRYPTOPHAN CATABOLISM | IDO EXPRESSION | TUMOR-IMMUNITY | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Gene Expression | Uterine Cervical Neoplasms - enzymology | Humans | Gene Expression Regulation | Uterine Cervical Neoplasms - immunology | Uterine Cervical Neoplasms - pathology | Lymphatic Metastasis | Disease Progression | T-Lymphocytes, Regulatory - immunology | Cervical Intraepithelial Neoplasia - enzymology | Forkhead Transcription Factors - metabolism | Female | Cervical Intraepithelial Neoplasia - immunology | Lymphocytes, Tumor-Infiltrating - immunology | T cells | Development and progression | Cervical cancer
DENDRITIC-CELLS | INTERFERON-GAMMA | ONCOLOGY | POOR-PROGNOSIS | TRANSCRIPTION FACTOR FOXP3 | OVARIAN-CANCER | 2,3-DIOXYGENASE EXPRESSION | PROGNOSTIC VALUE | TRYPTOPHAN CATABOLISM | IDO EXPRESSION | TUMOR-IMMUNITY | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Gene Expression | Uterine Cervical Neoplasms - enzymology | Humans | Gene Expression Regulation | Uterine Cervical Neoplasms - immunology | Uterine Cervical Neoplasms - pathology | Lymphatic Metastasis | Disease Progression | T-Lymphocytes, Regulatory - immunology | Cervical Intraepithelial Neoplasia - enzymology | Forkhead Transcription Factors - metabolism | Female | Cervical Intraepithelial Neoplasia - immunology | Lymphocytes, Tumor-Infiltrating - immunology | T cells | Development and progression | Cervical cancer
Journal Article
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, ISSN 1449-1907, 2019, Volume 16, Issue 8, pp. 1107 - 1115
Astragalus membranaceus has been shown to possess anti-inflammation and antitumor properties. Several studies have indicated that extracts of Astragalus...
RESVERATROL | PROTEIN | PROTECTION | JUNCTIONAL INTERCELLULAR COMMUNICATION | SALMONELLA | CHEMOPREVENTION | Connexin 43 | Combination therapy | MEDICINE, GENERAL & INTERNAL | CONNEXIN-43 | INHIBITION | Indoleamine 2, 3-dioxygenase | PG2 | Astragalus membranaceus
RESVERATROL | PROTEIN | PROTECTION | JUNCTIONAL INTERCELLULAR COMMUNICATION | SALMONELLA | CHEMOPREVENTION | Connexin 43 | Combination therapy | MEDICINE, GENERAL & INTERNAL | CONNEXIN-43 | INHIBITION | Indoleamine 2, 3-dioxygenase | PG2 | Astragalus membranaceus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2017, Volume 139, Issue 34, pp. 11887 - 11894
3-Substituted 2-oxindoles are important structural motifs found in many biologically active natural products and pharmaceutical lead compounds. Here, we report...
ENANTIOSELECTIVE SYNTHESIS | MECHANISM | 2ND ENZYME | CRYSTAL-STRUCTURE | INDOLEAMINE 2,3-DIOXYGENASE | PYRROLNITRIN BIOSYNTHETIC-PATHWAY | TUMORAL IMMUNE RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | SUBSTRATE RECOGNITION | SPIROOXINDOLES | INSIGHTS
ENANTIOSELECTIVE SYNTHESIS | MECHANISM | 2ND ENZYME | CRYSTAL-STRUCTURE | INDOLEAMINE 2,3-DIOXYGENASE | PYRROLNITRIN BIOSYNTHETIC-PATHWAY | TUMORAL IMMUNE RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | SUBSTRATE RECOGNITION | SPIROOXINDOLES | INSIGHTS
Journal Article
Immunology, ISSN 0019-2805, 02/2008, Volume 123, Issue 2, pp. 263 - 271
Summary The effects of immunostimulatory RNAs (isRNAs) on the expression of immuno‐suppressive factors are largely unknown. Indoleamine 2,3‐dioxygenase (IDO)...
indoleamine 2, 3‐dioxygenase | 2′‐modified RNA | siRNA | dendritic cells | Toll‐like receptors | Toll-like receptors | Dendritic cells | 2′-modified RNA | Indoleamine 2, 3-dioxygenase | IMMUNITY | CYTOKINES | IFN-GAMMA | TOLERANCE | INNATE | SUBSETS | INDUCTION | IMMUNOLOGY | SUPPRESSION | 2'-modified RNA | 3-dioxygenase | indoleamine 2 | INTERFERING RNA | 2,3-DIOXYGENASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Dendritic Cells - immunology | Humans | Cells, Cultured | Phytohemagglutinins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Cell Differentiation - immunology | Monocytes - enzymology | Signal Transduction - immunology | Toll-Like Receptor 8 - immunology | Lymphocyte Activation - immunology | STAT1 Transcription Factor - metabolism | RNA, Small Interfering - immunology | Dendritic Cells - enzymology | Toll-Like Receptor 7 - immunology | Adult | Ligands | T-Lymphocytes - immunology | Original | indoleamine 2, 3-dioxygenase
indoleamine 2, 3‐dioxygenase | 2′‐modified RNA | siRNA | dendritic cells | Toll‐like receptors | Toll-like receptors | Dendritic cells | 2′-modified RNA | Indoleamine 2, 3-dioxygenase | IMMUNITY | CYTOKINES | IFN-GAMMA | TOLERANCE | INNATE | SUBSETS | INDUCTION | IMMUNOLOGY | SUPPRESSION | 2'-modified RNA | 3-dioxygenase | indoleamine 2 | INTERFERING RNA | 2,3-DIOXYGENASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Dendritic Cells - immunology | Humans | Cells, Cultured | Phytohemagglutinins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Cell Differentiation - immunology | Monocytes - enzymology | Signal Transduction - immunology | Toll-Like Receptor 8 - immunology | Lymphocyte Activation - immunology | STAT1 Transcription Factor - metabolism | RNA, Small Interfering - immunology | Dendritic Cells - enzymology | Toll-Like Receptor 7 - immunology | Adult | Ligands | T-Lymphocytes - immunology | Original | indoleamine 2, 3-dioxygenase
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 05/2017, Volume 81, Issue 5, pp. 966 - 971
Ferulic acid (FA) is a phenol compound found in plants that has anti-inflammatory properties. Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan catabolic...
ferulic acid | inflammation | microglia | indoleamine 2, 3-dioxygenase, tryptophan | Biomarkers - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Microglia - cytology | Cell Line | Gene Expression Regulation, Enzymologic - drug effects | Microglia - metabolism | Microglia - drug effects | RNA, Messenger - genetics | NF-kappa B - metabolism | RNA, Messenger - metabolism | Tryptophan - metabolism | Animals | MAP Kinase Signaling System - drug effects | Lipopolysaccharides - pharmacology | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Coumaric Acids - pharmacology | Index Medicus
ferulic acid | inflammation | microglia | indoleamine 2, 3-dioxygenase, tryptophan | Biomarkers - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Microglia - cytology | Cell Line | Gene Expression Regulation, Enzymologic - drug effects | Microglia - metabolism | Microglia - drug effects | RNA, Messenger - genetics | NF-kappa B - metabolism | RNA, Messenger - metabolism | Tryptophan - metabolism | Animals | MAP Kinase Signaling System - drug effects | Lipopolysaccharides - pharmacology | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Coumaric Acids - pharmacology | Index Medicus
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 05/2019, Volume 10, p. 452
Depression is an incapacitating neuropsychiatric disorder. The serotonergic system in the brain plays an important role in the pathophysiology of depression....
LIPID-PEROXIDATION | KYNURENINE PATHWAY | INDOLEAMINE 2,3-DIOXYGENASE | quinolinic acid | MAJOR DEPRESSION | TERT-BUTYLHYDROQUINONE | serotonin | TRANSCRIPTION FACTOR NRF2 | Nrf2 | MOUSE MODEL | PHARMACOLOGY & PHARMACY | depression | STRIATAL NEURONS | oxidative stress | tryptophan | BRAIN | Depression, Mental
LIPID-PEROXIDATION | KYNURENINE PATHWAY | INDOLEAMINE 2,3-DIOXYGENASE | quinolinic acid | MAJOR DEPRESSION | TERT-BUTYLHYDROQUINONE | serotonin | TRANSCRIPTION FACTOR NRF2 | Nrf2 | MOUSE MODEL | PHARMACOLOGY & PHARMACY | depression | STRIATAL NEURONS | oxidative stress | tryptophan | BRAIN | Depression, Mental
Journal Article
Oncogene, ISSN 0950-9232, 05/2008, Volume 27, Issue 20, pp. 2851 - 2857
Agents that interfere with tumoral immune tolerance may be useful to prevent or treat cancer. Brassinin is a phytoalexin, a class of natural products derived...
Tryptophan | Targeted therapeutics | INDO | Tumoral immune tolerance | IDO | Immunotherapy | CANCER CHEMOPREVENTIVE ACTIVITY | SULFUR-CONTAINING PHYTOALEXINS | DENDRITIC CELLS | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREVENTION | SSP PEKINENSIS CRUCIFERAE | CABBAGE | TRYPTOPHAN CATABOLISM | CELL BIOLOGY | ONCOLOGY | immunotherapy | GENETICS & HEREDITY | tumoral immune tolerance | EXPRESSION | targeted therapeutics | tryptophan | T-CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - chemistry | Melanoma, Experimental - enzymology | Melanoma, Experimental - drug therapy | Mice, Inbred C57BL | Cercopithecus aethiops | Mice, Transgenic | Structure-Activity Relationship | Animals | Thiocarbamates - pharmacology | Mice, Nude | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Mice | COS Cells | Mammary Neoplasms, Experimental - enzymology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Mammary Neoplasms, Experimental - drug therapy | Care and treatment | Enzyme inhibitors | Phytoalexin | Genetic aspects | Dosage and administration | Research | Health aspects | Cancer | Oncology | Antibiotics
Tryptophan | Targeted therapeutics | INDO | Tumoral immune tolerance | IDO | Immunotherapy | CANCER CHEMOPREVENTIVE ACTIVITY | SULFUR-CONTAINING PHYTOALEXINS | DENDRITIC CELLS | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREVENTION | SSP PEKINENSIS CRUCIFERAE | CABBAGE | TRYPTOPHAN CATABOLISM | CELL BIOLOGY | ONCOLOGY | immunotherapy | GENETICS & HEREDITY | tumoral immune tolerance | EXPRESSION | targeted therapeutics | tryptophan | T-CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - chemistry | Melanoma, Experimental - enzymology | Melanoma, Experimental - drug therapy | Mice, Inbred C57BL | Cercopithecus aethiops | Mice, Transgenic | Structure-Activity Relationship | Animals | Thiocarbamates - pharmacology | Mice, Nude | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Mice | COS Cells | Mammary Neoplasms, Experimental - enzymology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Mammary Neoplasms, Experimental - drug therapy | Care and treatment | Enzyme inhibitors | Phytoalexin | Genetic aspects | Dosage and administration | Research | Health aspects | Cancer | Oncology | Antibiotics
Journal Article